The article is devoted to the issues of environmental protection in the conditions of new ecological, climatic and epidemiological challenges, which has an impact on the economy and social sphere of the state. The need for research in the complex is due to the fact that environmental challenges are global in nature and are interdependent. The aim of this article is a comprehensive study of approaches to understanding the specifics of the national strategy for environmental protection in the context of new climate challenges and finding mechanisms for implementing new environmental initiatives and the application of new environmental and energy-saving technologies.The article focuses on the analysis of modern environmental challenges that have increased scientific interest in the formation of a unified strategy for environmental protection. The necessity of joint efforts to build a collective security system and compensate for the damage caused to nature and to prevent further negative phenomena is summed up and stated. Among the directions and actions are: to develop the Strategy of Ukraine for environmental protection, to develop and formulate environmental education and environmental awareness of citizens; to develop a set of measures for the adaptation of various spheres of human life and industries.