Although the glaciers in the Antarctic periphery currently modestly contribute to sea level rise, their contribution is projected to increase substantially until the end of the 21st century. The South Shetland Islands (SSI), located to the north of the Antarctic Peninsula, are lacking a geodetic mass balance calculation for the entire archipelago. We estimated its geodetic mass balance over a 3–4-year period within 2013–2017. Our estimation is based on remotely sensed multispectral and interferometric SAR data covering 96% of the glacierized areas of the islands considered in our study and 73% of the total glacierized area of the SSI archipelago (Elephant, Clarence, and Smith Islands were excluded due to data limitations). Our results show a close to balance, slightly negative average specific mass balance for the whole area of −0.106 ± 0.007 m w.e. a−1, representing a mass change of −238 ± 12 Mt a−1. These results are consistent with a wider scale geodetic mass balance estimation and with glaciological mass balance measurements at SSI locations for the same study period. They are also consistent with the cooling trend observed in the region between 1998 and the mid-2010s.