Abstract Over the last decade, molecular systematics has undergone a change of paradigm as high-throughput sequencing (HTS) now makes it possible to reconstruct evolutionary relationships using genome-scale datasets. The advent of ‘big... Read More
Computational Biology Research Articles
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A practical guide to design and assess a phylogenomic study
- Genome Biology and Evolution
on Aug 10, 2022
Bioinformatics of Corals: Investigating Heterogeneous Omics Data from Coral Holobionts for Insight into Reef Health and Resilience
- Annual Review of Biomedical Data Science
- VOL. 5
on Aug 10, 2022
Coral reefs are home to over two million species and provide habitat for roughly 25% of all marine animals, but they are being severely threatened by pollution and climate change. A large amount of genomic, transcriptomic, and other omics data is be... Read More
Sherlock: an open-source data platform to store, analyze and integrate Big Data for computational biologists
- F1000Research
- VOL. 10
on Aug 10, 2022
In the era of Big Data, data collection underpins biological research more than ever before. In many cases, this can be as time-consuming as the analysis itself. It requires downloading multiple public databases with various data structures, and in g... Read More
Application of bioreactor technology for cell culture-based viral vaccine production: Present status and future prospects
- Frontiers in Bioengineering and Biotechnology
- VOL. 10
on Aug 9, 2022
Bioreactors are widely used in cell culture-based viral vaccine production, especially during the coronavirus disease 2019 (COVID-19) pandemic. In this context, the development and application of bioreactors can provide more efficient and cost-effect... Read More
Construction of a Deep Neural Network Energy Function for Protein Physics
- Journal of Chemical Theory and Computation
on Aug 8, 2022
The traditional approach of computational biology consists of calculating molecule properties by using approximate classical potentials. Interactions between atoms are described by an energy function derived from physical principles or fitted to expe... Read More
Drug repurposing: re-inventing therapies for cancer without re-entering the development pipeline\u2014a review
- Journal of the Egyptian National Cancer Institute
- VOL. 34
on Aug 8, 2022
While majority of the current treatment approaches for cancer remain expensive and are associated with several side effects, development of new treatment modalities takes a significant period of research, time, and expenditure. An alternative novel a... Read More
IN SILICO PREDICTION OF POTENTIAL INHIBITORS FOR THE M2 PROTEIN OF INFLUENZA A VIRUS USING MOLECULAR DOCKING STUDIES
- Asian Journal of Pharmaceutical and Clinical Research
on Aug 7, 2022
Objective: In this study, the M2 protein of influenza A virus was selected as a target for various phytochemical compounds and an attempt was made to determine their inhibitory activity against the target protein using computational biology. Thus, se... Read More
Nonunique UPGMA clusterings of microsatellite markers
- Briefings in Bioinformatics
on Aug 1, 2022
Abstract Agglomerative hierarchical clustering has become a common tool for the analysis and visualization of data, thus being present in a large amount of scientific research and predating all areas of bioinformatics and computational... Read More
Nanotechnological interventions of the microbiome as a next-generation antimicrobial therapy
- Science of The Total Environment
- VOL. 833
on Aug 1, 2022
The rise of antimicrobial resistance (AMR) impacts public health due to the diminished potency of existing antibiotics. The microbiome plays an important role in the host's immune system activity and shows the history of exposure to antimicrobials an... Read More
Computational models, databases and tools for antibiotic combinations
- Briefings in Bioinformatics
on Aug 1, 2022
Abstract Antibiotic combination is a promising strategy to extend the lifetime of antibiotics and thereby combat antimicrobial resistance. However, screening for new antibiotic combinations is both time-consuming and labor-intensive. I... Read More
An integrative transcriptome analysis reveals potential predictive, prognostic biomarkers and therapeutic targets in colorectal cancer
- BMC Cancer
- VOL. 22
on Jul 30, 2022
BackgroundA deep understanding of potential molecular biomarkers and therapeutic targets related to the progression of colorectal cancer (CRC) from early stages to metastasis remain mostly undone. Moreover, the regulation and crosstalk among differen... Read More
Integrating experience with databases, bioinformatics, and wet lab exercises for students in an introductory genetics course
- Biochemistry and Molecular Biology Education
on Jul 29, 2022
Students often have no exposure to the incredible amount of genomic and proteomic data that is freely and easily accessible online. Becoming familiar with these resources, and seeing how they could be applied to a specific research question, is a pre... Read More
Machine Learning for Endometrial Cancer Prediction and Prognostication
- Frontiers in Oncology
- VOL. 12
on Jul 27, 2022
Endometrial cancer (EC) is a prevalent uterine cancer that remains a major contributor to cancer-associated morbidity and mortality. EC diagnosed at advanced stages shows a poor therapeutic response. The clinically utilized EC diagnostic approaches a... Read More
RGS1 and related genes as potential targets for immunotherapy in cervical cancer: computational biology and experimental validation
- Journal of translational medicine
- VOL. 20
on Jul 25, 2022
BackgroundEffective treatment is needed for advanced, inoperable, or chemotherapy-resistant cervical cancer patients. Immunotherapy has become a new treatment modality for cervical cancer patients, and there is an urgent need to identify additional t... Read More
Screening of salt stress in the overexpressed type of Arabidopsis thaliana (L.) Heynh. for the identification of significant hub genes using a systems biology approach
- Plant Science Today
on Jul 23, 2022
Worldwide, it is known that abiotic and biotic stresses can affect the production of crops by a declining trend. To control the situation, SnRK2 (a subfamily 2 of SNF1-related protein kinase) overexpression levels can induce salt tolerance. This stud... Read More
‘Mechanistic insights into 5-lipoxygenase inhibition by active principles derived from essential oils of Curcuma species: Molecular docking, ADMET analysis and molecular dynamic simulation study
- PLOS ONE
- VOL. 17
on Jul 22, 2022
Inflammation is caused by a cascade of events, one of which is the metabolism of arachidonic acid, that begins with oxidation by the enzyme 5-lipoxygenase. 5-Lipoxygenase (5-LOX) plays an important role in the inflammation process by synthesizing leu... Read More
In Silico Analysis Using SARS-CoV-2 Main Protease and a Set of Phytocompounds to Accelerate the Development of Therapeutic Components against COVID-19
- Processes
- VOL. 10
on Jul 18, 2022
SARS-CoV-2, the virus that caused the widespread COVID-19 pandemic, is homologous to SARS-CoV. It would be ideal to develop antivirals effective against SARS-CoV-2. In this study, we chose one therapeutic target known as the main protease (Mpro) of S... Read More
The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia
- Gates Open Research
- VOL. 6
on Jul 18, 2022
Introduction: Many acutely ill children in low- and middle-income settings have a high risk of mortality both during and after hospitalisation despite guideline-based care. Understanding the biological mechanisms underpinning mortality may suggest op... Read More
Investigation of the Defective Growth Pattern and Multidrug Resistance in a Clinical Isolate of Candida glabrata Using Whole-Genome Sequencing and Computational Biology Applications
- Microbiology spectrum
on Jul 18, 2022
In this study, a cholesterol-dependent C. glabrata clinical isolate that confers azole and AmB resistance was investigated using artificial intelligence (AI) technologies and cloud computing applications. This is ... Read More
DNA Computing: Concepts for Medical Applications
- Applied Sciences
- VOL. 12
on Jul 8, 2022
The branch of informatics that deals with construction and operation of computers built of DNA, is one of the research directions which investigates issues related to the use of DNA as hardware and software. This concept assumes the use of DNA comput... Read More