Cube Volume Research Articles

Efficacy and safety analysis of intravitreal bio-similar products of bevacizumab in patients with macular edema because of retinal diseases

The purpose of this study was to evaluate retrospectively the efficacy and safety profile of intravitreal injection of bevacizumab bio-similar product Zybev(Z) for macular edema because of retinal diseases.A retrospective analysis was conducted on patients with macular edema because of retinal diseases, who had been administered intravitreal injections of bio-similar bevacizumab at a tertiary eye care center. Changes in the retinal thickness and visual acuity were evaluated to judge the efficacy, and adverse events were noted for the safety profile over a period of 6 weeks.A total of 104 patients were included in the study. The mean age of the patients was 53 ± 13.5 years. The mean pre-injection best corrected visual acuity (BCVA) was 1.32 ± 0.70 log minimum angle of resolution (logMAR) with a central subfield thickness (CST) of 429.26 ± 204.30 μm, and the post-injection BCVA at 6 weeks was 1.13 ± 0.71 logMAR with a CST of 302.26 ± 104.50 μm; this change was statistically significant (P < 0.05) for all groups. The mean average cube thickness (μm) decreased from 11.85 ± 1.96 pre-injection to 10.52 ± 1.75 post-injection, and the mean average cube volume (mm3) decreased from 329.30 ± 54.35 to 302.23 ± 49.56 (P < 0.05). During the follow-up period after injection, no patient had inflammation, endophthalmitis, an increase in intra-ocular pressure, or systemic side effects.This short-term retrospective analysis provides evidence regarding the efficacy and safety of intravitreal injection of bio-similar products of bevacizumab for the treatment of macular edema because of retinal diseases.

Two-dimensional echocardiographic estimates of left atrial volumes obtained from two different views in dogs are similar but not interchangeable

Left atrial (LA) volumes using a monoplane Simpson’s Method of Discs (SMOD) can be obtained from the right parasternal long axis four-chamber (RPLA) or from the left apical four-chamber (LA4C) views in dogs; however, little information exists regarding the agreement of LA volume estimates using a SMOD on images obtained from LA4C and RPLA views. Therefore, we sought to examine the agreement between the two methods of obtaining LA volumes in a heterogenous population of healthy and diseased dogs. Additionally, we compared the LA volumes obtained by SMOD with estimates obtained from simple cube or sphere volume formulae. Archived echocardiographic examinations were retrieved and, where both RPLA and LA4C views were adequately recorded, included in the study. We obtained measurements from 194 dogs that were either apparently healthy (n = 80) or had various cardiac diseases (n = 114). The LA volumes of each dog was measured using a SMOD, from both views, in systole and diastole. Estimates of LA volumes obtained from simple cube or sphere volume formulae from RPLA-derived LA diameters were also calculated. We then used Limits of Agreement analysis to determine agreement between the estimates obtained with each view, and those calculated from linear dimensions.The two methods obtained by SMOD provided similar estimates for both systolic and diastolic volumes but did not agree sufficiently to be interchangeable. The LA4C view often slightly underestimated the LA volumes at small LA sizes and overestimated the LA volumes at large LA sizes compared to RPLA method, with increasing disagreement as the LA size increased. Estimates based on cube method overestimated volumes compared to both SMOD methods, whereas those based on sphere method performed reasonably. Our study suggests that monoplane volume estimates from the RPLA and LA4C views are similar but not interchangeable. Clinicians can also perform a rough estimate of LA volumes using RPLA-derived LA diameters to calculate the sphere volume.

Perfectly packing a cube by cubes of nearly harmonic sidelength

AbstractLet d be an integer greater than $1$ , and let t be fixed such that $\frac {1}{d} &lt; t &lt; \frac {1}{d-1}$ . We prove that for any $n_0$ chosen sufficiently large depending on t, the d-dimensional cubes of sidelength $n^{-t}$ for $n \geq n_0$ can perfectly pack a cube of volume $\sum _{n=n_0}^{\infty } \frac {1}{n^{dt}}$ . Our work improves upon a previously known result in the three-dimensional case for when $\frac {1}{3} &lt; t \leq \frac {4}{11} $ and $n_0 = 1$ and builds upon recent work of Terence Tao in the two-dimensional case.

Macular Parameters Change during Silicon Oil Tamponade for Retinal Detachment Surgery.

Background and Objectives: To evaluate possible changes in macular thickness parameters during and after silicon oil tamponade and in pars plana rhegmatogenous retinal detachment surgery. Materials and Methods: Our retrospective study included 34 consecutive patients who underwent 23-gauge retinal detachment surgery with silicon oil tamponade. Central macular thickness (CMT), central macular volume cube (CMV) and average macular thickness cube (AVG) were measured by optical coherence tomography (OCT) before rhegmatogenous retinal detachment surgery with silicon oil tamponade during tamponade (seven days, one month and three months after surgery), and one month after silicon oil removal. Results: In our sample, macular parameters CMT, CMV and AVG in patients who underwent retinal detachment surgery were statistically reduced during silicon oil tamponade (p < 0.05). After silicon oil removal, all parameters recovered, reaching numeric values which were not statistically significant compared to preoperative values. The average span of silicon oil tamponade was 162 +/- 23 days. Conclusions: Silicon oil tamponade during 23-gauge rhegmatogenous retinal detachment surgery leads to a transitory reduction of central macular thickness, central macular volume cube and average macular thickness cube in eyes that underwent retinal surgery. After silicon oil removal, macular parameters returned to preoperative values in most of the patients.

Ostwald ripening of aqueous microbubble solutions.

Bubble solutions are of growing interest because of their various technological applications in surface cleaning, water treatment, and agriculture. However, their physicochemical properties, such as the stability and interfacial charge of bubbles, are not fully understood yet. In this study, the kinetics of radii in aqueous microbubble solutions are experimentally investigated, and the results are discussed in the context of Ostwald ripening. The obtained distributions of bubble radii scaled by mean radius and total number were found to be time-independent during the observation period. Image analysis of radii kinetics revealed that the average growth and shrinkage speed of each bubble is governed by diffusion-limited Ostwald ripening, and the kinetic coefficient calculated using the available physicochemical constants in the literature quantitatively agrees with the experimental data. Furthermore, the cube of mean radius and mean volume exhibit a linear time evolution in agreement with the Lifshitz-Slezov-Wagner (LSW) theory. The coefficients are slightly larger than those predicted using the LSW theory, which can be qualitatively explained by the effect of finite volume fraction. Finally, the slowdown and pinning of radius in the shrinkage dynamics of small microbubbles are discussed in detail.

Morphometric analyses in patients treated with subthreshold laser photocoagulation for central serous chorioretinopathy

Background and objectiveTo analyze changes in selected parameters in optical coherence tomography (OCT) after subthreshold laser coagulation (ST-LP) in patients with central serous chorioretinopathy (CSCR).Materials and methodsFifty-four eyes of 49 patients with CSCR were included in the study. Each patient underwent therapy with ST-LP with a frequency-doubled Neodym-YAG Laser and OCT imaging. In OCT the thickness of the central subfield, cube volume, average cube thickness, volume under the ETDRS grid, and average thickness under the ETDRS grid were collected.ResultsDecreases in total OCT volume and central retinal subfield thickness were statistically significant (p < 0.05). Possible correlations were observed between visual acuity at V3 (3 months after ST-LP) and Baseline and between central retinal subfield thickness at V1 (4 weeks after ST-LP) and visual acuity at BL.ConclusionA decrease in retinal thickness and retinal volume could be shown after ST-LP. Central retinal subfield thickness measured by OCT could be a more sensitive measure than mean retinal thickness or macular volume for early detection of disease recurrence occurring in some patients 3 months after ST-LP.

Meningkatkan Aktivitas, Berpikir Kritis, dan Hasil Belajar Matematika Menggunakan Model INTAN di Kelas V SDN Labat Muara

The problems contained in this study are students who have difficulty in mathematics content, especially in the cube volume material due to the lack of variation in learning, students have difficulty in absorbing material, and passive students in learning activities. This research is a CAR with 3 meetings, where the purpose of this study is to determine the activities of educators, students' critical thinking skills and learning outcomes through the application of the INTAN model. The results show an increase, namely for educator activities to achieve a maximum score with a percentage of 100%, with a very good category. For activities, students get percentages from 33.33% to 100% with Active and Very Active categories, critical thinking skills get percentages from 46.67% to 100% and learning outcomes from 20.00% to 100%. It can be concluded that the INTAN model is able to make students active and their learning outcomes increase both individually and as a whole.

PENINGKATAN HASIL BELAJAR MATEMATIKA SISWA MELALUI MODEL PROBLEM BASED INSTRUCTION (PBI) DENGAN METODE PENEMUAN TERBIMBING

The aim of this research is to improve students' mathematics learning outcomes through a problem-based learning model using the guided discovery method for class VIII students at SMP Negeri 2 Latambaga. This research was carried out in the even semester with a total of 28 students consisting of 9 men and 18 women. The procedures for this research are planning, implementing actions, observing and evaluating, and reflecting. The data sources in this research are mathematics teachers (partner teachers), observers and students. The type of data collected is quantitative data, in the form of student learning outcomes and qualitative data, namely the results of observations of teachers as researchers and of students. The data collected was analyzed using quantitative and qualitative analysis. The research results showed that the average value of students' mathematics learning outcomes in cycle I was 63.14% with a classical completion presentation of 37.03% but had not yet reached the predetermined performance indicators. In cycle II, the average score for mathematics learning outcomes was 74.62% with a classical completeness presentation of 81.48% and the performance indicators had been met, namely 80% of students got a score ≥ 72. Problem-based learning model (Problem Based Instruction) It can also increase students' enthusiasm, motivation to succeed and enthusiasm during learning, based on the results of observations by researchers, partner teachers and observers. From the results of this research, it can be concluded that by implementing a problem-based learning model (Problem Based Instruction) using the guided discovery method with Basic Competencies in calculating the surface area of the Volume of Cubes and Blocks, it can improve the mathematics learning outcomes of class VIII students at SMP Negeri 2 Latambaga.

Influence of Hot Band Annealing on Cold-Rolled Microstructure and Recrystallization in AA 6016

The influence of an intermediate heat treatment at the end of hot rolling and before cold rolling on Cube texture formation during the final solution annealing of AA 6016 is investigated. Three hot bands with different initial grain sizes and textures are considered: the first one without annealing before cold rolling, while the other two hot bands are heat treated at 540 °C for 1 hour in air before being cold rolled. One of the heat-treated hot bands was left to cool down in air and the other inside the furnace. Electron-backscatter diffraction (EBSD) maps of the cold-rolled specimens and crystal plasticity simulations show no difference in the amount of Cube remaining in the microstructure at the end of cold rolling for all three specimens. The initial grain size of the hot band has no influence on the Cube texture fraction left in the microstructure at the end of cold rolling for thickness reductions higher than 65 pct. Nevertheless, the grain size of the hot band affects the shape and distribution of the Cube grains left in the microstructure and the kernel average misorientation in the cold-rolled specimens. Moreover, the heat treatment decreases the intensity of the beta fiber components (Brass, Copper, and S) in the hot band and promotes the formation of a cold-rolled microstructure with a low kernel average misorientation. Both these factors lower the probability of preferential Cube nucleation during solution annealing and keep the Cube volume fraction after recrystallization below 10 pct, while it reaches 25 pct without intermediate annealing.

ANALISIS KEMAMPUAN PEMECAHAN MASALAH MATEMATIS PADA SOAL SETARA INSTRUMEN TIMSS UNTUK SISWA SMP NEGERI 1 MASOHI

Mathematical problem solving ability is one of the abilities that must be mastered by students in order to be able to mathematically solve problems often found in real life. The purpose of this study was to describe students' mathematical problem solving abilities on the volume of cubes and blocks equivalent to the TIMSS instrument. The research subjects are five students of class IX science at SMP Negeri 1 Masohi who were selected based on the category of problem solving ability. This type of research is a qualitative descriptive research supported by quantitative data. The data obtained from this study is data on mathematical problem solving ability tests such as written tests and interviews. The results show that students with very high abilities are able to interpret problems well, interpret strategies and problem-solving steps accaording to the plan, and consistently check back. Students with high abilities are able to apply the four steps in solving ploblems even though there are some questions that students make mistakes in setting strategies and substituting scores at the completion stage. Students with moderate abilities sometimes make mistakes in setting a strategy, make calculation errors, and do not check back to the maximum so that they get inaccurate results. Meanwhile students with low abilities unable to meet the completeness of the stage of understand the problem is writing down the things that are known and asked. As for students with low abilities cannot solve problems completely because of poor planning. Making mistakes in calculations and not checking again so that they do not get the right results

EFEKTIVITAS MEDIA PEMBELAJARAN DIGITAL BERBASIS KONTEKS BUDAYA DALAM MENINGKATKAN KOMUNIKASI MATEMATIS SISWA

This study aims to determine whether or not the use of cultural context-based digital learning media has an effect on improving students' mathematical communication skills in remote schools in East Aceh district. This research is a quasi-experimental research and the research design used is the Nonequivalent Control Group Design involving two groups, namely the experimental class that uses digital learning media and the control class that does not use digital learning media. The research was carried out in 3 Madrasah Ibtidaiyah inland, Peureulak District, East Aceh Regency, especially class V on the volume of cubes and beams. From the results of the two independent sample Kolmogrov-Smirnov test that has been carried out, it shows that the use of digital learning media based on cultural context has a significant and quite effective influence on improving students' mathematical communication skills in remote MIN, East Aceh Regency. This result can be seen from the calculation of the two independent sample Kolmogrov-Smirnov test with the asymp value. sig. for the same variance in each school, namely MIN 8 Aceh Timur, MIN 26 Aceh Timur and MIN 27 Aceh Timur respectively were 0.00, 0.01 and 0.00. This value shows a significance level of p &lt; 0.05 (0.00, 0.01 and 0.00 &lt; 0.05), which means Ho is rejected or Ha is accepted.

Accurate computation of partial volumes in 3D peridynamics

The peridynamic theory is a nonlocal formulation of continuum mechanics based on integro-differential equations, devised to deal with fracture in solid bodies. In particular, the forces acting on each material point are evaluated as the integral of the nonlocal interactions with all the neighboring points within a spherical region, called “neighborhood”. Peridynamic bodies are commonly discretized by means of a meshfree method into a uniform grid of cubic cells. The numerical integration of the nonlocal interactions over the neighborhood strongly affects the accuracy and the convergence behavior of the results. However, near the boundary of the neighborhood, some cells are only partially within the sphere. Therefore, the quadrature weights related to those cells are computed as the fraction of cell volume which actually lies inside the neighborhood. This leads to the complex computation of the volume of several cube–sphere intersections for different positions of the cells. We developed an innovative algorithm able to accurately compute the quadrature weights in 3D peridynamics for any value of the grid spacing (when considering fixed the radius of the neighborhood). Several examples have been presented to show the capabilities of the proposed algorithm. With respect to the most common algorithm to date, the new algorithm provides an evident improvement in the accuracy of the results and a smoother convergence behavior as the grid spacing decreases.

Student’s obstacles in learning volume of cube and cuboid

The concept of volume is a significant concept taught from elementary school to high school level. However, many students still have difficulty in learning the concept of volume, especially the concept of the volume of a cube and a cuboid. This study aims to identify learning obstacles that occur in junior high school students related to the concept of volume of cubes and cuboid. This research method uses an interpretive paradigm which is part of the Didactical Design Research (DDR). Data analysis was obtained from a test consisting of five questions related to the volume of cubes and cuboid, given to thirteen students from one of the junior high schools in Jambi City; and interviews with three students who said they had learning obstacles. The results showed that students experienced three types of learning obstacles: epistemological obstacles, ontogenic obstacles, and didactical obstacles. The results of this study can be used by other researchers as material for consideration in designing learning designs related to the concept of the volume of cubes and cuboids, then analyzing the process of implementing the design to create a revised design based on the results of the previous design implementation. Through this design can be used by teachers in the learning process for minimizing the occurrence of learning obstacles, so that the learning process can take place optimally.

Pengaruh Model Discovery Learning Berbantuan “Kuba-Kusa” Terhadap Hasil Belajar Matematika Siswa Kelas V

The purpose of this study was to determine whether the discovery learning model assisted by the "Cuban-Kusa" teaching aid had an effect on mathematics learning outcomes, especially on the volume of cubes and blocks for fifth-grade students at SDN 1 Duren. The sample of this research is the fifth-grade students at SDN 1 Duren as many as 14 students and the fifth-grade students at SDN 1 Dermosari as many as 13 students. The research method uses quantitative research, and the type of research is a non-equivalent pretest and posttest control group design. Mathematics learning outcomes are measured by a test instrument in the form of 20 multiple-choice questions. Based on the research results from hypothesis testing using an independent sample t-test, the results obtained are sig. (2-tailed) namely (0.003 &lt; 0.05), so the results show that Ha is accepted and H0 is rejected. It can be concluded that the mathematics learning outcomes of students at SDN 1 Duren are influenced by the discovery learning model assisted by the "Cuban-Kusa" teaching aids. It can be seen from the average posttest results of 80.00 in the experimental class and the average results of 66.92 in the control class.

MACULAR THICKNESS BY USING SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY IN CHILDREN AND ADOLESCENTS

To determine the distribution of macular and cube thickness and their normal range in the students aged 9 years to 15 years and to investigate their associated demographic and biometric factors. This study was based on the data of the second phase of the Shahroud School Children Eye Cohort Study, conducted in 2018. After measurements of visual acuity, biometry, and subjective and cycloplegic refraction, retinal examination was performed using the Zeiss Cirrus HD 4000 optical coherence tomography. The data of 5,043 right eyes were analyzed after applying the exclusion criteria. The central macular thickness was 239 ± 19.35 μ m. The mean cube volume and cube thickness were 9.94 ± 0.44 and 278 ± 12.20, respectively. According to multiple linear regression analysis, the central macular thickness was significantly lower in girls (coefficient [β]: -9.18; P < 0.001) and rural students (β: 3.86; P < 0.001) and had a direct association with axial length (β: 5.19; P < 0.001), lens thickness (β: 5.33; P = 0.003), and mean keratometry (β: 2.41; P < 0.001). The cube volume was lower in girls (β: -0.13; P < 0.001) and higher in rural students (β: 0.05; P < 0.001). Macular thickness was slightly higher in Iranian children. Sex, living place, axial length, lens thickness, and mean keratometry were the main associated factors with macular thickness.

Correlation between serum immunoglobulin levels and retinal structure in patients with newly diagnosed Vogt‑Koyanagi‑Harada disease.

Immunoglobulins serve immunomodulatory roles in numerous autoimmune diseases. The aim of the present study was to investigate the correlations between serum Ig levels and retinal structural parameters in patients with newly diagnosed acute Vogt-Koyanagi-Harada (VKH) disease. A total of 138 participants were enrolled and the foveal thickness (FT), serous retinal detachment (SRD), sensory retinal thickness, central FT (CFT), cube volume (V) and cube average thickness (AT) were assessed by optical coherence tomography. The patients were divided, according to the extent of SRD, into a high-detachment group (>500 µm) and a low-detachment group (≤500 µm). Rate-scattering turbidimetry was performed to measure the Ig levels. The high-detachment group comprised 51 (36.96%) patients. The proportion of males was significantly greater in the high-detachment group compared with the low-detachment group (58.82 vs. 40.23%; P<0.05) and best-corrected visual acuity was significantly worse in the high-detachment group compared with the low-detachment group (P<0.001). The IgE levels in the high-detachment group were significantly greater compared with the low-detachment group (P<0.05). FT, SRD, CFT, V and AT were significantly greater in the high-detachment group compared with the low-detachment group (P<0.001). The IgE levels were positively associated with SRD, CFT and AT (P<0.05). Multivariate binary logistic regression analysis demonstrated that male sex (B=2.447; P<0.05) and serum IgE levels (B=0.997, P<0.05) may be independent risk factors for severe SRD. The results of the present study demonstrated that males are more likely to develop severe SRD and that serum IgE levels were associated with the extent of detachment. These data suggested that IgE may be involved in the progression of VKH disease.

Pendekatan Contextual Teaching and Learning (Ctl) Pada Pembelajaran Volume Kubus Dan Balok Di Kelas V SD Dampak Transisi Pandemi Covid-19 Menuju Endemi

This research is based on the problem of low student learning outcomes, during the transition from covid-19 to endemic, learning that is usually done is only teacher-centered because most learning is done online so that it affects the low learning outcomes of students, especially in learning the volume of cubes and blocks. This study aims to determine learning through the Contextual Teaching and Learning (CTL) approach in learning the material for the volume of cubes and blocks in fifth grade elementary school. This study uses a quantitative approach to the type of experimental research. The sample in this study was the fifth grade elementary school students, totaling 24 students consisting of 13 boys and 11 girls. Data was collected using observation sheets and tests (pretest and posttest). While the data processing is done by calculating the average value (x), S2 variance, standard deviation (S) and t test. The conclusion of the study shows that the Contextual Teaching and Learning (CTL) approach cannot improve student learning outcomes on the material for the volume of cubes and blocks in fifth grade elementary school during the Covid-19 transition to endemic. Learning activities carried out by teachers and students obtained a percentage rate of 87% (very good), and student learning completeness in the volume of cubes and blocks only 6 students or 25% of students achieved the Minimum Completeness Criteria

Peningkatan Hasil Pembelajaran Matematika dengan Metode Penggunaan Media Bangun Ruang Datar pada Siswa Kelas V SDN No.15 Segedong Kabupaten Bengkayang

The lack of interest in learning and the impression as a difficult science causes low results in the mathematics learning process, especially at the elementary school level. This prompted research on teaching materials for calculating the area of a simple flat shape and calculating the volume of a cube through the use of media to improve learning outcomes in class V of SDN No 15 Segedong. The purpose of this study was to improve learning outcomes of mathematics through the use of media for geometric shapes and flat shapes in calculating the area of simple flat shapes and the volume of cubes and blocks in fifth grade students of SDN No 15 Segedong, Bengkayang Regency, West Kalimantan. The research is based on classroom action research (PTK) through the stages of observation, field observation and evaluation. This research activity was carried out in 2 cycles, where the evaluation in the first cycle showed the average score of the 14 students was 63.70, an increase in the evaluation results of the second cycle, which was 76.65 From this research, it shows that the use of learning media in calculating the area of the shape and volume of the cube can improve learning outcomes.

Long-Term Variations in Retinal Parameters after Uncomplicated Cataract Surgery.

Background: Cataract phacoemulsification surgery provides excellent refractive results; however, it also elicits changes in the posterior segment of the eye. This study aimed to determine changes in retinal parameters measured by spectral-domain optical coherence tomography (SD-OCT) and OCT angiography (OCTA) after an uncomplicated cataract surgery, including the impact of effective phacoemulsification time (EPT). Methods: The study included 44 patients without retinal abnormalities, followed up after unilateral uncomplicated cataract phacoemulsification in a single ophthalmological unit. Patients were evaluated for the following parameters at baseline and at 2 weeks, 3 months, and 12 months after the surgery: best corrected visual acuity, central retinal thickness (CRT), average central retinal thickness (CRTA), central retinal volume (cube volume (CV)), vessel density central (VDC), vessel density full (VDF), vessel perfusion central (VPC), and vessel perfusion full (VPF). The EPT recorded at each procedure was used as a covariant for the evaluation of changes in retinal parameters after the surgery. Analysis included 44 eyes for SD-OCT and 17 for OCTA evaluation, according to adopted scan quality thresholds. Results: A significant increase in CRT, CRTA, and CV was noted at each follow-up point compared with baseline. The rising tendency was observed in the first 3 months after the surgery, with a decline over the subsequent months. The VPF parameter showed a stable improvement after the surgery. The analysis of covariance did not confirm any significant effect of the EPT on variations in CRT, CV, CRTA, VDC, and VPF and there was a weak effect on the VDF parameter. Conclusions: Uncomplicated cataract surgery results in an increase in retinal thickness and volume in the first few months after the surgery, followed by a spontaneous decline in these parameters in the subsequent months. A long-standing improvement is noted in the VPF parameter.

Crystal plasticity simulations of Cube in-grain fragmentation in aluminium: Influence of crystal neighbor orientation

The orientation evolution and the in-grain microtexture of Cube-oriented FCC crystals in aluminium are investigated using crystal plasticity simulations. The influence of crystallographic orientation of neighbor grains on Cube microtexture is presented. Several loading conditions from ideal plane strain compression to compression with superimposed shear loadings are simulated both during cold-rolling and hot-rolling. During hot-rolling, activity of non-octahedral slip systems is considered. The obtained results highlight the strong influence of different neighbors on the development of in-grain Cube fragmentation and question or in other cases support early models describing evolution of in-grain Cube rotation. During hot-rolling, non-octahedral slip systems stabilize Cube, but this depends on orientations of neighboring grains. In hot rolling, when Cube is surrounded by grains of Brass crystallographic orientation, it undergoes significant fragmentation despite the activity of non-octahedral slip systems; while S, Copper, or Goss oriented adjacent grains do not promote Cube misorientation. During cold rolling, the most effective orientations to misorient Cube are Brass and S. Superposition of shear loadings to thickness compression is beneficial for Cube fragmentation but at the end of the deformation process, the remaining Cube volume fraction depends on the signs of the shear components. However, for all orientations of neighbor grains, ND-RD shear (FND-RD) of deformation gradient has stronger influence than RD-ND shear (FRD-ND) on promoting Cube in-grain splitting.