Conjugate Structure Research Articles

Density functional theory/time-dependent density functional theory investigations on the color-structure relationship of biopigment molecules

The study of molecular derivatives of biological dyes is of great importance for the green transformation of the printing, dyeing, and textile industries. In this study, B3LYP density functional methods are used to optimize the geometric configuration of the selected molecules and to explore the relationship between the structure and color of biological dye molecules and their color mechanism. This study focuses on the analysis of polyenes, quinones, indoles, and azide biological dyes in colors commonly used in the textile industry: blue, yellow, purple, red, green, and so on. Quantum chemical investigations show that the conjugate structure of a biological dye is directly related to its color and that the group or structure affecting the conjugate structure will in many cases cause a change in color. In addition, time-dependent density functional theory spectral calculations with the CAM-B3LYP functional for UV-Vis spectra show that in the visible band, the color of the remaining band after subtracting the absorption wavelengths was exactly the same as the color of the pigment. These results indicate that the color of the pigment is exactly complementary to the light absorption color of the material. Our study provides theoretical guidance for the design of molecular derivatives of biological dyes and is expected to promote the green transformation of the textile, printing, and dyeing industries to a certain extent.

Antioxidant activity of Schiff base ligands using the DPPH scavenging assay: an updated review.

Schiff base ligands, formed from primary amines and carbonyl compounds, are potential antioxidants because they scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals via hydrogen atom transfer (HAT) and single electron transfer (SET) routes. This review aims to help design, synthesize, and discuss the antioxidant activity of Schiff base ligands based on their structure. This study critically discussed the solvent effect and the structural changes of Schiff base ligands responsible for DPPH scavenging activity, such as proton donating, electron-donating, and electron-withdrawing substituents, conjugation and ring structure. The ligands with electron-donating substituent groups in the phenolic ring demonstrated greater activity by readily stabilizing the radical and some of them showed higher activity than the standard. The activity also depends on the solvent used; the activity increases in those solvents that promote the proton and electron donation of the Schiff base. Schiff bases are most important due to their versatile applications, which can be explained by their antioxidant activity. The data led to the conclusion that the Schiff base ligand will serve as a source of synthetic antioxidants. There should be lots of scope for research on the antioxidant activity of Schiff bases. This review will assist researchers in studying Schiff base-based antioxidants and their applications. All the data analyzed in this paper was found from in vitro tests; for more clearance supplementary tests and in vivo investigations are crucial.

Realizing one-step two-electron transfer of naphthalene diimides via a regional charge buffering strategy for aqueous organic redox flow batteries.

Naphthalene diimide derivatives show great potential for application in neutral aqueous organic redox flow batteries (AORFBs) due to their highly conjugated molecular structure and stable two-electron storage capacity. However, the two-electron redox process of naphthalene diimides typically occurs via two separate steps with the transfer of one electron per step ("two-step two-electron" transfer process), which leads to an inevitable loss of voltage and energy. Herein, we report a novel regional charge buffering strategy that utilizes the core-substituted electron-donating group to adjust the redox properties of naphthalene diimides, realizing two electron transfer via a single-step redox process ("one-step two-electron" transfer process). The symmetrical battery testing of NDI-DEtOH revealed exceptional intrinsic stability lasting for 11 days with a daily decay rate of only 0.11%. Meanwhile, AORFBs with NDI-DMe/FcNCl and NDI-DEtOH/FcNCl exhibited a remarkable 40% improvement in peak power density at 50% state of charge (SOC) in comparison to NDI/FcNCl-based AORFBs. In addition, the battery's energy efficiency has increased by 24%, resulting in much more stable output power and significantly improved energy efficiency. These results are of great significance to practical applications of AORFBs.

Preparation of sp2 carbon-bonded π-conjugated COF aerogels by ultrasound-assisted mild solvothermal reaction for multi-functional applications.

Molding COFs into aerogels from monomers can establish interpenetrating spatial network structures on the centimeter scale that increase the accessibility of dominant pore channels and the convenience of real application, which radically gets rid of the difficult reprocessing problems of insoluble and non-fusible powder COFs. However, the construction of bulk COF structures and achieving crystallinity are often incompatible, especially with sp2 carbon-based COFs, whose powder synthesis has been quite demanding. Herein, for the first time, we report an efficient method to prepare sp2 carbon-linked π-conjugated DFB-TMTA-COF (DT-COF) aerogels by an ultrasound-assisted mild solvothermal technique and freeze-drying. Particularly, unlike the typical synthesis methods of vacuum deoxygenation, high temperature and long reaction time, crystalline DT-COF aerogels can be obtained by reacting at 90 °C for 48 h without vacuum sealing. The fluffy, hierarchical porous flower-shaped microsphere clustering of DT-COF aerogels contributes to excellent mechanical properties and better host-guest interactions, which are favorable to utilize the benefits of the highly conjugated structure of channels. As a proof of concept, DT-COF aerogels have been used in absorption, batteries, and sensors, demonstrating enhanced functionality and effectiveness.

Novel electrochemical sensing strategy for ultrasensitive detection of tetracycline based on porphyrin/metal phthalocyanine-covalent organic framework

In this work, a novel two-dimensional semiconducting metal covalent organic framework (CuTAPc-TFPP-COF) was synthesized and used as biosensing platform to construct aptasensor for trace detection of tetracycline (TC). The CuTAPc-TFPP-COF integrates the highly conjugated structure, large specific surface area, high porosity, abundant nitrogen functional groups, excellent electrochemical activity, and strong bioaffinity for aptamers, providing abundant active sites to effectively anchor aptamer strands. As a result, the CuTAPc-TFPP-COF-based aptasensor shows high sensitivity for detecting TC via specific recognition between aptamer and TC to form Apt-TC complex. An ultralow detection limit of 59.6 fM is deduced from the electrochemical impedance spectroscopy within a wide linear range of 0.1–100000 pM for TC. The CuTAPc-TFPP-COF-based aptasensor also exhibits good selectivity, reproducibility, stability, regenerability, and excellent applicability for real river water, milk, and pork samples. Therefore, the CuTAPc-TFPP-COF-based aptasensor will be promising for detecting trace harmful antibiotics residues in environmental water and food samples.

Effect of molecular structure on ethylene‐vinyl alcohol copolymer thermal degradation and stability

AbstractTo study the effect of molecular structure on ethylene‐vinyl alcohol copolymer (EVOH) thermal stability during processing, EVOH samples with different molecular weights and comonomer distributions were prepared by solubility fractionation from two different commercial materials, and then, the structure features of samples were characterized by 1H‐NMR, viscometry, differential scanning calorimetry, and, especially, successive self‐nucleation and annealing. Their thermal stabilities were further analyzed by isothermal oxygen treatment and thermogravimetry. Attenuated total internal reflectance Fourier transform infrared spectroscopy and UV were used to obverse the structural changes in samples (the formation of chromogenic groups: CO and CC). According to the results of isothermal oxygen treatment at 200°C, at the same ethylene content, low‐molecular‐weight samples have worse thermal stability, which were extremely easy to yellowing and form insoluble gel. To investigate the structure differences between the low‐molecular‐weight samples, it was found that long vinyl alcohol segments may not worsen the thermal stability in the conditions of the same ethylene content. But samples with a uniform distribution of ethylene segments and a certain length of ethylene segments will have better thermal stability, which makes it more difficult to form carbonyl even diketene conjugation structure.

Surface implantation of ionically conductive polyhydroxyethylaniline on cation exchange membrane for efficient heavy metal ions separation

Extraction of heavy metal ions from aqueous could enable recycling of wastewater and reusing of high-value ion resources. Recently, electrodialysis (ED) technology has been applied in the removal of heavy metal ions from wastewater, however, developing high-efficient and stable heavy metal ions selective cation exchange membrane (CEM) remains an elusive challenge. Herein, we demonstrate the fabrication of high-efficient cations selective CEM with the surface implantation of ionically conductive polyhydroxyethylaniline (PANI-OH) on a commercial CEM membrane (CTG) containing sulfonic acid groups via the electrostatic attraction. Implanted hydrophilic and positively charged PANI-OH facilitates fast and selective transfer of Cu2+ over Zn2+ cations through the membrane. Meanwhile, the synergistic effect of rigid conjugate structure and hydrogen-bond interaction of PANI-OH renders the resultant membrane CTG-PANI-OH with stable structure and separation performance. As such, the Cu2+/Zn2+ permselectivity of CTG-PANI-OH membrane is ~1.70, which is about 190 % of that of the pristine CTG membrane. This work provides a facile design and strategy for the construction of high-efficient cations selective CEMs with great application prospects in the purification and extraction of heavy metal ions from wastewater.

Bioactive Dairy-Fermented Products and Phenolic Compounds: Together or Apart.

Fermented dairy products (e.g., yogurt, kefir, and buttermilk) are significant in the dairy industry. They are less immunoreactive than the raw materials from which they are derived. The attractiveness of these products is based on their bioactivity and properties that induce immune or anti-inflammatory processes. In the search for new solutions, plant raw materials with beneficial effects have been combined to multiply their effects or obtain new properties. Polyphenols (e.g., flavonoids, phenolic acids, lignans, and stilbenes) are present in fruit and vegetables, but also in coffee, tea, or wine. They reduce the risk of chronic diseases, such as cancer, diabetes, or inflammation. Hence, it is becoming valuable to combine dairy proteins with polyphenols, of which epigallocatechin-3-gallate (EGCG) and chlorogenic acid (CGA) show a particular predisposition to bind to milk proteins (e.g., α-lactalbumin β-lactoglobulin, αs1-casein, and κ-casein). Reducing the allergenicity of milk proteins by combining them with polyphenols is an essential issue. As potential 'metabolic prebiotics', they also contribute to stimulating the growth of beneficial bacteria and inhibiting pathogenic bacteria in the human gastrointestinal tract. In silico methods, mainly docking, assess the new structures of conjugates and the consequences of the interactions that are formed between proteins and polyphenols, as well as to predict their action in the body.

In-Depth Structure and Function Characterization of Heterogeneous Interchain Cysteine-Conjugated Antibody-Drug Conjugates.

Antibody-drug conjugates (ADCs), integrating high specificity of antigen-targeting antibodies and high potency of cell-killing chemical drugs, have become one of the most rapidly expanding therapeutic biologics in oncology. Although ADCs were widely studied from multiple aspects, overall structural elucidation with comprehensive understanding of variants is scarcely reported. Here, for the first time, we present a holistic and in-depth characterization of an interchain cysteine-conjugated ADC, focusing on conjugation and charge heterogeneity, and in vitro biological activities. Conjugation mapping utilized a bottom-up approach, unraveled positional isomer composition, provided insights into the conjugation process, and elucidated how conjugation affects the physicochemical and biological properties of an ADC. Charge profiling combined bottom-up and top-down approaches to interrogate the origin of charge heterogeneity, its impact on function, and best practice for characterization. Specifically, we pioneered the utilization of capillary isoelectric focusing-mass spectrometry to decode not only critical post-translational modifications but also drug load and positional isomer distribution. The study design provides general guidance for in-depth characterization of ADCs, and the analytical findings in turn benefit the discovery and development of future ADCs.

A highly sensitive and selective hybrid of molecularly imprinted poly(9H-carbazole-9-ethanamine) and porous CoZn-NC polyhedral nanocages for electrochemical detection of uric acid in plasma sample

A novel monomer, 9H-carbazole-9-ethanamine, was prepared in this study to prepare a molecularly imprinted polymer (MIP) on porous Co/Zn embedded N-doped carbon (CoZn-NC) material for the purpose of detecting uric acid (UA). The electro-polymerization of the carbazole derivatives obtained by introducing an amino group onto the rigid structure of the carbazole conjugate led to the creation of a polymer with a significant number of amino groups. This increased the number of binding sites available for the UA template and enhanced the selectivity of the sensor. Additionally, porous CoZn-NC polyhedral nanocages were used as the substrate material for the MIP sensor, which enhanced the sensing performance through a highly conductive sensing interface and an efficient UA catalytic capacity. The preparation conditions for the MIP@CoZn-NC were optimized to achieve high sensitivity in the detection of UA using differential pulse voltammetry (DPV). The detection range of UA is 1 to 300 μM using this method, and it exhibits good selectivity for compounds with similar structures. The developed sensor was successfully used to detect UA in rat plasma, with a recovery rate of 91.8% to 103.7%, demonstrating its potential for biomedical applications.

Preparation, structural characterization and properties of feruloyl oligosaccharide–rice protein hydrolysate conjugates

Rice protein hydrolysate (RPH) and feruloyl oligosaccharides (FOs) were conjugated under the catalysis of laccase and free radical, and the structure and properties of the resultant conjugates were studied. Electrophoresis analysis demonstrated that conjugation with FOs increased the molecular weight of some fractions in RPH, which confirmed the formation of both conjugates. The conjugation degree of laccase-induced conjugate and radical-induced conjugate was 60.45% and 22.70%, respectively. Laccase-catalyzed conjugation decreased the tyrosine residue content of RPH but had no significant effect on the free amino group content, which suggested that tyrosine residues were the conjugation site in the laccase-induced conjugate. However, radical-catalyzed conjugation decreased both the free amino group content and the tyrosine residue content, which indicated that both free amino groups and tyrosine residues were the conjugation site in the radical-induced conjugate. The ultraviolet, fluorescence and circular dichroism spectroscopy analysis revealed that conjugation with FOs significantly altered the secondary and tertiary structure of RPH. In addition, conjugation with FOs increased the solubility and antioxidant activity of RPH but decreased the emulsifying activity and stability. Particularly, the radical-induced conjugate had greater anti-aggregation capacity and antioxidant activity but lower emulsifying activity and stability than the laccase-induced conjugate, which might be due to that their conjugation site and degree were different.

Three‐dimensional Polymers as Organic Cathodes for Affordable and Sustainable Sodium/Potassium‐ion Batteries

AbstractRedox‐active polymers (RAPs) are promising organic electrode materials for affordable and sustainable batteries due to their flexible chemical structures and negligible solubility in the electrolyte. Developing high‐dimensional RAPs with porous structures and crosslinkers can further improve their stability and redox capability by reducing the solubility and enhancing reaction kinetics. This work reports two three‐dimensional (3D) RAPs as stable organic cathodes in Na‐ion batteries (NIBs) and K‐ion batteries (KIBs). Carbonyl functional groups are incorporated into the repeating units of the RAPs by the polycondensation of Tetrakis(4‐aminophenyl)methane and two different dianhydrides. The RAPs with interconnected 3D extended conjugation structures undergo multi‐electron redox reactions and exhibit high performance in both NIBs and KIBs in terms of long cycle life (up to 8000 cycles) and fast charging capability (up to 2 A g−1). The results demonstrate that developing 3D RAPs is an effective strategy to achieve high‐performance, affordable, and sustainable NIBs and KIBs.

Mechanistic insights into the adsorption and dissociation of nitrogen oxides on nickel phosphide (Ni2P) catalysts

The escalating concern regarding nitrogen oxides (NOx) emissions, linked to environmental challenges like smog, acid rain, ozone depletion, and global warming, necessitates effective strategies for their mitigation. DeNOx processes, including selective catalytic reduction (SCR), offer potential solutions, but costly precious metal catalysts hinder a widespread implementation. Alternatively, earth-abundant element compounds, particularly transition metal phosphides (TMPs), such as nickel phosphides (Ni2P), have garnered interest due to their promising catalytic performance. This study employed first-principles density functional theory (DFT) methods to investigate the catalytic properties of the (0001) Ni2P surface concerning NOx adsorption and dissociation. Both NO and NO2 are found to exhibit strong reactivity towards Ni2P-(0001)’s surface at the hollow triple-Ni sites, forming stable conjugated structures. Bader charge analysis indicates significant charge transfers during NOx adsorption from the interacting surface to the NOx, resulting in elongated N–O bond lengths, confirmed by vibrational frequency analyses. The dissociation process of NO2 was found to be both thermodynamically and kinetically favorable, with more heat being released than the subsequent NO dissociation’s activation barrier, resulting in a self-sustaining overall reaction. These insights provide valuable knowledge for designing efficient and sustainable Ni2P-based catalytic systems to address NOx emissions in environmental and industrial applications.

Polyploidy in the history of breeding at the Yaltushkiv Experimental Breeding Station: new methods of differentiation and stabilisation of sugar beet tetraploids

Purpose. To analyse the history of the polyploid breeding at the Yaltushkiv Experimental Breeding Station, in particular the improvement of genetic models of new hybrids, new methods of induction of meiotic tetraploids, differentiation and selection of breeding genotypes by genome ploidy.
 Methods. Cytological analysis of metaphase chromosomes of the apical meristems of the growth points of seed plants and beets of the first year for the selection of tetraploid plants 4x = 36 chromosomes; cytophotometric analysis using computer programs AP Partec to study ploidy based on the quantitative content of nuclear DNA; field methods (selection of tetraploid seed plants according to the types of pollen grains, formation of synthetic populations of tetraploid multigerm plants on a cytogenetic basis according to the structure of bivalent conjugation of homologous chromosomes in meiosis.
 Results. In the process of tetraploid induction, cytological methods of ploidy analysis at the station were improved using computer programs of AP Partec for the selection of sugar beets 4x by the quantitative content of nuclear DNA in the cell on plants of the first year of vegetation and for the formation of tetraploid populations after colchicine induction in seed plants. In the process of studying the structure of polyploid populations by ploidy, the percentage of tetraploids varied from 82.0±2.22% in Ya/Hen pollinator to 58.1±2.81% in Ya/Man pollinator. It was established that the selection for fertility and pollen uniformity depends on the genetic characteristics of the breeding genotypes and affects the pollen-forming ability in the first generations after induction with colchicine, reducing the number of 4x IIa and IIb biotypes according to cytological classification. Using the example of the multigerm pollinator Ya/Roi, it was established that selection for sugar content and productivity had, to a certain extent, a stabilising effect on the degree of ploidy. The biotechnological methods used to deposit 4x genotypes with a high percentage of bivalent conjugation of homologous chromosomes in metaphase I of meiosis (70–90%) contributed to the cytogenetic stability of polyploid gametes and their high yield – 92.9% of 4x in the next generation of seeds. It was investigated that the productivity of triploid hybrids obtained with the use of the tetraploid pollinator Ya/DA 4x based on the germplasm of the wild species Beta patula at the early stages of vegetative development varied in triploid plants from 325 to 465 g, and the sugar content in some numbers reached 21.5%.
 Conclusions. The development of polyploid selection at the Yaltushkiv Experimental Breeding Station evolved from the development polyhybrids to the development of triploid hybrids based on CMS using tetraploid multigerm pollinators. For the formation of populations of tetraploid multigerm pollinators, the methods of fluorescent cytophotometry and computer programs AP Partec were used, as well as biotechnological methods for creating synthetic populations of tetraploid multigerm pollinators on a cytogenetic basis, which ensure the yield of tetraploids in seeds up to 92.9%.

Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors

Inherited retinal dystrophies caused by dominant mutations in photoreceptor cell expressed genes, are a major cause of irreversible vision loss. Oligonucleotide therapy has been of interest in diseases that conventional medicine cannot target. In the early days, small interfering RNAs (siRNAs) were explored in clinical trials for retinal disorders with limited success due to a lack of stability and efficient cellular delivery. Thus, an unmet need exists to identify siRNA chemistry that targets photoreceptor cell expressed genes. Here we evaluated 12 different fully chemically modified siRNA configurations, where the valency and conjugate structure were systematically altered. The impact on retinal distribution following intravitreal delivery was examined. We found that the increase in valency (tetravalent siRNA) supports the best photoreceptor accumulation. A single intravitreal administration induces multi-months efficacy in rodent and porcine retinas while showing a good safety profile. The data suggest that this configuration can treat retinal diseases caused by photoreceptor cell expressed genes with 1-2 intravitreal injections per year.

Bistate-type ion storage of azo polymer for aqueous zinc ion battery

Azo organic molecules are emerging as promising electrode candidates for energy storage systems due to their high theoretical specific capacity and excellent kinetic performance. In general perception, conventional azo organic small molecules used as cathode material in aqueous batteries remain a challenge because of the poor cycling stability in aqueous electrolytes. Herein, azo organic polymers (AOPs) were synthesized using a diazo-coupling reaction under mild conditions and developed as cathode materials for aqueous zinc-ion batteries. Owing to the long conjugate structure, the AOPs afford extra-long stability with outstanding cyclability of >1000 cycles at 2 A g−1, a comparable capacity (170 mAh g−1 at 0.5 A g−1), and excellent rate performance from 0.5 g−1 to 10 A g−1 in aqueous electrolytes. Significantly, the hydroxyl oxygen and azo functional groups on AOPs can spontaneously form metal heterocyclic complexes with zinc ions in 1 M Zinc trifluoromethanesulfonate (Zn(OTF)2) electrolyte, leading to a notable increase in voltage (by 0.2 V) and capacity (by 43 mAh g−1 at a current density of 2 A g−1) in aqueous zinc-ion battery. Additionally, mechanistic analysis reveals that the AOPs are an active material for bistate storage of zinc ions during the charging and discharging process. The AOPs not only store zinc ions in fully charged state by forming metal heterocyclic complexes but also store zinc ions by a redox reaction between azo functional groups and zinc ions at the discharge process. The results put forward a novel storage mechanism for zinc ions and will pave the way for AOPs’ development in aqueous batteries.

Application of the VSP near-infrared fluorescence probe in hyperlipidemia viscosity monitoring

This study introduces a novel near-infrared fluorescent probe named VSP, designed to effectively and sensitively monitor viscosity changes both internally and externally. Through an enhanced conjugation structure of the fluorescent molecule and the incorporation of hydrophilic groups, the VSP probe showcases remarkable sensitivity, selectivity, and stability in its ability to detect viscosity alterations. Notably, the linear correlation between its fluorescence intensity and glycerol content presents the possibility of quantitative viscosity detection, holding significant promise for applications in biomedical research and clinical diagnostics. Moreover, its biocompatibility supports its use for monitoring viscosity within cellular environments. An exceptional attribute is its ability to accurately distinguish between hyperlipidemic model mice and normal mice in animal imaging as well as serum samples, underscoring its potential for early-stage diagnosis of elevated lipid levels and risk assessment for cardiovascular diseases. VSP's potential was demonstrated in cell imaging and differentiation between high-fat and normal mice based on blood serum viscosity. This promising tool holds significant potential for biomedical research and clinical applications in monitoring and analyzing changes in biological systems.

Effect of substituents on the performance of N-carbazolyl double benzylidene ketones in visible/NIR light one/two-photon polymerization

Developing high-performance photoinitiation systems with high sensitivity is of great significance in one/two-photon polymerization. Especially, photoinitiators with rapid photobleaching effects, deep curing abilities and potential for two-photon lithography have great commercial prospects. However, such photoinitiators often require complex organic synthesis, thus having relatively limited varieties. Double benzylidene ketone is widely used as a high-performance dye and can be constructed through a one-step classical aldol condensation reaction. The optimization of its structure often involves introducing extended conjugated structures or different terminal substituents. However, the synergistic impacts of side substituents with different electron effects are rarely studied. Here, six novel carbazolyl double benzylidene ketones with tert-butyl on the terminal position and F atom or N, N-dimethylamino groups substituted at the side position on conjugated structures are designed and prepared to explore the structure–activity relationships. Notably, results show that introducing electron-donating groups at both positions can effectively induce a redshift in the absorption spectra of molecules, and the introduction of an electron-withdrawing F atom on the side position induces impressive photobleaching during photopolymerization under visible LED irradiation. Moreover, CZs/MDEA with PETA exhibit fast writing speed and excellent nano-patterning capability under 780 nm laser in two-photon polymerization (TPP) and have potential applications in 3D microfabrication technologies.

Topology-Selective Manipulation of Two-Dimensional Covalent Organic Frameworks.

The manipulation of topological architectures in two-dimensional (2D) covalent organic framework (COF) materials for different applications is promising but remains a great challenge. Here, we first report the topology-selective synthesis of two distinct varieties of 2DCOFs, imine-based HT-COFs and benzimidazole-fused BI-HT-COFs, by simply altering acid catalysts. To HT-COFs, a superlattice of 1D channel with a persistent triangular shape is formed via Schiff base reaction, while to BI-HT-COFs, a hexagonal lattice structure with a highly conjugated structure and imidazole linkages is constructed due to an imine-based cyclization reaction. The two COFs exhibited marked differences in their bandgap, chemical stability, molecular adsorption, and catalytic activity, which make them have different fields of application. This work not only diversifies the hexaaminotriphenylene-based 2DCOF topologies but also provides vivid examples of structure-property relationships, which would facilitate fundamental research and potential applications of 2DCOFs.

Molecular design, gel properties, and anti-settling ability with natural rosin-based sulfonamide compounds regulated by conjugation

The design of compounds with excellent controllable weak forces is of great significance to solve current industrial problems. Herein, three natural rosin-based sulfonamide compounds (i.e., dehydroabietyl-based benzene sulfonamide (DBS-1); dehydroabietyl-based benzyl sulfonamide (DBS-2), and dehydrofiranic acid-based p-toluene sulfonamide (DBS-3)) were designed and synthesized by regulating the conjugation of sulfamide, carbonamide, and benzene. Organogels with rod-like, spherical, and layered morphologies were formed by π–π stacking and one-dimensional hydrogen bonding in the absence of an external driving force. Rheological studies emphasized the mechanical strength of these organogels, and gel three-dimensional networks at the nano- and micron-scales can effectively capture six volatile organic solvents. Notably, the presence of conjugation can effectively regulate the dynamic and static equilibrium of organogels to construct stable supermolecular assemblies. DBS-1, which contained abundant conjugated structures and weak intermolecular forces, exhibited amazing anti-settling ability in synthetic oil-based drilling fluids, with a static sedimentation factor of 0.512. Thus, industrial problems such as barite settlement can be solved by using DBS-1 as an additive agent. This report provides inspiration for the effective design of natural anti-settling agents.