Introduction. The quality of life and health in the young population is the main component that determines the potential of the country. Study in this area is necessary to determine the adequacy of medical care, as well as the effectiveness of therapeutic and preventive measures. Purpose. Assessment of the quality of life in the young population of Astrakhan region suffering from chronic diseases. Materials and methods. The article presents the results of a study of the quality of life of the young population of the city of Astrakhan, suffering from chronic diseases. The study involved 18–44 year four hundred one resident of Astrakhan. Russian version of questionnaire SF-36 was used as the main method for assessing the quality of life in the study group. Results. In general, the quality of life in young residents of Astrakhan suffering from chronic diseases is average. The physical and social activity of respondents does not decrease, according to the results of the analysis of the physical and psychological components of health. There is a decrease in daily activity, depending on the physical condition in participants with pathologies of the genitourinary system, the hematopoietic system, the respiratory and the circulatory system. Analysis of life activity, daily activity, depending on the emotional background, social functioning, as well as the mental health of respondents, regardless of pathology, showed average values. Research limitations. The limiting factors in the study are the age composition of the study group, the set of factors studied, structure of the diseases, regional characteristics. The study did not involve patients with disabilities, as well as those suffering from severe diseases. Conclusion. The results of the study are applicable in practical healthcare to improve the quality of management and conduct of medical examinations, preventive medical examinations and dispensary observation of the population; training of personnel in the field of prevention of non-communicable diseases and the formation of a healthy lifestyle.