The emergence of “cultural creative tourism” reflects the growing integration among tourism industry, culture industry and creative industry. With the booming development of the hotel industry in China, the hotel’s human resource management is also facing many challenges. There are some problems in the human resource management of mid-Sale hotel, including the lack of occupation career planning, no enough emphasis on employee training, imperfect compensation benefit and incentive mechanism, defective hotel performance management system, loose hotel labor relations management, and so on. Therefore, some countermeasures should be applied in hotel’s human resource management, such as correctly guiding employees to plan their career, paying attention to employee’s humanistic management, focusing on the advantages of resources and opening up more channels, establishing a sound and complete training incentive mechanism, scientific and effective hotel performance management, strengthening the construction of democratic management system in hotels, etc.