Conventional hydrogen production technologies mostly fossil fuels as energy and material basis. The rapid development of nuclear energy in recent years offers a new opportunity. Clean electricity and process heat generated by nuclear reactors can provide energy for hydrogen production, effectively reducing the environmental burden. This study used life cycle assessment (LCA) method to sort out the inputs and outputs of the nuclear hydrogen production processes and analyze the environmental impacts based on local data in China. In this study, we constructed frameworks for two nuclear energy-based processes and created four different scenarios to compare the effect of energy efficiency. Six indicators were used to quantify the environmental impact. The results showed that: (1) electrolysis cell manufacturing and spent fuel disposal generate the largest emissions in hydrogen production. (2) S–I cycle is sensitive to heat transfer efficiency, while high-temperature electrolysis is more sensitive to power generation efficiency; (3) The environmental impact of high-temperature electrolysis (without carrier gas) is slightly lower than that of S–I cycle, but the advantage will disappear as energy efficiency increases. At present, high-temperature electrolysis offers a clean alternative to conventional technologies for hydrogen energy and hydrogen economy. The S–I cycle might have a better prospect in the future. Our study results will provide a scientific assessment of the possibilities of developing nuclear energy for hydrogen production in China and help to make some decisions and policies.
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