The present study deals with the preparation and characterization of Melia azedarach L. twigs charcoal powder (MAT-CP) followed by batch and column adsorption experiments to appraise its Cd(II) removal efficiency from aqueous solution. The characterization of charcoal was done using XRD, FTIR, FESEM, EDX and BET analysis. Batch adsorption study was conducted with varied variables including adsorbent dose, contact time, temperature, pH and agitation speed. Resultant data was suitably fitted in Langmuir isotherm model exhibiting a maximum 196.078 mg/g adsorption capacity. Kinetic studies revealed that the adsorption followed Pseudo-second order kinetic while thermodynamic analysis (enthalpy (ΔH°), entropy (ΔS°) and Gibb’s free energy (ΔG°)) revealed the interaction to be thermodynamically favorable and endothermic. Regeneration of adsorbent was also done and the reactivated MAT-CP was repeatedly used as adsorbent. In fixed-bed column investigation, variables such as flow rate, initial metal concentration and column bed height were varied to obtain breakthrough curves (BTCs). The column adsorption was optimally obtained at 2.5 mL/min flow rate, 25 mg/L of Cd(II) concentration and 5 cm bed height. Column adsorption modeling reflected higher R2 and adsorption capacity using Thomas and Nelson-Yoon models. The present study advocates the MAT-CP as an efficient adsorbent for Cd(II) removal from aqueous solution.