Abstract
Four new mixed ligand complexes Me(II)/phenylalanine (phe)/HL [HL =4-(4-bromophenyl- aminoisonitrosoacetyl)biphenyl and Me = Co, Ni, Cu, Zn] were synthesized. These complexes are formulated as: [CoL(phe)(H2O)2], [NiL(phe)(H2O)2], [CuL(phe)(H2O)2] and [ZnL(phe)(H2O)2]. All the compounds were characterized by elemental analyses, FT-IR, magnetic susceptibility measurements, TG/DTA and cyclic voltammetry (CV) experiments. IR spectral data confirmed the coordination of the oxime ligand to the metal ions through the oxime and carbonyl oxygen. The geometrical structures of the complexes have been found to be octahedral. The measured molar conductance values of the complexes in DMF are in agreement with the non-electrolytic nature ofthe complexes. The elemental analyses confirm a 1:1:1 [metal:HL:L(phenylalanine)] molar ratio. Thermal behavior of the compound was investigated by thermal gravimetric analysis (TG) and differential thermal analysis (DTA) techniques. All the complexes were transformed into metal oxides after thermal degradation. The electrochemical properties of both ligand and their complexes were analyzed by cyclic voltammetry (CV) using glassy carbon electrode in DMF solution containing 0.1 M TBAP as supporting electrolyte.
 
 KEY WORDS: Oxime, electrochemical characterization, mixed ligand complexes, amino acid, phenylalanine
 
 Bull. Chem. Soc. Ethiop. 2020, 34(3), 543-556.
 DOI: https://dx.doi.org/10.4314/bcse.v34i3.10
Highlights
Oximes are noteworthy complexing agents due to the several electron-rich donor centers with unusual structural and chemical properties and they can form different types of coordination compounds with transition metal ions [1,2,3,4]
Amino acids bind to transition metal ions via the carboxylate-O and the amino-N donor atoms, thereby forming a thermodynamically stable five-membered chelate ring [13, 14]
The synthesized ligand and the mixed ligand complexes were investigated using various physiochemical properties like melting point (m.p.), color, yield, micro analytical data and molar conductance value are given in the experimental part
Summary
Oximes are noteworthy complexing agents due to the several electron-rich donor centers with unusual structural and chemical properties and they can form different types of coordination compounds with transition metal ions [1,2,3,4]. The ligand quantity, ligand type, and coordination geometry have important factors on the biological activity and the other properties of metal-based complexes. Many mixed amino acid complexes have considerable biological activity, such as antitumor properties, and usually increase the diffusibility of complexes and enhance their biological action inside the cell. Such systems are widely used in the field of chemotherapy [12, 14, 23]. The relative thermal stabilities of the complexes and their electrochemical behavior have been discussed
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