Singular Case Research Articles

Unveiling the uncommon nexus: kallmann syndrome and cardiomyopathy - a singular case study

Unveiling the uncommon nexus: kallmann syndrome and cardiomyopathy - a singular case study

Superacute onset of Guillain-Barré syndrome after elective spinal surgery: A case report and literature review.

Guillain-Barré syndrome (GBS) epitomizes an acute peripheral neuropathy hallmarked by an autoimmune retort directed at the myelin sheath enwrapping peripheral nerves. While it is widely acknowledged that a majority of GBS patients boast a history of antecedent infections, the documentation of postoperative GBS occurrences is progressively mounting. Drawing upon an exhaustive compendium of recent case reports, the disease's inception spans a gamut from within 1 hour to 1.2 years. At this juncture, we proffer a singular case: an instance involving a 51-year-old gentleman who underwent lumbar spine surgery, only to encounter immediate debilitation of limb and respiratory musculature. Post elimination of variables linked to anesthetic agents, encephalon, and spinal cord pathologies, a potent suspicion of superacute GBS onset emerged. Subsequent to immunoglobulin therapy, plasmapheresis, and adjunctive support, the patient's ultimate demise became manifest. No progress was found to date. Given GBS's potential to instigate paralysis, respiratory collapse, and autonomic nervous system aberrations, alongside other pernicious sequelae, coupled with the exceptional rarity of the temporal onset in this particular instance, it undeniably proffers an imposing conundrum for anesthetists in the realm of differential diagnosis and therapeutic conduct. During the postoperative convalescence phase under anesthesia, should the patient evince deviant limb musculature vigor and compromised respiratory sinews, the prospect of GBS must not be consigned to oblivion. Precision in diagnosis conjoined with apt therapeutic measures could well be the harbinger of a divergent denouement for the afflicted patient.

Narratives of Harm and the case for detention abolition

This essay aims to foreground the perspectives and lived experiences of asylum-seekers, refugees and other migrants in the growing calls to abolish immigration detention. While focused on a singular case study - the Tamil maritime arrivals to Canada in 2009 and 2010, our findings shed light on the broader harms of immigration detention. We begin by briefly describing the breadth and scope of immi-gration detention and the legal framework that governs detention in Canada. The heart of the essay follows with a sampling of the narratives drawn from the case study - all of which highlight the incalculable harms produced by the carceral state. The essay concludes by underscoring the imperative for detention abolition as both an aspirational and practical goal.

Small bowel obstruction in ruptured male pelvic dermoid with situs inversus totalis: a singular case presentation

BackgroundPelvic dermoid cysts are extremely rare in males, with an even rare occurrence of rupture. Only a handful of cases of male pelvic dermoid cysts have been published with no reported case of ruptured male pelvic dermoid causing small bowel obstruction to the best of our knowledge.Case presentationHerein we report a case of ruptured pelvic dermoid presenting with intestinal obstruction in an adult male patient with situs inversus totalis.ConclusionPelvic dermoid cyst should be considered even in males the presence of classical radiological signs. Knowledge of usual and unusual imaging signs as well as the associated life-threatening complications of a ruptured dermoid cyst can help in prompt diagnosis and timely patient management.

Research on Analysis and Optimization Strategies of Empresses in the Palace

This research delves into the intricacies of marketing strategies employed for the Chinese historical drama series “Empresses in the Palace." This study reveals vital insights through a comprehensive analysis of the existing marketing approaches and the unique challenges the historical drama genre poses. The “Empresses in the Palace” marketing strategies demonstrated innovation and creativity against intense competition within the historical drama landscape. Bridging the historical-contemporary gap and sustaining viewer engagement emerged as prominent challenges. This research has proposed various strategies tailored to address these challenges effectively. These strategies encompass diversified trailers, interactive engagement initiatives, and the integration of augmented reality experiences, aiming to optimize marketing endeavors. They seek to captivate contemporary audiences and maintain their interest throughout the series. The significance of the findings extends beyond this singular case, offering valuable lessons for historical drama marketing and its broader implications for the entertainment industry. This research recognizes the need for ongoing adaptation and innovation in engaging audiences with captivating historical narratives.

Unveiling the Diagnostic and Therapeutic Challenges: A Singular Case of Syphilitic Myelitis in an HIV-positive Patient (P9-13.004)

Unveiling the Diagnostic and Therapeutic Challenges: A Singular Case of Syphilitic Myelitis in an HIV-positive Patient (P9-13.004)

A Singular Case Study: Acupuncture Treatment with GB20, GB21, UB11, LI4, LI16 for Acute Pain Management in Cervical Spondylosis

A Singular Case Study: Acupuncture Treatment with GB20, GB21, UB11, LI4, LI16 for Acute Pain Management in Cervical Spondylosis

High Ecological Integration Within U.S. Art Teacher Education: A Collective Case Study

We live in a world of accelerating ecological devastation, where environmental violence is culturally and economically ingrained in dominant human societies. The term “Anthropocene” implies a threshold has been breached, and suggests radical reassessments of prevailing social, economic, political, and educational systems are needed. Some art teacher education programs in the United States deviate from predominant trends by embracing ecological integration and preparing art preservice teachers to implement ecological and environmental art pedagogies. Such “aberrant” programs offer rich sites to explore for methods that might be emulated beyond these singular cases. In this study, we examined how three U.S. art teacher education programs, identified as having high levels of ecological integration, infused ecological and environmental approaches into their course content and teaching methods. Themes included exposure to relational ways of being, entanglements with the land and community, collective productions of ecological integration, and infusion of art teacher educators’ multiple identities.

Obésité de type complexe : à la jonction entre obésité développementale et réactionnelle

ContextWhether medical or surgical, the management of obesity faces significant resistance to weight loss. In this context, Bruch's work (1973) on the concepts of developmental and reactive obesity is foundational for clinical practice. However, in the most severe cases of obesity, these concepts can be reductionist and can limit the complexity observed when caring for these patients. These questions are particularly present in hospital services that handle third-level care, especially in Specialized Obesity Centers. ObjectivesUsing a clinical vignette, we will illustrate the utility of the concept of complex obesity and emphasize the therapeutic challenges in the management of patients requiring third-level care, as defined by the Health Authority. MethodIn the context of research on obesity and trauma, we present a clinical vignette of a patient treated in a specialized obesity service. We rely on data collected during clinical research interviews. ResultsThis singular case highlights the challenge regularly faced by clinicians in differentiating developmental and reactive types of obesity. Indeed, listening to the life stories of patients with severe obesity often reveals a construction of this chronic disease through successive layers. Thus, including patients in a single typology would overlook fundamental aspects involved in the onset of their obesity. Faced with this difficulty, we suggest introducing the notion of complex obesity, which would precisely account for situations at the intersection between developmental and reactive obesity. The relevance of developing this third typology becomes clinically meaningful, allowing questioning of the proposed accompaniments, particularly for level 3 interventions. ConclusionThe use of this third typology is now necessary to consider issues of resistance to weight loss and to highlight the complexity of the psychogenic origin of this disease in interdisciplinary exchanges. These reflections also question the relevance of treatments that prioritize urgent weight loss. Thus, we emphasize the importance of focusing on individuals’ intrapsychic functioning of and on promoting long-term historical work. Finally, we propose several perspectives to address the challenges encountered in the transformations of hospital and healthcare institutions in France, and suggest research perspectives to demonstrate the long-term effectiveness of a comprehensive approach to individuals with obesity.

Clustering/Distribution Analysis and Preconditioned Krylov Solvers for the Approximated Helmholtz Equation and Fractional Laplacian in the Case of Complex-Valued, Unbounded Variable Coefficient Wave Number μ

We consider the Helmholtz equation and the fractional Laplacian in the case of the complex-valued unbounded variable coefficient wave number μ, approximated by finite differences. In a recent analysis, singular value clustering and eigenvalue clustering have been proposed for a τ preconditioning when the variable coefficient wave number μ is uniformly bounded. Here, we extend the analysis to the unbounded case by focusing on the case of a power singularity. Several numerical experiments concerning the spectral behavior and convergence of the related preconditioned GMRES are presented.

Degeneration phenomenon in linear ordinary differential equations

Abstract Given a linear constant coefficient ODE depending on a parameter, when this parameter approaches zero, the solution set converges to the solution set of the limit differential equation if the leading coefficient does not vanish. The situation is very subtle in the singular case, i.e., in the case when this coefficient becomes zero. The solution set then may even collapse completely. In this note, a formalism is developed in which the solution set of a linear constant coefficient ODE always depends continuously on the equation coefficients.

The efficacy of oral itraconazole in the treatment of otomycosis accompanied by a perforated tympanic membrane

: Managing otomycosis in patients with an existing tympanic membrane perforation can pose challenges. However, this study underscores the efficacy of oral itraconazole as a viable treatment option for such instances.The research encompassed 34 individuals experiencing both otomycosis and a perforated tympanic membrane. These participants received a combination of oral itraconazole and antibiotic ear drops as treatment. Over a period of six weeks, their progress was monitored to assess the treatment's effectiveness and to observe any potential instances of recurrence.Out of the total 34 subjects examined in the study, 25 individuals achieved complete recovery after just one week of oral itraconazole treatment. Among the remaining 9 patients, 6 experienced a successful resolution of the condition following two weeks of therapy. For 3 patients, an extended treatment duration was required, and in a singular case, a recurrence of the condition was observed at the six-week mark.Oral itraconazole treatment presents as an efficacious substitute for conventional approaches in addressing otomycosis accompanied by tympanic membrane perforation.

The sharp Hardy–Moser–Trudinger inequality in dimension 𝑛

Wang and Ye [Adv. Math. 230 (2012), pp. 294–320] prove a Hardy–Moser–Trudinger inequality in dimension two which improves both the classical Moser–Trudinger inequality and the classical Hardy inequality in the unit disc. In this paper, we generalize their result both to the higher dimensional unit ball and to the singular weighted cases as well. More precisely, we prove that \[ sup u ∈ W 0 1 , n ( B n ) , ∫ B n | ∇ u | n d x − ( 2 ( n − 1 ) n ) n ∫ B n | u | n ( 1 − | x | 2 ) n d x ≤ 1 ∫ B n e ( 1 − β n ) α n | u | n n − 1 | x | − β d x ≤ C \sup _{\substack {u\in W^{1,n}_0(\mathbb {B}^n),\\ \int _{\mathbb {B}^n} |\nabla u|^n dx -\left (\frac {2(n-1)}n\right )^n \int _{\mathbb {B}^n} \frac {|u|^n}{(1-|x|^2)^n} dx \leq 1}}\int _{\mathbb {B}^n} e^{(1-\frac \beta n)\alpha _n |u|^{\frac n{n-1}}} |x|^{-\beta } dx \leq C \] for any β ∈ [ 0 , n ) \beta \in [0,n) , n ≥ 3 n\geq 3 where α n = n ω n − 1 1 n − 1 \alpha _n = n \omega _{n-1}^{\frac 1{n-1}} and ω n − 1 \omega _{n-1} is the surface area of the n − 1 n-1 dimensional unit sphere. The proof of Wang and Ye is based on the blow-up analysis method which seems not work in the higher dimensions. In this paper, we propose a new approach based on the method of transplantation of Green’s functions to prove our inequality. As a consequence, we obtain a singular Moser–Trudinger inequality in the hyperbolic spaces which confirms affirmatively a conjecture by Mancini, Sandeep and Tintarev [Adv. Nonlinear Anal., 2 (2013), pp. 309–324].

Euclidean and circum-Euclidean distance matrices: characterizations and interlacing property

Motivated by the inverse formula of the distance matrix of a tree and the Moore–Penrose inverse of a circum-Euclidean distance matrix (CEDM), in this paper, we study a general real square matrix M whose Moore–Penrose inverse can be expressed as the sum of a Laplacian-like matrix L and a rank one matrix. In particular, for a symmetric hollow matrix M, under an assumption, we show that M is a Euclidean distance matrix if and only if L is positive semidefinite. Based on this, we obtain a new characterization for CEDMs involving their Moore–Penrose inverses. As an application, we show that the distance matrices of block graphs and odd-cycle-clique graphs are CEDMs. Finally, we establish an interlacing property between the eigenvalues of a Euclidean distance matrix M (including the singular case) and its associated Laplacian-like matrix L, which generalizes the interlacing property proved for the distance matrices of trees.

High-Throughput Prediction of the Thermal and Electronic Transport Properties of Large Physical and Chemical Spaces Accelerated by Machine Learning: Charting the ZT of Binary Skutterudites.

Thermal and electronic transport properties are the keys to many technological applications of materials. Thermoelectric, TE, materials can be considered a singular case in which not only one but three different transport properties are combined to describe their performance through their TE figure of merit, ZT. Despite the availability of high-throughput experimental techniques, synthesizing, characterizing, and measuring the properties of samples with numerous variables affecting ZT are not a cost- or time-efficient approach to lead this strategy. The significance of computational materials science in discovering new TE materials has been running in parallel to the development of new frameworks and methodologies to compute the electron and thermal transport properties linked to ZT. Nevertheless, the trade-off between computational cost and accuracy has hindered the reliable prediction of TE performance for large chemical spaces. In this work, we present for the first time the combination of new ab initio methodologies to predict transport properties with machine learning and a high-throughput framework to establish a solid foundation for the accurate prediction of thermal and electron transport properties. This strategy is applied to a whole family of materials, binary skutterudites, which are well-known as good TE candidates. Following this methodology, it is possible not only to connect ZT with the experimental synthetic (carrier concentration and grain size) and operando (temperature) variables but also to understand the physical and chemical phenomena that act as driving forces in the maximization of ZT for p-type and n-type binary skutterudites.

Hölder estimate for a tug-of-war game with $1\lt p\lt 2$ from Krylov–Safonov regularity theory

We propose a new version of the tug-of-war game and a corresponding dynamic programming principle related to the p -Laplacian with 1\lt p\lt 2 . For this version, the asymptotic Hölder continuity of solutions can be directly derived from recent Krylov–Safonov type regularity results in the singular case. Moreover, existence of a measurable solution can be obtained without using boundary corrections. We also establish a comparison principle.

“Everything came out of my vagina!”: Venezuelan migration and sex work in a singular case

Resumen: El objetivo de este artículo es analizar el caso particular de una trabajadora sexual migrante venezolana. Para ello, en primer lugar, se aborda el fenómeno de la feminización de las migraciones y, al interior de este fenómeno, el funcionamiento del mercado sexual transnacional. En segundo lugar, siguiendo el hilo de una entrevista semiestructurada en profundidad y varias interacciones posteriores, bajo la estructura del diálogo, se abordan algunas de las principales características de la migración venezolana, así como las lógicas del mercado sexual y el funcionamiento de las redes de trata y sujeción con base en la deuda y el cuidado. La investigación se sustenta metodológicamente en la perspectiva de la sociología de las migraciones, al considerar la unidad biográfica del migrante en un campo social transnacional en los que se articulan estructuras, agencias, poderes y resistencias.

The blow-up method applied to monodromic singularities

The blow-up method proves its effectiveness to characterize the integrability of the resonant saddles giving the necessary conditions to have formal integrability and the sufficiency doing the resolution of the associated recurrence differential equation using induction. In this work we apply the blow-up method to monodromic singularities in order to solve the center-focus problem. The case of nondegenerate monodromic singularities is straightforward since any real nondegenerate monodromy singularity can be embedded into a complex system with a resonant saddle. Here we apply the method to nilpotent and degenerate monodromic singularities solving the center problem when the center conditions are algebraic.

Diastereoselective access to C,C-glycosyl amino acids via iron-catalyzed, auxiliary-enabled MHAT coupling.

Access to C,C-glycosyl amino acids as a novel class of glycomimetics is reported by means of radical generation, intermolecular addition and stereoselective reduction via a metal-induced hydrogen atom transfer (MHAT) sequence. The 'matched' coupling of exo-D-glycals with an enantiopure dehydroalanine bearing a (R)-configured benzyl oxazolidinone enables a singular case of two-fold diastereocontrol under iron catalysis. In the common exo-D-glucal series, the nature of the C-2 substituent was found to play a key role from both reactivity and stereocontrol aspects.

Impact of Green Intellectual Capital on Sustainable Development Goals: Insights From Spain’s Wine Industry

This study seeks to explore the multifaceted impacts of the Green Intellectual Capital (GIC) within viticulture enterprises on the realization of the Sustainable Development Goals (SDGs). This endeavor holds significant academic value, as, to the best of our understanding, no prior investigations have delved into this specific correlation. The impetus for this inquiry is rooted in two foundational beliefs: firstly, that an enhanced GIC equips firms with the tools to more effectively navigate environmental hurdles; and secondly, that GIC serves as a transformative agent within entities, fostering enriched knowledge acquisition. To methodically address the stipulated aim, a qualitative methodology was employed, underpinned by a singular case study. The findings underscore the instrumental role of the three facets of GIC—Green Human Capital, Green Structural Capital, and Green Relational Capital—in facilitating the attainment of SDGs 3, 5, 6, 7, 8, 9, 11, 12, 13, 15, and 17.