Type 2 diabetes mellitus (T2DM) is a multifaceted metabolic syndrome defined through the dysfunction of pancreatic β-cells driven by a confluence of genetic and environmental elements. Insulin resistance, mediated by interleukins and other inflammato... Read More
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A systematic review on anti-diabetic plant essential oil compounds: Dietary sources, effects, molecular mechanisms, and safety
- Critical Reviews in Food Science and Nutrition
on Jan 28, 2023
- Essential Oil Compounds
- T2DM
- Dietary Plants
- Essential Oil
- Insulin Resistance
- Strong Anti-diabetic Effects
- More +
Gut Microbial Alteration in MPTP Mouse Model of Parkinson Disease is Administration Regimen Dependent
- Cellular and Molecular Neurobiology
on Jan 28, 2023
- Subchronic Mice
- Administration Regimen
- PD Mouse Models
- Gut Microbiota
- Gut Microbial Alteration
- PD
- More +
Parkinson Disease (PD) is one of the most common neurodegenerative disorders characterized by loss of dopaminergic neurons involved in motor functions. Growing evidence indicates that gut microbiota communicates with the brain known as the gut-brain ... Read More
Therapeutic potential of mesenchymal stem/stromal cells (MSCs)-based cell therapy for inflammatory bowel diseases (IBD) therapy
- European Journal of Medical Research
- VOL. 28
on Jan 27, 2023
- MSCs
- IBD
- TSG-6
- IBD Patients
- Inflammatory Bowel Diseases Therapy
- MSCs-derived Exosomes
- More +
Recently, mesenchymal stem/stromal cells (MSCs) therapy has become an emerging therapeutic modality for the treatment of inflammatory bowel disease (IBD), given their immunoregulatory and pro-survival attributes. MSCs alleviate dysregulated inflammat... Read More
Comparison of the effect of Triticum Vulgare and Hyperici Oleum on healing in traumatic membrane perforation: an animal study
- The Egyptian Journal of Otolaryngology
on Jan 27, 2023
- Animal Study
- Traumatic Membrane Perforation
- Traumatic Perforation
- Membrane Perforation
- Triticum Vulgare
Does the osteopathic pedal pump reduce lower limb volume in healthy subjects?
- Journal of Osteopathic Medicine
on Jan 27, 2023
- Lower Limb Volume
- Lower Limbs Of Healthy Subjects
- Central Circulatory System
- Lower Volume
- Pump Protocol
- Second-year Medical Students
- More +
Lymphatic treatments are gentle and passive techniques believed to enhance movement of lymph back into the central circulatory system. Animal studies provide supportive evidence, yet there are few studies in humans. The aim of this study is to invest... Read More
Reporting guidelines enhance the quality and impact of research in Dental Traumatology .
- Dental Traumatology
on Jan 27, 2023
- Reporting Guidelines
- Trials In Endodontics
- Dental Traumatology
- Quality Of Manuscripts
- Dental Disciplines
- Impact Of Research
- More +
Reporting guidelines assist basic scientists, translational healthcare researchers and clinicians to publish manuscripts of the highest standard by improving the accuracy, transparency, and completeness of the publications they submit to journals. Th... Read More
A Hypothalamic Perspective of Human Socioemotional Behavior
- The Neuroscientist
on Jan 26, 2023
- Studies In Animals
- Socioemotional Responses
- Human Behavior
- Socioemotional Behavior
- Lesion Studies In Humans
- Neuroimaging Findings
- More +
Historical evidence from stimulation and lesion studies in animals and humans demonstrated a close association between the hypothalamus and typical and atypical socioemotional behavior. A central hypothalamic contribution to regulation of socioemotio... Read More
Metabolic effects of L ‐citrulline in type 2 diabetes
- Acta Physiologica
on Jan 25, 2023
- Pathophysiology Of T2D
- T2D
- Management Of T2D
- Effects Of Cit
- Cit Supplementation
- Increased Glucose Uptake
- More +
The prevalence of type 2 diabetes (T2D) is increasing worldwide. Decreased nitric oxide (NO) bioavailability is involved in the pathophysiology of T2D and its complications. L-citrulline (Cit), a precursor of NO production, has been suggested as a no... Read More
Long-term neurocognitive outcomes after pediatric intensive care: exploring the role of drug exposure
- Pediatric Research
on Jan 25, 2023
- PICU Admission
- Neurocognitive Outcomes
- Long-term Neurocognitive Outcomes
- Neurocognitive Functioning
- Lower Neurocognitive Functioning
- Admission For Bronchiolitis
- More +
Concerns exist regarding the impact of widely used clinical drugs on brain development. This study investigates long-term neurocognitive functioning in relation to frequently used drug exposure at the Pediatric Intensive Care Unit (PICU). This study ... Read More
Microplastics: A Real Global Threat for Environment and Food Safety: A State of the Art Review
- Nutrients
- VOL. 15
on Jan 25, 2023
- Plastic Micro
- Small Plastic Particles
- Poor Waste Management
- Degradation Of Plastics
- Higher Trophic Levels
- Threat For Food Safety
- More +
Microplastics are small plastic particles that come from the degradation of plastics, ubiquitous in nature and therefore affect both wildlife and humans. They have been detected in many marine species, but also in drinking water and in numerous foods... Read More
Live births from urine derived cells
- PLOS ONE
- VOL. 18
on Jan 25, 2023
- Animal Studies
- UDC
- Number Of DNA Breaks
- Urine Derived Cells
- Use For Cloning
- Multiple Species
- More +
Here we report urine-derived cell (UDC) culture and subsequent use for cloning which resulted in the successful development of cloned canine pups, which have remained healthy into adulthood. Bovine UDCs were used in vitro to establish comparative dif... Read More
Epigenetics and the role of nutraceuticals in health and disease
- Environmental Science and Pollution Research
on Jan 25, 2023
- Animal Studies
- Role Of Epigenetic Modulations
- Nutraceuticals In Health
- Role Of Nutraceuticals
- Clinical Trial Protocols
- Epigenetic Aberrations
- More +
In the post-genomic era, the data provided by complete genome sequencing could not answer several fundamental questions about the causes of many noninfectious diseases, diagnostic biomarkers, and novel therapeutic approaches. The rapidly expanding un... Read More
The Role of the Microbiome in the Etiology of Inflammatory Bowel Diseases
- Clinics in Colon and Rectal Surgery
on Jan 25, 2023
- Postoperative Crohn's Recurrence
- Crohn's Recurrence
- Exclusive Enteral Nutrition
- Etiology Of Inflammatory Bowel Diseases
- Fecal Microbiota Transplant
- Pathogenesis Of IBD
- More +
AbstractInflammatory bowel diseases (IBDs) result from dysregulated immune responses to environmental and microbial triggers in genetically susceptible hosts. Many clinical observations and animal studies support the role of the microbiome in the pat... Read More
Investigation of the Protective Effect of Extracellular Vesicle miR-124 on Retinal Ganglion Cells Using a Photolabile Paper-Based Chip
- Investigative Opthalmology & Visual Science
- VOL. 64
on Jan 25, 2023
- EV
- Nonarteritic Anterior Ischemic Optic Neuropathy
- EV miRNAs
- Function Of Retinal Ganglion Cells
- Quantitative RT-PCR Analyses
- FVEPs
- More +
Photolabile paper-based chips were developed to isolate extracellular vesicles (EVs) from small-volume samples (less than 30 µL), such as vitreous humor. Putative neuroprotective effects of EVs' microRNAs were investigated by using the paper chip and... Read More
Plant production of a virus-like particle-based vaccine candidate against porcine reproductive and respiratory syndrome
- Frontiers in Plant Science
- VOL. 14
on Jan 24, 2023
- Studies In Animals
- PRRS
- Tobacco Mosaic Virus Coat Protein
- Immunogold Localization
- Respiratory Syndrome
- Tobacco Mosaic
- More +
Porcine reproductive and respiratory syndrome (PRRS) is a disease leading to spontaneous abortions and stillbirths in sows and lowered life quality and expectancy in growing pigs. PRRS is prevalent worldwide and has significant economic impacts to sw... Read More
Low-Grade Fibromyxoid Sarcoma of the Distal Upper Extremity: A Systematic Review
- HAND
on Jan 24, 2023
- LGFMS
- Distal Extremity
- non-English Publications
- MEDLINE
- Upper Extremity
- Negative Margins
- More +
Background: Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft-tissue tumor that usually occurs in the proximal extremities and trunk. The purpose of this systematic review was to assess patient demographics, treatment approach, and outcomes for pa... Read More
Hepatoprotective effects of moderate-intensity interval training along with ginger juice in an old male rat model
- Pflügers Archiv - European Journal of Physiology
on Jan 24, 2023
- MIIT
- LRG1
- Lipid Metabolism Regulators
- 8weeks Of Intervention
- Adipose Triglyceride Lipase
- Ginger Juice
- More +
Aging is a natural process coupled with oxidative stress and chronic inflammation, gradually associated with losing organ function over time. Therefore, the objective of the current work was to peruse the protective effects of 8-week moderate-intensi... Read More
Silencing SOX11 Alleviates Allergic Rhinitis by Inhibiting Epithelial-Derived Cytokines
- Balkan Medical Journal
- VOL. 40
on Jan 24, 2023
- Epithelial-derived Cytokines
- Allergic Rhinitis
- Human Nasal Epithelial Cells
- MUC5AC
- MUC5AC Levels
- Nasal Epithelial Cells
- More +
Allergic rhinitis is a chronic inflammatory disease of the nasal mucosa affecting the quality of life of patients. SRY-box transcription factor 11 (SOX11) was reported to play important roles in inflammatory responses, but its role in AR is poorly un... Read More
Ivermectin - an antiviral drug for the COVID-19 pandemic?
- The Southwest Respiratory and Critical Care Chronicles
- VOL. 11
on Jan 24, 2023
- Animal Studies
- Important Clinical Outcomes
- Favorable Safety Profile
- Design Flaws
- Off-label Use
- Respiratory Failure
- More +
Abstract
 The use of ivermectin for the treatment of COVID-19 infections has been a subject of significant interest and controversy. The drug has a history of off-label use for a variety of clinical disorders and has shown some potential as an a... Read More
A systematic review of optimal pharmacokinetic/pharmacodynamic parameters for beta-lactam therapy in infective endocarditis
- Journal of Antimicrobial Chemotherapy
on Jan 24, 2023
- Animal Studies
- OHAT
- IE
- Causes Of Infective Endocarditis
- Optimal Drug Exposure
- PRISMA
- More +
Abstract Background Beta-lactam antibiotics are the mainstay of therapy for most bacterial causes of infective endocarditis (IE). Traditionally considered as agents with a broad therapeutic index, t... Read More