Effective entrepreneurship education can not only cultivate students’ entrepreneurship awareness and inspire entrepreneurial potential, but also set up an entrepreneurial foundation and form entrepreneurial practice, but the current teaching system doesn’t have strong timeliness, due to the high interest of students and lack of rich teaching methods and means by college teachers. Taking “online + offline” entrepreneurship education courses as an example, an “online + offline” teaching mode based on case teaching method was developed in this paper. Based on curriculum theory, the author identified the attractive quality and must-be quality of this course by fully understanding students’ needs in the learning process of “online + offline” courses, and designed a questionnaire on the needs for the learning support services of “online + offline” course products, to understand the satisfaction degree of students corresponding to each need. At the same time, combined with the characteristics of the “online + offline” courses, by reference to the evaluation criteria of DEMATEL-ANP, course mentoring, communication, final exam, subtitles and video effect were taken as key indicators, to build an evaluation system to be used in this mode. Finally, the teaching practice proves that this mode can better increase students’ learning interest, expand the teaching content of entrepreneurship education course and improve students’ satisfaction with this course.