Cannabis has been widely used medically and recreationally for centuries. With a renewed interest in the therapeutic use of cannabinoids, which are active components of Cannabis sativa, it has become important to understand the cannabinoids' neurobio... Read More
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Effect of cannabinoids on brain metabolites: A review of animal and human studies.
- Experimental and Clinical Psychopharmacology
- VOL. 31
on Feb 1, 2023
- Animal Studies
- Brain Metabolites
- Major Cannabinoids
- Therapeutic Use Of Cannabinoids
- Use Of Cannabinoids
- Effect Of Cannabinoids
- More +
Probiotic Bifidobacteria in Managing Periodontal Disease: A Systematic Review
- International Dental Journal
- VOL. 73
on Feb 1, 2023
- Animal Studies
- Bifidobacterium Animalis Subspecies Lactis
- Different Strains Of Bifidobacteria
- Use Of Bifidobacteria
- Clinical Attachment Loss
- RCTs
- More +
Although various probiotic organisms have been evaluated for their utility in the management of periodontitis, their strain-specific mechanisms of action are still unclear. We aimed to systematically review the effect of bifidobacterial probiotics on... Read More
The impact of bariatric surgery on colorectal cancer risk
- Surgery for Obesity and Related Diseases
- VOL. 19
on Feb 1, 2023
- RYGB
- Impact Of Bariatric Surgery
- CRC Risk
- High Concentrations Of Bile Acids
- Reduction In Butyrate-producing Bacteria
- CRC
- More +
Obesity is considered a risk factor for different types of cancer, including colorectal cancer (CRC). Bariatric surgery has been associated with improvements in obesity-related co-morbidities and reductions in overall cancer risk. However, given the ... Read More
Commentary: On the merit of an early contributor of the “Preparation for Oxidative Stress” (POS) theory
- Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
- VOL. 276
on Feb 1, 2023
- Studies Of Animals
- Preparation For Oxidative Stress
- Hypoxia-tolerant Animals
- Oxyradical Formation
- Severe Dehydration
- Severe Hypoxia
- More +
This commentary acknowledges the contributions of the Ukrainian biologist, Dr. Volodymyr Lushchak, to the understanding of the physiological adaptive strategy called "Preparation for Oxidative Stress" (POS). In the 1990s, various studies revealed tha... Read More
Joint effects of per- and polyfluoroalkyl substance alternatives and heavy metals on renal health: A community-based population study in China
- Environmental Research
- VOL. 219
on Feb 1, 2023
- BKMR Models
- BKMR
- Heavy Metals
- Negative Association
- Health In Chinese Adults
- Renal Health
- More +
Previous studies have indicated that chlorinated polyfluorinated ether sulfonic acids (Cl-PFESAs), when used as an alternative to per- and polyfluoroalkyl substances (PFASs), result in kidney toxicity. However, their co-exposure with heavy metals, ha... Read More
Exposure to volatile organic compounds and polycyclic aromatic hydrocarbons is associated with the risk of non-alcoholic fatty liver disease in Korean adolescents: Korea National Environmental Health Survey (KoNEHS) 2015–2017
- Ecotoxicology and Environmental Safety
- VOL. 251
on Feb 1, 2023
- NAFLD Prevalence
- NAFLD
- ALT Activity
- NAFLD Risk
- PAHs Metabolites
- PAHs
- More +
Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent liver diseases among adolescents. Several animal studies have suggested that volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) increase NAFLD risk. Howe... Read More
Effects of transcranial direct current stimulation on improving performance of delayed- reinforcement attentional set-shifting tasks in attention-deficit/hyperactivity disorder rat model
- Behavioural Brain Research
- VOL. 437
on Feb 1, 2023
- SHRs
- WKY Rats
- Performance In SHRs
- Trial Omissions
- Animal Model Of ADHD
- Reversal-learning Tasks
- More +
Behavioral flexibility (or set-shifting), which is regulated by the prefrontal cortex (PFC), is often impaired in patients with attention-deficit/hyperactivity disorder (ADHD), which is characterized by poor inhibitory control and reinforcement learn... Read More
Therapeutic hypothermia demonstrates sex-dependent improvements in motor function in a rat model of neonatal hypoxic ischemic encephalopathy
- Behavioural Brain Research
- VOL. 437
on Feb 1, 2023
- HIE
- TH
- HIE Outcomes
- Neonatal HIE
- Accelerod Test
- Beam Walk Test
- More +
Neonatal hypoxic ischemic encephalopathy (HIE) is a neurological disease caused by restricted oxygen and blood flow to the brain at or around the time of birth. Long term cognitive and motor sequelae are common and demonstrate sexual dimorphism in an... Read More
Retraction notice to “Pluronic® F127 stabilized reduced graphene oxide hydrogel for transdermal delivery of ondansetron: Ex vivo and animal studies” [Colloids Surf. B Biointerfaces, 195, (2020), 111259]
- Colloids and Surfaces B: Biointerfaces
- VOL. 222
on Feb 1, 2023
- Animal Studies
- Colloids Surf
- Hydrogel For Delivery
- Reduced Graphene Oxide Hydrogel
- Graphene Oxide Hydrogel
- Oxide Hydrogel
- More +
Retraction notice to “ Pluronic ® F127 stabilized reduced graphene oxide hydrogel for transdermal delivery of ondansetron: Ex vivo and animal studies ” [ Colloids Surf.... Read More
Maternal Inheritance of Familial Hypercholesterolemia Gene Mutation Predisposes to Coronary Atherosclerosis as Assessed by Calcium Score in Adulthood
- Arteriosclerosis, Thrombosis, and Vascular Biology
- VOL. 43
on Feb 1, 2023
- CAC Score
- Calcium Score
- Subclinical Coronary Atherosclerosis
- Development Of Atherosclerotic Cardiovascular Disease
- Paternal Inheritance
- Potential Cardiovascular Risk Factor
- More +
Background: Animal studies have demonstrated that fetal exposure to high maternal cholesterol levels during pregnancy predisposes to aortic atheroma in the offspring. In humans, little is known about the consequences of this ... Read More
Updated systematic assessment of human, animal and mechanistic evidence demonstrates lack of human carcinogenicity with consumption of aspartame
- Food and Chemical Toxicology
- VOL. 172
on Feb 1, 2023
- Animal Studies
- Flaws In Study Design
- Aspartame Consumption
- RI
- Authoritative Bodies
- Mechanistic Data
- More +
Aspartame has been studied extensively and evaluated for its safety in foods and beverages yet concerns for its potential carcinogenicity have persisted, driven primarily by animal studies conducted at the Ramazzini Institute (RI). To address this co... Read More
Accurate and Early Metastases Diagnosis in Live Animals With Multimodal X-ray and Optical Imaging
- International Journal of Radiation Oncology*Biology*Physics
- VOL. 115
on Feb 1, 2023
- Imaging Capabilities
- Multimodal Imaging
- Efficacy In Animal Studies
- Higher Targeting Accuracy
- Multimodal Imaging System
- Optical Image Reconstruction
- More +
In vivo optical imaging systems are essential to track disease progression and evaluate therapeutic efficacy in animal studies. However, current approaches are limited by their inability to accurately capture 3-dimensional (3-D) image information. To... Read More
Assessment of Effect of Intra-pocket Delivery of Metronidazole Loaded NTrimethyl Quaternary Ammonium Chitosan Nanoparticles in Treatment of Periodontal Disease
- Current Drug Therapy
- VOL. 18
on Feb 1, 2023
- Inflammatory Changes In Tissues
- Ligature Induced Periodontitis Model
- Changes In Tissues
- Gingival Damage
- Tooth Mobility
- Periodontitis Model In Rats
- More +
Background: Conventional drugs like metronidazole for periodontitis has shown several drawbacks. So based on in-vitro and acute toxicity study of metronidazole loaded n-trimethyl quaternary ammonium chitosan nanoparticles (NTMET NPs), animal studies... Read More
Tumor-associated macrophages mediate gastrointestinal stromal tumor cell metastasis through CXCL2/CXCR2
- Cellular Immunology
- VOL. 384
on Feb 1, 2023
- GIST
- Mouse Liver Metastasis Model
- GIST Cells
- TAM
- GIST Tumor
- Differentiation Of THP-1 Cells
- More +
Tumor-associated macrophages (TAMs) are linked with the progression and poor prognosis of multifarious solid tumors, but the regulatory mechanisms involved in gastrointestinal stromal tumors (GIST) remain indistinct. This study intended to delve into... Read More
The FXR mediated anti-depression effect of CDCA underpinned its therapeutic potentiation for MDD
- International Immunopharmacology
- VOL. 115
on Feb 1, 2023
- CDCA
- Chinese MDD Patients
- CSDS Mice
- MDD
- CSDS
- Treatment Of MDD
- More +
Emerging evidence from animal and human studies has suggested that small microbial metabolites generated in the gut influence host mood and behavior. Our previous study reported that patients with major depressive disorder (MDD) reduced the abundance... Read More
Rutin co-treatment prevented cognitive impairment/depression-like behavior and decreased IDO activation following 35 days of ethanol administration in male Wistar rats
- Alcohol
- VOL. 106
on Feb 1, 2023
- Depressive-like Behavior In Rats
- Days Of Ethanol Administration
- Depressive-like Effects
- Increase In Indoleamine
- Decrease In Antioxidant Enzymes
- Markers Of Inflammatory Response
- More +
Alcohol (ethanol) is among the most popularly consumed beverages globally. Ethanol was earlier demonstrated to elicit cognitive impairment and depressive-like effects in both human and animal studies. Rutin (R) is known for its antioxidant, anti-infl... Read More
Multiple roles of fucoxanthin and astaxanthin against Alzheimer's disease: Their pharmacological potential and therapeutic insights
- Brain Research Bulletin
- VOL. 193
on Feb 1, 2023
- Pathologic Features Of AD
- AD
- Deposition Of Amyloid-β
- H2O2-induced Cytotoxicity
- Anti-inflammatory Characteristics
- Therapeutic Insights
- More +
Alzheimer's disease (AD) is the most devastating neurodegenerative disorder affecting the elderly. The exact pathology of AD is not yet fully understood and several hallmarks such as the deposition of amyloid-β, tau hyperphosphorylation, and neuroinf... Read More
Effects of metformin on the bioactivity and osseointegration of dental implants: A systematic review
- Journal of Taibah University Medical Sciences
- VOL. 18
on Feb 1, 2023
- Osseointegration Of Dental Implants
- ARRIVE
- Animal Models
- Osseointegration Of Implants
- Potential Sources Of Bias
- Peri-implant Bone Loss
- More +
Dental implants are prosthetic devices that are surgically placed in direct contact with the jawbone to support intra-oral functions and esthetics. Diabetes mellitus may contribute to peri-implant bone loss. During the last few years, there have been... Read More
Suppressive effects of ketamine on auditory steady-state responses in intact, awake macaques: A non-human primate model of schizophrenia
- Brain Research Bulletin
- VOL. 193
on Feb 1, 2023
- ASSRs
- Awake Macaques
- Ketamine Model Of Schizophrenia
- Event-related Spectral Perturbation
- Awake Macaque Monkeys
- Noncompetitive NMDA Receptor Antagonists
- More +
Auditory steady-state responses (ASSRs) are recurrent neural activities entrained to regular cyclic auditory stimulation. ASSRs are altered in individuals with schizophrenia, and may be related to hypofunction of the N-methyl-D-aspartate (NMDA) gluta... Read More
Olive oil consumption confers protective effects on maternal-fetal outcomes: A systematic review of the evidence
- Nutrition Research
- VOL. 110
on Feb 1, 2023
- Animal Studies
- Olive Oil Consumption
- Maternal-fetal Outcomes
- Prevalence Of Gestational Diabetes Mellitus
- Olive Oil
- Pregnancy Outcomes
- More +
Because of the maternal diet's importance, numerous studies have examined the effects of olive oil on pregnancy outcomes. This study provides a systematic review that evaluates the evidence between olive oil consumption and maternal-fetal outcomes. W... Read More