With the deepening of educational reform, the teaching of English majors should be further optimized. Teachers should actively introduce new educational concepts and teaching methods to better arouse students’ interest, strengthen their understanding and application level of the knowledge they have learned, and improve the effectiveness of education. Information technology, as an important auxiliary means of English major teaching, can greatly enrich the content of English major teaching, broaden the path of education and greatly promote the more comprehensive development of students. Given this, this article will analyze the cultivation of cross-cultural communication skills among English major students under the background of educational informatization, and propose some strategies to further stimulate their thinking awareness and improve their cross-cultural communication abilities.