The Mobile Wireless Sensor Networks (MWSN) are defined as the successor of Wireless Sensor Networks (WSN); geographically distributed autonomous mobile sensors for physical and environmental conditions monitoring. Mobile sensor networks are more flexible than static sensor networks as they can cope with rapid topology changes. Sensor networks are deployed by having their sensors collect information reliably and then relay the sensor readings to a central base station using wireless multi-hop transmission. Multi-hop routes within a rapid-changed topology requires a routing protocol that can adapt to network changes with an efficient communication mechanism among the nodes; to comply with the energy-constraint nature of the wireless sensor networks. Through significant simulation on this study using the AVRora simulator, the Collection Tree Protocol’s (CTP) capacity to respond to MWSN’s changing network topology was assessed by analysing the performance indicators; specifically, the average of packet loss and energy use of mobile nodes with different circumstances considering varied quantities of mobile nodes in the simulation region, with different velocities and network density. In several circumstances, the implementation of CTP in MWSN indicates a rise in energy usage because of broken linkages along with regular tree regeneration brought on by node mobility.