Collagen Supplementation Research Articles

Low dietary silicon supplementation may not affect bone and cartilage in mature, sedentary horses

As osteoarthritis is a major cause of lameness in horses in the United States, improving collagen health prior to onset and increasing collagen turnover within affected joints could improve health- and welfare-related outcomes. Through its positive effects on bone mineral content and density and its role in increasing collagen synthesis, silicon (Si) may slow the development and progression of osteoarthritis, thereby reducing lameness. This study evaluated the hypothesis that Si supplementation would increase cartilage turnover through increased collagen degradation and formation markers, as well as bone formation markers, resulting in reduced lameness severity when compared with controls. Ten mature Standardbred geldings were assigned to either a Si-treated (SIL) or control (CON) group and group-housed on pasture for 84 d. Horses were individually fed to ensure no cross-contamination of Si other than what was present in the environment. For the duration of the study, SIL horses received a Si-collagen supplement at the rate of 0.3 g supplement/(100 kg body weight day). Serum samples were taken weekly for osteocalcin, and plasma samples were taken on days 0, 42, and 84 for plasma minerals. On days 0, 42, and 84, subjective and objective lameness exams were performed, and radiographs and synovial fluid samples were taken from reference and osteoarthritic joints. Plasma minerals were similar in both groups and were lower on day 84 than on day 0 (P < 0.05). Si supplementation, fed at the manufacturer's recommended rate, did not improve lameness or radiographs when compared with controls, and supplemented horses did not show greater collagen degradation and/or synthesis markers in synovial fluid than controls, indicating that cartilage turnover remained unaffected. However, a minimum beneficial threshold and range for Si supplementation standardized to body weight need to be established.

Impacto de la suplementación con colágeno hidrolizado en mujeres fumadoras

Introducción: Por ser el rostro de la parte del organismo más expuesta y que sufre el proceso de envejecimiento prematuro, merece atención y prácticas que preserven su belleza. Objetivo: Analizar los beneficios de la suplementación con colágeno hidrolizado en la piel de mujeres fumadoras (n = 7). Métodos: Se complementó diariamente, durante 90 días, 10 mg de colágeno hidrolizado en polvo, que contiene 45 mg de vitamina C, 17 mcg de selenio, 3,5 mg de zinc y 9 g de colágeno hidrolizado. Se registró, a través de fotografías tomadas por un dermatólogo, el rostro de las mujeres antes y al final del tratamiento, para que a través de este se pudiera realizar la valoración cutánea por parte del médico. Se evaluó la textura, hidratación, arrugas, manchas y brillo de la piel. Resultados y Discusión: Las manchas y arrugas mostraron poca o ninguna mejoría, la hidratación y textura variaron entre mejoría y muy buena mejoría y el brillo tuvo el mejor resultado, con muy buena mejoría en todos los participantes. Conclusión: La suplementación de colágeno hidrolizado es beneficiosa para algunas características más superficiales de la piel, sin reducir el efecto de arrugas e imperfecciones. Sin embargo, se recomienda la suplementación ya que el colágeno es una sustancia natural en el cuerpo, que se degrada a lo largo de la vida, y esta degradación se acelera al fumar.

Collagen Supplements: Benefits, Uses and Side Effects

Collagen is a major component of connective tissue making up the structure of tendons, ligaments, skin, and muscles [1]. It is the most abundant protein in the extracellular matrix and has a characteristic triple helix of three polypeptide chains [2].

Collagen in the media: An analysis of news published between 2016 and 2018.

This study examines 102 news items related to collagen as a dietary supplement, written in Spanish and published over a period of 2 years, in both digital and print media. The objective of this study is to evaluate the scientific rigor and consistency of the news information included in the sample. Errors and incorrect uses relative to the current scientific knowledge were identified in the analyzed information, and these errors were classified according to the criteria extracted from previous research. The evidence gathered shows a relevant frequency of errors in the information examined. The results are discussed in light of the role that the media plays in the transmission of beliefs regarding the value of collagen supplements.

Complex Intraoral Rehabilitation with Collagen Supplements and Biomedical Infrared Radiation Reliance in TMJ Disorders

Techniques of balneo-physio-kinetotherapy and complex oral rehabilitation are general measures approach, which are addressed to all patients for maintaining the homeostasis of the whole body and also of the cephalic extremity, as well as specific measures, targeted in our case at the level of the stomatognathic system. These kind of appoach treatments are in accordance with an individualized therapeutical scheme and gradually complying with the principles and concepts of complex oral rehabilitation. Infrared radiation and masotheraphy is a form of balneo-physiotheraphy medicine in adjuvant and incresed results of benefits of clasic treatment in temporo-mandibular disorders. The association of these treatments, is favorited above monotherapy.

Understanding aesthetic interest in oral collagen peptides: A 5-year national assessment.

Oral supplementation with collagen peptides has recently grown in popularity. It has been marketed to offer skin rejuvenating properties, such as wrinkle reduction, skin plumping, and moisturizing effects. However, current data are limited regarding its effects on the skin. Despite the controversial status of oral collagen supplements, its popularity has continued to rise. Here, we examine the consumer interest in oral collagen peptides over a 5-year period in the United States.

Effects Of Vitamin C Enriched Hydrolyzed Collagen On Explosive Performance

The stiffness of a tendon is determined by the amount and cross-linking of collagen within the tissue. Acute exercise and possibly vitamin C-enriched collagen supplementation have been shown to increase collagen synthesis as well as the expression of the primary enzyme involved in collagen cross-linking (lysyl oxidase). The result may be a denser and stiffer tissue. Stiffness is directly related to force transfer. Whether this nutritional supplementation can further augment response to training, in particular rate of force development (RFD), and translate to improved explosive performance compared to training alone is unknown. PURPOSE: To determine if nutritional supplementation with vitamin C-enriched collagen improves RFD compared to placebo (PLA) with an explosive power-based training regime. METHODS: Healthy male collegiate football players (18-25 years) were enrolled in a 3-week double-blinded, parallel design study. Athletes were randomly assigned to the intervention group (COLL; 15g hydrolyzed collagen with 50mg vitamin C) or placebo group (PLA; 15g rice four). Supplements were ingested 60min prior to training 5 days per week and with breakfast on rest days. Athletes completed the same training program and progression. RFD was measured from the best of three maximal isometric squats, countermovement jumps and squat jumps (Kistler, Novi, MI) performed at the same time on each testing day (baseline and after 1,2 and 3 weeks of training). Two-way ANOVA (nutrition intervention and time) was used to compare RFD between groups. RESULTS: At time of analysis there were no significant difference for maximal RFD in the maximal isometric squat between the interventions. RFD data from CMJ and SJ are yet to be determined. CONCLUSION: Supplementation with vitamin C-enriched collagen prior to training throughout a 3-week explosive power-based training program does not improve maximal RFD compared to exercise alone. More comprehensive analysis of all RFD parameters is required to fully interpret results from this study and will be completed prior to abstract presentation.

Effect of Marine Phytoplankton (Oceanix) and Undenatured Type II Collagen in Combination with Exercise on Endurance Capacity and Oxidative Stress in Rats

Abstract Objectives To study the effect of exercise training alone and or in combination with marine phytoplankton (Oceanix, OCX) and undenatured type II collagen (UCII) supplementation on the endurance capacity, pro-inflammatory markers, and antioxidant defense markers in rats. Methods A total of 28 male Wistar albino rats were randomly divided into four groups (n = 7) (i) No exercise and no OCX (Control), (ii) Exercise, (iii) Exercise +OCX-I (2.55 mg d/rat) + UC-II (4 mg), iv) Exercise + OCX-2 (5.1 mg d/rat)+UC-II (4 mg). Levels of cholesterol, triglyceride, proinflammatory cytokines (IL-1β, IL-6, TNF-α, COMP, CRP), lactate and malondialdehyde (MDA) levels activities of antioxidant enzymes were determined in all the groups. Results Run to exhaustion (minutes) improved in the OCX + UC-II treated groups. Levels of cholesterol, triglyceride, proinflammatory cytokines (IL-1β, IL-6, TNF-α, COMP, CRP) decreased by OCX + UC-II supplementation. A significant decrease in lactate and malondialdehyde (MDA) levels and an increase in activities of antioxidant enzymes were observed in the combination of exercise and OCX + UC-II groups. Exercise + OCX + UC-II treated had lower TNF-α and IL-1β levels in muscle than exercise and control rats (P &amp;lt; 0.001). Muscle sterol regulatory element-binding protein 1c (SREBP-1c), liver X receptors (LXR), ATP citrate lyase (ACLY) and fatty acid synthase (FAS) levels in the exercise + OCX + UC-II group were lower than all groups (P &amp;lt; 0.05). The effectiveness of the high dose of OCX was more pronounced than the low dose of OCX. Conclusions These results suggest OCX and UC-II with exercise may enhance lipid metabolism by regulation of gene products involved in lipid and antioxidant metabolism including SREBP-1c, -γ, LXR, ACLY and FAS in rats. Funding Sources Lonza.

Collagen supplementation for skin health: A mechanistic systematic review.

Over the last decade, many researchers tried to evaluate the effects of collagen supplements on skin aging and surprisingly revealed that the interventions improved skin aging parameters without any inconsistency. This systematic review assesses the literature regarding the effects of collagen supplements on skin health parameters in healthy and patient subjects, focusing on mechanisms of action. At the first step of search in the databases, 9057 items were obtained. After removal of duplicate items, 6531 publications remained. Further screening by title and/or abstract resulted in removal of 6500 items. Finally, full texts of the 31 remained items were assessed for eligibility and 10 publications were included in this review. The evidences obtained from these systematic reviews indicated that oral administration of intact or hydrolyzed collagen improves clinical manifestation of skin health. Almost all of the included studies reported the beneficial effects of collagen supplementation, and no inconsistencies have been seen in this regard between studies. In this systematic review, three different mechanisms of action were clarified for the intervention. Direct effects of collagen peptides on fibroblasts, M2-like macrophages, and oral tolerance-related mechanisms are the possible mechanisms for the beneficial effects of collagen supplementation.

Oral Collagen Drink for Antiaging: Antioxidation, Facilitation of the Increase of Collagen Synthesis, and Improvement of Protein Folding and DNA Repair in Human Skin Fibroblasts.

This work unveils a fish collagen drink for improvement of skin aging. Previous studies frequently discussed the skin aging from the angle of the representative characteristics of collagen loss and the oxidative-induced expression of proteolytic enzymes matrix metalloproteinases (MMPs), but few groups comprehensively investigated the efficacy of oral hydrolyzed collagen for enhancing protein folding and DNA repair as well as improving notable cell behaviors. To delineate the broad perspective on delaying skin aging, we inspected the collagen drink-treated fibroblast cells from the molecular and cellular aspects. The results show that the collagen drink could perform the compact antiaging effects on ROS inhibition, the facilitation of the synthesis of extracellular matrix (ECM) proteins, the increase of mitochondrial activity, and improvement of the gene expression regarding correct protein folding, DNA mismatch repair (MMR) and base excision repair (BER). Although the experimental results are built on the cellular models, we believe that the positive outcomes can provide more details on the influence of oral hydrolyzed collagen supplement for antiaging. In short, we have successfully proved that the synergistic effect of the collagen drink could not only reduce the oxidative damage but also ameliorate the cell functionality to compensate the harmful effects induced by UVA.

Effects of undernatured collagen supplementation on rat knee osteoarthritis

Effects of undernatured collagen supplementation on rat knee osteoarthritis

A Dermonutrient Containing Special Collagen Peptides Improves Skin Structure and Function: A Randomized, Placebo-Controlled, Triple-Blind Trial Using Confocal Laser Scanning Microscopy on the Cosmetic Effects and Tolerance of a Drinkable Collagen Supplement.

The purpose of this randomized, placebo-controlled, triple-blind trial on 60 healthy female volunteers was to assess the cosmetic effects on skin quality of a food supplement containing special collagen peptides together with acerola extract, vitamin C, vitamin E, biotin, and zinc after an intake of 12 weeks (Elasten®, QUIRIS Healthcare, Germany). To reduce assessment bias maximally and increase the accuracy and objectivity of the outcomes, the trial design was triple blinded in a manner that neither the subjects nor the person administering the products nor the person who assessed the primary outcomes knew which subjects had received the test product and which had received the placebo. The expert grader assessing the confocal laser scanning microscopy images was additionally blinded regarding the time when the image was taken (on days 1 or 85). The objective, blinded, and validated image analyses using confocal laser scanning microscopy showed a significant improvement of the collagen structure of facial skin (primary endpoint) after intake of the test product, while no improvements were found after intake of the placebo. The proven positive nutritional effect on the collagen structure was fully consistent with positive subjective evaluations of relevant skin parameters such as elasticity, crinkliness/wrinkliness, and evenness in different body areas such as face, hands, décolleté, neck, backside, legs, and belly, all serving as secondary endpoints. The test product was found to be safe and very well tolerated. A cosmetically relevant improvement of the facial skin was demonstrated after administration of the collagen supplement.

Effectiveness of collagen supplementation on pain scores in healthy individuals with self-reported knee pain: a randomized controlled trial

The purpose of this study was to examine the effects of 12 weeks collagen peptide (CP) supplementation on knee pain and function in individuals with self-reported knee pain. Healthy physically active individuals (n = 167; aged 63 [interquartile range = 56-68] years) with self-reported knee pain received 10 g/day of CP or placebo for 12 weeks. Knee pain and function were measured with the Visual Analog Scale (VAS), the Lysholm questionnaire, and the Knee injury and Osteoarthritis Outcome Score (KOOS). Furthermore, we assessed changes in inflammatory, cartilage, and bone (bio)markers. Measurements were conducted at baseline and after 12 weeks of supplementation. Baseline VAS did not differ between CP and placebo (4.7 [2.5-6.1] vs. 4.7 [2.8-6.2], p = 0.50), whereas a similar decrease in VAS was observed after supplementation (-1.6 ± 2.4 vs. -1.9 ± 2.6, p = 0.42). The KOOS and Lysholm scores increased after supplementation in both groups (p values < 0.001), whereas the increase in the KOOS and Lysholm scores did not differ between groups (p = 0.28 and p = 0.76, respectively). Furthermore, CP did not impact inflammatory, cartilage, and bone (bio)markers (p values > 0.05). A reduced knee pain and improved knee function were observed following supplementation, but changes were similar between groups. This suggests that CP supplementation over a 12-week period does not reduce knee pain in healthy, active, middle-aged to elderly individuals. Novelty CP supplementation over a 12-week period does not reduce knee pain in healthy, active, middle-aged to elderly individuals. CP supplementation over a 12-week period does not impact on inflammatory, cartilage, and bone (bio)markers in healthy, active, middle-aged to elderly individuals.

A Multi-Type Collagen-Based Drink Supplement Significantly Improved Markers of Aging, both in vitro and in a Human Clinical Study

Introduction: Collagen is a ubiquitous structural protein found in skin, bone, muscle and connective tissue in humans and animals. Several studies have found significant positive impacts on skin health when collagen-containing dietary supplements are routinely ingested. A newly developed collagen product (4Life Transfer Factor Collagen (TF Collagen)) containing multiple types of collagen, transfer factors from colostrum, and other ingredients, was tested in vitro in a telomere model, and in vivo in a human skin health clinical study. Objective: The purpose of these studies was to determine if TF Collagen supplementation could significantly improve measures of aging and the overall skin health of the participants. Methods: The in vitro telomere study measured telomerase activity of lung tissue cells over 15 passages by optical density (OD). The telomerase activity was then compared between a control group and a TF Collagen-treated group at corresponding passages. For the human study, 26 subjects (aged 35-55) consumed one packet (eight grams) of TF Collagen daily for 84 days. Skin hydration, skin firmness, skin elasticity, and the appearance of fine lines and wrinkles were measured at day 42 and day 84. Results: The in vitro study found a significant increase in telomerase activity in cells treated with TF Collagen compared to the control. In the human clinical study, TF Collagen significantly improved skin hydration, skin firmness, and the appearance of fine lines and wrinkles, as well as subjective measures of skin health. Conclusion: A multi-type collagen supplement with other ingredients activated telomerase in vitro and significantly improved overall skin health in healthy men and women.

Effects of Whey Protein and Collagen Supplementation

Effects of Whey Protein and Collagen Supplementation

Formulation and Examination of Organic Oil and Shampoo from Fish Scales

Cosmetics are utilized to upgrade the appearance or scent of the human body. Beautifying agents incorporate skin creams, lotions, powders, aromas, lipsticks, fingernail and toe nail polish, eye and facial cosmetics, permanent waves, and numerous different kinds of items. To make the hair sound and gleaming, there are several manufactured oils and hair shampoos. But when in contrast to the artificial one, natural cosmetics have growing demand in the world market and are an priceless gift of nature, as it is secure and free from facet results like hair fall and damage. As it is safe and free from symptoms like hair fall and harm. As the age increases, people suffer from hair loss and damage due to the less secretion of keratin. As we age, our body’s natural levels of collagen decrease, leading to thinning and shedding of hair. Research shows that collagen may support and increase hair-building proteins (keratin) in the body. This can help strengthen hair strands, promote hair growth and prevent hair loss. Collagen may even help to prevent the appearance of grey hairs by supporting the healthy structure of the hair follicle, where the pigment of hair is produced. Collagen supplements also have been shown to be effective in treating dry, brittle hair, helping to maintain healthy moisture levels in the hair. The present work was aimed to formulate organic oil and shampoo using fish scales and various herbs. The formulated organic oil and shampoo were evaluated for homogeneity, appearance, odour, saponification value, pH etc.

A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study.

The purpose of this randomized, placebo-controlled, blind study was to investigate the effects of the drinkable nutraceutical ELASTEN® (QUIRIS Healthcare, Gütersloh, Germany) on skin aging and skin health. Drinking ampoules provides a blend of 2.5 g of collagen peptides, acerola fruit extract, vitamin C, zinc, biotin, and a native vitamin E complex. This controlled interventional trial was performed on 72 healthy women aged 35 years or older. They received either the food supplement (n = 36) or a placebo (n = 36) for twelve weeks. A skin assessment was carried out and based on objective validated methods, including corneometry (skin hydration), cutometry (elasticity), the use of silicon skin replicas with optical 3D phase-shift rapid in-vivo measurements (PRIMOS) (roughness), and skin sonography (density). The verum group was followed for an additional four weeks (without intake of the test product) to evaluate the sustainability of the changes induced by the intake of the test product. The test product significantly improved skin hydration, elasticity, roughness, and density. The differences between the verum group and the placebo group were statistically significant for all test parameters. These positive effects were substantially retained during the follow-up. The measured effects were fully consistent with the subjective assessments of the study participants. The nutraceutical was well tolerated.

Effect of Collagen Supplementation in Broiler Feed: Influence on Productive Performance and Muscle Quality in Broiler Chicken

Present study was conducted to evaluate different strategies for feed formulation in commercial broiler production. A total of 16 male newly hatched broiler chickens (Gallus gallus domesticus) were fed with different formulated diets in 3 feeding phases, starter (1–11 d), grower (12-22 d) and finisher (23–33 d). Four strategies of feed formulation (F1, F2, F3 and F4) were compared; where in F1 group was fed with traditional diet, F2 and F3 were fed with traditional diet after supplementation with 10% & 20 % paneer respectively. The last group (F4) was fed with traditional diet supplemented with 10% collagen and is incorporated into paneer to provide extra protein. The collagen used in the study was analyzed and characterized by UV-Vis spectroscopy, SDS-PAGE and FTIR which was confirmed type-I collagen. All the experimental birds had shown significantly high body weight (BW) for F4 birds compared with other groups. Feed conversion ratio was significantly lower for F3 birds compared to the birds in other groups. No differences were detected for feed intake and mortality. At 33 d, F4 birds (2.227) were significantly heavier than other groups and a remarkable difference was noticed in the decreasing order F3>F2>F1 (2.004 kg, 1.998 kg and 1.749 kg respectively). Notable differences were detected for carcass yield (%), breast yield (%) and breast-to-carcass ratio at 33 d. In conclusion, our results demonstrated that the enhancement in growth rate of birds was observed by providing them with collagen along with the regular diet.

Whey Protein Supplementation Compared to Collagen Increases Blood Nesfatin Concentrations and Decreases Android Fat in Overweight Women: A Randomized Double-Blind Study.

Protein supplements are usually used to control body weight, however, the impact of protein quality on body fat attenuation is unknown. We investigated the effects of isocaloric isoproteic supplementation of either whey protein (WG) or hydrolysed collagen supplementation (CG) on dietary intake, adiposity and biochemical markers in overweight women. Methods: In this randomized double-blind study, 37 women, [mean ± SE, age 40.6 ± 1.7 year; BMI (kg/m2) 30.9 ± 0.6], consumed sachets containing 40 g/day of concentrated whey protein (25 g total protein, 2.4 leucine, 1.0 valine, 1.5 isoleucine, n = 17) or 38 g/day of hydrolysed collagen (26 g total protein, 1.02 leucine, 0.91 valine, 0.53 isoleucine, n = 20) in the afternoon snack. The compliance was set at >70% of the total theoretical doses. The dietary intake was evaluated by a 6-day food record questionnaire. At the beginning and after eight weeks of follow-up, body composition was evaluated by using dual-energy X-ray absorptiometry and lipid profile, insulin resistance, C-reactive protein, adiponectin, leptin and nesfastin plasma concentrations were analyzed. Results: Supplements were isocaloric and isoproteic. There were no differences in caloric intake (p = 0.103), protein (p = 0.085), carbohydrate (p = 0.797) and lipids (p = 0.109) intakes. The branched chain amino acids (BCAA) (GC: 1.8 ± 0.1 g vs. WG: 5.5 ± 0.3 g, p < 0.001) and leucine intake (CG: 0.1 ± 0.1 g vs. WG: 2.6 ± 0.1 g, p < 0.001) were higher in WG compared to CG. BMI increased in the CG (0.2 ± 1.1 kg/m2, p = 0.044) but did not change in WG. WG decreased the android fat (−0.1 ± 0.3 kg, p = 0.031) and increased nesfatin concentrations (4.9 ± 3.2 ng/mL, p = 0.014) compared to CG. Conclusions: Whey protein supplementation in overweight women increased nesfatin concentrations and could promote increase of resting metabolic rate as part of body composition improvement programs compared to collagen supplementation for 8 weeks. Additionally, our findings suggest that collagen may not be an effective supplement for overweight women who are attempting to alter body composition.

Oral collagen supplementation for skin aging: A fad or the future?

In recent years, oral collagen supplements have become a popular and trendy treatment in the world of skin health. It has been widely marketed to consumers for purported benefits in wrinkle reduction, skin-rejuvenation, skin-aging reversal, and skin plumping. However, there are currently limited data available in the literature and much regarding its possible effects on the skin has yet to be fully elucidated and understood. Here, we summarize some of the prominent studies in the literature and offer an evaluation of oral collagen supplementation for skin health.