The work accident of road and bridge construction projects in Indonesia is quite severe. Every year there is always news about work accidents in the project. While the construction of roads and bridges, especially in Eastern Indonesia, continues to be carried out actively by the government. This research purpose of analyzing the causes of work accidents and their impact on the project. Data were collected at the research location, institutions related to the construction of projects, totaling 40 respondents. Based on the results of the analysis with a multiple linear regression method, it appears that 31 variables causing occupational accidents and 13 impact variables arising from accidents still occur and are very influential with high probability values. Four recommendations were made to prevent fatal accidents in the construction of roads and bridges, in Eastern Indonesia, to improve safety conditions in the construction industry.