Classical Pattern Research Articles

A pilot study investigating affective forecasting biases with a novel virtual reality-based paradigm

A body of research indicates that people are prone to overestimate the affective impact of future events. Here, we developed a novel experimental paradigm to study these affective forecasting biases under laboratory conditions using subjective (arousal and valence) and autonomic measures (skin conductance responses, SCRs, and heart rate). Thirty participants predicted their emotional responses to 15 unpleasant, 15 neutral, and 15 pleasant scenarios (affective forecasting phase) to which they were then exposed in virtual reality (emotional experience phase). Results showed that participants anticipated more extreme arousal and valence scores than they actually experienced for unpleasant and pleasant scenarios. The emotional experience phase was characterized by classic autonomic patterns, i.e., higher SCRs for emotionally arousing scenarios and greater peak cardiac acceleration for pleasant scenarios. During the affective forecasting phase, we found only a moderate association between arousal scores and SCRs and no valence-dependent modulation of cardiac activity. This paradigm opens up new perspectives for investigating affective forecasting abilities under lab-controlled conditions, notably in psychiatric disorders with anxious anticipations.

Effusion cytology of metastatic carcinosarcoma.

Carcinosarcomas (CSs) are rare gynecological neoplasms seen in elderly females. These are composed of malignant epithelial and mesenchymal components, which appear as adenocarcinoma and high-grade sarcoma. Effusions are encountered uncommonly in CS. The study focuses on the cytomorphology of 10 cases of metastatic CS in effusions. In 6 years, there were 10 (0.45%) cases of metastatic CS in effusion samples out of 2240 malignant effusion samples. The samples were processed by SurePath™ and centrifuge technique. Both May-Grünwald-Giemsa and Papanicolaou stained smears were evaluated for cytomorphological features, and the findings were correlated with subsequent histopathology. The cells were predominantly arranged in ball-like clusters and discretely. The cells had abundant vacuolated cytoplasm and enlarged pleomorphic nuclei. Occasional cases showed scattered spindle cells. The cases were diagnosed as metastatic adenocarcinoma (7/10) and positive for malignant cells (3/10). None of the cases was diagnosed as CS. The primary of these cases was in the uterus (7/10) and ovary (3/10). The cytological evaluation of such effusion samples rarely demonstrates the classical biphasic pattern of these tumors. Mostly, the carcinomatous component is evident, and the sarcomatous element is inapparent and readily missed.

Distinguishing Distinct Neural Systems for Proximal vs Distal Upper Extremity Motor Control After Acute Stroke.

The classic and singular pattern of distal greater than proximal upper extremity motor deficits after acute stroke does not account for the distinct structural and functional organization of circuits for proximal and distal motor control in the healthy CNS. We hypothesized that separate proximal and distal upper extremity clinical syndromes after acute stroke could be distinguished and that patterns of neuroanatomical injury leading to these 2 syndromes would reflect their distinct organization in the intact CNS. Proximal and distal components of motor impairment (upper extremity Fugl-Meyer score) and strength (Shoulder Abduction Finger Extension score) were assessed in consecutively recruited patients within 7 days of acute stroke. Partial correlation analysis was used to assess the relationship between proximal and distal motor scores. Functional outcomes including the Box and Blocks Test (BBT), Barthel Index (BI), and modified Rankin scale (mRS) were examined in relation to proximal vs distal motor patterns of deficit. Voxel-based lesion-symptom mapping was used to identify regions of injury associated with proximal vs distal upper extremity motor deficits. A total of 141 consecutive patients (49% female) were assessed 4.0 ± 1.6 (mean ± SD) days after stroke onset. Separate proximal and distal upper extremity motor components were distinguishable after acute stroke (p = 0.002). A pattern of proximal more than distal injury (i.e., relatively preserved distal motor control) was not rare, observed in 23% of acute stroke patients. Patients with relatively preserved distal motor control, even after controlling for total extent of deficit, had better outcomes in the first week and at 90 days poststroke (BBT, ρ = 0.51, p < 0.001; BI, ρ = 0.41, p < 0.001; mRS, ρ = 0.38, p < 0.001). Deficits in proximal motor control were associated with widespread injury to subcortical white and gray matter, while deficits in distal motor control were associated with injury restricted to the posterior aspect of the precentral gyrus, consistent with the organization of proximal vs distal neural circuits in the healthy CNS. These results highlight that proximal and distal upper extremity motor systems can be selectively injured by acute stroke, with dissociable deficits and functional consequences. Our findings emphasize how disruption of distinct motor systems can contribute to separable components of poststroke upper extremity hemiparesis.

P‐44: Real‐Content Based Method for HDR Tone Curve Characterization

The classic window pattern with a black background is the basis of any display characterization, but nowadays, displays, particularly smartphone displays, integrate complex image processing and adaptations, meaning that they cannot be entirely characterized with these simple patterns. In this paper we discuss a new EOTF (Electro‐Optical Transfer Function) measurement method performed directly on real‐life scene HDR videos and show how this method relates to the display system user‐experience.

Atrophy patterns in subjects at increased risk of Alzheimer’s Disease

AbstractBackgroundCognitively impaired individuals have multiple contributing conditions leading to heterogeneous atrophy patterns. Unfortunately, neuroimaging data is usually contaminated by noise, which can lead to spurious non‐clinically relevant clusters. Identification of true disease specific clusters requires techniques robust against noise.MethodWe developed an unsupervised approach named COllaborative Clustering based on Adaptive Laplace modeling (CoCAL) to simultaneously cluster individuals and features while removing noise. We derived the distributions of the coefficients produced by non‐negative matrix tri‐factorization (Fig. 1). We applied CoCAL to the PREVENT‐AD dataset, a cohort of cognitively unimpaired participants with a family history of Alzheimer’s Disease (AD). The groups clustered by CoCAL were compared by student’s t‐test with FDR correction, and each cluster is evaluated by Alzheimer’s Progression Score (APS).ResultExperimental results on a synthetic dataset demonstrated superior clustering performance of CoCAL over several benchmark clustering methods including k‐means and conventional matrix factorization based clustering methods. On the PREVENT‐AD dataset, two clusters (G1 and G2) were identified by CoCAL (Table 1). The corresponding t‐test statistic values of regions with p‐values &lt; 0.05 are plotted in Fig. 2. Cluster G1 showed higher APS compared to G2 (APS scores: 0.197 ± 0.0562 [G1] vs ‐0.080 ± 0.0539 [G2], p &lt; 0.001). There were no significant differences in sex, age and APOE ε4 status between the groups.ConclusionWhen applying CoCAL to the PREVENT‐AD cohort, two distinctive atrophy patterns emerge: a parietotemporal cluster (G1) and a fronto‐occipital cluster (G2). G1 corresponds well with classic patterns of cortical atrophy in AD, and participants in this group demonstrate higher APS than G2 participants. In contrast, the greater atrophy in the frontal and occipital lobes in the G2 cluster may reflect either gray matter atrophy from vascular contributions, or the frontal variant of AD. Further investigations into the progression of these different clusters and sub‐networks within the cluster could yield insight for more targeted management of AD.

Cervical cord compression with lower limb sensory disturbance: three case reports and a literature review.

Lower limb sensory disturbance can be a false localizing sign of cervical spondylotic myelopathy. It may lead to delayed or missed diagnosis, resulting in an inappropriate management plan, especially in the presence of concurrent lumbar lesions. Three Asian patients with lower limb sensory disturbance were ineffectively treated in the lumbar region. Magnetic resonance imaging showed cervical disc herniation and cervical spinal cord compression. The patients underwent anterior cervical discectomy and interbody fusion using a stand-alone cervical interbody fusion cage. Postoperative imaging showed that the spinal cord compression was relieved. On the first postoperative day, the lower limb sensory disturbance was also relieved. The patients showed good recovery at the 3-month postoperative follow-up. These three cases of cervical cord compression with lower limb sensory disturbance were easily misdiagnosed as lumbar spondylosis. Anterior cervical discectomy and fusion had a good therapeutic effect. Therefore, the presence of lower limb sensory disturbance in a non-radicular classic pattern should always raise suspicion of a possible cord compression at a higher level.

𝐻2-Conformal Approximation of Miura Surfaces

Abstract The Miura ori is a very classical origami pattern used in numerous applications in engineering. A study of the shapes that surfaces using this pattern can assume is still lacking. A constrained nonlinear partial differential equation (PDE) that models the possible shapes that a periodic Miura tessellation can take in the homogenization limit has been established recently and solved only in specific cases. In this paper, the existence and uniqueness of a solution to the unconstrained PDE is proved for general Dirichlet boundary conditions. Then an H 2 H^{2} -conforming discretization is introduced to approximate the solution of the PDE coupled to a Newton method to solve the associated discrete problem. A convergence proof for the method is given as well as a convergence rate. Finally, numerical experiments show the robustness of the method and that nontrivial shapes can be achieved using periodic Miura tessellations.

Biofilm-forming strains of P. aeruginosa and S. aureus isolated from cystic fibrosis patients differently affect inflammatory phenotype of macrophages

ObjectiveLung cystic fibrosis (CF) is characterized by chronic infections and hyperinflammatory response of neutrophils and macrophages. P. aeruginosa (PA) and S. aureus (MSSA, MRSA) are major pathogens of advanced CF. The main goal of this study was to compare the inflammatory phenotype of murine C57BL/6 macrophages exposed to PA57 with that exposed to MSSA60, both strains isolated from the same patient with severe CF. In the present study, we used C57BL/6 mice sensitive to lung infection with P. aeruginosa.MethodsWe measured the release of cytokines and the expression of phenotypic markers of murine neutrophils and macrophages exposed to bacterial cells and biofilm components (i.e., EPS) of the selected bacteria. In addition, a quantitative proteomic approach was used for the characterization of proteome-wide changes in macrophages.ResultsNeutrophils stimulated with PA57 and MSSA60 strains produced hyperinflammatory pattern of cytokines. The pro-inflammatory impact of PA57 was significantly higher than that of MSSA60 (IL-6/IL-10 ratio: PA57 = 9.3 vs. MSSA60 = 1.7). Macrophages produced significantly lower amount of cytokines, but showed classical pattern of M1 markers (iNOS-High; arginase-1 and mannose receptor MRC1-Low). Importantly, as evidenced by proteomic analysis, PA57 and PA57-EPS were stronger inducers of M1 macrophage polarization than the MSSA60 counterparts.ConclusionsOur study demonstrated that strong biofilm P. aeruginosa strains, CF isolates, are dominant inducers of M1 macrophages, termed biofilm-associated macrophages (BAMs). We suggest that repolarization of detrimental BAMs might be a new therapeutic strategy to ameliorate the airway damage in CF.

Identification of protease-sensitive but not misfolding PNLIP variants in familial and hereditary pancreatitis

Mutations in the PNLIP gene have recently been implicated in chronic pancreatitis. Several PNLIP missense variants have been reported to cause protein misfolding and endoplasmic reticulum stress although genetic evidence supporting their association with chronic pancreatitis is currently lacking. Protease-sensitive PNLIP missense variants have also been associated with early-onset chronic pancreatitis although the underlying pathological mechanism remains enigmatic. Herein, we provide new evidence to support the association of protease-sensitive PNLIP variants (but not misfolding PNLIP variants) with pancreatitis. Specifically, we identified protease-sensitive PNLIP variants in 5 of 373 probands (1.3%) with a positive family history of pancreatitis. The protease-sensitive variants, p.F300L and p.I265R, were found to segregate with the disease in three families, including one exhibiting a classical autosomal dominant inheritance pattern. Consistent with previous findings, protease-sensitive variant-positive patients were often characterized by early-onset disease and invariably experienced recurrent acute pancreatitis, although none has so far developed chronic pancreatitis.

Posterior reversible encephalopathy syndrome triggered by FLOT (5-fluorouracil, oxaliplatin, docetaxel, and calcium levofolinate) chemotherapy and thrombocytopenia (docetaxel and cisplatin) chemotherapy.

Posterior reversible encephalopathy syndrome is a clinical and imaging syndrome characterized by endothelial dysfunction, blood-brain barrier disruption, and vasogenic edema. The common clinical symptoms of posterior reversible encephalopathy syndrome include headache, altered consciousness, visual disturbances, and seizures, among which headache and seizures are the most common. The classic imaging patterns usually reveal vasogenic edema. We describe the case of a middle-aged woman with gastric cancer. She was under treatment by fluorouracil, leucovorin, oxaliplatin, and docetaxel regimen and thrombocytopenia regimen after tumor progression, but developed unconsciousness, irritability, and headache shortly after initiation of treatment. Her magnetic resonance imaging in our hospital shows abnormal signals in bilateral frontal parietal occipital lobes with hyperintensities on T2-weighted magnetic resonance imaging and fluid-attenuated inversion recovery imaging, accompanied by the increased value of apparent diffusion coefficient. And T1-weighted images illustrate hypointense foci, with increased diffusion-weighted imaging signals. After admission, she was treated to control blood pressure, reduce brain edema, expand blood vessels, improve consciousness, and symptomatic support treatment. 3 days after the onset of the disease, her headache symptoms and state of consciousness gradually improved, and her blood pressure can be controlled at about 130/80 mmHg. This is the first report that posterior reversible encephalopathy syndrome is caused by a thrombocytopenia regimen, and our case highlights the pathogenic role of a thrombocytopenia regimen in posterior reversible encephalopathy syndrome. However, the association between the thrombocytopenia regimen and previous fluorouracil, leucovorin, oxaliplatin, and docetaxel regimens needs further study.

A changing heart in tako-tsubo syndrome.

A 63-year-old female presented with acute chest pain and ECG showing T wave inversion in the anterior and inferior leads. Troponin T (TnT) was significantly elevated (peak 1378 ng/L; normal <14 ng/L), as was NT-proBNP (3091 ng/L; normal <400 ng/L). Invasive angiography showed unobstructed coronary arteries with mid-ventricular ballooning and hypokinesia on ventriculography (see Supplementary data online, Video S1) and echocardiography (see Supplementary data online, Video S2), suggesting a mid-ventricular tako-tsubo syndrome (TTS). Cardiac magnetic resonance (CMR) was booked but the patient was unable to attend. Focussed history using the InterTAK diagnostic score assessment revealed no emotional or physical triggers. The patient re-presented six months later with similar symptoms and elevated TnT. Inpatient echocardiography showed a reverse TTS pattern (see Supplementary data online, Video S3) and CMR at 1.5T showed basal hypokinesia with matching elevated native T1 (1220 ms; normal 950–1100 ms) and T2 (69 ms; normal <48 ms) (Panels A–B). Quantitative perfusion maps following adenosine stress perfusion to investigate microvascular disease showed basal to mid circumferential hypoperfusion with normal apical myocardial blood flow, not suggestive of specific coronary artery territory ischaemia (Panel D) and no late gadolinium enhancement (LGE) (Panel C), confirming a reverse TTS. The patient further presented two months later with chest pain and TnT elevation. Repeat inpatient CMR on this occasion showed a classic TTS pattern with apical hypokinesia and elevated T1 and T2 (1261 ms and 81 ms, respectively) at the mid to apical segments with no LGE (Panels E–G). The case was further explored but no triggers, including neurological or psychiatric abnormalities were found. Recurrent TTS with different phenotypes has previously been described but is rare, especially without a trigger. Our case illustrates the utility of multimodality imaging in the investigation of TTS; in particular, multiparametric tissue mapping by CMR. Furthermore, the novel quantitative perfusion maps characterising myocardial blood flow added diagnostic utility.

On the Jacobi Stability of Two SIR Epidemic Patterns with Demography

In the present work, two SIR patterns with demography will be considered: the classical pattern and a modified pattern with a linear coefficient of the infection transmission. By reformulating of each first-order differential systems as a system with two second-order differential equations, we will examine the nonlinear dynamics of the system from the Jacobi stability perspective through the Kosambi–Cartan–Chern (KCC) geometric theory. The intrinsic geometric properties of the systems will be studied by determining the associated geometric objects, i.e., the zero-connection curvature tensor, the nonlinear connection, the Berwald connection, and the five KCC invariants: the external force εi—the first invariant; the deviation curvature tensor Pji—the second invariant; the torsion tensor Pjki—the third invariant; the Riemann–Christoffel curvature tensor Pjkli—the fourth invariant; the Douglas tensor Djkli—the fifth invariant. In order to obtain necessary and sufficient conditions for the Jacobi stability near each equilibrium point, the deviation curvature tensor will be determined at each equilibrium point. Furthermore, we will compare the Jacobi stability with the classical linear stability, inclusive by diagrams related to the values of parameters of the system.

Computational Parametric Analysis of Cellular Solids with the Miura‐Ori Metamaterial Geometry under Quasistatic Compressive Loads

Origami‐based metamaterials have widespread application prospects in various industries including aerospace, automotive, flexible electronics, and civil engineering structures. Among the wide range of origami patterns, the fourfold tessellation known as Miura‐ori is of particular attraction to engineers and designers. More specifically, researchers have proposed different 3D structures and metamaterials based on the geometric characteristics of this classic origami pattern. Herein, a computational modeling approach for the design and evaluation of 3D cellular solids with the Miura‐ori metamaterial geometry which can be of zero or nonzero thicknesses is presented. To this end, first, a range of design alternatives generated based on a numerical parametric model is designed. Next, their mechanical properties and failure behavior under quasistatic axial compressive loads along three perpendicular directions are analyzed. Then, the effects of various geometric parameters on their energy absorption behavior under compression in the most appropriate direction are investigated. The findings of this study provide a basis for future experimental investigations and the potential application of such cellular solids for energy‐absorbing purposes.

Descent distribution on Catalan words avoiding ordered pairs of relations

This work is a continuation of some recent articles presenting enumerative results for Catalan words avoiding one or a pair of consecutive or classical patterns of length 3. More precisely, we provide systematically the bivariate generating function for the number of Catalan words avoiding a given pair of relations with respect to the length and the number of descents. We also present several constructive bijections preserving the number of descents. As a byproduct, we deduce the generating function for the total number of descents on all Catalan words of a given length and avoiding a pair of ordered relations.

Principles of the diagnostics of inborn errors of immunity

Inborn errors of immunity (IEI) are aheterogeneous group of nearly 500 diseases characterized by acongenital dysfunction of the immune system. The vast majority of IEIs are rare diseases but all IEIs share acumulative prevalence of 1:1200-1:2000. In addition to apathological susceptibility to infections, IEIs can also present with lymphoproliferative, autoimmune or autoinflammatory manifestations. There is often an overlap with classical rheumatic and inflammatory disease patterns. Therefore, abasic knowledge of the clinical presentation and the diagnostics of IEIs is also relevant for the practicing rheumatologist.

Imaging features of intraosseous hemangiomas: beyond the mobile spine and calvarium.

Describe imaging features of intraosseous hemangiomas located outside of the mobile spine and calvarium. Imaging and medical records were retrospectively reviewed for cases of intraosseous hemangiomas located outside of the calvarium and mobile spine. Evaluation included patient demographics, histologic confirmation, and imaging characteristics. Thirty-six patients were included (25 F, 11M; mean age 54 ± 17years, range 10-84years) with 37 total lesions (70% axial and 30% appendicular skeleton). Mixed lytic and sclerotic features were identified on 83-85% radiographs and CTs. Amorphous increased density mimicking osteoid matrix was present on 38-45% radiographs and CTs. Classic honeycomb or radial pattern was identified on 45% of CTs. Osseous expansion and cortical permeation were common features. CT identified periosteal reaction in 24% of lesions. All hemangiomas had heterogeneous MRI signal and most moderately or avidly enhanced. Intralesional fat was identified on 78% MRIs, often as a minor component and only detected on 24% of CTs. A soft tissue mass was present on 52% of MRIs. FDG PET/CT mean SUVmax of 3.2 ± 0.6 (range 1.9-5.0). Lesional FDG activity relative to background marrow was increased in 75% of lesions. Lesions with cortical permeation had higher metabolic activity versus those without (3.5 ± 0.7 versus 2.2 ± 0.3, p = 0.041). Intraosseous hemangiomas outside of the mobile spine and calvarium demonstrate more aggressive imaging features compared to vertebral hemangiomas, including cortical permeation, soft tissue mass, amorphous increased density mimicking osteoid matrix, and increased FDG activity.

Neutrosophic Log-Logistic Distribution Model in Complex Alloy Metal Melting Point Applications

The log-logistic distribution is more comprehensively applied in the area of survival and reliability engineering analysis for modeling the lifetime data practices of both human and electronic designs. The goal of this paper is to develop a generalization of the classical pattern log-logistic distribution, known as the neutrosophic log-logistic distribution (NLLD), to model various survival and reliability engineering data with indeterminacies. The developed distribution is especially useful for modeling indeterminate data that is roughly positively skewed. This paper discusses the developed NLLD’s main statistical properties such as neutrosophic survival function, neutrosophic hazard rate, neutrosophic moments, and neutrosophic mean time failure. Furthermore, the neutrosophic parameters are estimated using the well-known maximum likelihood (ML) estimation method in a neutrosophic environment. A simulation study is carried out to establish the achievement of the estimated neutrosophic parameters. As a final point, the proposed NLLD applications in the real world have been discussed with the help of real data. The real data illustrated that the efficiency of the proposed model as compared with the existing models.

Hepatitis E-associated neuralgic amyotrophy: a rare respiratory presentation.

Hepatitis E-associated neuralgic amyotrophy: a rare respiratory presentation.

Educational integration by the third generation? Placement and academic achievement of students with immigrant background in Germany

Studies show that minority students who were born abroad or whose parents were born abroad are less successful in school than their majority peers. However, little is known on whether these disadvantages persist for the grandchildren of immigrants, i.e., the third generation. Assimilation theories come to different predictions for third-generation students’ educational integration. We investigate third-generation students’ placement in different school types and their reading and mathematics achievements in Germany. Using data on ninth graders (N = 14,958) collected in the National Educational Panel Study enabled us to precisely identify third-generation students and to distinguish students by their ancestors’ countries of birth. Our results reveal that most third-generation students did not differ in their educational success from their majority peers, while first-generation and some groups of second-generation students, on average, were less successful in school. Overall, our findings are in line with classical and new assimilation theories and suggest that educational integration is mostly “completed” by the third generation in Germany. For some groups, however, we do not observe the major trends predicted by classical and new assimilation theories but patterns suggesting processes expected in segmented assimilation theory.

Pagetoid Spread in Basal Cell Carcinoma: Potential for Misdiagnosis.

Basal cell carcinomas are one of the most common cutaneous carcinomas and show classical histologic features of basaloid nests with peripheral palisading. Pagetoid and intraepidermal spread has not been described in basal cell carcinoma to the best of our knowledge. We report 5 cases of basal cell carcinoma with classic histologic patterns and overlying basaloid nests and single intraepidermal tumor cells. A panel of immunostains were performed that included CK7, MOC31, CEA-m, EMA, androgen receptor, and Bcl2. Most of our cases were positive for both MOC31 and CK7, and all cases were negative for CEA-m and EMA excluding extramammary Paget disease, one of the most common differential diagnoses. These cases expand the spectrum of findings that can be seen in basal cell carcinoma and can help prevent misdiagnoses of basal cell carcinomas as more aggressive tumors.