With roots in the early 1960s, decoloniality as a sub-sect of postcolonial studies made successful attempts at redefining and unearthing essentially Western conceptualizations of knowledge and knowledge formation across different fields of endeavor. Many academic disciplines have benefited from decolonial studies’ self-reflective theories and deconstructive approaches, and religion and science should not be an exception. Within religion and science as an academic field, Western and European intellectual frames have been overwhelmingly presented as definitive of globalized perspectives and knowledge, especially the definition of “religion” and “science” within the academic field. The subtle but evident impact of adopting Western epistemology as ‘the’ definitive reference frame for all peoples and cultures is the transposition of colonial and overtly Eurocentric conceptualizations and definitions of what religion and science mean as perfunctory for what religion and science should mean within non-Western frames as well as a disregard for the latter. This has led to the presentation (or overrepresentation, according to Sylvia Wynter) of a single homogenized perspective for meaning-making and interpretation of topics and themes within the field, a decision which has not only significantly impacted the field, in terms of ongoing dialectics about the relationship between religion and science, but which has also seen the exclusion of other forms of beneficial epistemic reference frames, which have been viewed as subaltern. Drawing from Wynter’s epistemic disobedience, this paper highlights decolonial approaches for engaging in the academic study of science and religion, and which will advance the path towards delinking the field from Euro-Western conceptualizations. This will unravel the rich epistemic formation within non-Western knowledge frames and the inclusion of which will greatly enrich and redefine the academic study of religion and science in the days ahead.