The prevalence of type 2 diabetes (T2D) is increasing worldwide. Decreased nitric oxide (NO) bioavailability is involved in the pathophysiology of T2D and its complications. L-citrulline (Cit), a precursor of NO production, has been suggested as a no... Read More
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Metabolic effects of L ‐citrulline in type 2 diabetes
- Acta Physiologica
on Jan 25, 2023
- Pathophysiology Of T2D
- T2D
- Management Of T2D
- Effects Of Cit
- Cit Supplementation
- Increased Glucose Uptake
- More +
Long-term neurocognitive outcomes after pediatric intensive care: exploring the role of drug exposure
- Pediatric Research
on Jan 25, 2023
- PICU Admission
- Neurocognitive Outcomes
- Long-term Neurocognitive Outcomes
- Neurocognitive Functioning
- Lower Neurocognitive Functioning
- Admission For Bronchiolitis
- More +
Concerns exist regarding the impact of widely used clinical drugs on brain development. This study investigates long-term neurocognitive functioning in relation to frequently used drug exposure at the Pediatric Intensive Care Unit (PICU). This study ... Read More
Microplastics: A Real Global Threat for Environment and Food Safety: A State of the Art Review
- Nutrients
- VOL. 15
on Jan 25, 2023
- Plastic Micro
- Small Plastic Particles
- Poor Waste Management
- Degradation Of Plastics
- Higher Trophic Levels
- Threat For Food Safety
- More +
Microplastics are small plastic particles that come from the degradation of plastics, ubiquitous in nature and therefore affect both wildlife and humans. They have been detected in many marine species, but also in drinking water and in numerous foods... Read More
Live births from urine derived cells
- PLOS ONE
- VOL. 18
on Jan 25, 2023
- Animal Studies
- UDC
- Number Of DNA Breaks
- Urine Derived Cells
- Use For Cloning
- Multiple Species
- More +
Here we report urine-derived cell (UDC) culture and subsequent use for cloning which resulted in the successful development of cloned canine pups, which have remained healthy into adulthood. Bovine UDCs were used in vitro to establish comparative dif... Read More
Epigenetics and the role of nutraceuticals in health and disease
- Environmental Science and Pollution Research
on Jan 25, 2023
- Animal Studies
- Role Of Epigenetic Modulations
- Nutraceuticals In Health
- Role Of Nutraceuticals
- Clinical Trial Protocols
- Epigenetic Aberrations
- More +
In the post-genomic era, the data provided by complete genome sequencing could not answer several fundamental questions about the causes of many noninfectious diseases, diagnostic biomarkers, and novel therapeutic approaches. The rapidly expanding un... Read More
The Role of the Microbiome in the Etiology of Inflammatory Bowel Diseases
- Clinics in Colon and Rectal Surgery
on Jan 25, 2023
- Postoperative Crohn's Recurrence
- Crohn's Recurrence
- Exclusive Enteral Nutrition
- Etiology Of Inflammatory Bowel Diseases
- Fecal Microbiota Transplant
- Pathogenesis Of IBD
- More +
AbstractInflammatory bowel diseases (IBDs) result from dysregulated immune responses to environmental and microbial triggers in genetically susceptible hosts. Many clinical observations and animal studies support the role of the microbiome in the pat... Read More
Investigation of the Protective Effect of Extracellular Vesicle miR-124 on Retinal Ganglion Cells Using a Photolabile Paper-Based Chip
- Investigative Opthalmology & Visual Science
- VOL. 64
on Jan 25, 2023
- EV
- Nonarteritic Anterior Ischemic Optic Neuropathy
- EV miRNAs
- Function Of Retinal Ganglion Cells
- Quantitative RT-PCR Analyses
- FVEPs
- More +
Photolabile paper-based chips were developed to isolate extracellular vesicles (EVs) from small-volume samples (less than 30 µL), such as vitreous humor. Putative neuroprotective effects of EVs' microRNAs were investigated by using the paper chip and... Read More
Plant production of a virus-like particle-based vaccine candidate against porcine reproductive and respiratory syndrome
- Frontiers in Plant Science
- VOL. 14
on Jan 24, 2023
- Studies In Animals
- PRRS
- Tobacco Mosaic Virus Coat Protein
- Immunogold Localization
- Respiratory Syndrome
- Tobacco Mosaic
- More +
Porcine reproductive and respiratory syndrome (PRRS) is a disease leading to spontaneous abortions and stillbirths in sows and lowered life quality and expectancy in growing pigs. PRRS is prevalent worldwide and has significant economic impacts to sw... Read More
Low-Grade Fibromyxoid Sarcoma of the Distal Upper Extremity: A Systematic Review
- HAND
on Jan 24, 2023
- LGFMS
- Distal Extremity
- non-English Publications
- MEDLINE
- Upper Extremity
- Negative Margins
- More +
Background: Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue tumor that usually occurs in the proximal extremities and trunk. The purpose of this systematic review was to assess patient demographics, treatment approach, and outcomes for pa... Read More
Hepatoprotective effects of moderate-intensity interval training along with ginger juice in an old male rat model
- Pflügers Archiv - European Journal of Physiology
on Jan 24, 2023
- MIIT
- LRG1
- Lipid Metabolism Regulators
- 8weeks Of Intervention
- Adipose Triglyceride Lipase
- Ginger Juice
- More +
Aging is a natural process coupled with oxidative stress and chronic inflammation, gradually associated with losing organ function over time. Therefore, the objective of the current work was to peruse the protective effects of 8-week moderate-intensi... Read More
Silencing SOX11 Alleviates Allergic Rhinitis by Inhibiting Epithelial-Derived Cytokines
- Balkan Medical Journal
- VOL. 40
on Jan 24, 2023
- Epithelial-derived Cytokines
- Allergic Rhinitis
- Human Nasal Epithelial Cells
- MUC5AC
- MUC5AC Levels
- Nasal Epithelial Cells
- More +
Allergic rhinitis is a chronic inflammatory disease of the nasal mucosa affecting the quality of life of patients. SRY-box transcription factor 11 (SOX11) was reported to play important roles in inflammatory responses, but its role in AR is poorly un... Read More
Ivermectin - an antiviral drug for the COVID-19 pandemic?
- The Southwest Respiratory and Critical Care Chronicles
- VOL. 11
on Jan 24, 2023
- Animal Studies
- Important Clinical Outcomes
- Favorable Safety Profile
- Design Flaws
- Off-label Use
- Respiratory Failure
- More +
Abstract
 The use of ivermectin for the treatment of COVID-19 infections has been a subject of significant interest and controversy. The drug has a history of off-label use for a variety of clinical disorders and has shown some potential as an a... Read More
A systematic review of optimal pharmacokinetic/pharmacodynamic parameters for beta-lactam therapy in infective endocarditis
- Journal of Antimicrobial Chemotherapy
on Jan 24, 2023
- Animal Studies
- OHAT
- IE
- Causes Of Infective Endocarditis
- Optimal Drug Exposure
- PRISMA
- More +
Abstract Background Beta-lactam antibiotics are the mainstay of therapy for most bacterial causes of infective endocarditis (IE). Traditionally considered as agents with a broad therapeutic index, t... Read More
In Vitro/In Vivo Translation of Synergistic Combination of MDM2 and MEK Inhibitors in Melanoma Using PBPK/PD Modelling: Part III
- International Journal of Molecular Sciences
- VOL. 24
on Jan 23, 2023
- PK Level
- MEK Inhibitors In Melanoma
- PK/PD
- Virtual Clinical Trial
- Inhibitors In Melanoma
- Vivo Translation
- More +
The development of in vitro/in vivo translational methods and a clinical trial framework for synergistically acting drug combinations are needed to identify optimal therapeutic conditions with the most effective therapeutic strategies. We performed p... Read More
In Vivo Studies on Radiofrequency (100 kHz–300 GHz) Electromagnetic Field Exposure and Cancer: A Systematic Review
- International Journal of Environmental Research and Public Health
- VOL. 20
on Jan 23, 2023
- Animal Studies
- Radiofrequency Electromagnetic Field
- Electromagnetic Field Exposure
- RF Exposure
- Onset Of Neoplasm
- Radiofrequency Electromagnetic Field Exposure
- More +
The increasing exposure of the human population to radiofrequency electromagnetic fields has increased concern about its possible health effects. The aim of this systematic review is to provide an update of the state of the research on this topic, th... Read More
High preoperative serum strontium levels increase the risk of acute kidney injury after cardiopulmonary bypass
- Clinical and Experimental Nephrology
on Jan 23, 2023
- BUN Levels
- AKI Patients
- Trace Metal Levels
- AKI
- Incidence Of AKI
- Risk Of Acute Kidney Injury
- More +
Acute kidney injury (AKI) is a common complication of cardiac surgeries. The incidence of AKI after cardiac surgeries using cardiopulmonary bypass (CPB-AKI) is high, emphasizing the need to determine strategies to prevent CPB-AKI. This study investig... Read More
The “Cruel Absurdity” of Human Violence and Its Consequences. A Vegan Studies Analysis of a Pandemic Novel
- Relations. Beyond Anthropocentrism
- VOL. 10
on Jan 23, 2023
- Vegan Studies
- Types Of Literary Texts
- Sarah Moss
- Literary Engagements
- Argument In Favour
- Causal Relationships
- More +
This article teases out what a Vegan Studies theoretical framework can offer a literary analysis of a selected pandemic novel, “The Fell” (2021), by Sarah Moss. Pandemic fiction accommodates texts from a wide range of genres, and these types of liter... Read More
Comparative Study of Different Acupoints for Treating Acute Myocardial Ischemia in Mice
- Journal of Cardiovascular Translational Research
on Jan 23, 2023
- Myocardial Ischemia In Mice
- MI Injury
- TCM
- Related Pathways
- Myocardial Injury
- Systolic Function
- More +
Abstract Acupuncture point specificity has been recognized as a key scientific issue in traditional Chinese medicine (TCM), but there is limited clinical trial or animal study to verify the characteristics of PC6, BL15, and ST36 in the protection fro... Read More
Statins In Preeclampsia Or Fetal Growth Restriction: A Systematic Review and Meta‐Analysis on Maternal Blood Pressure and Fetal Growth Across Species
- BJOG: An International Journal of Obstetrics & Gynaecology
on Jan 22, 2023
- MBP
- FGR
- SMD
- BW In Grams
- Effects Of Statins
- Route Of Administration
- More +
Several human RCTs are investigating the effects of statins on preeclampsia (PE) and fetal growth restriction (FGR). This cross-species meta-analysis summarizes the preclinical evidence of statin use for PE and FGR. Evaluate the effects of statins on... Read More
Long-Term Cola Intake Does Not Cause Evident Pathological Alterations in the Femoral Bone Microstructure: An Animal Study in Adult Mice
- Nutrients
- VOL. 15
on Jan 22, 2023
- Femoral Bone Microstructure
- Cola Intake
- Cola Consumption
- Vascular Canals
- BMD
- Association Studies In Humans
- More +
Short-term animal experiments and association studies in humans have shown that cola intake may have a detrimental impact on bone mineral density (BMD); however, other bone parameters have not been investigated. This study examined the effects of lon... Read More