Adverse Phenomena Research Articles

Nature Management and Adverse Hydrometeorological Phenomena in Northern Bukovina in the XVIII – Early XX Centuries

Climate change remains the most pressing issue in the world today, resulting in the intensification of adverse hydrometeorological phenomena. In the regional context, local peculiarities of climate change are important, as each region is characterized by a certain set of adverse phenomena. The purpose of the article is to analyze the distribution and frequency of recurrence of adverse hydrometeorological phenomena, as well as their impact on the natural resources of Northern Bukovina in the eighteenth and early twentieth centuries; changes in natural resources use within the plains, foothills and mountains of Northern Bukovina. In accordance with the purpose, a comparative characterization of the past and present climate of Northern Bukovina was carried out, documentary data on the manifestation of adverse phenomena in the eighteenth - early twentieth centuries in Northern Bukovina were analyzed. The frequency of these phenomena is also revealed; the most recurrent and widespread within the region are highlighted; the years with adverse events that caused the greatest damage are described; the largest floods and droughts are indexed by the scale of their consequences; changes in the use of natural resources in Northern Bukovyna are considered and the impact of floods and droughts on natural resources is revealed. The main unfavorable hydrometeorological phenomena within Northern Bukovyna in the eighteenth and early twentieth centuries are considered. Data from the archives of the Austro-Hungarian period show that the most recurrent and characteristic of these events are: droughts, floods, heavy rainfall with thunderstorms, hail and storms, cold winters. Documentary data on droughts and floods correlate with instrumental data. Keywords: climate, nature management, adverse hydrometeorological events, floods, droughts, Northern Bukovyna.

Establishing an Appropriate Voltage Window for Stable Cycling of Li/Mn-Rich Layered Oxide || Graphite Full Cells

Li/Mn-rich layered oxide cathode active materials (LMR) have gained attention due to their exceptionally high practical specific discharge capacity (>250 mAh g-1) originating from both conventional cationic as well as anionic oxygen redox contributions. To achieve this high capacity, the Li2MnO3-like regions of the material, which give rise to oxygen redox need to be electrochemically activated at high voltage (above 4.6 V versus Li+/Li0). This high voltage activation, however, results in the destabilization of lattice oxygen that creates subsequent adverse phenomena such as first-cycle hysteresis and the evolution of redox couples. The latter happens continuously during cycling and results in the activation of Mn3+/Mn4+ redox couple. This redox couple involving Mn3+ is problematic because, at this oxidation state, Mn disproportionation reaction can occur, resulting in the formation of highly soluble Mn2+ species. In a half-cell setup, the impact of Mn dissolution may be subtle, however, in LMR||Graphite full cells, the impact is consequential.This work focuses on investigating the degradation mechanism of LMR||Graphite full cells at different voltage windows applied during the activation cycles and the long-term cycling. These different voltage windows alter the redox contributions and thus affect the long-term performance of the cells. We observe that lowering the upper cut-off voltage (UCV) from 4.7 V to 4.5 V during the entire cycling process can increase capacity retention, although rapid degradation can still be observed. Only when the UCV during the long-term cycling is lowered to 4.3 V, can we obtain incremental degradation of the cells. We also show that lowering the activation cycles UCV to 4.5 V is beneficial for long-term cycling due to the lower contribution of Mn3+/Mn4+ redox couple after the activation cycles. Finally, we observe that increasing the lower cut-off voltage from 1.9 V to 2.4 V results in higher discharge voltage. Nevertheless it is followed by a reduction in discharge capacity, resulting in a lower specific energy. This study offers insights into the high-voltage cycling performance of practical LMR||Gr full cells that can be used for the foundation of material design to alleviate the adverse effect of oxygen redox in LMR.

Seismic performance of multi-span continuous reinforced concrete bridges considering flood-induced scour effects

Flood-induced scours near the pier foundation are an adverse phenomenon that may cause the collapse of bridges. However, in the seismic design of bridges, the scour impact is commonly ignored when evaluating the seismic response. This study aims to quantify the effect of flood-induced scours on nonlinear static and dynamic behaviors of typical reinforced concrete bridges. For this regard, three-dimensional finite element models of two- and three-span bridges with a multi-cell box girder, circular column bent, and extended pile-shaft foundation are first developed, where the column bent is modeled considering the material and geometry nonlinearity. The interaction between the soil and structure is also accounted for by using soil spring models. By considering different scour depths, the modal, static pushover, and dynamic time-history analyses of the bridges in both directions are investigated. It is observed from the modal analysis that the fundamental periods of the bridges increase with the increase of scour depth. In addition, the results in terms of the column drift ratio show that scour may increase the seismic damage to the bridges, which transfers damage from the column bent to the pile-shaft foundation. The findings of this study exhibit the significant effect of the scour on the seismic damage of reinforced concrete bridges; therefore, it is recommended that this phenomenon should be considered in the bridge seismic design.

Социальный капитал науки как фактор инновационного развития

This article distinguishes and describes the characteristic features of social capital formation in science and the factors influencing this process. It is emphasized that the above phenomenon is an integral part of the general social capital of the state and forms the foundation of the national capital. Consequently, the level of socio-economic development of a country correlates with the degree of R&D development in it. The data of the report “Global Innovation Index – 2020” are analyzed, on the basis of which the strengths and weaknesses of Russia’s modernization system are highlighted. An overview of the features of domestic science funding in comparison with some countries of the world is given. The data on the number of researchers in Russia for several years are studied, which revealed a negative trend towards a decrease in the number of those willing to professional-ly engage in science.Conclusion dwells upon the fact that the existence of this kind of activity is a key condition for the society’s progressive development, as its results ensure the renewal and improvement of all spheres of human life, so stagnation in research, caused, among other things, by inefficient and insufficient funding of the sphere of science, is capable of provoking adverse phenomena in society.

Stabilizing Zn Metal Anode Through Regulation of Zn Ion Transfer and Interfacial Behavior with a Fast Ion Conductor Protective Layer.

Aqueous Zn-ion batteries (AZIBs) attract intensive attention owing to their environmental friendliness, cost-effectiveness, innate safety, and high specific capacity. However, the practical applications of AZIBs are hindered by several adverse phenomena, including corrosion, Zn dendrites, and hydrogen evolution. Herein, a Zn anode decorated with a 3D porous-structured Na3 V2 (PO4)3 (NVP@Zn) is obtained, where the NVP reconstruct the electrolyte/anode interface. The resulting NVP@Zn anode can provide a large quantity of fast and stable channels, facilitating enhanced Zn ion deposition kinetics and regulating the Zn ions transport process through the ion confinement effect. The NASICON-type NVP protective layer promote the desolvation process due to its nanopore structure, thus effectively avoiding side reactions. Theoretical calculations indicate that the NVP@Zn electrode has a higher Zn ion binding energy and a higher migration barrier, which demonstrates that NVP protective layer can enhance Zn ion deposition kinetics and prevent the unfettered 2D diffusion of Zn ions. Therefore, the results show that NVP@Zn/MnO2 full cell can maintain a high specific discharge capacity of 168mAhg-1 and a high-capacity retention rate of 74.6% after cycling. The extraordinary results obtained with this strategy have confirmed the promising applications of NVP in high-performance AZIBs.

Hybrid Smart Strategies to Predict Amine Thermal Degradation in Industrial CO2 Capture Processes.

CO2 emission reduction is an essential step to achieve the climate change targets. Solvent-based post-combustion CO2 capture (PCC) processes are efficient to be retrofitted to the existing industrial operations/installations. Solvent degradation (and/or loss) is one of the main concerns in the PCC processes. In this study, the thermal degradation of monoethanolamine (MEA) is investigated through the utilization of hybrid connectionist strategies, including an artificial neural network-particle swarm optimization (ANN-PSO), a coupled simulated annealing-least squares support vector machine (CSA-LSSVM), and an adaptive neuro-fuzzy inference system (ANFIS). Moreover, gene expression programming (GEP) is employed to generate a correlation that relates the solvent concentration to the operating variables involved in the adverse phenomenon of solvent thermal degradation. The input variables are the MEA initial concentration, CO2 loading, temperature, and time, and the output variable is the remaining/final MEA concentration after the degradation phenomenon. According to the training and testing phases, the most accurate model is ANFIS, and the reliability/performance of its optimal network is assessed by the coefficient of determination (R2), mean squared error, and average absolute relative error percentage, which are 0.992, 0.066, and 2.745, respectively. This study reveals that the solvent initial concentration has the most significant impact, and temperature plays the second most influential effect on solvent degradation. The developed models can be used to predict the thermal degradation of any solvent in a solvent-based PCC process regardless of the complicated reactions involved in the degradation phenomenon. The models introduced in this study can be employed for the development of more accurate hybrid models to optimize the proposed systems in terms of cost, energy, and environmental prospects.

Post-Traumatic Stress Disorder among Polish Healthcare Staff in the Era of the COVID-19 Pandemic.

The COVID-19 pandemic has brought many adverse phenomena, particularly in the area of health for both individuals and society as a whole. Healthcare staff also suffered dire consequences. The aim of this study was to assess whether the COVID-19 pandemic increased the risk of post-traumatic stress disorder among healthcare professionals in Poland. The survey was conducted between 4 April 2022 and 4 May 2022. The study applied the Computer Assisted Web Interview (CAWI) technique using the standardised Peritraumatic Distress Inventory (PDI) questionnaire. The average score obtained by the respondents on the PDI was 21.24 ± 8.97. There was a statistically significant difference between the average PDI score obtained based on the gender of the subject (Z = 3.873, p = 0.0001.) The score obtained amongst nurses was statistically significantly higher compared to the paramedic group (H = 6.998, p = 0.030). There was no statistically significant difference between the average PDI score obtained based on the age of the participants (F = 1.282, p = 0.281), nor with their length of service (F = 0.934, p = 0.424). A total of 82.44% of the respondents received 14 PDI points, the cut-off point indicating the risk of PTSD that was adopted in the study. It was concluded that 6.12% of respondents did not require intervention (<7 PDI score); 74.28% of respondents needed further follow-up for PTSD and a reassessment of the PDI approximately 6 weeks after the initial testing; and 19.59% required coverage for PTSD prevention and mitigation (>28 PDI score). The study has shown a high risk of post-traumatic stress disorder among healthcare professionals in Poland. This risk is related to the gender of the respondents, with an indication of a higher risk of PTSD among women. The results have also shown a correlation between increased risk of post-traumatic stress disorder and occupation, with nurses being the most affected group. In contrast, no association has been found in terms of age and length of service for an increase in the risk of PTSD, following exposure to trauma in relation to healthcare services during the COVID-19 pandemic.

Role of anti-polyethylene glycol (PEG) antibodies in the allergic reactions to PEG-containing Covid-19 vaccines: Evidence for immunogenicity of PEG

A small fraction of recipients who receive polyethylene-glycol (PEG)-containing COVID-19 mRNA-LNP vaccines (Comirnaty and Spikevax) develop hypersensitivity reactions (HSRs) or anaphylaxis. A causal role of anti-PEG antibodies (Abs) has been proposed, but not yet been proven in humans.We used ELISA for serial measurements of SARS-CoV-2 neutralizing Ab (anti-S) and anti-PEG IgG/IgM Ab levels before and after the first and subsequent booster vaccinations with mRNA-LNP vaccines in a total of 291 blood donors. The HSRs in 15 subjects were graded and correlated with anti-PEG IgG/IgM, just as the anti-S and anti-PEG Ab levels with each other. The impacts of gender, allergy, mastocytosis and use of cosmetics were also analyzed. Serial testing of two or more plasma samples showed substantial individual variation of anti-S Ab levels after repeated vaccinations, just as the levels of anti-PEG IgG and IgM, which were over baseline in 98–99 % of unvaccinated individuals. About 3-4 % of subjects in the strongly left-skewed distribution had 15–45-fold higher values than the median, referred to as anti-PEG Ab supercarriers. Both vaccines caused significant rises of anti-PEG IgG/IgM with >10-fold rises in about ∼10 % of Comirnaty, and all Spikevax recipients. The anti-PEG IgG and/or IgM levels in the 15 vaccine reactors (3 anaphylaxis) were significantly higher compared to nonreactors. Serial testing of plasma showed significant correlation between the booster injection-induced rises of anti-S and anti-PEG IgGs, suggesting coupled anti-S and anti-PEG immunogenicity.Conclusions: The small percentage of people who have extremelevels of anti-PEG Ab in their blood may be at increased risk for HSRs/anaphylaxis to PEGylated vaccines and other PEGylated injectables. This risk might be further increased by the anti-PEG immunogenicity of these vaccines. Screening for anti-PEG Ab “supercarriers” may help predicting reactors and thus preventing these adverse phenomena.

When it rains it pours? A time-series approach to the relationship between homicide and other adverse health phenomena

AimThis paper aims to better understand the relationship between homicide and other public health outcomes, by studying their trends over time.Subject and methodsResearch in both criminology and public health has long identified that crime and violence tend to cluster together with adverse phenomena in the social and health domains. However, such work has relied primarily on cross-sectional analyses. Here, we instead study trends over time. We take data from the Netherlands, between 2000 and 2020, and ask whether homicide shows similar trends over time as other public health phenomena – such as smoking behaviour, alcohol use, child mortality, adolescent pregnancies, and suicide.ResultsWe observe, first, that all of the phenomena – with the exception of suicide – declined over the period under study. We then employ a time series analysis to examine whether these trends arise independently, or whether they are the result of structural similarities between phenomena. Results showed that the decline in homicide rates is linked to a similar decline in adolescent pregnancies – the rates of these phenomena ‘move together’ during the period under study.ConclusionThis work shows that the phenomenon of homicide shares structural similarities with teenage pregnancies – a decline in one is linked to a similar decline in the other. More generally, the current work furthers our understanding of the place of homicide in the domain of (public) health.

Agroecological assessment of the technology of processing ordinary chernozem deposits in the south of Central Siberia

Relevance. In the arid steppe zone, strong wind, weak water erosion and other adverse phenomena are manifested. Similar processes are observed in Siberia. At present, the re-development of deposits is beginning and soil degradation is again manifested in the steppe regions of the Republic of Khakassia. For the effective use of land resources, it is necessary to develop a soil protection technology for soil treatment of deposits in the steppe foothill zone of the south of Central Siberia.Methods. The study of the effectiveness of soil treatment technologies of the erosive agroecological group of fallow lands was carried out in the Baysky foothill steppe soil-geographical agrolandscape region of the Republic of Khakassia, located in the south of Central Siberia. Research for three years was carried out in the link of crop rotation: a four-year–old grain–grass deposit — buckwheat — buckwheat by the method of field experience of Boris Dospekhov. Mеthods of water-physical, agrochemical, economic and energy research were used in the performance of the work.Results. It was revealed that on four-year fallow lands there is soil compaction, low content of elements of mineral nutrition. The influence of the complex application of continuous herbicides (Tornado 500) and soil tillage technology on erosion resistance has been established. During summer tillage of the deposit and timely application of herbicide, there is an increase in wind resistance and productivity of the crop rotation link. In the foothill steppe region, with such a soil protection technology with the treatment of ordinary chernozem, the erodibility is 27.5–30.9 g / 5 min of exposure.

Feasibility study of a prestressed-concrete containment vessel for a novel GFR nuclear reactor

The latest modern nuclear energy systems currently researched and developed are the Generation IV (Gen IV) nuclear reactors, and one of the more promising Gen IV designs is the Gas-cooled fast reactor (GFR). Among the number of challenging problems of the design of GFR, the development of passive safety systems ensuring passive decay heat removal (DHR) during loss-of-coolant-accidents (LOCA) is of the highest importance. The currently proposed DHR strategy relies on intentionally increasing pressure inside a gas-tight guard vessel containing the reactor to approximately 4 bar. This, however, presents a significant engineering challenge as the vessel must be capable of withstanding high pressure of up to 10 bar, due to pressure spikes and safety coefficients, while also withstanding increased temperatures during the LOCA. As no GFR guard vessel has ever been designed, this paper presents a feasibility study establishing whether such vessel can be designed. The feasibility study is aimed at the assessment of a preconceptual design of a prestressed concrete vessel previously created by the authors. In the study, stresses in the structure induced by normal-operation loads and LOCA loads are calculated for three types of extreme constraint conditions covering all possible real constraints of the structure. The calculations are based on heat transfer equations, Euler–Bernoulli theory, and Lamé equation implemented in a in-house Python code. In the results, stresses in the vessel are presented and compared to design criteria. The main conclusion of the paper is that the vessel can be designed; however, certain adverse phenomena which complicate the design process, such as non-linear creep of concrete and occurrence of tensile stress up to 1MPa, will have to be addressed and considered during future detailed design. Following on from this affirmative conclusion, the authors will create the detailed design using advanced three-dimensional modelling in their future work.

WS2 Nanotube-Embedded SiOC Fibermat Electrodes for Sodium-Ion Batteries.

Layered transition metal dichalcogenides (TMDs) such as tungsten disulfide (WS2) are promising materials for a wide range of applications, including charge storage in batteries and supercapacitors. Nevertheless, TMD-based electrodes suffer from bottlenecks such as capacity fading at high current densities, voltage hysteresis during the conversion reaction, and polysulfide dissolution. To tame such adverse phenomena, we fabricate composites with WS2 nanotubes. Herein, we report on the superior electrochemical performance of ceramic composite fibers comprising WS2 nanotubes (WS2NTs) embedded in a chemically robust molecular polymer-derived ceramic matrix of silicon-oxycarbide (SiOC). Such a heterogeneous fiber structure was obtained via electrospinning of WS2NT/preceramic polymer solution followed by pyrolysis at elevated temperatures. The electrode capacity fading in WS2NTs was curbed by the synergistic effect between WS2NT and SiOC. As a result, the composite electrode exhibits high initial capacity of 454 mAh g-1 and the capacity retention approximately 2-3 times higher than that of the neat WS2NT electrode.

Optimised Voltage Distribution on Piezoelectric Actuators for Modal Excitations Damping in Tapered Beams

Vibration mitigation is a prominent matter in several engineering fields. Several adverse phenomena are related to vibrations, such as fatigue, noise, etc. The availability of smart materials increases the solutions for both vibration damping and energy harvesting applications. Piezoelectric materials seem to be the most promising for these applications. However, their positioning significantly affects their efficiency. Several studies were performed on the positioning of piezoelectric actuators to dampen a target resonance in cantilever beams with constant cross-sections. Here, an analytical model for the optimal voltage distribution on an array of piezoceramic (PZT) actuator pairs is proposed in the case of tapered beams. The effect of tapering on the optimal voltage distribution was investigated for several eigenmode excitations and tapering ratios. The model outcomes were corroborated via FEM simulations and a fair agreement was found for each considered case.

НАУКОВІ ЗАСАДИ ТА ОСОБЛИВОСТІ КОНТРОЛІНГУ СТРАТЕГІЧНОГО УПРАВЛІННЯ ТЕЛЕКОМУНІКАЦІЙНИМИ ПІДПРИЄМСТВАМИ В УМОВАХ ЦИФРОВОЇ ЕКОНОМІКИ

Today, digital transformations change people's lives, the principles and forms of functioning of enterprises, and also have an impact on all levels of the economy. The formation and development of the digital economy necessitates the processing and transmission of a large flow of data at a high exchange rate. The authors of the article identified the key trends of strategic management of enterprises in the conditions of the digital economy and sharp changes in the external and internal environments of enterprises in these conditions. This necessity is technically and physically ensured thanks to the work of telecommunication enterprises. This situation requires constant monitoring and analysis of the external environment from telecommunication companies. Thus, the development of the digital economy determines the search by telecommunications enterprises for modern tools for identifying risks, analyzing trends, setting benchmarks, preventing adverse phenomena, and finding alternative development options for the enterprise. This becomes possible thanks to the implementation of such an economic tool as strategic management controlling, which is characterized by the use of modern digital technologies and the application of modern accounting and information processing methods. This ensures the company's survival in changing conditions and strengthens the strategic advantages of the telecommunications company and the services it provides and plans to provide in the two-term perspective. The article defines the effectiveness of the strategic management system of a telecommunications enterprise and proposes the implementation of strategic management controlling, which is a new phenomenon in the theory and practice of strategic enterprise management. The functions of the strategic management control group are outlined and the criteria that must be taken into account by enterprise management for business survival and preservation are specified. A model of the interaction of strategic controlling functions and controlling criteria for telecommunications enterprises is proposed. The necessity of using controlling as a strategic management tool, which allows forecasting and identifying risks at enterprises for timely change of strategy or its adjustment in accordance with new threats and opportunities, is emphasized.

Gully erosion prediction method from geoenvironmental data and supervised machine learning techniques

Predictive models are statistical representations that indicate, based on the historical data analysis, the probability of triggering a given phenomenon in the future. In geosciences, such models have been essential to predict the occurrence of adverse phenomena commonly associated with environmental disasters, such as gully erosion. Therefore, this paper presents a method for producing gully erosion predictive models based on geoenvironmental data and machine learning techniques. The method's effectiveness test was produced in a region of approximately 40,000 km² in southeastern Brazil and compared the predictive performance of four models designed with different machine learning algorithms. The results demonstrated that the technique is capable of producing models with high predictive ability, with emphasis on the random forest algorithm, which, in addition to having achieved the highest levels of accuracy, also produced highly realistic maps for the study area.•The method is straightforward and may be applied to predict other geological processes.•The application of the method does not require knowledge of programming language.•The models produced achieved high predictive performance.

РОЛЬ ЕКОНОМІЧНОГО АНАЛІЗУ ПІДПРИЄМСТВА В УМОВАХ КРИЗИ

The article examines the role of economic analysis of the enterprise in crisis conditions and suggests methods of increasing the effective operation of the enterprise. At the current stage of the development of the world economy, along with the strengthening of the phenomena of the global financial crisis, the current and future level of solvency of enterprises is a decisive factor for success in business. Entrepreneurs will be able to maintain their positions in the market only if they apply economic analysis to raise the expectations of their partners about the company's ability to fulfill its obligations to them. The key elements of this approach are maintaining the appropriate level of liquidity of the enterprise, preserving and improving the achieved performance indicators, ensuring the stability of income and their balance with the amount of expenses necessary for the normal functioning of the business, full and timely fulfillment of obligations. Effective business management is important for management, business founders, creditors, investors, government agencies and other business entities. The development of adverse phenomena in the global and national economy, especially as a result of restrictions introduced to fight the COVID-19 pandemic, military actions, showed how vulnerable domestic business is to such things as a sharp increase in the number of non-payments. and accounts payable, as well as a decrease in the turnover of receivables. All this contributes to the further worsening of the situation with a lack of financial resources among entrepreneurs and, as a result, the financial stability of business due to the lack of flexible and timely state approaches to the adaptation of tax legislation to the new crisis. Execution of production plans and provision of production needs with necessary resources directly depends on solvency. Therefore, solvency as a part of economic activity is aimed at ensuring planned income and spending of funds, compliance with accounting discipline, compliance with reasonable proportions of equity and loan capital, and its most effective use. Adapting to the risks, losses and circumstances of an escalating financial crisis has now become the norm. Businesses will fail and fail if they do not adapt to the changes sweeping the modern world. A company's ability to perform economic analysis affects how well it performs. In today's business environment, it is imperative for businesses to consider factors such as solvency, financial stability, and business activity.

Atmospheric circulation types and floods' occurrence; A thorough analysis over Greece

Floods have a direct impact on the society and the environment, causing human losses, affecting individual incomes and national economic activity including infrastructure damages. Atmospheric circulation is strongly related to both mean and extreme climate, with the latter being the driving force of adverse phenomena, such as inundations. The overarching goal of the research is the identification of those atmospheric circulation patterns that are associated with catastrophic flood events over Greece. An updated atmospheric classification scheme consisted of 12 circulation types (5 anticyclonic and 7 cyclonic) is implemented to detect and highlight the flood-dominant circulation types over the domain of interest. It is established that for a 7-year period (from 2012 to 2018), where reliable flood inventories are available as a derivative of the European Union (EU) Flood Directive implementation process, the dominant circulation type is the cyclonic type C with its center to be located over the Cyclades area. The study also reveals that during the most severe floods, the prevailing cyclonic types are substantially deeper than their mean anomaly field. Finally, out of the 14 River Basin Districts of Greece, Thrace (EL14) is the more flood prone area, while Eastern Macedonia (EL11) is far less flood affected. The introduced Floods' Frequency Vulnerability index (FFVI) showed that in the case of significant floods, Western Peloponnese (EL01) and Epirus (EL05) are the most vulnerable River Basin Districts. The proposed methodology of coupling circulation types with flood occurrences can be applied in all EU Member-States and set the base of effective floods' prediction mechanisms at River Basin Districts scales.

How to Make the Rational Return of Housing Price

As a bright spot in economic development, housing price is one of the most talked about issues, but also an important challenge facing China. According to survey, the house price of the real estate industry in our country rises too fast. Real estate prices are getting out of control due to the high profits of the real estate industry and the emergence of speculative activities such as sky-high price speculation groups. At present, the state has found these problems and adopted certain measures and regulation policies to reduce the existence of adverse phenomena and avoid adverse phenomena in the real estate industry affecting the overall development of people's lives.

39 ECHOCARDIOGRAPHIC FINDING BETWEEN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION IN TREATMENT WITH ARNI AND SGLT2I

Abstract Background Cardiac remodelling is an adverse phenomenon linked to heart failure progression. Cardiac remodelling could represent the real therapeutic goal in the treatment of patients with heart failure with reduced ejection fraction (HFrEF), being potentially reversed through different pharmacotherapies. Currently, there are well-established drugs such as angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers and β-blockers with anti-remodelling effects; recently, angiotensin receptor neprilysin inhibitor effects on inhibiting cardiac remodelling were demonstrated. Benefits of gliflozins on left ventricular hypertrophy, dilation, and systolic and diastolic function were also described. Aim of study to evaluate possible echocardiographic differences between patients with HFrEF in treatment with ARNI or SGLT2I and patients with HFrEF in therapy with ARNI plus SGLT2i. Materials Between June 2021 and April 2022, consecutive patients with HFrEF underwent to conventional and advanced echocardography (TDI, 2DSTE). After 3 month, these patients underwent to echocardiographic follow-up. Results 76 patients (68 male, 66,51±9,68 years old) with HFrEF were enrolled in the study. After 3 month of therapy, there was an inverse relation between number of HFrEF drugs (0, 1 or 2) and echocardiographic parameters [E/E’ (r: -0,28; p: 0,036) and E/A (r: -0,37; p: 0,012)]. Conclusions About cardiac remodelling, there are not significant echocardiographic differeces but a better trend for the diastolic dysfunction in patients with HFrEF in treatment with ARNI plus SGLT2i vs HFrEF patients in therapy with ARNI or SGLT2i was showed.

Eye problems and musculoskeletal pain in Pokémon Go players

Individuals benefit from Pokémon Go (PG) gaming because this mobile augmented reality geolocation video game provides an attractive opportunity to increase physical activity outdoors and socialize. However, based on gaming and electronic media studies, intense involvement with PG is likely related to adverse phenomena, such as arm pain or eye-related problems. We aimed to test how PG use (problematic vs. non-problematic gaming and gaming time) is related to physical symptoms (pain in three body regions and computer vision syndrome). To dissect game-specific effects, we controlled for general problematic smartphone use, phubbing, and electronic media usage. PG players (N = 455) completed an online survey. We found that PG players with problematic game use reported more pain and vision problems. Problematic PG use was a better predictor of physical symptoms than PG gaming time and variables related to electronic media use. Problematic PG use and problematic smartphone use were correlated but independent predictors of physical symptoms. We conclude that the type of participation rather than the time spent playing predicts poorer physical health among PG players.