Multipliers are widely used in various fields of engineering, and they are considered to have complex designs. The efficient design of multipliers to meet various design requirements is still an active area of research. In this paper, a thermo-inspired metaheuristic called population-based simulated annealing algorithm, for the design of multipliers using four different resource types, is proposed. Metaheuristics suffers from the problem of scalability and non-convergence as the size and complexity of the circuit increase. Four types of partitioning approaches- output, input, input-output and hybrid-output partitioning are proposed to overcome the same. Proposed partitioning approaches have increased the success rate and reduced the time to realize the circuit. The multipliers designed are synthesized on Cadence Genus with 90 nm technology and compared with traditional designs such as Array, Wallace tree, Dadda and Booth multipliers to conclude that metaheuristics are capable of generating near-optimal solutions in terms of power, area and delay.