Cinnamon Extract Research Articles

EVALUASI UJI EFEKTIVITAS EKSTRAK KAYU MANIS (Cinnamomum burmanni) SEBAGAI LARVASIDA TERHADAP KEMATIAN JENTIK NYAMUK (Aedes aegypti)

Alternative larvicides against Aedes aegypti larvae and safe for the environment, one of which is cinnamon oil which has been shown to have a larvicidal effect on larvae. Cinnamon contains flavonoid compounds which are strongly suspected to have a larvicidal effect. It can be said that this research is to determine the effectiveness of extracts from cinnamon as a larvicide against the death of Aedes aegypti mosquito larvae. And for the extraction method used in this study using the maceration method. For a concentration of 2% it can kill a total of 32 (53%) larvae, and for a concentration of 4% it can kill 43 (72%) total lava, and a concentration of 6% can kill 53 (88%) larvae, and for a positive control, namely abate (temephos). ) has the best larvicidal effect with an average % larval mortality of 100% within 1 hour. Cinnamon extract test treatments with a concentration of 2% (2ml/100ml) experienced larval death 32 (43%), and for a concentration of 4% (4ml/100ml) experienced larvae mortality 43 (53%). and for a concentration of 6%, 53 (88%) larvae died. And for temephos, it was able to kill a total of all larvae, while for negative control it did not die. The most effective concentration of cinnamon extract in killing larvae was 6%, the higher the concentration, the higher the larval mortality value.

In Vivo Incision Wound Healing Studies using Ethanolic Cinnamon’s (Cinnamomum burmannii) Leaves Extract in White Male Rats

Cinnamon leaves are traditional plants that contain secondary metabolites such as flavonoids,
 tannins, saponins, alkaloids, and phenols. All of these compounds play an essential role in the wound healing process. This study aimed to determine the effects of cinnamon (Cinnamomum burmannii) on incision wound healing in male rats. The research method used a post-test only control group design approach that uses five treatment groups: positive control (Bioplacenton® Gel), negative control (Vaseline flavum), and ethanol extract of cinnamon leaves at concentrations of 10%, 20%, and 30%. The results showed that the ethanol extract of cinnamon leaves affected wound healing, as observed from the day of wound healing, the AUC length of the wound, and levels of hydroxyproline. The statistical test results showed a significant difference between the groups (p<0.05), where the best concentration was 30%, followed by 20% and 10%. Therefore, we concluded that the ethanolic extract of cinnamon leaves can heal wounds in male rats.

Characterization of the Biological Activities of a New Polyphenol-Rich Extract from Cinnamon Bark on a Probiotic Consortium and Its Action after Enzymatic and Microbial Fermentation on Colorectal Cell Lines.

Cinnamon polyphenols are known as health-promoting agents. However, their positive impact depends on the extraction method and their bioaccessibility after digestion. In this work, cinnamon bark polyphenols were extracted in hot water and subjected to an in vitro enzymatic digestion. After a preliminary characterization of total polyphenols and flavonoids (respectively 520.05 ± 17.43 µgGAeq/mg and 294.77 ± 19.83 µgCATeq/mg powder extract), the extract antimicrobial activity was evidenced only against Staphylococcus aureus and Bacillus subtilis displaying a minimum inhibition growth concentration value of 2 and 1.3 mg/mL, respectively, although it was lost after in vitro extract digestion. The prebiotic potential was evaluated on probiotic Lactobacillus and Bifidobacterium strains highlighting a high growth on the in vitro digested cinnamon bark extract (up to 4 × 108 CFU/mL). Thus, the produced SCFAs and other secondary metabolites were extracted from the broth cultures and determined via GC-MSD analyses. The viability of healthy and tumor colorectal cell lines (CCD841 and SW480) was assayed after the exposition at two different concentrations (23 and 46 µgGAeq/mL) of the cinnamon extract, its digested, and the secondary metabolites produced in presence of cinnamon extract or its digested, showing positive protective effects against a tumorigenic condition.

Anti-inflammatory, cytotoxicity and antilipidemic properties: novel bioactivities of true cinnamon (Cinnamomum zeylanicum Blume) leaf

BackgroundThe leaf of Ceylon cinnamon (true cinnamon) is traditionally claimed for a variety of health benefits. However, reported scientific information is scanty and needs urgent attention for value addition.MethodsEthanolic (95%) and Dichloromethane:Methanol (DM, 1:1 v/v) leaf extracts of Ceylon cinnamon were evaluated for a range of medically important bioactivities namely anti-inflammatory [nitric oxide scavenging activity (NOSA), superoxide scavenging activity (SCA), COX1 and COX2 inhibition], growth inhibition & cytotoxicity against MCF7, HePG2 and AN3CA carcinoma cell lines, glutathionase-S-transferase (GST) inhibition and antilipidemic (anti-HMG-CoA reductase, anti-lipase, anti-cholesterol esterase, and cholesterol micellization inhibition) properties in vitro (n = 3). Further, a range of bioactive compounds in both leaf extracts was also quantified (n = 3).ResultsBoth leaf extracts had all the investigated bioactive compounds and possessed moderately potent bioactivities compared to the reference drugs used in the study. Ethanolic leaf extract (ELE) exhibited the highest activities (IC50: μg/mL) for NOSA (40.26 ± 0.52), SCA (696.24 ± 40.02), cholesterol esterase inhibition (110.19 ± 1.55), cholesterol micellization inhibition (616.69 ± 7.09), GST inhibition (403.78 ± 2.70) and growth inhibition (GI50: 144.84 ± 1.59-269.00 ± 0.51) & cytotoxicity (LC50: 355.44 ± 9.38-717.71 ± 23.69) against studied cancer cell lines. In contrast, COX1 & COX2 (IC50: 6.62 ± 0.85 and 44.91 ± 3.06 μg/mL) and HMG-CoA reductase & lipase inhibitory activities (36.72 ± 4.74 and 19.71 ± 0.97% inhibition at 200 and 600 μg/mL) were highest in DM extract. ELE also showed the highest quantities (0.81 ± 0.06-104.38 ± 1.79) of tested compounds (mg/g extract) where eugenol was the highest and gallic acid was the lowest among quantified.ConclusionBoth leaf extracts of Ceylon cinnamon had all the tested bioactive compounds and possess all the investigated bioactivities. This is the 1st study to report all the investigated bioactivities of the leaf of Ceylon Cinnamon.

Antifungal activity of cinnamon and mint extracts against white and basal rot of garlic

Antifungal activity of cinnamon and mint extracts against white and basal rot of garlic

Potential of selected plant extracts to control severe subacute ruminal acidosis in vitro as compared with monensin

BackgroundIn recent years, researchers have become increasingly interested in developing natural feed additives that can stabilize ruminal pH and thus prevent or eliminate the risk of severe subacute rumen acidosis. Herein, 3 experiments were conducted using a semi-automated in vitro gas production technique. In the experiment (Exp.) 1, the efficacy of 9 plant extracts (1.5 mg/ml), compared to monensin (MON; 12 μg/ml), to counteract ruminal acidosis stimulated by adding glucose (0.1 g/ml) as a fermentable carbohydrate without buffer was assessed for 6 h. In Exp. 2, cinnamon extract (CIN) and MON were evaluated to combat glucose-induced acidosis with buffer use for 24 h. In Exp. 3, the effect of CIN and MON on preventing acidosis when corn or barley grains were used as substrate was examined.ResultsIn Exp. 1, cinnamon, grape seeds, orange, pomegranate peels, propolis, and guava extracts significantly increased (P < 0.05) pH compared to control (CON). Both CIN and MON significantly increased the pH (P < 0.001) but reduced cumulated gas production (P < 0.01) compared to the other treatments. In Exp. 2, the addition of CIN extract increased (P < 0.01) pH value compared to CON at the first 6 h of incubation. However, no significant differences in pH values between CIN and CON at 24 h of incubation were observed. The addition of CIN extract and MON decreased (P < 0.001) lactic acid concentration and TVFA compared to CON at 24 h. The CIN significantly (P < 0.01) increased acetate: propionate ratio while MON reduced it. In Exp. 3, both CIN and MON significantly increased (P < 0.05) ruminal pH at 6 and 24 h and reduced lactic acid concentration at 24 h compared to CON with corn as substrate. However, CIN had no effect on pH with barley substrate at all incubation times.ConclusionsIt can be concluded that CIN can be used effectively as an alternative antibiotic to MON to control ruminal acidosis when corn is used as a basal diet.

EFFECTIVITY OF CINNAMON (Cinnamomum burmanii) TO DECREASE UREA LEVELS

Urea or Blood Urea Nitrogen (BUN) is a non-protein blood nitrogen molecule that results from the catabolism of protein and amino acids through the urea cycle and is eliminated by the kidneys as urine, perspiration, and degraded by intestinal bacteria. BUN levels can indicate renal disease. Cinnamon (Cinnamomum burmanii) is an Indonesian herb that functions as an anti-inflammatory and antioxidant, reducing urea levels and contributing to improved kidney function. The search was conducted using Google Scholar, Pubmed, and Science Direct. "cinnamomum burmannii", "cinnamon", "cinnamon extract", "blood urea nitrogen", "serum urea", "urea", "ureum", and "kidney" were used as keywords. Cinnamon, which contains cinnamaldehyde, coumarins, tannins, flavonoids, polyphenols, glycosides, terpenoids, and anthraquinone compounds, might protect the kidneys by reducing urea levels through the decrease of oxidative stress

Cinnamon extract and sodium hypochlorite in the in vitro control ofFusarium oxysporumf. sp.lycopersiciandAlternaria alternatafrom tomato

AbstractBotanical fungicides are an interesting alternative for pathogen control and plant protection in sustainable production systems. Thus, this study aimed to evaluate the potential of cinnamon for use in inhibiting pathogens in tomato crop. Three main strains ofFusarium oxysporumf. sp.lycopersiciand a strain ofAlternaria alternatawere grown in in vitro conditions, and later used for tests of antifungal effect of cinnamon extract, compared to sodium hypochlorite. As a result, complete growth inhibition of the three strains ofFusarium oxysporumf. sp.lycopersiciandAlternaria alternatawere achieved only when using sodium hypochlorite from a concentration of 3%, and a partial inhibition with the use of cinnamon extract. Both, cinnamon extract and sodium hypochlorite solution, at concentrations above 2%, reduced Mycelial Growth Speed Index values. Cinnamon extract demonstrated its antifungal potential, indicating the possibility of its use in the in vitro control of phytopathogenic fungi in tomato crops. In addition, this study also showed the main effects of cinnamon extract on hyphae and conidia of these phytopathogens.[Correction added on 01 November 2022, after first online publication: The full form of 'MGRI' has been updated in the abstract of this version].

Effectiveness of plant extracts for repressing stem rust disease severity of wheat caused by Puccinia graminis f.sp. tritici Pers under field conditions

BackgroundStem rust caused by Puccinia graminis f.sp. tritici Pers is one of the most devastating fungal foliar diseases, and causes substantial yield losses to wheat crops cultivated under field conditions. This study aimed to evaluate the efficacy of plant extract-based foliar sprays for wheat with carnation, ginger and cinnamon on the severity of stem rust infection of three wheat cultivars cultivated under field conditions for two consecutive winter seasons of (2020/21 and 2021/22).ResultsIn both seasons our data showed that all treatments were associated with some degree of disease suppression recorded as a range of 2.3–8.6% compared to 15.3–24.5% in untreated control treatment. The plant extract treatment was more effective than Amistar, a commercial fungicide. They recorded disease severity as: scores ranged between 2.3 and 3.2%; 3.0–4.5%, and 3.0–6% for wheat cvs. Giza 1, Misr 2, and Sids 14, in respective order. Meanwhile, scores of 4.1, 7.5, and 8.6% were recorded at fungicidal treatment. Spaying wheat plants with carnation extract showed the lowest disease prevalence followed by ginger and cinnamon extract, respectively. Increased in grain yield was associated with reduced disease severity.ConclusionsThe present investigation demonstrated the efficacy using plant extracts against foliar diseases caused by Puccinia and it was suggested that they may be an alternative to traditional chemical treatment.

The possible protective and therapeutic effects of ginger and cinnamon on the testis and coda epididymis of streptozotocin-induced-diabetic rats: Histological and biochemical studies

Diabetes mellitus (DM) is a metabolic condition characterized by high blood sugar levels with serious system complications. Ginger (Zingiber officinale) and Cinnamon (Cinnamomum zeylanicum) have anti-diabetic activities. The goal of this study is to evaluate the possible protective and therapeutic effects of ginger and Cinnamon against histological, Ki67 Immunohistochemistry (IHC) and biochemical studies in testis and coda epididymis of Streptozotocin (STZ) induced diabetic rats. The experimental rats were divided into six groups: G1 was the control, G2 induced diabetic without treatment, G3 was treated with ginger before induction of DM (ginger protective), G4 were given ginger after DM induction (ginger therapeutic), G5 were given cinnamon before induction of DM (cinnamon protective) and G6 were given cinnamon after DM induction (cinnamon therapeutic). In diabetic rats’ significant increases in fasting blood sugar and body weight were observed after three weeks. Ginger and cinnamon effectively decreased serum glucose levels. Histopathological evaluations of seminiferous tubules and coda epididymis sections from diabetic rats showed severe damage to them. Furthermore, the sections of seminiferous tubules and coda epididymis rats administered ginger and cinnamon extract showed normal structure, healthy lining epithelium and sperm contents compared to diabetic rats. The results of the study show that both Ginger and Cinnamon aqueous extracts are effective as both hypoglycemic natural supplements that can protect against diabetic-induced testicular damage as well as share in the reservation of the cauda epididymal structure and sperm contents.

ANTIDIABETIC ACTIVITIES OF CINNAMON EXTRACT IN MICE BY THE METHOD OF INDUCTION OF ALLOXANE

Diabetes mellitus or sugar disease is a metabolic disease with hyperglycemia characteristics that occur due to abnormalities in insulin secretion, insulin work, or both are currently experienced by many Indonesian people. Based on Basic Health Research in Indonesia, diabetics have increased significantly over the past five years. In 2013, the prevalence rate of diabetes in adults in Indonesia itself, based on the latest data from the 2018 Basic Health Research, in general the prevalence rate of diabetes in adults reached 6.9% and in 2018 the figure increased to 8.5%. This study aims to analyze the antidiabetic activity of cinnamon extract in alloxane-induced mice and the content of bioactive compounds that have antidiabetic activity. Cinnamon extract was carried out by maceration using 96% methanol compounds for 4 weeks followed by ethyl acetate extraction 4 times. Purification was performed using chromatographic columns with solvents CHCl3, 3% MeOH-CHCl3, 20% MeOH-CHCl3, MeOH. Each purification fraction was tested In Vivo on mice. The test results showed that cinnamon powder extract at a fraction of MeOH-CHCl3 3% can significantly reduce blood glucose levels compared to the control treatment of 113: 392 (mg/dL).

Synergistic effect of secondary metabolites of locale isolates of lactic acid bacteria with some plant extract against Aspergillus Niger

&#x0D; Food is important for survival organisms. Food preservation is an important method preserving food. There are many issues on it, to avoid these problems and reduce side effects when using traditional methods of food preservation. The use of probiotics has been resorted to. Lactic Acid Bacteria (LAB) is among the distinct groups of bacteria as probiotics. It produces many antimicrobial contents, including antifungal. Therefore, secondary metabolites were extracted for some locale LAB isolates (Pediococcus sp., Enterococcus sp. and Lactobacillus sp.) in synergy with aqueous extracts of Syzygium and Cinnamon and Aspergillus niger was treated with these extracts. The results of statistical analysis showed a synergistic antifungal activity of these extracts against A.niger The highest synergistic effect was of Lactobacillus sp (L2) extract that synergy with Syzygium extract with a significant difference at probability 0.05 and it was % 96 with growth area 50.24 mm2 as compared with area growth of control 1674.66 mm2, while the synergistic activity of bacterial extracts with Cinnamon extract were less than with Syzygium extract. As the highest inhibition against A. niger was reached for Lactobacillus sp (L2) that synergistic with Cinnamon extract, the percentage was %57 with growth area as 706.5 mm2 compared with control.

Effects of Turmeric, Cinnamon, and Lemon Extracts on Shelf Life, Nutrients, and Preservation of Carp Fish in Cold Storage

The present study aimed to investigate the effect of extracts of turmeric, cinnamon, and lemon on shelf life, macronutrients, and oxidative spoilage of the carp fish in cold storage at 4°C. Fishes were divided into five groups: control (NT); immersed fish in extracts of cinnamon, turmeric, and lemon (CTL); immersed fish in extracts of lemon and turmeric (LT); immersed fish in extracts of cinnamon and turmeric (CT); and immersed fish in extracts of lemon and cinnamon (LC). Results showed immersion of the carp fillet in extracts of turmeric, cinnamon, and lemon improved spoilage indices such as thiobarbituric acid, volatile nitrogen bases, and pH. The used extracts maintained the nutritional value and increased the fish’s shelf life. The compounds existed in the studied extracts decreased the values of the spoilage indices during cold storage. The highest spoilage indices were found for CL and CT treatments, and the lowest was for CTL treatment. The total bacterial load as well as the number of psychrophilic bacteria in the fish fillet found a significant decrease compared to the NT. Therefore, the best treatment was CTL, and inappropriate treatments were CT and CL. The fish shelf life for nine days was extended with the used extracts because the total count of cryophilic bacteria was 0.41 × 104 ± 0.50, which was the lowest compared to other treatments.

Efficiency of alcoholic cinnamon extract on ERG3and ERG11 genes in Candida albicans isolated from oral children candediasis

In the current study, it was highlighted to know the inhibitory effect of the alcoholic extract of cinnamon bark Against Candida yeast As well as evaluating the effectiveness of this extract on the viability of cell membrane formation, By knowing the gene expression level of C.albiacns gene for yeast Using the polymerase chain reaction in time 50 samples of Candida were collected and diagnosed by diagnostic tests C.ablicans method on yeast (cinnamon) from the alcoholic extract of cinnamon bark qRT- PCR and through the use of Microdilution Method To find out the inhibitory effect of the extract on the membrane (measurement of the level of gene expression of the gene) 1 Able to form C.albiacns (51.6%) from the bio-yeast, and the results showed that The results also showed that the concentration of 150 mg / ml showed the highest inhibition area with a value of 22 . mm while the concentration of 12.5 mg/ml showed the lowest inhibition logic with a value of 9 mm, and so was done For the extract against yeast if its value was 12.5 mg / (MIC) Calculation of the minimum inhibitory concentration.

Antitumor Activities of Aqueous Cinnamon Extract on 5637 Cell Line of Bladder Cancer through Glycolytic Pathway.

Background Pharmacotherapy with medicinal plants is a promising approach to treat cancer. Cinnamon is a medicinal plant whose properties have been proven in various fields of medical sciences. Among its biological activities, its antioxidant and antiviral effects can be mentioned. In this study, the antitumor effects of Cinnamon with a focus on glucose metabolism in bladder cancer carcinoma cell-line 5637 were investigated. Methods Aqueous extract of Cinnamon was prepared from Cinnamon bark. Bladder cancer 5637cell line were treated with different concentrations of aqueous extract of Cinnamon. MTT was used to evaluate cell viability at 24, 48, and 72 h. The concentration of 1.25, 2.50, and 5 mg/ml was used. Apoptosis was assessed with Hochest33258 staining. For evaluating of aqueous extract of Cinnamon effect on glycolysis, the gene expression of epidermal growth factor receptor 2 (ErbB2), heat shock protein transcription factor1 (HSF1), and lactate dehydrogenase A (LDHA), as well as protein levels of HSF1 and LDHA, LDH activity, glucose consumption, and lactate production, were measured. Results Aqueous extract of Cinnamon significantly decreased ErbB2, HSF1, and LDHA gene expression and also decreased the protein level of HSF1 and LDHA, LDH activity, glucose consumption, and lactate production dose-dependently (p < 0.05). Conclusion Our finding showed that the aqueous extract of Cinnamon can inhibit proliferation in 5637 cells by inhibition of glycolysis and induction of apoptosis.

Effect of Phytoestrogens in the Treatment of Polycystic Ovary Syndrome in Rat Model

Polycystic Ovary Syndrome is one of the most commonly occurring endocrine diseases with 5 % to 10 % prevalence worldwide. Different types of drugs being used for the treatment of PCOS have some side effects. This study is aimed to investigate the effect of Cinnamon and Flaxseed extract alone and in combination in maintaining the gonadotropins to treat Polycystic Ovary Syndrome and to compare the effect of Cinnamon and Flaxseed extract with standard drug of PCOS (Clomiphene citrate). Estradiol Valerate was used to induce PCOS in rats. 30 female Albino rats were divided into six different groups; control group (received normal saline 0.2 mg), positive control group (0.4 mL of Estradiol Valerate), Clomiphene citrate treated group (20 mg Clomiphene), Cinnamon treated group (40 mg cinnamon extract), Flaxseed treated group (60 mg flaxseed extract) and Cinnamon plus Flaxseed treated group (40 mg cinnamon extract + 60 mg flaxseed extract). The serum concentration of Progesterone, Testosterone and Estrogen were evaluated while the serum level of FSH was reduced in PCOS induced groups as compared to control group but after the treatment statistically significant results were observed (p value0.05). Combined therapy treatment showed satisfactory results in restoring the normal hormonal serum levels and the histopathological results showed no cystic follicle in ovaries. Cinnamon plus flaxseed combined therapy treatment improved the serum level of hormones and the histology of ovary in PCOS induced rats.

Cinnamon extract and its essential oil nanoliposomes – preparation, characterization and bactericidal activity assessment

Cinnamon extract and its essential oil nanoliposomes – preparation, characterization and bactericidal activity assessment

The use of selected herbal preparations for the disinfection of Japanese quail hatching eggs

The aim of study was to evaluate microbial and hatchability traits as well as chicks quality after hatching eggs disinfection with aqueous solutions of ginger (GR), garlic (GC), oregano (O), and cinnamon (C) extracts. The experiment was divided into 2 stages, at preliminary in vitro stage antimicrobial susceptibility of plant extracts (PEs) was tested against reference strains from the American Type Culture Collection. O and GC extracts had the best antimicrobial properties (P < 0.05). Then in in vivo stage 2,400 Japanese quails hatching eggs were divided into 6 groups, 400 eggs each. Eggs from first group were not disinfected (NC, negative control), eggs from second group were disinfected by formalin fumigation (C, positive control), in other groups 5% aqueous solutions of plant extracts of GR, GC, O, C were applied by spraying respectively. After standard incubation fertility, hatchability and periodical embryonic mortality were calculated as well as the body weight and livability of chickens during 14 d of rearing. Egg disinfection by aqueous solution of PEs led to maintain the hatchability, chick weight at hatch and post hatch body weight and early mortality of birds. Exclusion of any fungal isolates on eggshell surface was induced by GC followed by O and C groups (P < 0.05). In case of the bacteria colonies reduction only GR extract was effective. Chosen plant extracts may be treated as safe and alternative substances to traditional disinfectants of hatching eggs.

Cinnamon extract improves abnormalities in glucose tolerance by decreasing Acyl-CoA synthetase long-chain family 1 expression in adipocytes

We previously demonstrated that cinnamon extract (CE) alleviates streptozotocin-induced type 1 diabetes in rats. The present study aimed to elucidate the detailed molecular target of cinnamon in cultured adipocytes and epididymal adipose tissue of type 2 diabetes model mice. Two-dimensional gel electrophoresis was employed to determine the molecular target of cinnamon in adipocytes. The function of Acyl-CoA synthetase long-chain family-1 (ACSL1), a molecular target of cinnamon that was identified in this study, was further investigated in 3T3-L1 adipocytes using specific inhibitors. Type 2 diabetes model mice (KK-Ay/TaJcl) were used to investigate the effect of CE on glucose tolerance, ACSL1 expression, and related signal molecules in vivo. CE decreased ACSL1 mRNA and protein expression in 3T3-L1 adipocytes but increased glucose uptake and AMPK signaling activation; moreover, a similar effect was observed with an ACSL1 inhibitor. CE improved glucose tolerance and downregulated ACSL1 in mice adipose tissue in vivo. ACSL1 was demonstrated as a molecular target of CE in type 2 diabetes both in a cell culture system and diabetic mouse model.

Variation of bioactive secondary metabolites in Ceylon cinnamon (&lt;em&gt;Cinnamomum zeylanicum&lt;/em&gt; Blume) in different climatic conditions, maturity status and propagation types

This paper presents the variation of phytochemical quantities of leaves and bark of Cinnamomum zeylanicum Blume (Ceylon cinnamon) under different conditions such as ecological variation, maturity and physical state of the tree, and the propagation type. Among 49 climatic zones in Sri Lanka, six cinnamon growing zones including three wet zones (WL 1a, WL 2a, and WU 2b), two intermediate zones (IL 1a, IL 1b) and one dry zone (DL5) were selected for collecting cinnamon leaves and bark samples. The quantities of phytochemicals in leaves and bark extracts of Ceylon cinnamon according to the climatic difference, maturity stages (1-3, 3-5 and &gt;5 y) and physical stage (flowering, fruiting, flushing), and seed and vegetative propagates (Sri Gamunu and Sri Wijaya) were evaluated. The results showed that climatic zones of WL 1a and IL 1a were the best climatic zones for obtaining high quantities of phytochemical classes in seeding and vegetative propagation types, respectively. Besides, the best phytochemical composition was observed in the leaves with &gt;5 y and the bark of 3-5 y maturity of seed propagation varieties. Comparatively, bark from Sri Wijaya and leaves from Sri Gamunu which belonged to &gt;5 y maturity contained better phytochemical composition in vegetative propagated varieties. According to the physical variations, the best phytochemical composition was observed in the bark samples which were collected in the flowering season, and the leaves samples collected in the fruiting season. Therefore, leaves in &gt;5 y matured stage and bark in 3-5 y matured stage of seed propagation varieties of Ceylon cinnamon which are grown in WL 1a climatic zone are the best Cinnamon cultivar for the purpose of enhancing value chain and development cinnamon into different value adduct products.