To fabricate highly reliable Al cables/Cu terminals components and elucidate the microstructure evolution of the joint during ultrasonic welding, ultrasonically welded structures of 50 mm2 Al cables and 2 mm-thick copper terminals were conducted at welding energies from 1200 J to 2800 J and an amplitude of 54.6 μm in this paper. As the welding energy increased, the degree of plastic deformation of the Al wires gradually increased, the microstructure of the Cu side remained basically unchanged, and the effective contact area of the Cu/Al interface was gradually enlarged, enhancing the coherence between the Al wires, and the Cu-Al interfacial structure changed from an unbonded area to continuous mechanical interlocking. Parallelly, the Al grains transformed from fine serrated to equiaxed and lamellar crystals driven by geometric dynamic recrystallization (GDRX), continuous dynamic recrystallization (CDRX), and dynamic recovery (DRV), forming distinct shear textures of B/B̅{111}<110>, Rt Goss{110}<110>, Rt Cube{001}<110> and the recrystallization texture F{111}<112>, and the content of shear textures increased from 2.9% to 17.4%. In addition, the tensile shear failure load of the joint reached 2962 N, which met the requirements of cable installations in the field of new energy vehicles (>1650 N). Fracture analysis showed the fracture location transitioned from the Cu-Al interface to the Al-Al interface with an increase in welding energy from 1600 to 2400 J. This work has theoretical guidance for the continuous promotion of vehicle light-weighting.