Ameliorative Effect Of Vitamin Research Articles

Ameliorative Effect of Vitamin C against Hydroxyurea-Induced Hepatic Toxicity in Male Rats

Ameliorative Effect of Vitamin C against Hydroxyurea-Induced Hepatic Toxicity in Male Rats

Ameliorative Effect of Vitamin D on Articular Cartilage Thickness in Arthritic Rat Model

Objective: To determine the protective effect of vitamin D on the articular cartilage of formalin-induced arthritis in rats.Study Design: Lab–based Experimental study.Place and Duration of Study: The study was carried out at the Department of Anatomy, Islamic International Medical College from September 2020 to September 2021.Methods: We randomly split thirty adult male albino rats weighing between 250 and 300 grams into three groups. (10 in total). On days 1 and 3 of the experiment, formaldehyde was subcutaneously injected into the right paw of every animal, with the exception of those in group A. The usual rat food was given to the rats in Groups A and B. Throughout the trial, Rats in group C were given vitamin D 4000IU/kg orally by adding cholecalciferol (Vitamin D3) injection in a standard diet for 28 days. All of the animals were dissected after the experiment, and the right hind leg was taken out, processed, and stained with H&E for a microscopic assessment of the thickness of the unclarified cartilage. Version 21 of SPSS was used to analyze the results.Results: The oral administration of vitamin D exhibited a significant increase in unclarified cartilage thickness on intergroup comparison.Conclusion: Vitamin D is an effective antiarthritic agent in ameliorating the thickness of articular cartilage thickness in arthritic rat models.
 How to cite this: Shahid A, Beenish H, Khurshid T, Rashid A, Shahid U, Khan M. Ameliorative Effect of Vitamin D on Articular Cartilage Thickness in Arthritic Rat Model. Life and Science. 2024; 5(1): 107-112. doi: http://doi.org/10.37185/LnS.1.1.570

The Ameliorative Effect of Vitamin C against Sub-chronic Thiamethoxam Toxicity in Male Rats

The Ameliorative Effect of Vitamin C against Sub-chronic Thiamethoxam Toxicity in Male Rats

The role of vitamin D through SphK1/S1P in the regulation of MS progression

Sphingosine-1-phosphate (S1P) is biologically active lipid, leading to neuroinflammation and macrophage invasion in central nervous system, plays an important role in the development of multiple sclerosis (MS) model in experimental allergic encephalomyelitis (EAE) rats. Vitamin D is observed to be a key factor in regulating cell S1P levels. We detected vitamin D can alleviate the symptoms of EAE rats, but the exact mechanism is unclear. In PC12 cells, vitamin D can reverse S1P-induced cell death, but the signaling pathway unclear. This study was aimed to investigate S1P regulation mechanism or signaling pathway mediated by vitamin D in EAE and PC12 model. In our experiments, S1P and Sphingosine kinase type 1 (SphK1) mRNA and protein expression in EAE rats group, control group, vitamin D feeding group were detected by HPLC, ELISA, RT-PCR and western blot. PC12 cell death was detected by Propidium (PI) staining. VDR plasmid overexpression and RNA interference, immunofluorescence, real-time cell analysis, protein immunoblotting was used to detect SphK1 transcriptional regulation, cell-substrate attachment quality, the signaling pathway of cell apoptosis and inflammation related gene expression (Bax/Bcl-2, Casepase-3, Il-6, TGF-β, TNF-α). Our study showed vitamin D can reverse the elevation of S1P level in EAE rats, reduce the severity and shorten the course of EAE. 1,25-(OH) 2D3 coupled with vitamin D receptor (VDR) inhibited SphK1 transcription. 1,25-(OH)2D3 significantly reduced PC12 cell death rate induced by S1P, in addition improved the cell substrate attachment quality. 1,25-(OH) 2D3 can block S1P-induced p-ERK activation and PI3K /Akt signaling pathway reduced Il-6, TGF-β, TNF-α cytokine release and Bax/Bcl-2, Casepase-3 apoptosis protein expression. On the other hand, immunofluorescence staining showed 1,25-(OH) 2D3 can increase the expression of neuronal perinuclear protein MAP2 in PC12 cells probably protect nerve cells further. In summary, the ameliorative effect of vitamin D was derived from its ability to reduce S1P levels, provides an idea for vitamin D as a combination therapy for disease.

Ameliorative Activity of Vitamin C against Alcohol Induced Cardio-toxicity in Adult Male Wistar Rats

Highlights: 1. Ameliorative effects of vitamin C against alcohol in this research are very interesting to be observed. 2. Vitamin C may have some beneficial effects on heart function by acting as an antioxidant. - Background: Alcohol and it metabolites causes cardiomyopathy, which is one of the main form of alcohol induced heart damage. The aim of the present study was to investigate the protective effect of vitamin C against alcohol-induced heart toxicity and selected indices. Material and Methods: Forty healthy male Wistar rats were used in this experiment, which lasted 21 days. The rats were divided into eight groups, with five rats in each group. Group A received only distilled water, Group B received 6000 mg/kg of alcohol, and Groups C to H received different doses of vitamin C and alcohol in varying combinations. Blood samples were collected and analyzed for levels of sodium, potassium, and chloride ions. The hearts were also analyzed for antioxidant activities and histo-pathological changes. Results: The findings indicated that alcohol administration caused a decrease in blood electrolyte levels compared to the control group, while treatment with vitamin C and co-administration of vitamin C and alcohol improved blood electrolyte levels. The antioxidant enzymes activity of the heart improved in the vitamin C and co-administration groups, as evidenced by increased GSH, SOD, and CAT activity and decreased MDA levels when compared to the alcohol-only group. Conclusion: Therefore, this study suggests that commercial grade vitamin C at doses of 100 mg/kg, 200 mg/kg, and 300 mg/kg can protect the heart against alcohol-induced toxicity. However, further research is necessary to examine the anti-inflammatory effect of commercial grade vitamin C.

Ameliorative Effects of Vitamin C and Methanolic Extract of Broccoli on Cyclophosphamide-induced Poisoning in Ovary of Rat

Introduction: Considering the importance of using herbal compounds to reduce the side effects of cyclophosphamide (CPH), the current study aimed to evaluate the effects of broccoli extract and Vitamin C on ovarian poisoning with CPH. Materials and methods: Four equal groups of 48 adult female Wistar rats were formed. The first group that was control received physiological saline orally without treatment. A 200 mg/kg dose of CPH was administered intraperitoneally to the second group. For the third group, CPH was supplemented with 300 mg/kg of Vitamin C, and methanol extract of broccoli 300 mg/kg was used in the fourth group. The serum total antioxidant capacity (TAC), interleukin-1 and tumor necrosis factor alpha (TNFα) and ovarian tissue glutathione peroxidase (GPx), superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), were measured. At the end of the study, the ovarian tissue was cut and stained for histopathological investigations. Results: Ovarian tissue GPx, CAT, and SOD values indicated a significant decrease in the CPH group compared to other groups. In the CPH plus broccoli group, there was a significant decrease in MDA ovarian tissue and IL-1 and TNF-α in serum, compared to the CPH group. There were significant negative changes in ovarian cells of the CPH group, compared to the control and other treatment groups. Conclusion: The current study suggested that administrating broccoli extract plus CPH could increase the superior antioxidant potential, compared to Vitamin C. This can potentially decrease CPH-induced damage to the ovary of rats, thereby improving their fertility status.

Ameliorative Effects of Vitamin C and Vanillin against Potassium Bromate Toxicity in Male Albino Rats: Biochemical, Hematological and Histological study

Ameliorative Effects of Vitamin C and Vanillin against Potassium Bromate Toxicity in Male Albino Rats: Biochemical, Hematological and Histological study

The possible ameliorative effects of vitamin E against cisplatin-induced injury on adult rat liver and testes

Cisplatin is one of the most potent cytotoxic drugs used to treat cancer, but clinical use is linked to testicular and liver damage. According to a number of studies, antioxidant supplementation may have an impact on the toxicity caused by cisplatin. The purpose of the current investigation was to determine how vitamin-E supplementation protected rats from cisplatin-induced damage. Thirty laboratory adult male albino rats were divided into three groups: Group I received saline orally, once daily for 21 days. Group II received cisplatin on day 0, 7, 14 and were sacrificed on day 21. Group III received cisplatin on day 0, 7, 14 and received orally vitamin E daily, starting 5 days before the first dose of cisplatin until day 21. Liver and both testes were obtained and fixed. Sections from the liver and both testes were stained by H&E and Trichrome stain, and then examined under light microscope. Alterations included a significant increase in malondialdehyde (MDA) level in the cisplatin group compared with the other groups (p value for comparing between control and each other group, statistically significant at p ≤ 0.05). Histopathologically, cisplatin induced signs of hepatic injury; it also showed signs of testicular degeneration in all rats. However, the cisplatin induced disturbances significantly improved by treatment with Vitamin E. Statistical analysis showed a significant difference among the three groups in all signs of injury (p<0.001). According to this research, cisplatin has a toxic impact on the liver and testicles, and when it is administered along with vitamin E, a noticeable improvement is seen.

Lambda cyhalothrin and chlorantraniliprole caused biochemical, histological, and immunohistochemical alterations in male rabbit liver: Ameliorative effect of vitamins A, D, E, C mixture

Pesticides can cause serious environmental and human health consequences such as metabolic disruption and even cancers. Preventive molecules such as vitamins can be an effective solution. The present study aimed to investigate the toxic effect of an insecticide mixture formulation of lambda cyhalothrin and chlorantraniliprole (Ampligo® 150 ZC), on the liver of male rabbits (Oryctolagus cuniculus) and the possible ameliorative effect of vitamins A, D3, E, and C mixture. For that, 18 male rabbits were divided into 3 equal groups: Control (distilled water), AP (20 mg/Kg bw of the insecticide mixture every other day, orally for 28 days), AP+ADEC (20 mg/Kg bw of the insecticide mixture + 0,5 ml of vitamin AD3E+ 200 mg/kg bw of vitamin C every other day). The effects were evaluated on body weight, food intake changes, biochemical parameters, liver histology, and immunohistochemical expression of AFP, Bcl2, E-cadherin, Ki67, and P53. Results indicated that AP reduced weight gain (6.71%) and feed intake, increased ALT, ALP, and TC plasma levels, and caused hepatic tissular damages such as dilatation and congestion of the central vein, sinusoidal dilatation, inflammatory cells infiltration, and collagen deposition. Hepatic immunostaining showed an increase in the tissular expression of AFP, Bcl2, Ki67, and P53 and a significant (p < 0,05) decrease in E-cadherin expression. In contrast, supplementation of vitamins A, D3, E, and C mixture improved the previous observed alterations. Our study revealed that a sub-acute exposure to an insecticide mixture of lambda cyhalothrin and chlorantraniliprole induced numerous functional and structural disorders in the rabbit liver and the addition of vitamins ameliorated these damages.

Ameliorative Effect of Vitamin E on Paraquat Induced Nephrotoxicity in Rat

The kidney is a very vital organ required for excretion of metabolic waste products in the body and when the kidney is damaged, this function is compromised. Paraquat is a toxicant that is known to have toxic injuries in different organs. Therefore, the aim of this study was to uncover the treatment effect of vitamin E in paraquat inflicted kidney injury. The experimental animals (male rats) were 200 and they were classified into 4 groups designated as A, B, C and D. The A served as the control group, B, C and D were test groups classified based on dose of paraquat administered. A was not treated with paraquat, B, C and D were treated with 0.02g, 0.04g and 0.06g of paraquat respectively every two weeks for three months. Each group mentioned had subgroups designated “0” and “VE”; “0” subgroups were subgroups not treated with vitamin E while “VE” were subgroups treated with 500mg of vitamin E. Treatment of vitamin E occurred weekly for one month. Both vitamin E and paraquat treatments occurred orally. After treatment period rats were sacrificed and blood sample collected via cardiac puncture for urea and creatinine assay. The results showed that there was no significant difference in urea levels among paraquat alone treated groups but there was a significant increase in creatinine levels among paraquat alone treated groups. There was a significant decrease in creatinine level after vitamin E treatment. This study has shown that vitamin E is a therapeutic hope for paraquat inflicted nephrotoxicity in rats.

Ameliorative Effect of Vitamin E and C on Paraquat Induced Nephrotoxicity in Rat

The kidney is an exceptionally essential organ required for metabolic byproducts elimination in the body and when the kidney is impaired, this role is compromised. Paraquat is a poison that is known to have harmful effect in various organs. Subsequently, the point of this study was to reveal the treatment impact of vitamin E and C in paraquat poisoned kidney in rat. The rat were 200 and they were classified into 4 groups assigned as A, B, C and D. The A group was the control, B, C and D were test groups classified in light of dose of paraquat given. “A” was not treated with paraquat, B, C and D were treated with 0.02g, 0.04g and 0.06g of paraquat separately at regular intervals of 2 weeks for 3 months. Each group had subgroups assigned "0" and "VEC"; "0" subgroups were subgroups not treated with vitamin E while "VEC" were subgroups treated with 500mg of vitamin E and 2000mg/dl vitamin C. Treatment of vitamin E and C happened week after week for one month. Both vitamins and paraquat treatment happened orally. After treatment period, the rats were sacrificed and blood sample collected through cardiac puncture for urea and creatinine assay. The outcomes showed that there was no significant difference in urea levels among only paraquat treated groups yet there was a significant increase in creatinine levels among only paraquat treatment groups. There was a significant decrease in creatinine level after vitamin E and C treatment. This study has shown that vitamin E and C is capable of restoring kidney function paraquat induced nephrotoxicity in rat.

Vitamin C supplementation for diabetes management: A comprehensive narrative review.

Growing evidence suggests that vitamin C supplementation may be an effective adjunct therapy in the management of people with diabetes. This paper critically reviews the current evidence on effects of vitamin C supplementation and its potential mechanisms in diabetes management. Evidence from meta-analyses of randomized controlled trials (RCTs) show favourable effects of vitamin C on glycaemic control and blood pressure that may be clinically meaningful, and mixed effects on blood lipids and endothelial function. However, evidence is mostly of low evidence certainty. Emerging evidence is promising for effects of vitamin C supplementation on some diabetes complications, particularly diabetic foot ulcers. However, there is a notable lack of robust and well-designed studies exploring effects of vitamin C as a single compound supplement on diabetes prevention and patient-important outcomes (i.e. prevention and amelioration of diabetes complications). RCTs are also required to investigate potential preventative or ameliorative effects of vitamin C on gestational diabetes outcomes. Oral vitamin C doses of 500-1000mg per day are potentially effective, safe, and affordable for many individuals with diabetes. However, personalisation of supplementation regimens that consider factors such as vitamin C status, disease status, current glycaemic control, vitamin C intake, redox status, and genotype is important to optimize vitamin C's therapeutic effects safely. Finally, given a high prevalence of vitamin C deficiency in patients with complications, it is recommended that plasma vitamin C concentration be measured and monitored in the clinic setting.

Ameliorative Effect of Vitamin E on Paraquat Induced Haematological Disorder in Male Albino Rats

Paraquat is a controversial herbicide that can increase reactive oxygen species levels by undergoing redox cycling and producing reactive oxygen species such superoxide anion. Vitamin E is a fat soluble vitamin that modulates oxidation processes in the body due to its particular antioxidant activity. It is a powerful chain-breaking antioxidant that limits the synthesis of reactive oxygen species molecules. The goal of the study was to see if vitamin E had a short-term therapeutic impact on paraquat-induced male albino rats. For the experiment, 200 male albino rats were employed. The 200 rats were separated into four primary groups (A, B, C, and D), each of which included 50 rats and was then subdivided into two subgroups, each with 25 rats. The "A" group was not induced paraquat, but the "B," "C," and "D" groups were induced 0.02g, 0.04g, and 0.06g of paraquat, respectively. The "A" group was divided into two subgroups: "A0" and "AVE," which represented the subgroups that were not given Vit E and those who were given Vit E (500 mg) respectively. This design was similar for groups "B," "C," and "D." The frequency of paraquat introduction was fortnightly for three months, then followed by vitamin E treatment weekly for two month. After the treatment with Vit E, the rats were sacrificed and blood was taken to analyze several hematological parameters (Hemoglobin concentration [Hb], Packed Cell volume [PCV], Total White blood cell count [T-WBC], Neutrophils and Lymphocytes). These hematological parameters differed significantly across the "Ao," "Bo," "Co," and "Do" groups, at p-value &lt; 0.05. This was equally true for the "Ave," "Bve," "Cve," and "Dve," groups at p-value &lt; 0.05. The findings also revealed that intra-group comparisons of Hb, PCV levels between B0 vs Bve, C0 vs Cve, and D0 vs Dve were significant different, p-value&lt;0.05 whereas WBC, neutrophils and lymphocytes were not p-value&gt;0.05. This study has shown that PQ insult on anaemia indicators in rats can be corrected by a weekly administration of the vitamin.

Ameliorative effect of vitamin E and selenium against bisphenol A-induced toxicity in spinal cord and submandibular salivary glands of adult male albino rats

ABSTRACT Bisphenol A (BPA) used in plastic industry. This study evaluate ameliorative effect of vitamin E and selenium in combating BPA toxicity in spinal cord (SC) and submandibular glands (SMGs). Thirty rats divided into three groups [Group I, controls; Group II, BPA orally (25 mg/kg) three times a week, 60 days; Group III, BPA (25 mg/kg) plus vitamin E and selenium in water (1 ml/L/day)]. By histopathological, immunohistochemical, and biochemical investigations. Bisphenol A group showed degenerative alterations. SC gray matter showed pyknotic nuclei and white matter revealed neuropil degeneration. Myelinated fibers showed dispersed myelin. SMGs, exhibited vacuolated cytoplasm in acinar cells. Intense glial fibrillary acidic protein in SC and strong proliferating cell nuclear antigen in acinar and ductal cell nuclei of SMGs. Malondialdehyde elevated in SC and catalase decreased in SMG. Group III, SC and SMG revealed partial recovery. Vitamin E and selenium displayed protective effects against BPA toxicity in SC and SMGs.

Histomorphometric features of hepatic toxicity caused by carbamazepine and its amelioration with vitamin E.

Background: Carbamazepine, a commonly prescribed anti-epileptic drug, is potentially hepatotoxic. This laboratory-based experimental study was designed to observe the toxicity of Carbamazepine and the ameliorative effects of Vitamin E on liver tissue.&#x0D; Methodology: A total of 54 rats were randomly divided into 3 groups. Group A was the control; group B was given oral Carbamazepine, and group C was given Carbamazepine with Vitamin E daily for 6 weeks. At the end of the study period, animals were sacrificed, their liver was preserved, and tissue was stained with Hematoxylin and Eosin.&#x0D; Results: The mean final body weights of Carbamazepine treated group B (147.27 ± 13.72 gm) and Carbamazepine + Vitamin E protected group C (164.43 ± 10.73 gm) were decreased significantly in comparison to control A (194.03 ± 14.87 gm). Mean absolute and relative liver weights were increased significantly in groups B &amp; C as compared to group A. Histological examination of liver in group B showed disturbed architecture of hepatic lobules including congested central vein, dilated sinusoids, pyknotic nuclei, steatosis, portal vein dilatation, hemorrhages, and mononuclear infiltration in the portal triad and around the central vein. These changes were reduced in group C. Micrometry confirmed the histological findings, with a significant decrease in mean hepatic cell count and mean hepatocyte nuclear diameter of group B as compared to control group A (6.00 ± 1.41 &amp; 5.62 ± 0.69 µm respectively), and a significant increase in mean hepatocyte diameter of group B in comparison to group A (17.44 ± 1.29 µm).&#x0D; Conclusion: This study showed that Carbamazepine caused hepatotoxicity while Vitamin E was helpful in its amelioration.

Ameliorative effect of vitamin C on cypermethrin-induced hepatotoxicity and renal malfunction of adult male rats.

Cypermethrin is a widely used insecticide belongs to type II pyrethroids. It is highly used in developing countries to control many species of insects as it plays an important role in pest control. Vitamin C is an important intracellular antioxidant against insecticides. The aim of the present study is to analyze the toxic effects of cypermethrin (CYP) and the positive effect of vitamin C (VC) with graded doses (0 CYP, 200 VC, 12 CYP and 12 CYP+200 VC mg/kg body weight of male rats/day) for 30 days on liver and kidney functions. Moreover, antioxidant enzymes, oxidative stress markers, glycogen and glucose levels and also serum lipid profile were studied. Also, this study aimed to evaluate the possible protective role of vitamin C against cypermethrin toxicity

Ameliorative Effect of Vitamin E and Panax ginseng Against Some Adverse Effects of Levofloxacin in Male Rats

Ameliorative Effect of Vitamin E and Panax ginseng Against Some Adverse Effects of Levofloxacin in Male Rats

Ameliorative effect of vitamins (E and C) on biochemical alterations induced by sublethal concentrations of zinc oxide bulk and nanoparticles in Oreochromis niloticus

The comparison between bulk and nano ZnO particles were antecedently studied but describing the dose-dependent toxicity and the ameliorative effect of vitamins (E and C) in Oreochromis niloticus, have not been previously documented. Therefore, the present study was designed to investigate the ameliorative effect of vitamins (E and C) against oxidative stress and biochemical alterations induced by sublethal concentrations of zinc oxide bulk particles (ZnOBPs) and zinc oxide nanoparticles (ZnONPs). Toxicity tests were carried out on O. niloticus and showed that 96 h LC50 values of ZnOBPs and ZnONPs were 84 mg/l and 5.6 mg/l respectively. Exposure of the studied fish to these sublethel concentrations for 7, 14, 21 & 28 days showed a significant increase (p < 0.05) in serum glucose, AST, ALT, creatinine, urea and uric acid compared to control groups while, fish groups exposed to ZnOBPs or ZnONPs and supplemented with vitamins E and C, their serum enzyme concentrations were decreased compared to the groups without supplementation after 7, 14, 21 and 28 day. On the other hand, antioxidant defense enzymes (SOD, CAT and GST) activity in O.niloticus fish were increased significantly (p < 0.05) when exposed to sublethal concentrations of ZnOBPs or ZnONPs compared to the control value. However, fish groups supplemented with vitamins (E and C) have a decrease in SOD, CAT and GST enzymes activity when compared to unsupplemented groups and the values returned to similar levels established in the control at low concentrations but still higher than control at the high concentrations.

Ameliorative effect of Vitamin C, Electrolyte and Jaggery on Transportation Stress at different flocking densities in Hot Humid and Winter Seasons on Hormonal parameters of goats

The present study evaluated the seasonal effects of transportation of goats (Alpine x Beetal) at different flocking densities, supplemented with Vitamin C in group I, Vitamin C + Electrolyte in group II and in group III Jaggery, 3 days before transport of animal, during winter and hot-humid seasons. The goats were selected from LRC, NDRI Karnal and were between 10-12 months old. Each group consisted of 25 goats each, divided into high (15) and low (10) flocking densities, with an average speed of 25 Km/h transported for 8h. During the transportation period, all the animals were kept off-feed and deprived of water. Blood samples were taken just before transportation, immediately after transportation, 6hrs, 12 hrs, 24 hrs and 2 days post transportation from all the three groups. The blood samples were further analyzed for the estimation of different hormonal parameters (Cortisol, Prolactin, T3, and T4). In all the three groups of goats, higher pre transportation values of T4 and T3 (P<0.05) were observed in both the seasons and in all the density groups of goats whereas cortisol and prolactin levels were maximum (P<0.05) just after unloading. Supplementation with Vitamin C, Vitamin C + Electrolyte and Jaggery aided in reducing transportation stress but Vitamin C + Electrolyte combination proved more beneficial in alleviating transportation stress in the goats.

Ameliorative effect of vitamin E against radiofrequency radiation emitted from mobile phone-induced hematological and histopathological alterations in male albino mice

Abstract Radiofrequency radiation is widespread in the surrounding environment and their frequent sources are mobile phones. Consequently, the present research was aimed to study the effect of radiofrequency radiation released from mobile phones on some hematological parameters (RBC, HB, MCV, MCH, MCHC, WBC, P LT, LYM %) and histopathological changes in male white mice. In this work, forty adult male albino mice (25-30 gm weight) divided into four equal groups; A, B, C, and D. Group A was used as a negative control group, Group B used as a negative control group for vitamin E solution, group C was exposed to EMR for 2hr ⁄day for 3 weeks without vitamin E and Group D, treated with Vitamin E solution and exposed to EMR for 2hr ⁄day for 3 weeks. The obtained results revealed that significant changes in RBCs, Hb, HCT, MCV, MCHC, PLT, and WBCs were observed in group C. Additionally, variable histopathological alterations in the liver, kidney, lung, heart, spleen, and brain post-exposure to mobile phone radiation were also demonstrated. Vitamin E has improved these harmful effects induced by radiofrequency radiation on different investigated tissues via their capacity to decline the pathological alterations demonstrated in these organs post-exposure to mobile phone radiation as well as via improving different evaluated blood parameters. Consequently, we could conclude that, vitamin E was able extensively to reduce the harmful influences of mobile phone radiation on blood parameters and the histopathological changes in the liver, kidney, lung, heart, spleen and brain tissues.