The efficacy of oral itraconazole in the treatment of otomycosis accompanied by a perforated tympanic membrane

Abstract

: Managing otomycosis in patients with an existing tympanic membrane perforation can pose challenges. However, this study underscores the efficacy of oral itraconazole as a viable treatment option for such instances.The research encompassed 34 individuals experiencing both otomycosis and a perforated tympanic membrane. These participants received a combination of oral itraconazole and antibiotic ear drops as treatment. Over a period of six weeks, their progress was monitored to assess the treatment's effectiveness and to observe any potential instances of recurrence.Out of the total 34 subjects examined in the study, 25 individuals achieved complete recovery after just one week of oral itraconazole treatment. Among the remaining 9 patients, 6 experienced a successful resolution of the condition following two weeks of therapy. For 3 patients, an extended treatment duration was required, and in a singular case, a recurrence of the condition was observed at the six-week mark.Oral itraconazole treatment presents as an efficacious substitute for conventional approaches in addressing otomycosis accompanied by tympanic membrane perforation.