Biochemical Parameters In Patients Research Articles

The mechanism of blood coagulation in COVID-19 pathogenesis

One of the formidable complications of SARS-COV-2 infection leading to death is coagulopathy. The mechanisms of the development of this pathology at the present stage have not been studied, and clinical blood tests indicate that against the background of normal blood clotting indices, only the Ddi-D-dimer protein exceeds the norm many times over. The aim of the study was to study and analyze biochemical parameters in patients of Primorsky Region (Russia) infected with SARS-COV-2 against the background of concomitant vascular pathology and the development of DIC syndrome. The authors came to the conclusion about the existence of two mechanisms of circulatory disorders in the vessels of the microvasculature, associated with the violation of the integrity of the vascular wall and destruction of erythrocytes. Further research is needed to study the mechanisms of SARS-CoV-2 aggression, leading to thrombotic complications.

Haemoadsorption by CytoSorb® in patients with acute liver failure: A case series.

Acute liver failure (ALF) is a life-threatening disease associated with multi-organ failure and increased mortality. Severe inflammation is now considered the main pathophysiological mechanism for organ dysfunction, thus rebalancing pro- and anti- inflammatory cytokines may improve liver function and outcome. The aim of this study was to assess the clinical effects of a haemoadsorption column on biochemical parameters in patients with ALF. We prospectively included 28 patients with ALF who were treated with three consecutive sessions of continuous venovenous haemofiltration in combination with CytoSorb®. Our results show an improvement in liver functional tests and a decrease in Creactive protein. Thrombocytopenia remains one of the most important side effects of this treatment and careful consideration should be made before initiation of treatment.

Study of prevalence of metabolic syndrome in obese children in Konaseema region of India

Background: The rising prevalence of overweight and obesity is associated with development of growing number of early complications in children and adolescents among that type 2 diabetes mellitus and metabolic syndrome (MS) is common. Present study has been designed to identify the prevalence of MS in children with overweight risk, overweight or obesity and to compare anthropometric and biochemical parameters in patients with metabolic syndrome and without MS.Methods: This is a cross sectional descriptive study conducted in the department of paediatrics where 120 patients with obesity were enrolled for this study and various metabolic parameters were compared.Results: In our study the prevalence of metabolic syndrome was 30% among obese and overweight children. Fasting insulin (18.65±13.64 mg/dl versus 16.48±10.32 mg/dl) was significantly higher in patients with MS than without MS (p is less than 0.05). Homeostatic model assessment of insulin resistance (HOMA-IR) was 5.84±1.43 in MS group and 4.54±1.34 in without MS group. The p value was 0.00. The glycocylated haemoglobin was significantly higher in MS group than without MS group (5.84±0.78 versus 4.54±0.34).Conclusions: From our study we can conclude that metabolic syndrome is a common problem in children with overweight and obesity in our region. Insulin resistance and metabolic abnormality were more common in children with MS.

Кореляційні зв’язки між цитокіновими показниками імунного запалення, ендотеліальним фактором росту та біохімічними параметрами у пацієнтів з подагрою

The correlations between cytokine status, vascular endothelial growth factor (VEGF) content, clinical and biochemical parameters in patients with various forms of gout were studied to improve the algorithm for monitoring of clinical condition and effectiveness of treatment. For patients with gout and volunteers clinical and biochemical studies were performed. The content of interleukins (IL-1β, IL-17, IL-22, IL-10), tumor necrosis factor alpha (TNF-α) and VEGF were investigated. Concentrations of TNF-α, IL-1β and IL-17 characterized of inflammation intensity at all stages of gout and increased linearly as the disease progressed. At the stage of asymptomatic hyperuricemia, there were an increased (75% of the control group) concentration of IL-22 on the background of lymphopenia, low concentrations of IL-10 and VEGF. This indicates that the content of IL-22 is a potentially informative biomarker of inflammation intensity as well as a possible predictor of the development of immune-dependent complications and vascular catastrophes in the early stages of gout without signs of joint damage. The concentration of TNF-α positively correlates with the content of IL-10 (r = 0.534); whereas the concentration of IL-1β is independent of the content of IL-10. The relationship between IL-1β and VEGF concentrations (r = 0.40) suggests that IL-1β is more closely associated with endothelial dysfunction and the risk of vascular complications. IL-22 levels do not correlate with other cytokine status, but are associated with lymphocyte counts, so signs of Th22-dependent immune inflammation may be a potential biomarker of lymphocytic depression status in gout. Cytokine status changes in different phases and stages of hyperuricemia. Comparing these changes with the clinical and laboratory picture improves monitoring of the disease development and effectiveness of treatment.

The Relationship between Prebiotic Supplementation and Anthropometric and Biochemical Parameters in Patients with NAFLD-A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

We aim to systematically review the efficacy of prebiotics in reducing anthropometric and biochemical parameters in individuals with non-alcoholic fatty liver disease (NAFLD). A systematic search using PubMed/MEDLINE, Embase, clinicaltrials.gov, Cinahl, and Web of Science of articles published up to 20 March 2020 was performed for randomized controlled trials enrolling >20 adult patients. Random-effect meta-analysis for metabolic outcomes in NAFLD patients was performed for anthropometric data in addition to liver enzyme, carbohydrate, and lipid parameters. We found six trials (comprising a total of 242 patients) with NAFLD, with subjects aged 38–52 years. The mean time of fiber administration varied between 10 and 12 weeks. The main fiber types were psyllium (seeds or powder), Ocimum basilicum (seeds), and high-performance inulin and oligofructose powder at doses of either 10 or 16 g per day. The control group received either maltodextrin (powder or capsules) or crushed wheat (powder). Patients on the diet with added fiber had improvements in body mass index (BMI) (standardized mean difference (SMD) = −0.494, 95% confidence interval (CI): −0.864 to −0.125, p = 0.009); alanine aminotransferase (ALT) (SMD = −0.667, 95% CI: −1.046 to −0.288, p = 0.001); aspartate aminotransferase (AST) (SMD = −0.466, 95% CI: −0.840 to −0.091, p = 0.015); fasting insulin (SMD = −0.705, 95% CI: −1.115 to −0.295, p = 0.001); and homeostasis model assessment for insulin resistance (HOMA-IR) (SMD = −0.619, 95% CI: −1.026 to −0.211, p = 0.003). Hence, the results show that fiber supplements result in favorable changes as reflected in the measurement of anthropometric, metabolic, and liver-related biomarkers, i.e., body mass index (BMI), homeostasis model assessment for insulin resistance (HOMA-IR), insulin, alanine aminotransferase (ALT), and aspartate aminotransferase (AST). These effects suggest the potential benefits of fiber consumption for NAFLD populations. More prospective, controlled studies should be conducted to reveal specific details regarding the fiber type, dosage, and duration for optimal intervention.

Clinical and Biochemical Parameters of Patients with Oral Galvanosis

Clinical and Biochemical Parameters of Patients with Oral Galvanosis

The Effect of Serum Electrolyte Disturbances and Uric Acid Level on the Mortality of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

The aim of the study was to determine the prevalence of electrolyte and uric acid disturbances and their effects on mortality in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). This study included all consecutive AECOPD patients who were managed at our Chest Diseases department between May 2017 and December 2017. Medical records of all the subjects were reviewed, and data were collected retrospectively. Eighty-one patients with AECOPD and 103 subjects in the control group were enrolled retrospectively. The association between the COPD and control groups and biochemical parameters in patients with and without long-term oxygen therapy and noninvasive mechanical ventilation treatment in COPD patients were compared with mortality. Serum magnesium, phosphorus, potassium, sodium, and calcium (Ca levels were higher in control subjects than in COPD patients (p=0.006, p=0.015, and p<0.001, respectively). While serum levels of Ca and K were significantly lower and serum level of uric acid was higher in deceased COPD patients than in alive AECOPD patients (p=0.023, p=0.001, and p=0.033, respectively), serum levels of Mg, P, and other biochemical parameters were similar. Serum Ca, K, and uric acid levels during the exacerbation period were significant predictors of mortality in COPD patients. In conclusion, the levels of these parameters should be measured and corrected during AECOPD treatment to decrease mortality.

Urtica Dioica Root Extract on Clinical and Biochemical Parameters in Patients with Benign Prostatic Hyperplasia, Randomized Controlled Trial.

Benign Prostatic Hyperplasia (BPH) is a common urological disorder as men get older. BPH can cause uncomfortable urinary tract symptoms. Given the high incidence of the disease, further research is an undeniable necessity for its better management. In this research, the efficacy of Urtica Dioica root extract (UDE) on clinical and biochemical parameters were evaluated in this type of patients. Participants were 60 men with BPH that randomly allocated to two equal groups (Intervention = 30 and Comparison = 30). Block balanced Randomization method was performed using a computer by a trained nurse. Intervention and comparison groups received 450 mg day-1 UDE and placebo as tablets for 12 weeks, respectively. The main outcome was changes in International Prostate Symptoms Score (IPSS) from baseline to end of treatment. Data were collected by completing a standard questionnaire and performing relevant tests based on common laboratory methods. UDE had an intermediate effect on IPSS, a small effect on serum high-sensitivity C-reactive protein (hs-CRP), intermediate to large effect on malondialdehyde (MDA) levels and intermediate effect on superoxide dismutase (SOD) activity. The magnitude of the effects of UDE on other parameters was overall negligible compared to the comparison and not significant. No side effects were seen in these patients following tablet usage. UDE consumption for 12 weeks among BPH patients had clinically significant effects on IPSS, serum hs-CRP, MDA and SOD activity.

Anthropometric, Biochemical, and Food Consumption Parameters are Associated with Venous Leg Ulcer Area and Duration.

To describe the dietary habits and anthropometric and biochemical parameters of patients with active venous leg ulcers and to verify the association of these variables with wound duration and area. A cross-sectional study conducted with 33 participants diagnosed with venous leg ulcers in outpatient care. Socioeconomic data, anthropometric parameters, biochemical parameters, food consumption, and wound characteristics were analyzed by an interprofessional team. Participants were an average of 58 ± 13 years, 57.6% women, 84.8% overweight, and had a median wound duration of 10 months (range, 1-192 months) and an average wound area of 5 cm (range, 0.22-61.1 cm). Diets were typically hypocaloric and hypoproteic, with a low amount of vitamin A and magnesium. Wound duration was negatively associated with polyunsaturated fat intake (P = .032), whereas wound area was significantly associated with lipid intake (P = .002) and C-reactive protein (P = .040). Patients with active venous leg ulcers were overweight (leading to systemic inflammation) and had low consumption of calories, protein, and micronutrients that could support cicatrization. Wound area was associated with a high-fat diet, whereas wound duration was negatively associated with polyunsaturated fat intake.

The diagnostic and prognostic utility of insulin growth factor of squamous cell carcinoma in oral cavity.

Objective:The present study was conducted to find the utility of insulin growth factors (IGFs) as diagnostic and prognostic biochemical parameters in patients suffering from squamous cell carcinoma of oral cavity.Materials and Methods:A total of 360 male and female patients diagnosed with precancerous conditions (PCC) and oral squamous cell carcinoma (OSCC) of Stage I to IV were selected for the present study. Patients were interviewed using a structured questionnaire to ascertain their demographic and medical history. After completing the history and physical examination, patients were subjected to routine blood investigations along with determining insulin growth factor (IGF-1, IGFBP-3) levels. The data obtained were then subjected to statistical analysis using SPSS 20.0 version.Results:The mean values of IGF-1, insulin-like growth factor-binding protein-3 (IGFBP-3), and ratio of IGF-1 and IGFBP-3 were obtained. The intergroup comparison was done between PCC and all the stages of OSCC for all the IGFs. The result obtained was found to be statistically significant (P < 0.05).Conclusion:The present study concluded that a positive correlation was observed for various insulin growth factors (IGF-1, IGFBP-3; and ratio of IGF-1 and IGFBP-3) between OSCC and PCC such as erythroplakia and oral submucous fibrosis. Thus, the study highlighted the use of IGFs as diagnostic and prognostic parameters in patients suffering from cancerous conditions.

Successful quantification of symptom load by a disease-specific questionnaire HPQ 40/28 and analysis of influencing biochemical parameters in patients with postsurgical hypoparathyroidism

Successful quantification of symptom load by a disease-specific questionnaire HPQ 40/28 and analysis of influencing biochemical parameters in patients with postsurgical hypoparathyroidism

A Comparative Assessment of Metabolic Syndrome and its Association with Vitamin D and Other Risk Factors in Type 2 Diabetes Mellitus Patients.

To determine the overall prevalence of metabolic syndrome using the World Health Organization (WHO); National Cholesterol Education Program (NCEP), and the International Diabetes Federation (IDF) guidelines and to study its association with vitamin D and other biochemical parameters in patients with type 2 Diabetes mellitus, as well as to identify the set of biochemical parameters that jointly influence the metabolic syndrome using different diagnostic criteria. A cross-sectional study was carried out at a private health care center in -a total of 291 diabetic patients. Socio-demographic, clinical, and laboratory data were obtained from the medical records of patients. Statistical analysis was carried out using the Statistical Package for the Social Sciences (SPSS, version 23). A total number of 291 patients with T2DM were included in this study. The overall prevalence of metabolic syndrome among the study subjects was 48.1%, 87.3%, 64.9% using the WHO, IDF, and NCEP-ATPIII criteria, respectively. The highest prevalence was reported following IDF diagnostic criteria. Sex, triglyceride, and fasting blood sugar were associated factors of metabolic syndrome by all the three diagnostic criteria of metabolic syndrome. The study revealed a high prevalence rate of metabolic syndrome among type 2 diabetic patients, which was highest at 87.3% according to IDF and lowest was observed according to the WHO criteria i.e, 48.1%. A significant variance in the prevalence of metabolic syndrome was reported between WHO, IDF, and NCEP criteria.

Blood Biochemical Parameters In Yakut Women With Type 2 Diabetes Mellitus Versus Their Somatotypes

Objective — Investigating the features of blood biochemical parameters in patients with type 2 diabetes mellitus (DM2), depending on the somatotype sensu the Rees-Eysenck body index. Material and methods — We examined 88 women of Yakut nationality (39-74 years old) with an established diagnosis of DM2. An anthropometric examination with consequent somatotyping according to the Rees-Eysenck body index, along with determination of BMI were carried out. The biochemical blood test results were copied from the anamneses of female subjects. Statistical analysis was performed using the SPSS Statistics software package for Windows (version 17). Methods of parametric and nonparametric statistics were used. Results — We established that the anthropometric parameters and BMI of women with DM2 were significantly higher. According to the BMI gradation, obesity was more common in people with DM2. The results of somatotyping implied that 11.4%, 50.0% and 38.6%of the examined women belonged to the asthenic, normosthenic and pyknic somatotypes, correspondingly. The distribution of somatotypes among women with DM2 differed from the general population distribution in a smaller fraction of individuals with asthenic somatotype. Blood biochemical parameters in subjects with asthenic body type were within the reference limits (except for glucose), in contrast to those of women with other somatotypes. Conclusion — Women with asthenic somatotype are less at risk of developing DM2. Even if the ailment develops, their blood biochemical parameters remain within reference limits, with the exception of glucose.

Indicators of oxidative stress, inflammation, and endothelial dysfunction in patients with coronary atherosclerosis while taking statins

The aim of the study was to study the changes in clinical and biochemical parameters in patients with different severity of coronary atherosclerosis, depending on the administration of lipid‑lowering therapy. The study included 354 patients with coronary heart disease. All patients underwent coronary angiography with the calculation of the Gensini index. Patients were determined the level of oxidative modification of proteins, RF‑reactive protein, homocysteine and superoxide dismutase activity depending on the administration of lipid‑lowering therapy (statins). A statistical relationship between the group of patients divided by the Gensini index and statin intake was revealed. In the assessment of clinical and anthropometric indicators, significant differences in BMI, waist circumference, systolic blood pressure level were established. In assessing the lipid profile revealed significant differences between the study groups in the level of total cholesterol and the level of HDL‑cholesterol. Low adherence to lipid‑lowering therapy was noted in patients with hemodynamically significant coronary atherosclerosis. In this regard, it remains necessary to search for residual risk markers, taking into account the importance of non‑lipid risk factors.

Quantification of Symptom Load by a Disease-Specific Questionnaire HPQ 28 and Analysis of Associated Biochemical Parameters in Patients With Postsurgical Hypoparathyroidism.

ABSTRACTIn hypoparathyroidism (HypoPT), patients suffer severely from reduced quality of life. The complexity of HypoPT demands a disease‐specific control instrument to characterize symptom load. We employed a newly developed disease‐specific Hypoparathyroid Patient Questionnaire (the HPQ 40/28) to investigate and quantify HypoPT patients' complaints and contributing factors. In this cross‐sectional, two‐center study, patients with postsurgical HypoPT (n = 49) were matched for gender and age and compared with patients having undergone thyroid surgery without HypoPT (n = 39) and patients with primary hyperparathyroidism (n = 35). The HPQ 40/28 was completed when patients visited the respective center. Clinical background information, blood tests, and current medication were documented by the physician. Serum calcium lay within the reference range in 87% of HypoPT patients, serum phosphate in 95.7%, and calcium–phosphate product (CPP) in 100%. HPQ 40/28 scores for the scales “pain and cramps” (PaC), “neurovegetative symptoms” (NVS), “numbness or tingling,” and “heart palpitations” were significantly elevated in comparison with control groups. Correlations between complaints and laboratory parameters could be demonstrated in the HypoPT group, with serum calcium correlating with NVS (r = 0.309, p < 0.05) and serum phosphate with loss of vitality (r = 0.349, p < 0.05). CPP was the main contributor to symptom load with an influence on PaC (r = 0.295, p < 0.05), loss of vitality (r = 0.498, p < 0.001), numbness or tingling (r = 0.328, p < 0.05), and memory problems (r = 0.296, p < 0.05). In conclusion, the newly developed HPQ 40/28 successfully identified and quantified symptoms typical in HypoPT patients. Using the HPQ 40/28, the CPP was identified as the predominant factor in the severity of complaints in HypoPT. © 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

The Assessment of Biochemical Parameters in Patients with Venous Thromboembolism

Assessing the biochemical parameters in patients with pulmonary embolism (PE), deep vein thrombosis (DVT) or both brings complimentary information for the cardiovascular (CV) and death risk stratification. The purpose of the study was to evaluate the association between biochemical parameters and PE, DVT or both. The study was prospective, conducted over a 12-month period and included 151 patients diagnosed with PE, DVT or both pathologies. These patients were extensively analysed taking into account biochemical parameters associated with the above-mentioned pathologies. Mean age was 59.23 � 18.22 years and 55% were women. 38.40% patients had PE, 48.30% had DVT and 13.20% had both pathologies. GFR upon admission was strongly negatively associated with age, r(148)= -0.75, p[0.01, intra-hospital death r(148)= -0.18, p=0.02 and with AST levels r(144)= -0.21, p=0.01 and positively statistically significant with the number of days of hospitalization r(8)= +0.79, p=0.0. Moreover, for one unit decrease in GFR the number of days of hospitalization decreased with 0.231. Moreover, AST correlated with intra-hospital death r(146)= 0.25, p[0.01, creatinine upon admission r(144)= 0.24, p[0.01, urea upon admission r(143)= 0.16, p=0.04 and glucose levels r(139)= 0.19, p=0.02, but negatively associated with GFR upon admission with r(144)= -0.21, p=0.01; for each one unit decrease of GFR there was an increase in AST levels by 0.21. Also there was a significant correlation between the thrombolysis therapy and the number of days of hospitalization r(151)= 0.21, p[0.01 and between positive inotropic support and intra-hospital death with r(151)= 0.27, p[0.01. In patients with PE, DVT or both, renal function, AST levels and the number of days of hospitalization were associated with an increased risk of death, especially in patients with PE � DVT.

Serum Salusin-α and Salusin -b levels with some Biochemical Parameters in Patients with Major Thalassemia

Thalassemias are a heterogeneous group of genetic disorders in which the production of normal hemoglobin partially or completely is suppressed because of defective synthesis of one or more globin chain. It is sometimes called Mediterranean anemia. Many biochemical changes in the blood accompany this disease. In this research, some biochemical parameters were measured in thalassemic patients and compared with healthy control group. These parameters include serum Iron, ferritin , TIBC, transferrin, transferrin saturation percentage, Salusin-? , salusin-?, insulin ,and lipid profile. The aim of this study was to Measuring the level of cytokine(salusin- ? and salusin -b ) lipid profile, blood sugar level and resistance to insulin in serum of thalassemia patients and Find interconnectivity between cytokine(salusin- ? and salusin -b ), iron , lipid profile, blood sugar level and insulin resistance. The results of the research showed that there is a significant increase (P 0.05) in Age,TIBC,Transferrin, and VLDL-C.

Physical Activity and Biochemical Parameters in Patients with Acute Coronary Syndrome: A Cross-Sectional Study

Physical Activity and Biochemical Parameters in Patients with Acute Coronary Syndrome: A Cross-Sectional Study

Comparison of Clinical Profile of Pleural Effusion with Special References to Various Biochemical Parameters in Patients Admitted to Government Tertiary Care Center

Comparison of Clinical Profile of Pleural Effusion with Special References to Various Biochemical Parameters in Patients Admitted to Government Tertiary Care Center

Evaluation of Serum Nitric Oxide Levels and Some Biochemical Parameters in Patients with Liver Cirrhosis

Chronic liver diseases may possibly classify into liver cirrhosis and chronic active hepatitis. Liver illnesses it could be attended by portal hypertension. Several systemic changes may occur with liver cirrhosis and portal hypertension [1].