Mutations in the voltage-gated sodium channel Nav1.7 are linked to human pain. The Nav1.7/N1245S variant was described before in several patients suffering from primary erythromelalgia and/or olfactory hypersensitivity. We have identified this varian... Read More
Biophysical Research Articles
Overview
2274 Articles
Published in last 50 years
Articles published on Biophysical
Journals
Select journals
Duration
Select duration
2364 Search results
Recency
Assessing the impact of pain-linked Nav1.7 variants: An example of two variants with no biophysical effect.
- Channels (Austin, Tex.)
- VOL. 15
on Dec 1, 2021
Immunomagnetic separation is a suitable method for electrophysiology and ion channel pharmacology studies on T cells.
- Channels (Austin, Tex.)
- VOL. 15
on Dec 1, 2021
Ion channels play pivotal role in the physiological and pathological function of immune cells. As immune cells represent a functionally diverse population, subtype-specific functional studies, such as single-cell electrophysiology require proper subs... Read More
The biophysics of bacterial infections: Adhesion events in the light of force spectroscopy.
- Cell surface (Amsterdam, Netherlands)
- VOL. 7
on Dec 1, 2021
Bacterial infections are the most eminent public health challenge of the 21st century. The primary step leading to infection is bacterial adhesion to the surface of host cells or medical devices, which is mediated by a multitude of molecular interact... Read More
Acid-Sensing Ion Channel 3: An Analgesic Target.
- Channels (Austin, Tex.)
on Dec 1, 2021
Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin (ENaC/DEG) superfamily. It consists of one of 7 different ASIC subunits encoded by 5 different genes. Most ASIC subunits form trimeric ion channels that upon activa... Read More
Acid-sensing ion channel 3: An analgesic target.
- Channels (Austin, Tex.)
- VOL. 15
on Dec 1, 2021
Acid-sensing ion channel 3 (ASIC3) belongs to the epithelial sodium channel/degenerin (ENaC/DEG) superfamily. There are 7 different ASIC subunits encoded by 5 different genes. Most ASIC subunits form trimeric ion channels that upon activation by extr... Read More
Design and Analysis of Mechanical Microswimmers
- Journal of Bioscience & Biomedical Engineering
on Nov 4, 2021
The fascinating field in present civilization scenario at the edge of science is micro-swimmers, which is a combination of bio physics with self-propulsion mechanisms involving swimming strategies at low Reynolds number. These micro swimming robots o... Read More
A multiscale continuum model of the vertebrate outer retina: The temporal dynamics of background-induced flicker enhancement.
- Journal of Theoretical Biology
- VOL. 525
on Sep 21, 2021
The retina is a part of the central nervous system that is accessible, well documented, and studied by researchers spanning the clinical, experimental, and theoretical sciences. Here, we mathematically model the subcircuits of the outer plexiform lay... Read More
Inhibition of microtubule assembly and cytotoxic effect of graphene oxide on human colorectal carcinoma cell HCT116.
- Archives of Biochemistry and Biophysics
- VOL. 708
on Sep 15, 2021
Nanomaterials, such as graphene oxide (GO), are increasingly being investigated for their suitability in biomedical applications. Tubulin is the key molecule for the formation of microtubules crucial for cellular function and proliferation, and as su... Read More
Therapeutic lithium alters polar head-group region of lipid bilayer and prevents lipid peroxidation in forebrain cortex of sleep-deprived rats.
- Biochimica et biophysica acta. Molecular and cell biology of lipids
- VOL. 1866
on Sep 1, 2021
Lithium is regarded as a unique therapeutic agent for the management of bipolar disorder (BD). In efforts to explain the favourable effects of lithium in BD, a wide range of mechanisms was suggested. Among those, the effect of clinically relevant con... Read More
Identification of new lead molecules against anticancer drug target TFIIH subunit P8 using biophysical and molecular docking studies
- Bioorganic Chemistry
on Sep 1, 2021
The long chain base unsaturation has a stronger impact on 1-deoxy(methyl)-sphingolipids biophysical properties than the structure of its C1 functional group.
- Biochimica et Biophysica Acta
- VOL. 1863
on Aug 1, 2021
Abstract 1-deoxy-sphingolipids, also known as atypical sphingolipids, are directly implicated in the development and progression of hereditary sensory and autonomic neuropathy type 1 and diabetes type 2. The mechanisms underlying their patho-physiolo... Read More
Carotenogenesis of Staphylococcus aureus: New insights and impact on membrane biophysical properties.
- Biochimica et biophysica acta. Molecular and cell biology of lipids
- VOL. 1866
on Aug 1, 2021
Staphyloxanthin (STX) is a saccharolipid derived from a carotenoid in Staphylococcus aureus involved in oxidative-stress tolerance and antimicrobial peptide resistance. STX influences the biophysical properties of the bacterial membrane and has been ... Read More
Biophysical impact of sphingosine and other abnormal lipid accumulation in Niemann-Pick disease type C cell models.
- Biochimica et biophysica acta. Molecular and cell biology of lipids
- VOL. 1866
on Aug 1, 2021
Niemann-Pick disease type C (NPC) is a complex and rare pathology, which is mainly associated to mutations in the NPC1 gene. This disease is phenotypically characterized by the abnormal accumulation of multiple lipid species in the acidic compartment... Read More
Does membrane curvature elastic energy play a role in mediating oxidative stress in lipid membranes?
- Free radical biology & medicine
- VOL. 171
on Aug 1, 2021
The effects of oxidative stress on cells are associated with a wide range of pathologies. Oxidative stress is predominantly initiated by the action of reactive oxygen species and/or lipoxygenases on polyunsaturated fatty acid containing lipids. The d... Read More
The renaissance in biophysics and molecular biology enabled by the interface of DNA repair and replication with cancer
- Progress in Biophysics and Molecular Biology
on Aug 1, 2021
QModeL: A plug-and-play model-based reconstruction for highly accelerated multi-shot diffusion MRI using learned priors.
- Magnetic Resonance in Medicine
- VOL. 86
on Aug 1, 2021
To introduce a joint reconstruction method for highly undersampled multi-shot diffusion weighted (msDW) scans. Multi-shot EPI methods enable higher spatial resolution for diffusion MRI, but at the expense of long scan-time. Highly accelerated msDW sc... Read More
Inhaled aerosols: Their role in COVID-19 transmission, including biophysical interactions in the lungs
- Current Opinion in Colloid & Interface Science
on Aug 1, 2021
Chromatin-mediated epigenetic regulation of HSV-1 transcription as a potential target in antiviral therapy.
- Antiviral research
- VOL. 192
on Aug 1, 2021
The ability to establish, and reactivate from, latent infections is central to the biology and pathogenesis of HSV-1. It also poses a strong challenge to antiviral therapy, as latent HSV-1 genomes do not replicate or express any protein to be targete... Read More
Understating complex interactions in socio-ecological systems using system dynamics: A case in the tropical Andes.
- Journal of Environmental Management
- VOL. 291
on Aug 1, 2021
The high dependence of human communities on ecosystems' well-functioning has transformed and degraded ecosystems at alarming rates. Strategies for sustainability are an urgent need and requires the understanding of the complex interactions between hu... Read More
Low doses of zeolitic imidazolate framework-8 nanoparticles alter the actin organization and contractility of vascular smooth muscle cells.
- Journal of hazardous materials
- VOL. 414
on Jul 15, 2021
Zeolitic imidazolate framework-8 (ZIF-8) nanoparticles have emerged as a promising platform for drug delivery and controlled release. Considering most ZIF-8 nanoparticle drug carriers are designed to be administered intravenously, and thus would dire... Read More