Civilian Population Research Articles

INCREASED RISK OF CHEMICAL TERROR ATTACKS

The risk of using highly toxic chemicals in a terrorist attack is resurfacing. Over the last fewdecades, terrorists have proven that they can source, develop and produce their own toxicchemicals. These substances are particularly dangerous for civilians who do not have access tothe protective equipment to be used in the event of contamination. It is impossible to guaranteefull public security in relation to the threats of chemical terrorism. Only trained, functioningand cooperating elements of state crisis response systems (mainly: medical rescue services,fire brigades, the police and the army) are capable of minimising the negative effects of theseattacks on the civilian population. This problem is becoming particularly important in view of theongoing Russian-Ukrainian war and the potential use of chemical weapons by the Russian army.An important problem impacting the extent of poisoning after a chemical attack is secondarycontamination of people and emergency equipment. The authors, through a detailed descriptionof the sources of secondary pollution, propose a number of solutions aimed at minimizing the riskof poisoning in people who are not directly exposed to chemical hazardous agents as a result ofsecondary contamination. The proposed solutions are based on the experience of chemical troopsin the elimination of chemical contamination of a large number of people, as well as the experienceof the authors related to the implementation of research and development projects regarding theprotection and operating procedures of rescue services in CBRN contamination zones.

ABOUT THE HISTORICAL PREREQUISITES OF THE FORMATION OF PUBLIC SAFETY CENTERS IN THE CONDITIONS OF UKRAINE

The purpose of publication is analysis of literary and archival sources in order to establish the historical stages of the formation of the Service of Emergency Situations, ascertaining of its main tasks, and mainly to identify the features of the structural and functional organization of historical prototypes for modern centers of public safety. In general, the process of formation and development of the fire protection system, its transformation into an emergency service has so deep roots, starting with the laws of the state Kievan Rus until today. An analysis of the development of the fire service on the example of separate cities of Ukraine showed, that in the process of its development it was placed in buildings of sacred (churches) and administrative (town halls) purpose. Later, a single network of a separate type of architectural objects was gradually formed (watchtowers, fire stations), which were expanding according to the development of the city. Buildings where fire service personnel were placed, contained all the necessary means for notifying the population, quick reaction, and counter measuring in the case of an emergency situation and updated with the advent of modern technologies. It should be noted separately that during certain periods of fire protection development this service was located together with the police service, which is an important prerequisite for the formation of a structural and functional organization of modern centers of public safety. Also noteworthy is the fact that the civilian population was involved in fire protection on a voluntary basis. In general, we can say that during the development of the fire service of Ukraine prototypes of networks of public safety centers in cities already existed, but they were not considered as a separate typological group of architectural and urban planning objects. Historically, it happened that the fire service, and in the 20th century - also the civil defense service (which initially was developing separately), during the last decade were united into a single state structure – SESU. The main stages (periods) of the development of which begin with the historical period (before 1494) and end with the modern period of development (arrangement of SESU) from 2012 to the present time.

The effects of state presence on the mental mapping of security: Evidence from an experiment in Kashmir

What is the relationship between governance and security? What impact, if any, does state presence have on civilians’ perceptions of security in militarized conflict zones? The existing literature suggests that government control over a restive region means order and security for the local population. We propose a ‘mental mapping’ framework for the relationship between state presence and security perceptions in militarized ethnic peripheries, drawing on prior research in urban planning about how attitudes are shaped by living environments. We use a survey experiment to measure the effect of the physical presence of government institutions on civilians’ sense of how safe they imagine their city to be, demonstrating a mental mapping mechanism between the physical presence of the state and perceptions of safety. We show that residents who encounter images of state institutions on a map of Srinagar – the largest city and summer capital of Jammu and Kashmir, India – are more likely to perceive their city as less secure than those who encounter a map without images or a placebo map. This experimental evidence implies that government security presence is not always perceived as security by the civilian population.

Putin’s power play: Russia’s attacks on Ukraine’s electric power infrastructure violate international law

International humanitarian law is a branch of public international law that seeks to moderate the conduct of wars to protect those who are not taking part in the hostilities. Under international humanitarian law, belligerents may not intentionally target civilians or installations that are indispensable to the survival of the civilian population. While collateral harm to civilians and civilian infrastructure may occur, international humanitarian law prohibits attacks that may be expected to cause incidental loss of civilian life, injury to civilians, damage to civilian objects, or a combination thereof which would be excessive in relation to the concrete and direct military advantage anticipated. In practice, these principles have not always been honored or enforced. State and non-state actors have deliberately targeted civilians and/or disregarded civilian impacts, often for the purpose of pressuring political leaders to capitulate. The increasing occurrence and severity of harm to civilians and civilian infrastructure in modern conflicts calls into question the continuing relevance of what were once viewed as fundamental protections. In this paper, we present a case study involving Russia’s 2022–23 attacks on Ukraine’s electric power infrastructure, which left millions of civilians without heat, water, or other basic services for extended periods in harsh winter conditions. Considering the scope, scale, and long-term impacts of these attacks, we conclude that Russia violated international law. We also suggest that a new international protocol may be necessary in order to more effectively deter and punish attacks on civilian infrastructure in future armed conflicts and military occupations.

Lifetime Suicide Attempts in Otherwise Psychiatrically Healthy Individuals

Not all people who die by suicide have a psychiatric diagnosis; yet, little is known about the percentage and demographics of individuals with lifetime suicide attempts who are apparently psychiatrically healthy. If such suicide attempts are common, there are implications for suicide risk screening, research, policy, and nosology. To estimate the percentage of people with lifetime suicide attempts whose first attempt occurred prior to onset of any psychiatric disorder. This cross-sectional study used data from the US National Epidemiologic Study of Addictions and Related Conditions III (NESARC-III), a cross-sectional face-to-face survey conducted with a nationally representative sample of the US civilian noninstitutionalized population, and included persons with lifetime suicide attempts who were aged 20 to 65 years at survey administration (April 2012 to June 2013). Data from the NESARC, Wave 2 survey from August 2004 to September 2005 were used for replication. Analyses were performed from April to August 2023. Lifetime suicide attempts. The main outcome was presence or absence of a psychiatric disorder before the first lifetime suicide attempt. Among persons with lifetime suicide attempts, the percentage and 95% CI of those whose first suicide attempt occurred before the onset of any apparent psychiatric disorders was calculated, weighted by NESARC sampling and nonresponse weights. Separate analyses were performed for males, females, and 3 age groups (20 to <35, 35-50, and >50 to 65 years). In the total sample of 36 309 respondents, 1948 persons had lifetime suicide attempts; 66.8% (95% CI, 64.1%-69.4%) were female, and 6.2% (95% CI, 4.9%-7.4%) had no apparent lifetime psychiatric diagnoses when surveyed. In addition, 13.4% (95% CI, 11.6%-15.2%) made their first suicide attempt prior to psychiatric disorder onset. Thus, an estimated 19.6% of respondents first attempted suicide without an antecedent psychiatric disorder. No significant age or sex differences were detected in the percentage of those with lifetime suicide attempts absent psychiatric disorders, although females were more likely than males to attempt suicide in the year of psychiatric disorder onset (14.9% [95% CI, 12.5%-17.3%] vs 8.6% [95% CI, 6.0%-11.2%]; P < .001), and attempts were less frequent among those older than 50 to 65 years (3.9% [95% CI, 3.5%-4.4%] vs 6.1% [95% CI, 5.4%-6.8%] for 35-50 years and 6.2% [95% CI, 5.6%-6.9%] for 20 to <35 years; P < .001). In this study, an estimated 19.6% of individuals who attempted suicide did so despite not meeting criteria for an antecedent psychiatric disorder. This finding challenges clinical notions of who is at risk for suicidal behavior and raises questions about the safety of limiting suicide risk screening to psychiatric populations.

Experimental Study on Rapid Hemostasis Using Peptide Hydrogels.

Uncontrolled hemorrhaging resulting from trauma, surgery, and disease-associated or drug-induced blood disorders can cause significant morbidities and mortalities in civilian and military populations. Self-assembling peptide nanofibers are particularly attractive due to their rapid and efficient hemostasis, biocompatibility, and wound-healing properties. In this study, we designed two types of 12-residue peptides by using a strong fishnet-like peptide sequence and a pro-cell adhesion sequence (Arg-Gly-Asp, RGD). The peptides are HN2-X-Ser-Phe-Cys-Phe-Lys-Phe-Glu-X-Arg-Gly-Asp-OH (where X is Pro or Tyr), which dissolve in deionized (DI) water and form stable and transparent functional hydrogels. Transmission electron microscopy and scanning electron microscopy demonstrated that the two peptides self-assemble into nanowebs and nanofibers, forming a fishnet-like and three-dimensional network structure. Circular dichroism and Fourier transform infrared spectroscopy analysis demonstrated that the self-assembled peptides mainly adopt a β-sheet structure with β-turn and α-helix as auxiliary assembly growth. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and SEM analysis showed that the cell survival rates were very good, delivering an obvious promotion of cell proliferation of fibroblasts and hepatocytes. Importantly, in vivo hemostasis delivered that the self-assembled peptide nanowebs and nanofibers had a good hemostatic effect on rat saphenous vein and liver bleeding, achieving 38 s faster hemostasis, which was better than commercial "Instantaneous" hemostatic powder. Accoupling the fast hemostasis and effective promotion of liver defect rapid repair, the peptide self-assembly strategy offers a clinically promising treatment option for life-threatening liver bleeding and serves as a renewed impetus for the development of peptide hydrogels as effective hemostatic agents.

The wage curve after the Great Recession

AbstractMost economists maintain that the labour market in the USA (and elsewhere) is ‘tight’ because unemployment rates are low, and the Beveridge curve (the vacancies‐to‐unemployment ratio) is high. They infer from this that there is potential for wage‐push inflation. However, real wages fell rapidly in 2022, and prior to that, real wages had been stagnant for some time. We show that unemployment is not key to understanding wage formation in the USA, and has not been since the Great Recession. Instead, we show that rates of underemployment (the percentage of workers with part‐time hours who would prefer more hours) and the rate of inactivity (the percentage of the civilian adult population who are out of the labour force) reduce wage pressure in the USA. This finding holds in panel data with state and year fixed effects in both annual and quarterly data for the period 1980–2022, and is supportive of a wage curve that fits the data much better than a Phillips curve. The unemployment rate no longer enters significantly negative in wage equations, however specified, in the years since 2008.

Does cognitive load influence expressive flexibility? Comparing civilian and veteran populations

ABSTRACT Expressive flexibility (EF) is a component of emotion regulation flexibility repertoire that constitutes the ability to enhance or suppress the expression of emotion in accordance with a given situational context. Previous research has associated EF with healthy adjustment to adversity. This association has also been observed in combat veterans with elevated post-traumatic stress. EF and other elements of regulatory flexibility are believed to rely on functions of cognitive control, such as working memory. However, previous research has yet to investigate this link. Accordingly, we examined performance in veterans (N = 42) and non-veterans (N = 75) on an EF Task with and without the inclusion of a numerical cognitive load task. Results indicate an interaction between cognitive load and expressive condition. Specifically, suppression abilities were weaker in cognitive load conditions. These findings did not vary in veteran and non-veteran samples. These results add to a growing body of work indicating a relationship between cognitive control and regulatory flexibility, and suggest similar mechanisms between veteran and non-veteran populations.

THE STRUGGLE FOR THE SURVIVAL OF THE CIVILIAN POPULATION OF BELARUS DURING THE NAZI PUNITIVE OPERATIONS (BASED ON ORAL HISTORY MATERIALS)

The article is based on the memories of residents of the Vitebsk region of Belarus who experienced the German occupation from 1941 to 1944. It characterizes the everyday survival practices of people during punitive operations by the Nazis. The region under consideration was distinguished by significant resistance to the German occupiers. The occupation authorities responded to partisan actions by carrying out numerous punitive operations, during which the civilian population was either completely destroyed or taken as forced labor to be sent to Germany. As a result, residents, in order to escape the punishers, were forced to flee to the forests and spent many months in forest camps, deprived of practically everything necessary. They were forced to adapt to the situation and develop specific practices that allowed them to find food, build shelter, and survive in extreme conditions.

Dopuszczalność wojny w myśli chrześcijańskiej. Refleksja polemologiczna

Aim: The article aims to conduct a multifaceted analysis regarding the permissibility of war in Christian thought within the context of contemporary security, attempting to answer questions such as whether Christians should condemn wars as incompatible with God's law and Christian morality, or if there are situations where war becomes a necessity. What stance should Christians adopt towards war itself? Methods: The article employs an analytical-synthetic method. Analyzing the content of the issues allowed for breaking down the components into parts, examining each separately. Meanwhile, synthesis brought these elements together into a new whole, providing a holistic approach. As a result, this facilitated drawing general conclusions based on acknowledged specific assertions. Results: Reflection on the addressed issues indicates that a pivotal concern in today's world is the reality of the danger of war and the pursuit of maintaining peace. Christian teachings unequivocally state that every possible effort should be made to put an end to wars. Despite the idea of just war and the right to legitimate defense remaining unchanged, this cannot exempt individuals from the obligation to act in favor of peace. This is exceedingly challenging since wars cannot be avoided by mere desires. It should be the duty of a Christian to vehemently protest against tendencies leading to war. Additionally, there should be a search for and discovery of new peaceful means to resolve international disputes. Conclusion: The phenomenon of war and peace is deliberated upon in most publications addressing contemporary civilization's problems, nature, and future. It also finds a place in polemological reflection. Thus far, within the domain of contemporary polemological thought, Catholic reflection deserves distinction. It holds the greatest contribution to the analysis of war and peace issues, especially since the Second Vatican Council and the pontificate of John XXIII. Christians believe that war is a manifestation of disorder existing in the world. They are convinced that in the face of war, they cannot remain indifferent and should react to injustice and suffering primarily affecting civilian populations. Presently, Catholics firmly reject war to solve any international problems. Originality: This work fills a specific gap in an exceedingly interesting area of scientific exploration, providing significant suggestions and conclusions based on the author's analysis and assessments. Keyword: security, peace, war, Catholicism, religion, Christian concept of just war

MINING OF UKRAINE - A HUGE THREAT TO THE CIVIL POPULATION AND A SERIOUS CHALLENGE FOR SAPER DEPARTMENT

The article is an attempt to present the threats to the security of the civilian population resulting from the mining of the territory of Ukraine during military operations related to the attack on this country by the troops of the Russian Federation (FR). Mining in Ukraine is caused both by: the massive use of mine-barrage measures used to build classic minefields (both anti-tank and anti-personnel minefields), the widespread use of Improvised Explosive Devices (IEDs) in combat operations, various types of unexploded ordnance and other explosive and dangerous items. The author of the article describes the means of combat used during the fighting on the territory of Ukraine, the use of which contributes to the contamination of the area and causes a deadly threat to the civilian population. It also presents the tasks carried out by the state services of Ukraine in order to clear the territory of this country in order to neutralize the threats generated by explosive and dangerous items of military origin as soon as possible and to enable the civilian population to return to a normal, safe life. In the final part of the article, the author presents the Polish implementation system clearing the territory of the country from explosive and dangerous objects.

The Demographic Factor in Shaping State Policy for Higher Education of Ukraine

The article examines key indicators of the demographic crisis in Ukraine, highlighting manifestations of the nation’s aging and natural population decline.It’s determined that understanding and analyzing the demographic situation allows for predicting changes in the size and structure of the student population, which is crucial for the effective development of higher education in Ukraine. Considering the trends of declining birth rates and an aging population, it is important to adapt admission strategies for students and educational programs accordingly. The examination of the demographic crisis helps identify key challenges, such as a decrease in the number of high school graduates, which can impact competition within the higher education environment.The trends examined in the article, including the decline in the birth rate of the Ukrainian population, the aging of the nation, the level of migration, and the loss of the civilian population due to the war, enable us to characterize the situation in Ukraine as depopulation. Notable changes in the demographic landscape and shifts in the population structure occurred after February 24, 2022, including irreversible human losses, population emigration (over 10 million people), and a decline in the average birth rate. A correlation was identified between the number of births each year and the dynamics of educational services’ capacity. It was observed that higher education in Ukraine will confront significant demographic challenges in the next 17 years. In the context of the strategic goal to restore Ukraine’s human capital, the article suggests viewing higher education as an effective instrument of state policy in a cyclical process: attaining higher education, integrating graduates into the national economy, ensuring financial stability, fostering active citizenship, and promoting loyalty to the state—all contributing to an improvement in the demographic situation.

Measuring civilian moral injury: Adaptation and validation of the Moral Injury Events Scale (Civilian) and Expressions of Moral Injury Scale (Civilian).

Moral injury (MI) research has been expanded to populations beyond the military in recent years. A key barrier to further research into MI in civilian populations is the lack of valid, reliable measures of the construct appropriate for general civilian use. This article addresses this barrier by adapting two existing military measures and exploring their psychometrics in a general civilian sample: the Moral Injury Events Scale-Civilian (MIES-C) and Expressions of Moral Injury Scale-Military (EMIS-C). A sample of civilian women (n = 192) and men (n = 88) completed the above measures, and additional scales designed to capture theoretically supported primary and secondary markers of MI (guilt, shame, anger; depression, posttraumatic stress symptoms, anxiety). Confirmatory factor analyses found that the factor structure of the MIES-C and EMIS-C replicated well within our civilian sample. Discriminant validity was indicated through a significant negative correlation with well-being. Both measures correlated as predicted with each other and measures of MI markers at the total score level. Correlations of individual subscales with each of these measures were more varied. Results shed light on differential relationships between the type of MI event and clinical outcomes, suggesting some conceptual differences in how MI is experienced in general civilian populations. Results suggest that civilian populations are also susceptible to MI, but that existing measures may have problems capturing this effectively. While the MIES-C and EMIS-C are supported for civilian use, further scale construction efforts for this population are warranted. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

A comparison of computed tomography angiography and digital subtraction angiography for the diagnosis of penetrating cerebrovascular injury: a prospective multicenter study.

In this research, the authors sought to characterize the incidence and extent of cerebrovascular lesions after penetrating brain injury in a civilian population and to compare the diagnostic value of head computed tomography angiography (CTA) and digital subtraction angiography (DSA) in their diagnosis. This was a prospective multicenter cohort study of patients with penetrating brain injury due to any mechanism presenting at two academic medical centers over a 3-year period (May 2020 to May 2023). All patients underwent both CTA and DSA. The sensitivity and specificity of CTA was calculated, with DSA considered the gold standard. The number of DSA studies needed to identify a lesion requiring treatment that had not been identified on CTA was also calculated. A total of 73 patients were included in the study, 33 of whom had at least 1 penetrating cerebrovascular injury, for an incidence of 45.2%. The injuries included 13 pseudoaneurysms, 11 major arterial occlusions, 9 dural venous sinus occlusions, 8 dural arteriovenous fistulas, and 6 carotid cavernous fistulas. The sensitivity of CTA was 36.4%, and the specificity was 85.0%. Overall, 5.6 DSA studies were needed to identify a lesion requiring treatment that had not been identified with CTA. Cerebrovascular injury is common after penetrating brain injury, and CTA alone is insufficient to diagnosis these injuries. Patients with penetrating brain injuries should routinely undergo DSA.

The prevalence factor of post-traumatic stress disorders among students of Mariupol

The subject of the study is post-traumatic stress disorder (PTSD) of people exposed to stress factors in the city of Mariupol during the active phase of the Special Military Operation in the city. Taking into account the tasks of socio-psychological rehabilitation of the civilian population located in an area of increased risk of psychological and physical trauma, identifying the level of prevalence of PTSD in Mariupol is extremely relevant from both a scientific and applied point of view. Obtaining relevant information is important both for further in-depth research and for the development and implementation of appropriate programs of socio-psychological and (or) depth psychological rehabilitation. In addition, this information is relevant in the context of solving the problem of forming the all-Russian civic identity among new generations of Russians. The study used structured clinical interview technology, as well as the Clinical-Administered PTSD Scale (CAPS) and a PTSD screening questionnaire. Based on the data obtained during the study, it was concluded that, in comparison with similar indicators identified among the civilian population of Afghanistan and Chechnya, who were in the territory of intense military operations and experienced the effects of powerful stress factors, as well as among people who witnessed the shooting of the Russian parliament in 1993, the prevalence of PSTD among residents of Mariupol who were in the city during the operation to liberate it is quite low. In the opinion of the authors of the article, this fact is explained by the fact that the majority of Russian citizens who remained in Mariupol and returned to it perceive the military actions of 2022 as a “forced necessity”. This leads to the conclusion about the extreme importance of using psychological and psychological-pedagogical technologies in the sphere of protecting traditional values.

Decolonising the Civilian in Third World National Liberation Wars

Within international humanitarian law (IHL) the legal figure of the civilian is conceived as a passive victim of war in need of protection, while civilians who become actively involved in hostilities lose their protections. The distinction between civilians and combatants is accordingly a fundamental principle informing IHL and is considered a standard of civilisation and humane warfare. This paper interrogates what happens when this standard is applied to anticolonial wars, where entire civilian populations participated in self-emancipatory violence and actively blurred this distinction in order to advance their own liberation. Advancing a theory aimed at decolonising the legal figure of the civilian, I analyse the specific nature of anticolonial violence and the call of anticolonial thinkers to deliberately undermine the distinction between civilians and combatants. Building on the ethos of civilian participation articulated by different anticolonial thinkers and adopting a ‘revisionist’ approach, I argue that the passive conception of the civilian at the heart of the Geneva Conventions and the Additional Protocols faces the risk of outlawing anticolonial violence and its political ethos of liberation. Décoloniser la figure du civil dans les guerres de libération nationale du tiers monde

“Genocide of the Soviet People”: Putin’s Russia Waging Lawfare by Means of History, 2018–2023

This article exposes the political underpinnings of the term “genocide of the Soviet people,” introduced and actively promoted in Russia since 2019. By reclassifying mass crimes committed by the Nazis and their accomplices against the civilian population—specifically Slavic—as genocide, Russian courts effectively engage in adjudication of the history of the Second World War. In the process, genocide trials, ongoing in twenty-five Russian provinces and five occupied Ukrainian territories, present no new evidence or issue new indictments, thus fulfilling none of the objectives of a standard criminal investigation. The wording of the verdicts, and a comprehensive political project put in place to promote it, suggests three main objectives behind the novel genocide of the Soviet people trope, absolving the Soviet Union of responsibility for the outbreak of the Second World War, counterbalancing the efforts of the Ukrainian government to seek international recognition of Holodomor as an act of genocide, and drawing a parallel between Nazi crimes and those ascribed to “Ukrainian neo-Nazis.” Russian genocide trials are a crass example of sham justice and a manifestation of lawfare.

A Pathophysiological Approach for Selecting Medications to Treat Nociceptive and Neuropathic Pain in Servicemembers.

The prevalence of chronic pain of service members (SMs) in the U.S. is estimated to be higher (roughly 31-44%) compared to that of civilian population (26%). This higher prevalence is likely due to the high physical demands related combat and training injuries that are not immediately resolved and worsen over time. Mental Health America reports that chronic pain can lead to other mental health conditions such as severe anxiety, depression, bipolar disorder, and post-traumatic stress disorder. Such mental health conditions can negatively affect job performance, reduce readiness for military duties, and often lead to patterns of misuse of opioid after SMs entering civilian life. The primary objective of this narrative review is to present a summarized guideline for the treatment of two types of pain that likely affect SMs, namely nociceptive somatic pain and neuropathic pain. This review focused on a stepwise approach starting with nonopioid interventions prior to opioid therapy. The secondary objective of this review is to elucidate the primary mechanisms of action and pathways associated with these two types of pain. We followed the Scale for Assessment of Narrative Review Articles when transcribing this narrative review article to enhance the quality and brevity of this review. This Scale has 0.77% an intra-class coefficient of correlation, 95% confidence interval and 0.88 inter-rater reliability. We searched PubMed, Google Scholar, WorldCAT, and the Cochrane Library for the primary and secondary articles that targeted mechanisms of action, pathways, and pharmacological modalities for nociceptive somatic and neuropathic pain that were published from 2011 to 2022. We excluded articles related to pediatric, some specific pain conditions such as cancer-related pain, palliative care, end-of-life care, and articles that were not written in English language. For pharmacologic selection, we adopted the guidelines from the Policy for Implementation of a Comprehensive Policy on Pain Management by the Military Health Care system for the Fiscal Year 2021; the Clinical Practice Guidance for Opioid Therapy for Chronic Pain by the Department of Defense/Veterans Health Administration (2022); the (2021) Implementation of a Comprehensive Policy on Pain Management by the Military Health Care System; and the (2022) Guideline for Prescribing Opioids for Chronic Painby the Centers for Disease Control. From the knowledge of the mechanisms of action and pathways, we can be more likely to identify the causative origins of pain. As a result, we can correctly diagnose the type of pain, properly develop an efficient and personalized treatment plan, minimize adverse effects, and optimize clinical outcomes. The guideline, however, does not serve as a substitute for clinical judgment in patient-centered decision-making. Medication choices should be individualized judiciously based on the patient's comorbid conditions, available social and economic resources, and the patient's preferences to balance the benefits and risks associated with various pain medications and to achieve optimal pain relief and improve the patient's quality of life.

Implementation of Web-Based Dukcapil Ceiling Program in Improving Population Administration Services

This study aimed to analyze the implementation of Dukcapil Web Plavon in improving population administration service in Glagaharum village. Descriptive research with a qualitative approach was conducted, using interviews, observations, and documentation as data collection techniques. T.B. Smith's theory was used to analyze four indicators: Policy Wanted, Target Targeted, Organizational Implementation, and Environmental Factors. The desired policy indicator showed that the program was implemented in accordance with the objectives set by the Civil Registration and Population Service. However, the target indicator revealed that many people still cannot use Dukcapil's Web Plavon. The organizational implementation indicator showed that socialization related to the existence and use of Dukcapil Web Platoon has not been maximized, causing a large number of people to not understand how to use it. The environmental factors indicator revealed barriers associated with frequent power outages, unstable internet connection, lack of printer, and lack of room cooling air conditioner. The study implies that the implementation of Dukcapil Web Plavon faces various challenges that need to be addressed to improve population administration service. Highlight : The study analyzed the implementation of Dukcapil Web Plavon in improving population administration services in Glagaharum Village using a qualitative approach The organizational implementation indicator revealed that the socialization of the program has not been maximized, leading to a lack of understanding among the people on how to use it Environmental factors such as frequent power outages, unstable internet connection, lack of printer, and absence of room cooling air conditioner were identified as barriers to the implementation of Dukcapil Web Plavon Keywords: Dukcapil Web Plavon, population administration, Glagaharum Village, implementation, challenges

Matrix-bound nanovesicle-associated IL-33 supports functional recovery after skeletal muscle injury by initiating a pro-regenerative macrophage phenotypic transition

Injuries to skeletal muscle are among the most common injuries in civilian and military populations, accounting for nearly 60% of extremity injuries. The standard of care for severe extremity injury has been focused upon limb salvage procedures and the utilization of tissue grafts or orthotics in conjunction with rehabilitation to avoid amputation. Nonetheless, many patients have persistent strength and functional deficits that permanently impact their quality of life. Preclinical and clinical studies have shown that partial restoration of functional skeletal muscle tissue following injury can be achieved by the implantation of a biologic scaffold composed of extracellular matrix (ECM). These favorable outcomes are mediated, at least in part, through local immunomodulation. The mechanisms underlying this immunomodulatory effect, however, are poorly understood. The present study investigates a potential mechanistic driver of the immunomodulatory effects; specifically, the effect of selected ECM components upon inflammation resolution and repair. Results show that the host response to skeletal muscle injury is profoundly altered and functional recovery decreased in il33−/− mice compared to age- and sex-matched wildtype counterparts by 14 days post-injury. Results also show that IL-33, contained within matrix-bound nanovesicles (MBV), supports skeletal muscle regeneration by regulating local macrophage activation toward a pro-remodeling phenotype via canonical and non-canonical pathways to improve functional recovery from injury compared to untreated il33−/− counterparts. Taken together, these data suggest that MBV and their associated IL-33 cargo represent a novel homeostatic signaling mechanism that contributes to skeletal muscle repair.