This article aims, as the proposed theme suggests, to analyze the crime of drug trafficking committed by women, critically verifying the conditioning factors of female criminality. The research question that guides this research is: what factors condition the entry of women into the practice of the crime of drug trafficking? Based on the question presented, the phenomenon of female criminality in drug trafficking was analyzed from a critical perspective, seeking to understand, through studies of marginal feminist criminology and theories that justify entry into criminal activity, the main motivations that influence women's entry into the crime in question. Once the research problem was overcome, alternatives capable of producing positive effects regarding the reduction of female incarceration for drug trafficking were sought, highlighting that decarceration measures present themselves as a possible solution to the problem, since the current prohibitionist drug policy is ineffective. Thus, to achieve the results obtained in this research, the following methodological techniques and procedures were used: i) bibliographic review in works of social sciences, criminal law and criminology, as well as authors who focus on women's relationships with crime from a feminist theoretical framework; ii) analysis of quantitative and qualitative data extracted from official bodies, paying attention to the limitations they present, since there is a great restriction of information.