Abstract
In this work, a novel two-dimensional semiconducting metal covalent organic framework (CuTAPc-TFPP-COF) was synthesized and used as biosensing platform to construct aptasensor for trace detection of tetracycline (TC). The CuTAPc-TFPP-COF integrates the highly conjugated structure, large specific surface area, high porosity, abundant nitrogen functional groups, excellent electrochemical activity, and strong bioaffinity for aptamers, providing abundant active sites to effectively anchor aptamer strands. As a result, the CuTAPc-TFPP-COF-based aptasensor shows high sensitivity for detecting TC via specific recognition between aptamer and TC to form Apt-TC complex. An ultralow detection limit of 59.6 fM is deduced from the electrochemical impedance spectroscopy within a wide linear range of 0.1–100000 pM for TC. The CuTAPc-TFPP-COF-based aptasensor also exhibits good selectivity, reproducibility, stability, regenerability, and excellent applicability for real river water, milk, and pork samples. Therefore, the CuTAPc-TFPP-COF-based aptasensor will be promising for detecting trace harmful antibiotics residues in environmental water and food samples.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
