Accurate pressure measurement is crucial for understanding ocean dynamics in marine research. However, pressure sensors based on strain measurement principles are significantly affected by temperature variations, impacting the accuracy of depth measurements. This study investigates the SBE37-SM sensor and presents an improved calibration method based on a constant-pressure, variable-temperature scheme that effectively addresses temperature-induced deviations in pressure measurement. Experiments were conducted across a pressure range of 2000 dbar to 6000 dbar and a temperature range of 2 °C to 35 °C, establishing a comprehensive pressure–temperature calibration grid. The results show that, at a pressure of 6000 dbar, temperature-induced variations in readings for brand new SBE37-SM sensors can reach up to 9 dbar, while, for used sensors, they exceed 12 dbar, following a U-shaped trend. After applying a polynomial regression model for calibration, these variations were reduced to within ±0.5 dbar, significantly reducing the measurement uncertainty of the sensors in complex marine environments. This method underscores the necessity of further optimizing the CTD system’s temperature compensation mechanism during calibration and highlights the importance of regular calibration to minimize measurement uncertainty.
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