Abstract
Cypermethrin is a widely used insecticide belongs to type II pyrethroids. It is highly used in developing countries to control many species of insects as it plays an important role in pest control. Vitamin C is an important intracellular antioxidant against insecticides. The aim of the present study is to analyze the toxic effects of cypermethrin (CYP) and the positive effect of vitamin C (VC) with graded doses (0 CYP, 200 VC, 12 CYP and 12 CYP+200 VC mg/kg body weight of male rats/day) for 30 days on liver and kidney functions. Moreover, antioxidant enzymes, oxidative stress markers, glycogen and glucose levels and also serum lipid profile were studied. Also, this study aimed to evaluate the possible protective role of vitamin C against cypermethrin toxicity
Highlights
Pyrethroid is a group of highly potent lipophilic insecticides and is broadly divided into two types: Type 1 pyrethroids affect the sodium channels in nerve membranes, opening them for relatively short periods
For vitamin C (VC) treated group, there is slightly non-significant difference in alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), acid phosphatase (ACP) and lactate dehydrogenase (LDH) compared to the control group
For the group treated with cypermethrin in combination with VC, these is slightly a significant decrease in ALT, AST, ALP and LDH but no significant decrease in ACP was observed compared with cypermethrin -only treated rats
Summary
Pyrethroid is a group of highly potent lipophilic insecticides and is broadly divided into two types: Type 1 pyrethroids affect the sodium channels in nerve membranes, opening them for relatively short periods. Type II pyrethroids produce a longer delay in sodium channels inactivation, leading to persistent depolarization of the nerve membrane without repetitive discharge (Lamberth et al, 2013). Studies on pyrethroid I and II and first generation synthetic pyrethroids showed low mammalian toxicity. Previous studies have reported data indicating that these pyrethroids have induced oxidative stress via the generation of free oxygen radicals. Huang et al, (2007) has indicated that abnormal production of free radicals leads to damage of some macromolecules, including lipid, proteins, and nucleic acid, this is believed to be included in the etiology of many chemicals and diseases
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