Complexes In DMF Research Articles

Bidentate bromhexine drug coordination modes with various transition metal ions: Synthesis, characterization, and in vitro antibacterial and anti-breast cancer activity tests

BackgroundBromhexine (BHX) is a mucolytic drug used in treatment the respiratory disorders which are associated with excessive or viscid mucus. Transition metal complexes have made tremendous progress in the treatment of a variety of human ailments, according to reported articles. Transition metal complexes are being developed as medications with a lot of effort. Metal complexes can form a variety of coordination geometries, giving them distinct forms. So, binary metal complexes of bromhexine drug have been prepared to enhance the biological activity and stability of the free drug. MethodsA new series of binary complexes with bromhexine drug (BHX) has been prepared with some transition metal ions namely Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), and Cd(II). Elemental analyses, FT-IR, mass spectrometry, thermal studies and UV-Vis spectra have been used to characterize and structurally elucidate the produced metal complexes. Antibacterial activity has been tested for the ligand and metal complexes against a variety of pathogenic bacterial species (Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus). In addition, the ligand has been tested for anticancer efficacy against the MCF-7 breast cancer cell line, as opposed to binary metal complexes. The binding orientation or conformation of the free BHX ligand and Co(II) complex in the active region of the protein of crystal structure of Escherichia coli (PDB ID: 3T88) and Pseudomonas aeruginosa (PDB ID: 6NE0) has been performed using molecular docking studies. ResultsThe BHX ligand coupled in neutral bidentate mode to the metal ions, according to FT-IR and 1H-NMR spectral results. The molar conductivity measurements of the complexes in DMF proved the electrolytic nature of all binary complexes. Co(II) complex showed the highest inhibition zone diameter against S. aureus, E. coli and P. aeruginosa. Zn(II) complex had the greatest inhibitory effect against P. aeruginosa and B. subtilis. Also, Cd(II) chelate appeared high efficacy as antibacterial agent against Pseudomonas aeruginosa and Staphylococcus aureus. ConclusionAll the output data conjugated to confirm the octahedral geometry of the metal complexes. The biological findings revealed that metal complexes can be more active than the free BHX ligand. Against MCF-7 cell line, Cd(II)-L complex is highly active complex (4.95 µg/mL) but BHX free drug is the most active compound (3.96 µg/mL).

New nano-complexes targeting protein 3S7S in breast cancer and protein 4OO6 in liver cancer investigated in cell line

Cancer, a lethal ailment, possesses a multitude of therapeutic alternatives to combat its presence, metal complexes have emerged as significant classes of medicinal compounds, exhibiting considerable biological efficacy, especially as anticancer agents. The utilization of cis-platin in the treatment of various cancer types, including breast cancer, has served as inspiration to devise novel nanostructured metal complexes for breast cancer therapy. Notably, homo- and hetero-octahedral bimetallic complexes of an innovative multifunctional ether ligand (comprising Mn(II), Ni(II), Cu(II), Zn(II), Hg(II), and Ag(I) ions) have been synthesized. To ascertain their structural characteristics, elemental and spectral analyses, encompassing IR, UV–Vis, 1H-NMR, mass and electron spin resonance (ESR) spectra, magnetic moments, molar conductance, thermal analysis, and electron microscopy, were employed. The molar conductance of these complexes in DMF demonstrated a non-electrolytic nature. Nanostructured forms of the complexes were identified through electron microscopic data. At ambient temperature, the ESR spectra of the solid complexes exhibited anisotropic and isotropic variants, indicative of covalent bonding. The ligand and several of its metal complexes were subjected to cytotoxicity testing against breast cancer protein 3S7S and liver cancer protein 4OO6, with the Ag(I) complex (7) evincing the most potent effect, followed by the Cu(II) with ligand (complex (2)), Cis-platin, the ligand itself, and the Cu(II)/Zn(II) complex (8). Molecular docking data unveiled the inhibitory order of several complexes.

Multiple Noncovalent Binding in the Intermediates and Products of the Reaction of <i>N,N</i>-Dimethylformamide with Bromine

Reaction of nonionic N,N-dimethylformamide (DMF) with bromine under controllable conditions leads to a number of ionic compounds, mainly to bis(N,N-dimethylformamide)hydrogen dibromobromate. Computations with DFT (ωB97xV/dgdzvp) were made for geometry, thermochemistry and electron configuration of products and supposed intermediates. Two labile particles [bis(N,N-dimethylformamide)hydrogen cation and dibromobromate-anion] form stable highly conductive ionic liquid that can be distilled in vacuo without losses or decomposition. A number of molecular complexes of DMF with bromine and water presumed to be intermediates of this reaction. It is a set of halogen and hydrogen bonding that provide an intramolecular binding in these complexes.

Synthesis of Sodium Myristyl Sulfate with Myristyl Alcohol Sulfation using SO3-DMF

The sulfation reaction between myristyl alcohol and the SO3-DMF complex has been successfully carried out to produce sodium myristyl sulfate. Formation of the SO3-DMF complex by reacting DMF and SO3 gas obtained from the reaction of phosphorus pentaoxide and H2SO4. The variables studied were the time of formation of the complex, the time and temperature of sulfation and the concentration of NaOH at neutralization. The results of myristyl alcohol sulfation with SO3-DMF were tested by FTIR spectroscopic analysis, surface tension test, and foam stability test. The formation time of the SO3- DMF complex of 5 hours is the result of the highest surface tension reduction and the most optimal foam stability. The results of the foam stability test analysis showed the highest value at 80oC with a foam stability of 0.5 cm. The best result of sulfation neutralized with 40% NaOH solution was able to reduce the surface tension value and has foam stability up to 66% with a decrease in foam height of 0.3 cm

Hydrogen Evolution Electrocatalysis with a Molecular Cobalt Bis(alkylimidazole)methane Complex in DMF: a Critical Activity Analysis.

[Co(HBMIMPh2 )2 ](BF4 )2 (1) [HBMIMPh2 =bis(1-methyl-4,5-diphenyl-1H-imidazol-2-yl)methane] was investigated for its electrocatalytic hydrogen evolution performance in DMF using voltammetry and during controlled potential/current electrolysis (CPE/CCE) in a novel in-line product detection setup. Performances were benchmarked against three reported molecular cobalt hydrogen evolution reaction (HER) electrocatalysts, [Co(dmgBF2 )2 (solv)2 ] (2) (dmgBF2 =difluoroboryldimethylglyoximato), [Co(TPP)] (3) (TPP=5,10,15,20-tetraphenylporphyrinato), and [Co(bapbpy)Cl](Cl) (4) [bapbpy=6,6'-bis-(2-aminopyridyl)-2,2'-bipyridine], showing distinct performances differences with 1 being the runner up in H2 evolution during CPE and the best catalyst in terms of overpotential and Faradaic efficiency during CCE. After bulk electrolysis, for all of the complexes, a deposit on the glassy carbon electrode was observed, and post-electrolysis X-ray photoelectron spectroscopy (XPS) analysis of the deposit formed from 1 demonstrated only a minor cobalt contribution (0.23 %), mainly consisting of Co2+ . Rinse tests on the deposits derived from 1 and 2 showed that the initially observed distinct activity was (partly) preserved for the deposits. These observations indicate that the molecular design of the complexes dictates the features of the formed deposit and therewith the observed activity.

Tunable Multicolor Circularly Polarized Luminescence via Co-assembly of One Chiral Electron Acceptor with Various Donors

Tunable Multicolor Circularly Polarized Luminescence via Co-assembly of One Chiral Electron Acceptor with Various Donors

Square planar Ni(II) thiosemicarbazone complexes as functional models for carbon monoxide dehydrogenase

Two Ni(II) complexes, [Ni(dmoTSCH)Cl] (1) and [Ni(dmoPhTSCH)Cl] (2) of the tridentate thiosemicarbazone ligands diacetylmonooxime thiosemicarbazone (dmoTSCH2) and diacetylmonooxime (4-phenyl)thiosemicarbazone (dmoPhTSCH2) have been synthesized. X-ray crystal structure of [Ni(dmoTSCPhTSCH)Cl] (2) indicates that the Ni(II) assumes a square planar geometry in the complexes, with the ligand coordinated in a monoanionic N,N,S donor mode and the fourth coordination position of Ni(II) is occupied by a chloride ion. Cyclic and differential pulse voltammetric experiments suggest that the Ni(II) complexes can undergo a two electron reduction at about −1.0V. It is shown that the Ni(II) complexes in DMF or DMSO solutions can mimic CO-dehydrogenase activity by oxidizing CO to CO2 in presence of a base like NaOAc and a sacrificial electron acceptor like methyl viologen and the colour of the resultant MV.+ can be used to monitor the reaction.

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL STUDIES OF SOME DIVALENT METAL(II) COMPLEXES DERIVED FROM 1-[(4-IODO-PHENYLIMINO)-METHYL]-NAPHTHALEN-2-OL SCHIFF BASE

Schiff base derived from condensation of 2-hydroxy-1-naphthaldehyde and 4-iodoaniline was synthesized and used for the preparation of Co(II) and Ni(II) complexes. The complexes were characterized by IR, Powder-XRD, Solubility test, thermal analysis, conductivity measurement, magnetic susceptibility and elemental micro analysis. IR study indicated a strong band in the spectra of the Schiff base at 1603 cm-1 assigned to azomethine v(C=N) stretching vibration. It shifted to new frequency regions (1618 - 1622 cm-1) in the spectra of the complexes indicating the formation of the desired complexes. The decomposition temperatures of the complexes are in the range of (260-265) oC , molar conductance values are in the range of (4.51 -11.31) Ohm-1cm2 mol-1, indicating non electrolytic nature of the synthesized complexes in DMF. Magnetic susceptibility measurement indicated that Co(II) and Ni(II) complexes are paramagnetic and exhibit magnetic moment in the range of 2.92-3.24 BM, the values correspond to the square planar geometry. The Powder x-ray diffraction analysis showed the patterns of the metal(II) complexes were different from the reactants, signifying that reactants were changed to product. The CHN analysis results show the formation of 1:2 metal to ligand ratio. The synthesized compounds have been studied for antimicrobial activity using pathogenic bacteria and fungal pathogens by disc diffusion method. The results indicated that metal complexes (10 – 15 mm inhibition zone) are more active compared to Schiff base (8 – 12 mm inhibition zone) against the test organisms.

Synthesis, Spectral, Thermal and Biological Studies of Some Transition and Inner Transition Schiff base Metal Complexes

The new bidentate Schiff base ligand (L) named N1-(diphenylmethylene)naphthalene-1,8-diamine was prepared by the condensation reaction of benzophenone and 1,8-naphthylenediamine. The complexes with Mn(II), Ni(II), Zn(II), La(III), Er(III), and Yb(III) metal ions were prepared and characterized by using elemental analyses (C, H, N and M), FT-IR, 1H NMR, molar conductivity, magnetic moment, UV-Vis, mass and scanning electron microscope (SEM). The temperatures of decomposition of the Schiff base ligand and metal complexes were investigated using thermal analyses. The metal complexes were found to have the formulae [M(L)(H2O)3Cl]Cl.nH2O (M = Mn(II) (n = 4); Ni(II) (n = 2))], [Zn(L)(H2O)2Cl2] and [M(L)(H2O)2Cl2]Cl (M = La(III), Er(III) and Yb(III)) according to the elemental analyses data. The geometrical structure of all complexes was found to be octahedral. The molar conductivity of the complexes in DMF indicated the electrolytic nature of all complexes except Zn(II) complex was non-electrolyte. From the spectroscopic data, the Schiff base ligand acts as NN-bidentate ligand. The biological and anticancer activities of the Schiff base ligand and its complexes were investigated against two bacterial strains, two fungal strains and breast cancer cell line (MCF-7). Docking studies were performed to study the possible interaction between the Schiff base ligand with the active sites of the 3HB5 and 5JPE receptors.

Towards High‐Performance Zinc‐Based Hybrid Supercapacitors via Macropores‐Based Charge Storage in Organic Electrolytes

AbstractZn‐based aqueous supercapacitors are attracting extensive attention. However, most of the reported long‐life and high‐power performances are achieved with low Zn‐utilization (<0.6 %) and low mass loading in cathode (<2 mg cm−2). And, many obtained high energy densities are generally evaluated without considering the mass of Zn‐anode. Herein, we propose a Zn‐based hybrid supercapacitor, involving a metal organic framework derived porous carbon cathode, a Zn‐anode and an N, N‐dimethylformamide (DMF)‐based electrolyte containing Zn2+. We demonstrate that the charge storage of cathode mainly occurs in macropores, showing high rate performance at high mass loading (40 mg cm−2). Furthermore, the aprotic nature of electrolyte and formation of Zn2+‐DMF complex avoid the Zn‐corrosion and dendrite formation. Therefore, the supercapacitor shows a long‐life (9,000 cycles) with a high Zn‐utilization (2.2 %). When calculated with the total mass of cathode (40 mg cm−2) and Zn‐anode, the energy density reaches 25.9 Wh kg−1.

Towards High-Performance Zinc-Based Hybrid Supercapacitors via Macropores-Based Charge Storage in Organic Electrolytes.

Zn-based aqueous supercapacitors are attracting extensive attention. However, most of the reported long-life and high-power performances are achieved with low Zn-utilization (<0.6 %) and low mass loading in cathode (<2 mg cm-2 ). And, many obtained high energy densities are generally evaluated without considering the mass of Zn-anode. Herein, we propose a Zn-based hybrid supercapacitor, involving a metal organic framework derived porous carbon cathode, a Zn-anode and an N, N-dimethylformamide (DMF)-based electrolyte containing Zn2+ . We demonstrate that the charge storage of cathode mainly occurs in macropores, showing high rate performance at high mass loading (40 mg cm-2 ). Furthermore, the aprotic nature of electrolyte and formation of Zn2+ -DMF complex avoid the Zn-corrosion and dendrite formation. Therefore, the supercapacitor shows a long-life (9,000 cycles) with a high Zn-utilization (2.2 %). When calculated with the total mass of cathode (40 mg cm-2 ) and Zn-anode, the energy density reaches 25.9 Wh kg-1 .

Synthesis, structural elucidation and electrochemical behavior of some oxime-phenylalanine mixed ligand complexes

Four new mixed ligand complexes Me(II)/phenylalanine (phe)/HL [HL =4-(4-bromophenyl- aminoisonitrosoacetyl)biphenyl and Me = Co, Ni, Cu, Zn] were synthesized. These complexes are formulated as: [CoL(phe)(H2O)2], [NiL(phe)(H2O)2], [CuL(phe)(H2O)2] and [ZnL(phe)(H2O)2]. All the compounds were characterized by elemental analyses, FT-IR, magnetic susceptibility measurements, TG/DTA and cyclic voltammetry (CV) experiments. IR spectral data confirmed the coordination of the oxime ligand to the metal ions through the oxime and carbonyl oxygen. The geometrical structures of the complexes have been found to be octahedral. The measured molar conductance values of the complexes in DMF are in agreement with the non-electrolytic nature ofthe complexes. The elemental analyses confirm a 1:1:1 [metal:HL:L(phenylalanine)] molar ratio. Thermal behavior of the compound was investigated by thermal gravimetric analysis (TG) and differential thermal analysis (DTA) techniques. All the complexes were transformed into metal oxides after thermal degradation. The electrochemical properties of both ligand and their complexes were analyzed by cyclic voltammetry (CV) using glassy carbon electrode in DMF solution containing 0.1 M TBAP as supporting electrolyte.&#x0D; &#x0D; KEY WORDS: Oxime, electrochemical characterization, mixed ligand complexes, amino acid, phenylalanine&#x0D; &#x0D; Bull. Chem. Soc. Ethiop. 2020, 34(3), 543-556.&#x0D; DOI: https://dx.doi.org/10.4314/bcse.v34i3.10

One-dimensional La(III) coordination polymer displaying multi-responsive luminescence activities towards Fe3+, acetone and benzothiozoles

Through reaction of La(NO3)3 with a flexible carboxylic acid ligand named 3,5-bis[(2-carboxyphenyl)oxy]benzoic acid (H3L) under solvothermal condition, the complex with the formula of [La(L)(DMF)2] (1) was obtained. One-dimensional chain of the complex was generated through the connection of binuclear units of La2(COO)4 across the flexible acid ligands. Luminescence results showed that different pollutants (Fe3+, acetone and benzothiophene organic compounds) could quench the luminescence of the blue emission of the complex in DMF with much low detection limit. Among several 2-substituted benzothiophene compounds, 2,2′-dithiobisbenzothiazole (DM) has a strongest binding constant of 10.8 ​× ​104 ​M−1 and lowest detection limit of 0.332 ​μM (0.110 ​ppm). All quenching effect was found within 15 ​s. The sensing mechanism was investigated through a series of experiments and theoretical calculation. Complex 1 could be employed as a multi-responsive chemsensor for detection of different pollutants with high sensitivity and fast response.

Electrochemical reduction of purpurin, its Mn(II) complex in DMF and aqueous-DMF mixed solvent: A cyclic voltammetric study

Electrochemical reduction of purpurin, its Mn(II) complex in DMF and aqueous-DMF mixed solvent: A cyclic voltammetric study

Zinc-Organic Battery with a Wide Operation-Temperature Window from -70 to 150 °C.

Aqueous zinc (Zn) batteries have been considered as promising candidates for grid-scale energy storage. However, their cycle stability is generally limited by the structure collapse of cathode materials and dendrite formation coupled with undesired hydrogen evolution on the Zn anode. Herein we propose a zinc-organic battery with a phenanthrenequinone macrocyclic trimer (PQ-MCT) cathode, a zinc-foil anode, and a non-aqueous electrolyte of a N,N-dimethylformamide (DMF) solution containing Zn2+ . The non-aqueous nature of the system and the formation of a Zn2+ -DMF complex can efficiently eliminate undesired hydrogen evolution and dendrite growth on the Zn anode, respectively. Furthermore, the organic cathode can store Zn2+ ions through a reversible coordination reaction with fast kinetics. Therefore, this battery can be cycled 20 000 times with negligible capacity fading. Surprisingly, this battery can even be operated in a wide temperature range from -70 to 150 °C.

Zinc–Organic Battery with a Wide Operation‐Temperature Window from −70 to 150 °C

AbstractAqueous zinc (Zn) batteries have been considered as promising candidates for grid‐scale energy storage. However, their cycle stability is generally limited by the structure collapse of cathode materials and dendrite formation coupled with undesired hydrogen evolution on the Zn anode. Herein we propose a zinc–organic battery with a phenanthrenequinone macrocyclic trimer (PQ‐MCT) cathode, a zinc‐foil anode, and a non‐aqueous electrolyte of a N,N‐dimethylformamide (DMF) solution containing Zn2+. The non‐aqueous nature of the system and the formation of a Zn2+–DMF complex can efficiently eliminate undesired hydrogen evolution and dendrite growth on the Zn anode, respectively. Furthermore, the organic cathode can store Zn2+ ions through a reversible coordination reaction with fast kinetics. Therefore, this battery can be cycled 20 000 times with negligible capacity fading. Surprisingly, this battery can even be operated in a wide temperature range from −70 to 150 °C.

Design, Spectroscopic Characterization and Theoretical Studies of Organotin(IV) and Organosilicon(IV) Complexes with Schiff Base Ligands Derived from Amino Acids

A new series of organotin(IV) and organosilicon(IV) complexes were synthesized using the Schiff base ligands [2-((3,4-dimethoxybenzylidene)amino)-3-(1H-indol-3-yl)propanoic acid (L1H) and 2-((3,4-dimethoxybenzylidene)amino)-3-methylbutanoic acid (L2H)]. The synthesized compounds were characterized by IR, NMR (1H and13C), elemental analysis and theoretical studies. The molar conductivity values of the complexes in DMF implied the presence of non-electrolyte species. Spectral data showed that in these complexes the metal atoms are coordinated with the Schiff base ligand acts as a bidentate ON moiety, coordinating to the metal through its carboxylate oxygen and imine nitrogen. The IR spectra of the complexes showed large differences between νasy(COO) and νsy(COO), Δν (νasy(COO)–νsy(COO)) of 260-276 cm–1, indicating monodentate nature of the carboxylate group. Furthermore, the density functional theory (DFT) calculations were executed at the B3LYP/6-31G(d,p)/ LanL2DZ basis set of theory for the optimized geometry of Schiff base complexes. The structural parameters, bond length, bond angles, chemical potential, electronegativity, hardness, softness, global electrophilicity index have been studied theoretically by density functional theory (DFT) to support the experimental results.

Synthesis, characterization, biological screening and molecular docking of Zn(II) and Cu(II) complexes of 3,5‐dichlorosalicylaldehyde‐N4‐cyclohexylthiosemicarbazone

A 3,5‐dichlorosalicylaldehyde‐N4‐cyclohexylthiosemicarbazone (C14H16Cl2N3OS) and its complexes [Zn(dsct)(phen)]·DMF (1), [Zn(dsct)(bipy)]·DMF (2), [Cu(dsct)(bipy)]·DMF (3) (phen = 1,10‐phenathroline, bipy = 2,2’bipyridine) were synthesized and characterized by CHN analysis, FT‐IR, UV–vis and NMR spectra. The molecular structure of the thiosemicarbazone (H2dsct) and its complexes have been resolved using single crystal XRD studies. In the complexes, thiosemicarbazone exist in the thioiminolate form and acts as dideprotonated tridentate ligand coordinating through phenolic oxygen, thioiminolate sulfur and azomethine nitrogen. The antibacterial activity of the prepared compounds were screened against Escherichia coli, Salmonella typhi, Enterobacter aerogenes, Shigella dysentriae, Bacillus cereus, Staphylococcus aureus. All the complexes showed activity against bacterial strains E.coli and Salmonella typhi. The thiosemicarbazone showed activity against three bacterial strains such as E. coli, Enterobacter aerogenes and Shigella dysentriae. Complex 2 showed very good antibacterial activity as compared to standard drug (Ampicillin) against the bacterial strain, Salmonella typhi. Finally, the thiosemicarbazone and its complexes have been used to accomplish molecular docking studies against an Epidermal Growth Factor Receptor (EGFR) and breast cancer mutant 3hb5‐oxidoreductase to determine the most preferred mode of interaction. The results confirm that the complex [Cu (dsct)(bipy)]·DMF(3) showed the highest docking score as compared to other complexes under study. The [Cu(dsct)(bipy)]·DMF(3) complex was evaluated for their anticancer activities against breast cancer cell line (MCF‐7) and normal L929 (Mouse Fibroblast) cell line. It was found that the compound showed an LC50 of 6.25 μg/mL against breast cancer cell line (MCF‐7).

FeCl3-DMF complex as efficient catalyst for the synthesis of 6-acyl-2(3H)-benzoxazolones and 6-acyl-2(3H)-benzothiazolones

ABSTRACT . FeCl 3 -DMF complex has been tested on Friedel-Crafts reaction of 2(3 H )-benzoxazolone and 2(3 H )-benzothiazolone with acid chlorides and anhydrides as acylating agents. In these conditions, the 6-acyl-2(3 H )-benzoxazolones and 6-acyl-2(3 H )-benzothiazolones were obtained in yields ranging from 52 to 89%. Among the various commonly catalysts; AlCl 3 -DMF, ZnCl 2 -DMF and PPA, explored in this study, the best conditions using FeCl 3 -DMF were found the most convenient one KEY WORDS : FeCl 3 -DMF, AlCl 3 -DMF, ZnCl 2 -DMF, PPA, 6-Acyl-2(3 H )-benzothiazolones, 6-Acyl-2(3 H )-benzothiazolones Bull. Chem. Soc. Ethiop. 2019 , 33(3), 579-585. DOI: https://dx.doi.org/10.4314/bcse.v33i3.18

Tetra-2,3-pyrazinoporphyrazines with Peripherally Appended Pyridine Rings. 20. Mono- and Pentanuclear AlIII and GaIII Complexes: Synthesis and Physicochemical and Photoactivity Studies.

The autocyclotetramerization of the precursor 2,3-dicyano-5,6-di(2'-pyridyl)pyrazine [(CN)2Py2Pyz] in the presence of MCl3 compounds (M = AlIII, GaIII) leads to the formation of the new mononuclear porphyrazine complexes [Py8TPyzPzMCl]·xH2O (Py8TPyzPz = tetrakis-2,3-[5,6-di(2-pyridyl)pyrazino]porphyrazinato anion). From these species, the hydroxide analogues [Py8TPyzPzMOH]·xH2O were obtained by contact with hot water, and their corresponding pentanuclear species [(PdCl2)4Py8TPyzPzMCl]·xH2O could be easily formed by the reaction with PdCl2. Physicochemical characterization of the mono- and pentanuclear macrocycles was based on elemental analysis, and mass, powder X-ray, and IR spectra. UV-vis spectral studies of the mononuclear species in solutions of DMF, DMSO, or pyridine (c ≈ 10-5-10-6 M) indicate (mainly in DMF and DMSO) the initial presence of aggregation, in some cases accompanied by the concomitant occurrence for the complex of a one-electron reduction. While disaggregation into a single species evolves spontaneously over time, the -1 charged species, eventually also found present, can be brought back to its neutral form by addition of a slight amount of HCl, the final spectrum showing the presence of the starting neutral species in its pure monomeric form. Similar aspects were faced also for the parent pentanuclear complexes. Cyclic voltammetry experiments, conducted for the mono-/pentanuclear complexes in DMF and DMSO (c ≈ 10-4 M), exhibit progressive one-electron reductions (1 → 4) characterized by E1/2 values (V vs SCE) positioned to significantly less negative values than those known for the phthalocyanine (Pc) analogues, these data confirming the previously already proven higher electron-deficient character of the MII derivatives of the Py8TPyzPz macrocycle with respect to Pc. The role of the present new series of AlIII and GaIII macrocyclic species to act as photosensitizers for the generation of singlet oxygen, 1O2, the cytotoxic agent in the anticancer treatment known as photodynamic therapy (PDT), has been explored in DMF/HCl. Among the quantum yields ΦΔ, the value found for the GaIII complex [Py8TPyzPzGaCl] (0.68), practically coincident with that observed for the TTDPz analogue (0.69), is well above those of most porphyrazines analogues (ΦΔ = 0.4-0.6), a result encouraging further research work for potential applications in the biochemical field.