The generation and transmutation process of the transplutoniums in the conversion chains for 252cf production is calculated and analyzed. The production and conversion efficiency of the chains with different target nuclides and neutron spectrums including fast, thermal and moderated neutron spectrums is computed. The conversion paths for 252cf under different neutron spectrums and neutron flux levels are analyzed. The multi-group depletion program STEP1.0 based on linear chain method is used to calculate the nuclide densities. The model of the reactor is simulated by the transport-burnup coupling system based on the STEP1.0 and MCMG-II for the detailed description of the target designs in the fast reactor. The differences of the conversion efficiency caused by the neutron spectrums can be qualified more accurately with the multi-group cross section calculations. The higher conversion efficiency than the typical thermal neutron spectrum can be obtained by some moderated spectrum optimized for absorption reaction in fast reactor (CEFR China Experimental Fast Reactor) through the irradiation of some transplutoniums (242Pu, 241Am, 244Cm). The neutron flux of large scale demonstration fast reactor or prototype fast breeder reactor is usually higher than the experimental fast reactor (CEFR) or reactor device. China is also developing the demonstration fast reactor (CFR China Fast Reactor) which will have a maximum neutron flux higher than 5.0E15 n/(cm2·s). Therefore, the 252cf production will be more practical and efficient with CFR.