In DC distribution networks, the uncertainties of renewable energies and loads cause frequent voltage fluctuations. In this paper, a voltage regulation strategy based on the combined coordination of centralized optimal control (COC) and adaptive droop control (ADC) is proposed for droop-controlled DC distribution networks. In the COC strategy, the operation reference power of voltage source converters (VSCs) is optimized using the bus injection power measurements to improve the voltage profile and balance the power loading rates of different VSCs. The VSC capacity margin constraint is established to ensure that the capacity margin of each VSC is sufficient to cope with the unexpected fluctuation of loads and renewable energies. Then, an ADC strategy is adopted to handle voltage fluctuation between adjacent two COCs. In the ADC strategy, the operation reference power of the VSCs is further adjusted to recover the voltages. The voltage regulation is achieved based on the relationship among the VSC voltages and the minimum/maximum voltages of the whole network, which does not depend on the information of each nodal voltage and thus real-time network communication is avoided. The simulation results show that the proposed voltage regulation strategies can effectively improve the voltage profile under various uncertain environments.