Effect of Phytoestrogens in the Treatment of Polycystic Ovary Syndrome in Rat Model

Abstract

Polycystic Ovary Syndrome is one of the most commonly occurring endocrine diseases with 5 % to 10 % prevalence worldwide. Different types of drugs being used for the treatment of PCOS have some side effects. This study is aimed to investigate the effect of Cinnamon and Flaxseed extract alone and in combination in maintaining the gonadotropins to treat Polycystic Ovary Syndrome and to compare the effect of Cinnamon and Flaxseed extract with standard drug of PCOS (Clomiphene citrate). Estradiol Valerate was used to induce PCOS in rats. 30 female Albino rats were divided into six different groups; control group (received normal saline 0.2 mg), positive control group (0.4 mL of Estradiol Valerate), Clomiphene citrate treated group (20 mg Clomiphene), Cinnamon treated group (40 mg cinnamon extract), Flaxseed treated group (60 mg flaxseed extract) and Cinnamon plus Flaxseed treated group (40 mg cinnamon extract + 60 mg flaxseed extract). The serum concentration of Progesterone, Testosterone and Estrogen were evaluated while the serum level of FSH was reduced in PCOS induced groups as compared to control group but after the treatment statistically significant results were observed (p value0.05). Combined therapy treatment showed satisfactory results in restoring the normal hormonal serum levels and the histopathological results showed no cystic follicle in ovaries. Cinnamon plus flaxseed combined therapy treatment improved the serum level of hormones and the histology of ovary in PCOS induced rats.