Effervescent Tablets Research Articles

Availability of Authorizations from EMA and FDA for Age-Appropriate Medicines Contained in the WHO Essential Medicines List for Children 2019.

Lack of age-appropriate commercially drug products availability is a common problem in pediatric therapeutics; this population needs improved and safer drug delivery. In addition, biopharmaceutic aspects, dosage requirements, and swallowing abilities demand pediatric forms different to adult formulations. The objective of this study was to evaluate the authorization availability from United States Food and Drug Administration (FDA) and European Medicines Agency (EMA) of oral essential medicines for children and analyze its age-appropriateness for oral administration in children. All oral drugs from 7th List of Essential Medicines for Children by World Health Organization (WHO) were selected. Availability of commercial drug products was collected from OrangeBook, Spanish drug product catalogue, British electronic Medicines Compendium, and the International Vademecum. Tablets, effervescent tablets, and capsules were considered as not age-appropriate forms. Liquid forms, powder for oral suspension, mini tablets, granules, and soluble films were considered as age-appropriate forms due to their flexibility. More than 80% of the studied drugs possess a commercial authorization in oral forms in both EMA and FDA. Nevertheless, around 50% of these formulations are not age-appropriate for most pediatric groups. This study shows the lack of age-appropriate medicines for children. More efforts are needed to improve development and approval of pediatric medicines.

Pengembangan Ekstrak Etanol Buah Pepino (Solanum Muricatum Aiton) dalam Bentuk Granul Effervescent dengan Variasi Bahan Pengikat

The aim of the investigation is to obtain a good preparations of effervescent granules of ethanol extract of pepino fruit (Solanum muricatum Aiton) based on parameter of flowability and repose angle, density, moisture content, loss on drying and dispersibility. Maceration method and ethanol 96% as the solvent is use to obtain the extract of pepino fruit (Solanum muricatum Aiton). There are three formula design of effervescent granules formula 1,2 and 3 each of which in variation of binder PVP K30 2%, 4% and 6% (w/w). The granules is obtain by wet granulation method in which ethanol extract of pepino fruit as the active ingredient. Results of evaluation showed that angle of repose range from 33.425-34.352o while flowability range from 5.84-6.66 g/second. Bulk density range from 0.519-0.570 g/ml, tap density 0.552-0.53 g/ml, true density 0.2005-1.22 g/ml. Uji porositas berkisar 6.36-44.609 % while the dispersibility range from 1.407-1.477 gram/second. Based on the results can be concluded that all granules possess good properties pharmaceutically.

FORMULATION AND EVALUATION OF GREWIATENAX FRUITS AS EFFERVESCENT TABLETS FOR TREATMENT OF IRON DEFICIENCY ANEMIA

Grewiatenax fruits as nutritional supplement are being widely used in traditional medicine in most parts of Sudan to treat anemic patients. This study was conducted to specify the most productive method for extractingG. tenax fruits and to standardize and formulate the extract into effervescent tablets. The fruits were extracted by hot and cold extraction with maceration using 80%, 65%, and 50% ethanol strength and the extracts were standardized. Two formulae (F1 and F2) were prepared from the extract and compressed into tablets. The formulated tablets were subjected for quality control tests. The 80% ethanol extract showed the highest extract yield and iron contents comparing to other extracts. The formulated tablets of both formulae showed good quality and pass all quality control tests.G. tenax fruitsextract could be pharmaceutically formulated into tablets which exhibited good quality control.To maximize yield value ofG. tenax fruitsextract, maceration method using 80% ethanol strength is of paramount importance.

Protective effect of N-acetylcysteine on oxaliplatin-induced neurotoxicity in patients with colorectal and gastric cancers: A randomized, double blind, placebo-controlled, clinical trial.

Neuropathy is one of the most prevalent and dose-limiting side effects of platinum chemotherapeutic agents. N-acetylcysteine is an antioxidant thiol which is able to increase whole blood concentration of glutathione, which may be protective against chemotherapy-induced neuropathy. The aim of this study was to evaluate the effect of N-acetylcysteine on neurotoxicity induced by oxaliplatin in patients with gastric or colorectal cancers. During this randomized, double-blinded, placebo-controlled clinical trial, the preventive effect of N-acetylcysteine effervescent tablets was assessed in comparison with placebo, on neuropathy occurrence. Thirty-two patients with colorectal or gastric cancer randomly received N-acetylcysteine (two 600 mg tablets) or placebo tablets 1 h before receiving oxaliplatin in dose in XELOX (oxaliplatin and capecitabine regimen) for eight courses of chemotherapy. Neuropathy severity was assessed after eight courses of chemotherapy based on National Cancer Institute Common Terminology for Adverse Events (NCI-CTCAE) criteria neuropathy grading scale and also sensory and motor electrophysiological assessment was performed by a neurologist. The NCI-CTCAE scale grade of patients in intervention group was significantly lower than placebo group after eight course of oxaliplatin (P = 0.01); however, the sensory electrophysiological assessment result was not significantly different (P = 0.501). No patient in both group had motor electrophysiological changes. The results of this study showed that N-acetylcysteine could reduce the incidence of the neuropathy induced by oxaliplatin and delay its occurrence in patients with gastric or colorectal cancers.

Effect of Denture Cleansing Solutions on the Retention of Locator Attachments Over Time

To evaluate and compare the alterations in retention of three Locator attachments after immersion in various denture cleansers at defined time intervals. Two implants were embedded in an acrylic block. Pink, blue, and clear Locator attachments (n = 10 for each subgroup) were immersed into three different cleansing solutions (Corega, Protefix and NaOCl) and tap water (control) at different time intervals that simulate 1 (T1 ), 6 (T2 ) and 12 (T3 ) months of clinical use. Universal testing machine set at a crosshead speed of 50 mm/min was used for pull-out tests. After the immersion procedure, the peak force to dislodgement was recorded to demonstrate the changes in retention of Locator attachments. Data were analyzed using repeated-measures ANOVA followed by Tukey's Honestly Significant Difference (HSD) tests (α = .05). All denture cleansing solutions affected the retentive values of all Locator attachments at defined time intervals (F = 4.299, p = 0.001). NaOCl affected all groups significantly after 12-month immersion time (p = 0.001). The least retention loss at all subgroups was observed in Corega for clear Locator attachments (106.17 ±5.21 N). The difference in retention values for pink attachments were not statistically significant for tap water, Protefix and Corega immersion at all time intervals (p > 0.05). Following NaOCl (blue; 33.31 ±4.72 N, clear; 52.3 ±8.5 N), tap water decreased the retention value of blue (41.14 ±3.93 N) and clear (76.72 ±8.42 N) Locator attachments at T3 . Corega caused the least retention loss to clear attachments at T1 (106.17 ±3.55 N). The retention of Locator attachments decreases over time after exposure to various denture cleansing solutions. As NaOCl significantly decreased the retentive values of all attachments, patients must be informed about that disadvantage. Also, tap water remarkably decreased retentive ability of all attachments. Periodic addition of an effervescent tablet into tap water may be recommended to patients that wear implant retained overdentures with Locator attachments. This article is protected by copyright. All rights reserved.

English

This paper seeks to investigate how students’ performance in Chemistry can be enhanced by using kitchen resources in Calabar. The kitchen resources used included a piece of white paper, a swab, lemon juice and candle. These were used to show that paper cellulose was oxidized by flame due to the catalysis of lemon juice acid. Other materials used were empty bottles of water, a balloon, a teaspoon, a glass, vinegar and sodium bicarbonate to inflate balloons without blowing. Volcano being made with a large glass, water, liquid dye, oil, effervescent tablet and a lantern was to demonstrate immiscibility, and carbon dioxide was formed because of effervescent tablet dissolution. The sample comprised 50 students drawn from two secondary schools in Ikom Education Zone of Cross River State. Two instruments were used to collect data: Chemistry Interest Questionnaire (CIQ) and Chemistry Achievement Test (Cat). Cronbach was used to establish reliability for CIQ and was found to be 078. Richardson formula 21 was used to establish reliability for Cat, 0.83. The research used a mixed design (quasi experimental and survey design). Data obtained were analyzed using independent t-test and Pearson product moment correlation coefficient. The results gave a significant t test of 4.96 and positive r =0.90 at 0.05 alpha level. The null hypothesis was not accepted which stated that there is no significant relationship between students' interest when taught with and without kitchen resources. The second null hypothesis with regard to Chemistry interest and academic achievement was also not accepted. Teachers are encouraged to use kitchen resources in the teaching of Chemistry to foster interest which will lead to high academic performance. Key words: Kitchen resources, academic achievement, interest students, teachers.

Rapid Extraction and Analysis of Volatile Solutes with an Effervescent Tablet.

Extraction of volatile compounds from complex liquid matrices is a critical step in volatile compound analysis workflows. Recently, green chemistry principles are increasingly implemented in extraction processes. Some of the available approaches are solvent-free but still require concentration or trapping of analytes. Here, we propose effervescent tablet-induced extraction (ETIE) as a method of transferring volatile/semivolatile compounds from liquid matrices to the gas phase for analysis. This technique relies on the release of carbon dioxide produced in situ during a neutralization reaction, which occurs when a tablet is inserted into an aqueous sample matrix. In this process, many bubbles of carbon dioxide are instantly formed in the sample matrix. The bubbles rapidly extract and liberate volatile compounds from the sample. The gaseous effluent is then immediately transferred to a detector (atmospheric pressure chemical ionization mass spectrometry (MS) or gas chromatography (GC) hyphenated with MS). ETIE-GC-MS can be used for analysis of volatile compounds present in real samples. The method was validated for analysis of selected ethyl esters present in a yogurt drink. The calibration data set was linear over a range from 5 × 10-7 to 1 × 10-5 M. The limits of detection ranged from 1.51 × 10-7 to 6.82 × 10-7 M, while the recoveries ranged from 71 to 118%. Inter- and intraday precision of selected ethyl esters in aqueous solution was satisfactory (relative standard deviation, 3.6-18.3%). Furthermore, it is shown that ETIE improves the performance of headspace solid-phase microextraction while eliminating the need for heating and shaking samples.

A systematic review on the clinical experience with melevodopa/carbidopa fixed combination in patients with Parkinson disease

We have performed a systematic literature review to evaluate the current evidence of the pharmacokinetic (PK), efficacy and safety profile of oral melevodopa/carbidopa fixed combination in the management of motor fluctuations in patients with Parkinson disease (PD). Search has been started from common libraries and was then restricted to articles of studies in humans with melevodopa/carbidopa as fixed combination. Abstracts of international congresses have been also explored. The search has led to the identification of one PK study and five efficacy/safety studies that included more 743 PD patients overall, 488 of which treated with melevodopa/carbidopa effervescent tablets (Sirio®, Chiesi Farmaceutici S.p.A., Parma, Italy). Melevodopa/carbidopa has a more rapid absorption, less apparent drug accumulation, less inter-patient variability and more effective LD delivery after the early morning and early afternoon dose compared to standard LD. Although they differed in used dose regimens, duration of treatment and endpoints, the results of the efficacy/safety studies suggest that treatment with melevodopa/carbidopa may determine improvements in motor fluctuations compared to treatment with standard LD/CD formulations, with no increased risk of adverse effects or LD-induced dyskinesias. Data from literature have shown that melevodopa/carbidopa in a highly soluble formulation as effervescent oral tablets is effective in improving control of motor complications in PD patients compared to conventional levodopa. Further research is needed to confirm this evidence in large controlled trials and to explore if melevodopa/carbidopa may have a potential role in the earlier phases of the disease or in special PD populations.

Formulation of Effervescent Granule from Robusta Green Coffee Bean Ethanolic Extract (Coffea canephora).

ABSTRACTIntroduction:Robusta coffee (Coffea canephora) is one of the many crops cultivated in Aceh, and at present is only being used as a drink. Research has shown the potential of many pharmacological uses for coffee, including its use as a remedy to treat diabetes. Effervescent granules are one of the oral dosage forms that can not only mask the unpleasant taste of bioactive substances, but also have a high aesthetic value and can contain relatively large doses of bioactive substances. Previous research has shown that ethanolic extract of robusta green coffee beans at 100 mg/kg body weight (BW) rat yielded the highest percentage of glucose reduction. On the basis of that research, the dosage was used in this study to be formulated into effervescent granule.Aims:This study aimed to find the best formulation of effervescent granules preparation using various concentrations of effervescent salt that meets the general requirements of effervescent dosage forms. The concentrations of citric acid, tartaric acid, and sodium bicarbonate used in sequence were 7.35%, 14.7%, and 25% (F1); 8.08%, 16.17%, and 27.5% (F2); and 8.82%, 17.64%, and 30% (F3), respectively. Robusta green coffee beans were extracted using the maceration method.Results:Secondary metabolite screening of extract showed that it contained alkaloid, saponin, phenolic, and flavonoid metabolites. Effervescent granules were evaluated and F1 and F2 did not qualify the flowability standard of the granules, whereas F3 qualified in all the evaluation standards.Conclusion:On the basis of these results, F3 produced the best effervescent granules that met the general standards of the effervescent dosage forms.

Physical Properties of the Probiotic Effervescent Tablet from Tapioca and Maltodextrin Coatings

The purpose of this study was to determine the physical properties of probiotic effervescent tablets with two different coatings that are tapioca and maltodextrin to improve water quality in shrimp farming ponds. This study used probiotics to improve the environmental quality of shrimp pond waters. Liquid probiotics from Research Institute for Coastal Aquaculture in Maros, South Sulawesi that containBrevibacillus laterosporus. Probiotics that have been used are liquid and difficult to transport, therefore microencapsulation is carried out on liquid probiotics aimed at facilitating their distribution. The use of microencapsulating materials is to entrap or immobilize probiotic bacteria within microcapsule and to protect the bacteria during the drying process. Effervescent tablets were prepared in a dosage of 800 mg by wet granulation methods. This experiment was replicated 3 times. Tablets were evaluated for their physical properties there are mean weight, friability, hardness, disintegration time and pH. The results showed that mean weight for effervescent tablets with maltodextrin coatings was 796 mg, had a friability value 0.09%, a hardness value of 13.7 N and disintegration time of 10.68 minutes. Both probiotic effervescent tablets meet the standards pH of 7.07 and 6.67. The maltodextrin coatings was the best treatment of this study.

Physical Characteristics of Probiotic Effervescent Tablets with Various Concentration of Maltodextrin as Coating Materials

The application of RICA (Research Institute for Coastal Aquaculture) liquid probiotic bacteria proved to be able to prevent attacks of both types of vibriosis disease and White Spot Syndrome Virus (WSSV) through improved pond water quality. This RICA liquid probiotics is coated using maltodextrin with 3 variations of concentration which are then formed into probiotic effervescent tablets. Apart from making it easy to distribute, this solid probiotic is easily applied without fermentation such as the use of liquid probiotics. The aims of this study was to determine the physical characteristics of probiotic effervescent tablets from maltodextrin coatings with different concentration. The concentration maltodextrin as coating materials were is 20%, 30% and 40% (b/v). The parameters test are average weight, friability, hardness and disintegration time. The results showed that the effervescent tablets of probiotics with a concentration of maltodextrin 40% had a mean weight higher than other concentrations at 798.88 mg. While the effervescent tablets of probiotic with a maltodextrin concentration of 20% had a lower friability and disintegration time compared to other concentrations of 0.05% and 12.96 minutes. And has a higher level of hardness that is equal to 10.89 N compared to other concentrations that is 30% and 40% concentration maltodextrin. The concentration of 20% maltodextrin was the best treatment of this study.

Effect of Iles-Iles (Amorphophallus oncophyllus) Synbiotic Effervescent Tablet to Decrease in Blood Sugar Levels in Hyperglycemic White Rat (Rattus norvegicus)

This study aims to determine the effect of giving Iles-iles synbiotic effervescent tablets to decrease blood sugar levels of hyperglycemic white rats and find out the lowest dose of effervescent tablets in decreasing blood sugar levels. This study used the Completely Randomized Design (CRD) with single factor (dose of Iles-iles synbiotic effervescent tablet) with 4 levels (dose 0.045 gram/day (½ normal dose), dose 0.09 gram/day (normal dose), dose 0.18 gram/day (2X normal dose) and Control (without treatment dose). The analysis carried out was blood sugar levels and rat body weight. The administration of Iles-iles synbiotic effervescent tablets can reduce blood sugar levels in white mice but does not affect changes in the weight of white mice. The biggest decrease in blood sugar levels in white rats for synbiotic month was obtained from the administration of a dose of 0.18 grams/day (normal 2X dose) which was as much as 49.16% The administration of effervescent tablets in the fourth week with a normal dose of 0.09 grams/200 grams of weight has been able to reduce blood sugar levels in white rats to normal levels. 

Unos natrijuma putem lekova - upozorenje pri lečenju kardiovaskularnih bolesti

Introduction: Hypertension is a condition which represents one of the main risk factors for the development of cardiovascular diseases. High sodium intake contributes to occurrence of hypertension, increasing the volume of extracellular fluid. Therefore, World Health Organization (WHO) and other associations involved with hypertension research advise to decrease intake of sodium. Effervescent dosage forms usually contain high levels of sodium which could lead to above mentioned health issues. Aim: The aim of this study was to evaluate the levels of sodium in the effervescent dosage forms available in the Serbian drug market. Methods: Data about sodium levels, and excipients was obtained from Summary of Product Characteristics from website of Medicines and Medical Devices Agency of Serbia (ALIMS). Maximum daily doses recommended by the manufacturer and approved by ALIMS were observed. Exposure to sodium through consumption of maximum daily doses was calculated as percentages of the adequate daily intake given by Food and Nutrition Board (Institute of Medicine, National Academies, Washington D.C., USA), and also as percentage of recommended daily intake of sodium given by WHO. Results: There are five formulations with exposure to sodium through consumption of maximum daily doses higher than 100% of the adequate daily intake (2 g), all of which are effervescent tablet formulations. The highest exposure to sodium was found in effervescent tablets containing acetylsalycic acid (500 mg) as active pharmaceutical ingredient: 250.62 % for people aged 51 to 70 years; 271.50 % for people aged 70 and older. Conclusion: In effervescent dosage forms available on Serbian market, level of sodium can be very high, even up to 271.50% of adequate daily intake when maximum daily doses are consumed. Major cause for concern is for vascular patients who use effervescents for chronic therapy. This data should be considered during prescribing and dispensing this category of medicines as well as during analyzing pharmacovigilance.

Research and Exploration on the Process of mangosteen Compound Effervescent Tablets

This article mainly studies a new type of compound effervescent tablet for hot pot soup base, which is made of mangosteen as the main material, adding mangosteen glycoside and kumquat to improve the taste, and adding starch slurry and PEG-6000 as a granulating agent. A single factor test was used to select the optimal level of each factor, the sensory score was used as the response value, and the response surface analysis method was used to optimize the formulation of the compound effervescent tablet, and the moisture absorption rate and sensory condition of the finished tablet after several days of placement were determined. The results showed that the optimized main formula of mangosteen compound effervescent tablets was: mangosteen powder 5.3%, kumquat powder 1.3%, mangosteen glycoside 1.3%, effervescent disintegrant 90.7%, of which citric acid: bicarbonate Sodium is 1.6:1. In this process, starch slurry and PEG-6000 are used as the granulation agent for the semi-dry tableting method. The composite effervescent tablet prepared after drying at 50°C for 3 hours is sweet and sour, rich in special aroma, short in foaming time, and has the lowest moisture absorption rate. The sensory score was 94.96 points.

In Vitro Antimicrobial Activity of Choline Effervescent Tablets against Some Pathogenic Bacteria and Fungi

In Vitro Antimicrobial Activity of Choline Effervescent Tablets against Some Pathogenic Bacteria and Fungi

Characterization of Physical and Chemical Properties of Effervescent Tablets Temulawak (Curcuma zanthorrhiza) in the Various Proportion of Sodium Bicarbonate and Tartaric Acid

The purpose of this study was to determine the effect of comparative treatment of the proportion of Sodium bicarbonate and tartaric acid on the physical and chemical properties of effervescent tablets temulawak, as well as knowing the proportions of sodium bicarbonate and tartaric acid right to produce a good effervescent tablets temulawak. The research method uses a single completely randomized design namely the ratio of sodium bicarbonate: tartaric acid, (F1 = 2.0: 2.5; F2 = 2.5: 2.0; F3 = 3.0; 1.3; F4 = 3 , 5: 1,0, and F5 = 4.0: 0.5y). each treatment was repeated 3 (three) times. The resulted data were analyzed by ANOVA test. The results showed that the proportion of sodium bicarbonate and tartaric acid significantly affected color lightness, hardness, hygroscopicity, solubility times, water content, ash content, and not significantly affect viscosity and pH. The right proportion of sodium bicarbonate acid tartaric acid for making effervescent tablets temulawak is A1 treatment (proportion of sodium bicarbonate and tartaric acid 2.0: 2.5) with the attributes of water content of 66.72%, hardness of 2.20 kg, hygroscopicity of 25.43 g, solubility times of 35 seconds, viscosity 1.75 MPa.S, water content 1.19%, ash content 3.10%, and pH = 5.1.

In Vitro Antimicrobial Activity of Chlorine Effervescent Tablets against Some Pathogenic Bacteria and Fungi

In Vitro Antimicrobial Activity of Chlorine Effervescent Tablets against Some Pathogenic Bacteria and Fungi

海藻酵素苏打泡腾片制备方法的研究

海藻酵素苏打泡腾片制备方法的研究

Evaluating the Clinical Application Value of Ferric Citrate Effervescent Granules (FAC) in Magnetic Resonance Cholangio-Pancreatography (MRCP) Inspection

Objective: Assessing the clinical application value of Ferric Citrate Effervescent granules (FAC) in magnetic resonance cholangio-pancreatography (MRCP) inspection. Methods: We invited 10 patients who were diagnosed with diseases of the pancreas system and bile duct system and undergoing magnetic resonance cholangio-pancreatography and use Ferric Citrate Effervescent granules in the MRCP process. The time of their MRCP is from May 2018 to February 2020. In addition, we collected the information from the participants, that the information included Sequence and scanning parameters of Mr Cholangiopancreatography, Image quality score before and after MRCP administration, contrast to noise ratio (CNR) score and comparison score of different parts in MRCP images before and after drug administration. Result: In scanning parameters, the data is standard in research, that the TR and TE of 2d MRCP and 3D MRCP are similar, that are > 6000 and > 500. But Layer thickness/Layer spacing between the objects had big gap in data, that are 50/0 and 1.8/0. Additionally, FOV had little different length, which is 40 vs 36. In NEX, they are same. In image quality score, it has higher score after taking the FAC. The CNR score research is similar, that FAC affect the CNR outcome. Conclusion: the FAC provide the improvement to the outcome of patient in MRCP process, that it improves image quality of MRCP.

COMPRESSIVE STRENGTH OF ACRYLIC RESIN PLATE AFTER IMMERSING IN DENTURE CLEANSHER ALGA CHOCOLATE

Background:Immersion of acrylic resin plates in effervescent granules of 10% sargassum policystum as denture cleansher can inhibit the growth of Streptococcus Mutansand Candida Albicans.It is not yet known whether the resin can cause changes in compressive strength after immersion. Aims:To determinethechanges in compressive strength of acrylic resin plates after immersionin denture cleansherof 10% SargassumPolicystum. Method:This laboratory experimental study used acrylic samples with a size of 25mm × 15 mm × 2 mm totaling 18 pieces. The sample were divided into 3 groups, SodiumPerboratgroups, Sargassum policystum10% effervescentgranules groupsand aquadestgroups.Immersion is carried out atroom temperature with a immersiontime of 4.8, and 12 hours. Compressive strength is measured using Universal Testing Mechine after immersion. The statistical tests used are the ANOVATest and the LSD Test. Results:There was a decrease in the strength of the acrylic resin plate after being immersed in denture cleanshercleansher of 10% SargassumPolicystum, but it was not statistically significant.Conclusion: Immersion of acrylic resin plate in denture cleansher of 10% SargassumPolicystumdoes not reduce compressive strength of acrylic resin plates.