Analog front-end (AFE) circuits play an important role in the acquisition of physiological signals with low-level amplitudes (from tens of μV to tens of mV) and broadband low-frequency ranges (from sub-Hz to several hundred Hz). Possessing a high input impedance, an instrumentation amplifier (IA) accurately amplifies signals with low amplitude and low frequency, making it suitable for AFE circuits. This work demonstrates a capacitively coupled IA whose feedback resistance is realized by the proposed hybrid resistor, consisting of a switched-capacitor low-pass filter, a switched-capacitor resistor, and a continuous-time low-pass filter. The capacitively coupled IA achieves tera-ohm (TΩ) resistance and is insensitive to process, voltage, and temperature (PVT) variations. The simulation results show that the proposed IA illustrates a high-pass corner of 73.9 mHz, and the change of its high-pass corner with temperature is 0.05 mHz/°C. With the variation in the PVT corners, the difference between the maximum and minimum values of the high-pass corner of the proposed capacitively coupled IA is only 0.06 Hz. The design was implemented in a 130 nm standard CMOS process. The AFE with the proposed capacitively coupled IA achieves a 53.9 dB signal-to-noise and distortion ratio (SNDR) and 69.5 dB total harmonic distortion (THD).
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