The natural fire in the mining area is the main source of mine fires, and the distribution of spontaneous combustion “three zones” is a key issue in mine fire prevention and suppression. In order to study the change law of spontaneous combustion “three zones” in the mining area with multiple air leakage paths, a segmented numerical simulation method is proposed. In order to consider the common influence of various factors, we firstly establish the coupled model of oxygen consumption rate of coal relics, the regional fluidity model of the porous medium and the three-dimensional distribution model of void rate in the mining area. Then, based on this, the corresponding conditions of air leakage speed, air leakage location and oxygen concentration are set in each stage of numerical simulation. The mathematical model shows that: the oxygen consumption rate of coal shows an approximate exponential growth trend with the increase in temperature, which is proportional to the original oxygen concentration; the void rate of the mining area shows a logarithmic distribution with a tendency of “double hump” proportional coupling. The numerical simulation results show that: the width of the “oxidation zone” decreases gradually along the tendency when there is only air leakage from the working face; the smaller airflow and lower oxygen concentration in the overlying mining area will increase the width of the “oxidation zone” in the coverage area; air leakage from the shelf road will form an “oxidation zone” near the entrance of the shelf road. The leakage of air from the shelf road will form an “oxidized zone” near the entrance of the shelf road; the leakage of air from the adjacent mining area will increase the width of the overall “dispersal zone” and “oxidized zone” due to the larger air flow and higher oxygen concentration. The comparison with the monitoring data of the downhole bundle tube verifies the rationality of the mathematical model and the accuracy of the numerical simulation results.