AbstractInhaled drug delivery is a promising approach to achieving high lung drug concentrations to facilitate efficient treatment of tuberculosis (TB) and to reduce the overall duration of treatment. Rifampicin is a good candidate for delivery via t... Read More
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A review of formulations and preclinical studies of inhaled rifampicin for its clinical translation
- Drug Delivery and Translational Research
on Sep 21, 2022
Issues and Challenges in the Primary Prevention of Type 2 Diabetes Mellitus: A Systematic Review.
- Journal of prevention (2022)
on Sep 21, 2022
Primary prevention of type 2 diabetes mellitus (T2DM) is possible in at-risk populations, and prevention programmes have been shown to be effective in real-world scenarios. Despite this evidence, diabetes prevalence has tripled in recent decades and ... Read More
BAKUNANAYS guidelines for communicating COVID-19 vaccination information to pregnant women in the Philippines and other developing countries
- Frontiers in Communication
- VOL. 7
on Sep 20, 2022
COVID-19 remains a pressing global health disaster, and pregnant women and their unborn child/ren continue to be extremely at risk. In the Philippines, a developing country in Southeast Asia, pregnant women were generally excluded from initial vaccin... Read More
Animal evidence considered in determination of cannabis smoke and Δ 9 ‐tetrahydrocannabinol as causing reproductive toxicity (developmental endpoint): Part III . Proposed neurodevelopmental mechanisms of action
- Birth Defects Research
on Sep 20, 2022
This review summarizes the most common potential pathways of neurodevelopmental toxicity due to perinatal exposure to Δ9 -tetrahydrocannabinol (Δ9 -THC) that lead to behavioral and other adverse outcomes (AOs). This is Part III in a set of reviews hi... Read More
Ultraviolet A radiation exposure and melanoma: a review
- Melanoma Research
- VOL. Publish Ahead of Print
on Sep 20, 2022
The incidence of cutaneous melanoma has been increasing worldwide, and melanoma disproportionately contributes to skin cancer mortality. The pathogenesis of melanoma involves genetic and environmental factors, and while the effects of ultraviolet B r... Read More
Defensins: defenders of human reproductive health
- Human Reproduction Update
on Sep 20, 2022
Abstract BACKGROUND Reproductive tract infection is an important factor leading to male and female infertility. Among female infertility factors, microbial and viral infections are the main factors ... Read More
Therapeutic potential and research progress of diosgenin for lipid metabolism diseases
- Drug Development Research
on Sep 20, 2022
Diosgenin, a steroidal saponin, is a natural product found in many plants. Diosgenin has a wide range of pharmacological activities, and has been used to treat cancer, nervous system diseases, inflammation, and infections. Numerous studies have shown... Read More
The role of fibroblast growth factor 19 in the pathogenesis of non-alcoholic fatty liver disease
- Expert Review of Gastroenterology & Hepatology
on Sep 20, 2022
Non-alcoholic fatty liver disease (NAFLD) has emerged as the predominant cause of chronic liver injury worldwide. Bile acids and their receptors are profoundly implicated in the pathogenesis of NAFLD and its progression to non-alcoholic steatohepatit... Read More
Photobiomodulation for the treatment of neuroinflammation: A systematic review of controlled laboratory animal studies
- Frontiers in Neuroscience
- VOL. 16
on Sep 20, 2022
BackgroundNeuroinflammation is a response that involves different cell lineages of the central nervous system, such as neurons and glial cells. Among the non-pharmacological interventions for neuroinflammation, photobiomodulation (PBM) is gaining pro... Read More
Immune Responses to Gene Editing by Viral and Non-Viral Delivery Vectors Used in Retinal Gene Therapy
- Pharmaceutics
- VOL. 14
on Sep 19, 2022
Inherited retinal diseases (IRDs) are a leading cause of blindness in industrialized countries, and gene therapy is quickly becoming a viable option to treat this group of diseases. Gene replacement using a viral vector has been successfully applied ... Read More
The Fifty Most Cited Publications on Concentrated Bone Marrow Aspirate With Application in Orthopedic Surgery
- The Journal of Knee Surgery
on Sep 19, 2022
Background: Concentrated bone marrow aspirate (cBMA) has garnered widespread and increasing attention in recent years. We aimed to characterize the most influential articles in cBMA research while clarifying controversies surrounding its use and clin... Read More
Early detection of radiation-induced myocardial damage by [18F]AlF-NOTA-FAPI-04 PET/CT imaging
- European Journal of Nuclear Medicine and Molecular Imaging
on Sep 19, 2022
Retrospective analysis revealed increased [18F]AlF-NOTA-FAPI-04 uptake in the myocardium of patients with esophageal squamous cell cancer (ESCC) treated with concurrent chemoradiotherapy (CCRT). This study investigated and verified the feasibility of... Read More
Moral decision‐making in pettism: The influence of animal type, pet ownership status, and social distance
- PsyCh Journal
on Sep 19, 2022
Speciesism prioritizes humans over animals and pets. Nevertheless, pet owners have a strong attachment bond with their pets, which makes their hierarchical view of pets less clear. Aiming to examine this issue, we present a dilemma involving animals ... Read More
Pilot Scale Production and Characterization of Next Generation High Molecular Weight and Tense Quaternary State Polymerized Human Hemoglobin
- Biotechnology and Bioengineering
on Sep 19, 2022
Polymerized human hemoglobin (PolyhHb) is being studied as a possible red blood cell (RBC) substitute for use in scenarios where blood is not available. While the O2 carrying capacity of PolyhHb makes it appealing as an O2 therapeutic, the commercial... Read More
Early‐life social stress induces permanent alterations in plasticity and perineuronal nets in the mouse anterior cingulate cortex
- European Journal of Neuroscience
on Sep 18, 2022
Child maltreatment disrupts trajectories of brain development, but the underlying pathways are unclear. Stressful stimuli in early life interfere with maturation of local inhibitory circuitry and deposition of perineuronal nets (PNNs), specialized ex... Read More
CTLA4-Linked Autoimmunity in the Pathogenesis of Endometriosis and Related Infertility: A Systematic Review
- International Journal of Molecular Sciences
- VOL. 23
on Sep 18, 2022
Several studies, although with conflicting results, have sought to determine the concentration of soluble CTLA4 antigens in peripheral blood plasma and peritoneal fluid in patients with endometriosis-related infertility. A systematic review was perfo... Read More
Immunogenic Cell Death Role in Urothelial Cancer Therapy
- Current Oncology
- VOL. 29
on Sep 18, 2022
Purpose: Bladder cancer is the 13th most common cause of cancer death with the highest lifetime cost for treatment of all cancers. This scoping review clarifies the available evidence on the role of a novel therapeutic approach called immunogenic cel... Read More
Neuropharmacological Effects of Terpenoids on Preclinical Animal Models of Psychiatric Disorders: A Review
- Antioxidants
- VOL. 11
on Sep 18, 2022
Terpenoids are widely distributed in nature, especially in the plant kingdom, and exhibit diverse pharmacological activities. In recent years, screening has revealed a wide variety of new terpenoids that are active against different psychiatric disor... Read More
Animal evidence considered in determination of cannabis smoke and Δ 9 ‐tetrahydrocannabinol ( Δ 9 ‐THC ) as causing reproductive toxicity (developmental endpoint); part II . Neurodevelopmental effects
- Birth Defects Research
on Sep 16, 2022
This review focuses on neurodevelopmental effects observed in animal studies of cannabis smoke and Δ9 -THC. Effects in offspring after preconceptional, prenatal, or perinatal exposure to cannabis smoke or Δ9 -THC were considered. Locomotor and explor... Read More
Differential proMMP-2 and proMMP-9 secretion in human pre-implantation embryos at day 5 of development
- Acta Biochimica Polonica
- VOL. 69
on Sep 16, 2022
Morphological development is the most common non-invasive criterion used to select in vitro human embryos for implantation. With this criterion, however, embryos in cellular arrest go unnoticed. A more accurate criterion is needed to improve the succ... Read More