Distributed anode current (DAC) is a high-dimensional spatial-distributed signal that can be measured online in the industrial aluminum electrolysis process. The difference of physicochemical properties in different spatial regions in an aluminum electrolysis cell can be obtained by spatial clustering analysis of DAC data. In this study, a dynamic spatial distributed information clustering method (DSDIC) for aluminum electrolysis cell is proposed. This method can effectively capture the complex dynamic spatio-temporal correlations in DAC. Firstly, the dynamic graph is identified to capture the complex dynamicity of the DAC. Then, the anode-spatial structure information (ASSI) extends the one-dimensional current signal generated by each carbon anode into a feature matrix to achieve the fusion of data and spatial structure knowledge. Finally, the adjacency matrix of dynamic graph performs low-pass filtering on the feature matrix to obtain low-frequency information that is beneficial to downstream learning tasks. Meanwhile, a fixed graph structure based on process mechanism knowledge is designed to capture the spatial correlation caused by external periodic operations in industrial process. The experimental results on the actual industrial aluminum electrolysis datasets show that our method improves the clustering accuracy by 3.96% compared with existing clustering methods.