Type 2 diabetes mellitus, obesity and metabolic syndrome are becoming more prevalent worldwide and will present an increasingly challenging burden on healthcare systems. These interlinked metabolic abnormalities predispose affected individuals to a p... Read More
Animal Studies Research Articles
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Circadian rhythms and pancreas physiology: A review
- Frontiers in Endocrinology
- VOL. 13
on Aug 10, 2022
Formulation, Characterization, and In Vitro/In Vivo Efficacy Studies of a Novel Liposomal Drug Delivery System of Amphiphilic Jaspine B for Treatment of Synovial Sarcoma
- Marine Drugs
- VOL. 20
on Aug 10, 2022
Sphingomyelin is a cell membrane sphingolipid that is upregulated in synovial sarcoma (SS). Jaspine B has been shown to inhibit sphingomyelin synthase, which synthesizes sphingomyelin from ceramide, a critical signal transducer; however, jaspine B’s ... Read More
Experimental studies on androgen administration in animal models: current and future perspectives
- Current Opinion in Endocrinology, Diabetes & Obesity
- VOL. Publish Ahead of Print
on Aug 10, 2022
This review aims to report the most recent (2020-2022) experimental scientific studies conducted on animal models, in order to highlight the relevant findings on the adverse effects related to androgen administration. Forty-one studies published betw... Read More
Expression of unfolded protein response genes in post-transplantation liver biopsies
- BMC Gastroenterology
- VOL. 22
on Aug 10, 2022
Abstract Background Cholestatic liver diseases are a major source of morbidity and mortality that can progress to end-stage liver disease and hyperbilirubinemia is a hallmark of cholestasis. There are few effective med... Read More
Efficacy of terpenoids in attenuating pulmonary edema in acute lung injury: A meta-analysis of animal studies
- Frontiers in Pharmacology
- VOL. 13
on Aug 10, 2022
Background: The clinical efficiency of terpenoids in treating human acute lung injury (ALI) is yet to be determined. The lipopolysaccharide-induced rat model of ALI is a well-established and widely used experimental model for studying terpenoids’ eff... Read More
Bedside interpretation of cerebral energy metabolism utilizing microdialysis in neurosurgical and general intensive care
- Frontiers in Neurology
- VOL. 13
on Aug 10, 2022
The microdialysis technique was initially developed for monitoring neurotransmitters in animals. In 1995 the technique was adopted to clinical use and bedside enzymatic analysis of glucose, pyruvate, lactate, glutamate and glycerol. Under clinical co... Read More
Investigation of the mechanism of Isobavachalcone in treating rheumatoid arthritis through a combination strategy of network pharmacology and experimental verification.
- Journal of ethnopharmacology
- VOL. 294
on Aug 10, 2022
Isobavachalcone (IBC) is a natural chalcone compound widely distributed in traditional Chinese medicine Psoralea corylifolia L., and Tibetan medicine Abelmoschus manihot (L.) Medik. Etc.. Among them, Psoralea corylifolia has the effect of tonifying t... Read More
Using Artificial Intelligence in the COVID-19 Pandemic: A Systematic Review
- ACTA MEDICA IRANICA
on Aug 9, 2022
Artificial intelligence applications are known to facilitate the diagnosis and treatment of COVID-19 infection. This research was conducted to investigate and systematically review the studies published on the use of artificial intelligence in the CO... Read More
The effect of pro-/synbiotic supplementation on the brain-derived neurotrophic factor: a systematic review and meta-analysis of randomized controlled trials.
- Food & function
on Aug 9, 2022
There is growing interest in supplementation with pro-/synbiotics for brain and mental health. Animal studies have reported that pro-/synbiotic administration can increase the brain-derived neurotrophic factor (BDNF), a key regulator of neuronal func... Read More
Rhythmic cueing, dance, resistance training, and Parkinson's disease: A systematic review and meta-analysis
- Frontiers in Neurology
- VOL. 13
on Aug 9, 2022
ObjectivesThe aim of the present systematic review and meta-analysis was to synthesize evidence associated with the functional and clinical effectiveness of rhythmic cueing, dance, or resistance training (RT) on motor and non-motor parameters in Park... Read More
Sphingosine‐1‐phosphate receptor modulators in stroke treatment
- Journal of Neurochemistry
on Aug 9, 2022
Sphingosine-1-phosphate (S1P) is a bioactive lysophospholipid that can influence a broad range of biological processes through its binding to five distinct G protein-coupled receptors. S1P receptor modulators are a new group of immunosuppressive agen... Read More
Eugenol: A novel therapeutic agent for the inhibition of Candida species infection
- Frontiers in Pharmacology
- VOL. 13
on Aug 9, 2022
The high occurrence and mortality rates related to candidiasis emphasize the urgent need to introduce new therapeutic approaches to treat this infection. Eugenol, the main phenolic component of Clove and Cinnamomum essential oil, has been used to inh... Read More
Enhanced hair growth effects through low‐level vortex beams radiation: an experimental animal study
- Journal of Biophotonics
on Aug 9, 2022
Regulation of social hierarchy learning by serotonin transporter availability
- Neuropsychopharmacology
on Aug 9, 2022
AbstractLearning one’s status in a group is a fundamental process in building social hierarchies. Although animal studies suggest that serotonin (5-HT) signaling modulates learning social hierarchies, direct evidence in humans is lacking. Here we det... Read More
Encore: Behavioural animal models of stress, depression and mood disorders
- Frontiers in Behavioral Neuroscience
- VOL. 16
on Aug 8, 2022
Animal studies over the past two decades have led to extensive advances in our understanding of pathogenesis of depressive and mood disorders. Among these, rodent behavioural models proved to be of highest informative value. Here, we present a compre... Read More
Race for Applicable Antimicrobial Dental Implant Surfaces to Fight Biofilm-Related Disease: Advancing in Laboratorial Studies vs Stagnation in Clinical Application.
- ACS biomaterials science & engineering
- VOL. 8
on Aug 8, 2022
Across years, potential strategies to fight peri-implantitis have been notoriously explored through the antimicrobial coating implant surfaces capable of interfering with the bacterial adhesion process. However, although experimental studies have sig... Read More
Circular BANP knockdown inhibits the malignant progression of residual hepatocellular carcinoma after insufficient radiofrequency ablation
- Chinese Medical Journal
- VOL. Publish Ahead of Print
on Aug 8, 2022
Circular RNAs (circRNAs) are endogenous non-coding RNAs, some of which have pathological roles. The current study aimed to explore the role of circRNA BTG3-associated nuclear protein (circ-BANP) binding with let-7f-5p and its regulation of the toll-l... Read More
A Mouse Holder for Awake Functional Imaging in Unanesthetized Mice: Applications in 31P Spectroscopy, Manganese-Enhanced Magnetic Resonance Imaging Studies, and Resting-State Functional Magnetic Resonance Imaging
- Biosensors
- VOL. 12
on Aug 8, 2022
Anesthesia is often used in preclinical imaging studies that incorporate mouse or rat models. However, multiple reports indicate that anesthesia has significant physiological impacts. Thus, there has been great interest in performing imaging studies ... Read More
Antiarrhythmic effects and mechanisms of sodium-glucose cotransporter 2 inhibitors: A mini review
- Frontiers in Cardiovascular Medicine
- VOL. 9
on Aug 8, 2022
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a new type of oral hypoglycaemic agent with good cardiovascular protective effects. There are several lines of clinical evidence suggest that SGLT2i can significantly reduce the risks of heart fa... Read More
Transcranial near-infrared light in treatment of neurodegenerative diseases
- Frontiers in Pharmacology
- VOL. 13
on Aug 8, 2022
Light is a natural agent consisting of a range of visible and invisible electromagnetic spectrum travels in waves. Near-infrared (NIR) light refers to wavelengths from 800 to 2,500 nm. It is an invisible spectrum to naked eyes and can penetrate throu... Read More