Active Phase Research Articles

Digital Technologies in the Process of Forming Sustainable Strategies for Agricultural Enterprises in International Markets

The active phase of applying digital technologies contributed to their implementation in forming sustainable strategies for agricultural enterprises in international markets. It is proved that the development of certain functions of international marketing and their active extension beyond the enterprise, the development of a scheme of interaction with the consumer, and intra-company integration with increased feedback in modern conditions have gained practical importance and ensured the formation of sustainable strategies of agricultural enterprises.
 Ukrainian enterprises, having not yet fully resumed business activity after the COVID-19 pandemic, have entered a new risk zone caused by the armed aggression of the Russian Federation against Ukraine. Ukrainian companies understand the responsibility of business for the state of economic recovery in Ukraine and are trying to act here and now to stay afloat.
 Digital technologies are being actively implemented in various economic sectors, so Ukrainian agricultural enterprises have to use digital progress to effectively develop sustainable strategies in international markets to remain competitive in today's market. 
 It has been proven that in the current conditions of international business activity, only those companies that can use promising digital technologies in the early stages of business development will remain competitive.
 It is substantiated that, depending on the specialization of the enterprise and the specifics of the goods or services provided there, the segments of domestic and international markets in which goods and services are sold, it is worth choosing connectivity platforms that will act as information support for enterprises in the process of forming sustainable strategies in international markets. 
 International marketing research was conducted to select new international markets based on information collected from the "Trade Map" and "Theglobaleconomy" connectivity platforms, which operate on a user's request.
 Using the example of the product group "1512 Sunflower oil", two segments of attractive international markets for Ukrainian agricultural producers were identified. The first segment is the markets of Ireland, Switzerland, Austria, and Belgium, where there are favorable business conditions for Ukrainian farmers. The second segment is the markets of Poland, Bulgaria, and the United Kingdom, where there is an opportunity to increase sales of sunflower oil. It is substantiated that the intensification of business activities of agricultural producers of the product group "1512 Sunflower oil" will allow in the short term to ensure the implementation of the sustainable development strategy, despite all the difficulties that have arisen as a result of the active phase of the war in Ukraine. 
 Keywords: digital technologies, sustainable development strategy, international business activities, a system of indicators of attractiveness of international markets, connectivity platforms, segmentation of international markets, agricultural enterprises

Active smectics on a sphere

The dynamics of active smectic liquid crystals confined on a spherical surface is explored through an active phase field crystal model. Starting from an initially randomly perturbed isotropic phase, several types of topological defects are spontaneously formed, and then annihilate during a coarsening process until a steady state is achieved. The coarsening process is highly complex involving several scaling laws of defect densities as a function of time where different dynamical exponents can be identified. In general the exponent for the final stage towards the steady state is significantly larger than that in the passive and in the planar case, i.e. the coarsening is getting accelerated both by activity and by the topological and geometrical properties of the sphere. A defect type characteristic for this active system is a rotating spiral of evolving smectic layering lines. On a sphere this defect type also determines the steady state. Our results can in principle be confirmed by dense systems of synthetic or biological active particles.

COVID-19 Linked Social Stigma Among Arab Survivors: A Cross-Sectional Experiences from the Active Phase of the Pandemic.

This study aimed to explore the magnitude and variability of the disease-linked stigma among COVID-19 survivors and their experiences of social stigma, coping strategies, contextual challenges, and preferences for support. An Arabic version of the social stigma survey questionnaire was designed and validated to obtain socio-demographic characteristics and quantitative measures of stigma encountered by the survivors. 482 COVID-19 survivors completed the survey, and the data were analyzed using descriptive statistics and thematic analysis. The results of this study revealed the prevalence of high levels of both perceived external stigma and enacted stigma among participants. Enacted and Internalized stigma were associated with survivors' educational background/ status. The participants suggested three levels of support: organizational, social, and personal. Establishing an online stigma reduction program and national psychological crisis interventions at the organizational level. It is crucial to assist coping mechanisms and societal reintegration techniques at the social level. These results provide valuable insights for holistic health policy formation and preparedness strategies for future pandemics, helping survivors promote health and reintegrate into society, where stigma reduction and psychological crisis interventions are underdeveloped.

The prevalence factor of post-traumatic stress disorders among students of Mariupol

The subject of the study is post-traumatic stress disorder (PTSD) of people exposed to stress factors in the city of Mariupol during the active phase of the Special Military Operation in the city. Taking into account the tasks of socio-psychological rehabilitation of the civilian population located in an area of increased risk of psychological and physical trauma, identifying the level of prevalence of PTSD in Mariupol is extremely relevant from both a scientific and applied point of view. Obtaining relevant information is important both for further in-depth research and for the development and implementation of appropriate programs of socio-psychological and (or) depth psychological rehabilitation. In addition, this information is relevant in the context of solving the problem of forming the all-Russian civic identity among new generations of Russians. The study used structured clinical interview technology, as well as the Clinical-Administered PTSD Scale (CAPS) and a PTSD screening questionnaire. Based on the data obtained during the study, it was concluded that, in comparison with similar indicators identified among the civilian population of Afghanistan and Chechnya, who were in the territory of intense military operations and experienced the effects of powerful stress factors, as well as among people who witnessed the shooting of the Russian parliament in 1993, the prevalence of PSTD among residents of Mariupol who were in the city during the operation to liberate it is quite low. In the opinion of the authors of the article, this fact is explained by the fact that the majority of Russian citizens who remained in Mariupol and returned to it perceive the military actions of 2022 as a “forced necessity”. This leads to the conclusion about the extreme importance of using psychological and psychological-pedagogical technologies in the sphere of protecting traditional values.

Utility of positron emission tomography as a new tool for muscle involvement in patients with idiopathic inflammatory myositis: a controlled study.

Idiopathic inflammatory myositis (IIM) represents a rare group of disease that can affect multiple organs in addition to the muscles. 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is an emerging scanning method that is widely used in diagnosing, staging and response to treatment in patients with cancer. In this study, we aimed to evaluate the muscle involvement in PET/CT which was performed for malignancy screening and its correlation with myositis-specific antibodies (MSA) and/or myositis-associated antibodies (MAA) in patients with IIM. IIM patients who fulfilled 2017 EULAR/ACR classification criteria and had PET-CT scans during the active phase of myositis (within two weeks of starting steroids) were included into the study. Age and sex matched participants with history of malignancy (non-IIM patients) were defined as control group. Data of 160 IIM patients were evaluated and 34 patients (of 64.7% female) whose PET/CT results were available, included into the study. Fourteen patients with diagnosis of malignancy without IIM (non-IIM patients) defined as the control group. Sensitivity and specificity of a positive FDG muscle uptake were 37.1% and 100%, 65.7% and 92.9%, 91.4% and 7.1% compared to liver, mediastinum and LTM uptakes, respectively. In multivariate analysis, higher baseline CRP (p=0.017, confidence interval [CI] 95%: 1.03-1.36, OR:1.18) and LDH (p=0.029, CI 95%:1.001-1.017, OR:1.01) levels were associated with muscle PET/CT positivity. In patients with active IIM, median muscle FDG uptake with PET/CT was higher compared to non-IIM. PET/CT may be used for the evaluation of extent and activity in patients with IIM.

Circulating Podocalyxin, Tumstatin/Col-IVα3 and Chitinase 1: New Culprits in Vitiligo Occurrence.

The roles of anti-adhesive podocalyxin (PODXL), anti-angiogenetic tumstatin/ Col-IVα3 and neuro-inflammation and innate immunity modulator Chitinase 1 (CHIT-1) in the etiology of vitiligo have not been studied yet. This study was planned to detect changes in serum PODXL, tumstatin/Col-IVα3 and CHIT1 levels in vitiligo patients. This case-controlled study was performed on a total of 50 patients, 25 with vitiligo and 25 healthy controls. Participants in the vitiligo and control groups were matched in pairs for age and sex. At least 8-10 hours of overnight fasting, venous blood samples were taken from the participants in both groups and serum levels of podocalyxin, tumstatin/Col-IVα3 and CHIT 1 levels were measured by sandwich enzyme immunoassay. In the classification made according to the vitiligo European Task Force evaluation criteria, 18 of 25 vitiligo patients were in the slowly progressive phase and 7 patients were in the active progressive phase. Serum podocalyxin levels increased significantly in the vitiligo group compared to the controls (7.03±2.09 ng/ml vs. 4.99±1.20 ng/ml, p<0.02). However, serum tumstatin levels in vitiligo patients showed a significantly lower course compared to controls (4.88±1.76 ng/ml vs. 6.05±2.19 ng/nl, p<0.03). Serum CHIT-1 levels of vitiligo patients (42.4±7.22 ng/ml) were found to be significantly higher than the serum levels of the control group (34.5±5.33 ng/ml) (p<0.01). High podocalyxin and CHIT1versus low tumstatin levels are new biomarkers that support the role of anti-adhesive, anti-angiogenic and neuroinflammatory pathways in the formation of vitiligo.

Pemberdayaan Masyarakat LKSA Aisyiyah Balikpapan melalui Pengembangbiakkan Ikan Lele dengan Pakan Otomatis

Catfish breeding using an automatic feeding system involves four crucial stages to achieve success in this endeavor. The first stage in this process is the survey stage, which involves a field survey by visiting the Aisyiyah Children's Social Welfare Institution (LKSA). The second stage is the tool preparation stage. This process begins with purchasing the necessary equipment based on the results of the survey that has been conducted. The third stage is the tool installation stage. This stage begins with the land preparation, including leveling the land where the catfish ponds will be installed. As a further step, bricks are used around the perimeter of the catfish pond to support the pond foundation and prevent collapse. Then, an automatic feed device was installed to support the automatic feeding system according to a predetermined schedule. The last stage is the equipment handover stage. This stage marks the completion of the installation and preparation process and signifies the start of the active phase in catfish farming using the automatic feed system. Success in the implementation of each of these stages has direct implications for the success and sustainability of the catfish farming business at LKSA Aisyiyah.

The effect of effleurage massage on decreasing active first period labor pain: A literature review

Introduction: Labor pain is a visceral nociceptive pain caused by contractions and cervical dilatation. Pain that occurs can affect the mother's condition in the form of fatigue, fear, worry, and stress. Effleurage massage is one of the effective non-pharmacological methods to overcome labor pain. Effleurage massage aims to improve blood circulation, warm abdominal muscles, and promote physical and mental relaxation. This study aims to determine v in the first phase of active labor. Method: This study uses a literature review method with a quasi-experiment research design. Literature search sources used five databases namely Google Scholar, PUBMED, and Science Direct with published years 2018-2023. Study selection according to inclusion criteria with a prism checklist of abstract titles, full text and assessed the feasibility of further studies analyzed from the study findings. Result and Discussion: The search results found 6 journals that met the inclusion criteria. From the overall review of 6 journal articles, it was found that 5 journal articles had a significant effect of giving effleurage massage on labor pain during the active phase I. In contrast, 1 article did not have a significant effect between effleurage and counter-pressure in reducing labor pain. Conclusion: Effleurage massage affects reducing the level of labor pain during the active phase I.

Traffic Light Control Systems: Requirements Engineering

Requirements Engineering (RE) is the most important activity and pivot phase in the software development life cycle. It consists mainly of requirements analysis, design, and specification. The application of RE in a business domain aims to generalize its different specific approaches by meta-models under which each specific approach is an instance or specialization. RE is being applied more and more in different business domains, and its application benefits are found to be valuable. Despite these active RE applications and their added values in different domains, the Traffic Light Control (TLC) domain has not yet been approached, regardless of its everyday interest. The work presented in this paper is part of a TLC enhancement project that explores RE's potential contributions to leveraging TLC quality. Thus, in this work, different recent specific approaches to TLC are analyzed, and a large part of this business domain's functional/ non-functional requirements are elicited and specified. Moreover, the traffic context-aware traffic light control systems (CTLC) are also considered. They are deeply analyzed and compared to the typical TLC systems. As a primary result, the tangling of different concerns was stated, and a separate concerns paradigm was applied. This leads to requirements specification through separated agents. This should lead to TLC and CTLC systems development and maintenance cost reduction. An important agent dealing with security aspects and their evolving technologies is introduced. The impact evaluations of the RE on some TLC and CTLC current approaches are also presented.

Mesoporous Silica MCM-41 from Fly Ash as a Support of Bimetallic Cu/Mn Catalysts for Toluene Combustion.

The main outcome of this research was to demonstrate the opportunity to obtain a stable and well-ordered structure of MCM-41 synthesized from fly ash. A series of bimetallic (Cu/Mn) catalysts supported at MCM-41 were prepared via grinding method and investigated in catalytic toluene combustion reaction to show the material's potential application. It was proved, that the Cu/Mn ratio had a crucial effect on the catalytic activity of prepared materials. The best catalytic performance was achieved with sample Cu/Mn(2.5/2.5), for which the temperature of 50% toluene conversion was found to be 300 °C. This value remains in line with the literature reports, for which comparable catalytic activity was attained for 3-fold higher metal loadings. Time-on-stream experiment proved the thermal stability of the investigated catalyst Cu/Mn(2.5/2.5). The obtained results bring a valuable background in the field of fly ash utilization, where fly ash-derived MCM-41 can be considered as efficient and stable support for dispersion of active phase for catalyst preparation.

Low Concentrations of Gold Nanoparticles as Electric Charge Carriers in Piezoelectric Cement-Based Materials.

Piezoelectric cement-based composites could serve to monitor the strain state of structural elements or act as self-powered materials in structural health monitoring (SHM) applications. The incorporation of piezoelectric materials as an active phase within cement matrices has presented a highly attractive avenue until today. However, their application is challenged by the low electrical conductivity of the hydrated cement matrix. Gold nanoparticles (Au NPs) possess substantial potential for elevating the free electrical charge within the matrix, increasing its electrical conductivity between the Au NPs and the cement matrix, thereby enhancing the piezoelectric response of the composite. In this sense, the objective of this study is to investigate the effects of incorporating low concentrations of gold nanoparticles (Au NPs) (442 and 658 ppm) on the electrical and piezoelectric properties of cement-based composites. Additionally, this study considers the effects of such properties when the material is cured under a constant electric field. Electrical impedance spectroscopy was used to evaluate the polarization resistance and piezoresistive properties of the material. Additionally, open-circuit potential measurements were taken alongside the application of mechanical loads to assess the piezoelectric activity of the composites. The findings revealed a notable decrease in the composite's total electrical resistance, reaching a value of 1.5 ± 0.2 kΩ, almost four times lower than the reference specimens. In the realm of piezoelectricity, the piezoelectric voltage parameter g33 exhibited a remarkable advancement, improving by a factor of 57 when compared to reference specimens. This significant enhancement can be attributed to both the concentration of Au NPs and the electrical curing process. In summary, the outcomes of this study underscore the feasibility of creating a highly electrically conductive cement-based matrix, using low concentrations of gold nanoparticles as electric charge carries, and indicate the possible piezoelectric behavior of the studied compposite.

ARGINASE 2 AMELIORATES EXPERIMENTAL COLITIS THROUGH ANTIOXIDANT EFFECTS VIA SPERMIDINE PRODUCTION

Abstract BACKGROUND Spermidine which is a type of polyamine, shows elevated levels in patients with ulcerative colitis and is implicated in the pathogenesis of ulcerative colitis (UC). Arginase 2 (ARG2) plays a critical role in spermidine production. This study aimed to determine the role and mechanism of endogenous spermidine by using ARG2-deficient mice. METHODS The protective role of spermidine against oxidative stress was examined by intracellular reactive oxygen species levels and cell viability. The physiological role of spermidine was investigated using Arg2 knockdown cells with reduced spermidine. The importance of ARG2 in inflammation was examined in the dextran sulfate sodium-induced colitis model. Protein expression levels of ARG2 and accumulation of spermidine in patients with UC were evaluated by immunohistochemistry of the rectum. RESULTS ARG2 protein expression and the accumulation of spermidine were upregulated in the rectum of mice with dextran sulfate sodium colitis. Spermidine upregulated antioxidant genes in the cells. Arg2 knockdown cells showed reduced antioxidant activity. Dextran sulfate sodium colitis was more severe in Arg2-deficient mice, and organoids derived from Arg2-deficient mice showed diminished tolerance to oxidative stress. Furthermore, in the rectum of patients with UC, ARG2 and spermidine expression levels were higher in the active phase than in the remission phase. CONCLUSIONS Endogenous spermidine in the intestinal epithelium induced by ARG2 has a protective role in colitis. Spermidine may be a promising new therapeutic target for inflammatory bowel disease.

Transcriptional effects of carbon and nitrogen starvation on Ganoderma boninense, an oil palm phytopathogen.

Ganoderma boninense is a phytopathogen of oil palm, causing basal and upper stem rot diseases. The genome sequence was used as a reference to study gene expression during growth in a starved carbon (C) and nitrogen (N) environment with minimal sugar and sawdust as initial energy sources. This study was conducted to mimic possible limitations of the C-N nutrient sources during the growth of G. boninense in oil palm plantations. Genome sequencing of an isolate collected from a palm tree in West Malaysia generated an assembly of 67.12Mb encoding 19,851 predicted genes. Transcriptomic analysis from a time course experiment during growth in this starvation media identified differentially expressed genes (DEGs) that were found to be associated with 29 metabolic pathways. During the active growth phase, 26 DEGs wererelated to four pathways, including secondary metabolite biosynthesis, carbohydrate metabolism, glycan metabolism and mycotoxin biosynthesis. G. boninense genes involved in the carbohydrate metabolism pathway that contribute to the degradation of plant cell walls were up-regulated. Interestingly, several genes associated with the mycotoxin biosynthesis pathway were identified as playing a possible role in pathogen-host interaction. In addition, metabolomics analysis revealed six metabolites, maltose, xylobiose, glucooligosaccharide, glycylproline, dimethylfumaric acid and arabitol that were up-regulated on Day2 of the time course experiment. This study provides information on genes expressed by G. boninense in metabolic pathways that may play a role in the initial infection of the host.

Strategies for phase matching control in a multidimensional Floquet state spectroscopy.

Floquet state spectroscopy is an optical analogue of multiple quantum coherence nuclear magnetic resonance (MQC-NMR). Tunable ultrafast excitation pulses resonantly excite multiple states in a sample to form the Floquet state. The Floquet state emits multiple coherent beams at frequencies and in directions that conserve energy and momenta. The different output beams differ in the time ordering and coherences created by the excitation beams. They correspond to the different methodologies in the NMR family. Isolating a specific beam and monitoring the output intensity as a function of excitation frequencies creates multidimensional spectra containing cross-peaks between coupled states. The frequency range of the multidimensional spectra is limited by phase matching constraints. This paper presents a new, to the best of our knowledge, active phase matching strategy that increases the versatility of multidimensional Floquet state spectroscopy through both longer sample path lengths and larger spectral ranges.

Finite-size security proof of binary-modulation continuous-variable quantum key distribution using only heterodyne measurement

Continuous-variable quantum key distribution (CV-QKD) has many practical advantages including compatibility with current optical communication technology. Implementation using heterodyne measurements is particularly attractive since it eliminates the need for active phase locking of the remote pair of local oscillators, but the full security of CV QKD with discrete modulation was only proved for a protocol using homodyne measurements. Here we propose an all-heterodyne CV-QKD protocol with binary modulation and prove its security against general attacks in the finite-key regime. Although replacing a homodyne measurement with a heterodyne measurement would be naively expected to incur a 3-dB penalty in the rate-distance curve, our proof achieves a key rate with only a 1-dB penalty.

P079 Low-intensity Pulsed Ultrasound reflects the status of mucosal injury and repair through stage-specific miRNAs in experimental model of Ulcerative Colitis

Abstract Background Diagnosis and therapeutic efficacy monitoring of Ulcerative Colitis (UC) are based on a multidisciplinary approach comprising symptomatology and invasive endoscopic assessment coupled to the histopathological characterization of gut tissue biopsies. New technologies that non-invasively reflect tissue-specific changes remains an unmet need. Here we exploited Low Intensity Pulsed Ultrasound (LIPUS) to induce tissue stage-specific miRNAs in circulating blood as a non-invasive approach to reflect the status of the colonic mucosa in experimental model of colitis. Methods Based on our previous study, LIPUS was applied at a frequency of 38 kHz and at an intensity of 0 (as control) or 150 mW/cm2 for 3 min, using a device dedicated for in vivo studies. Acute and chronic colitis were induced in C57BL/6N mice (5 animals/group) by administration of 2 and 2.5% ad libitum dextran sodium sulfate (DSS) respectively in their drinking water for 7 days for the acute and three cycles of 7 days for the chronic model. miRNA array profiling was performed on extracellular vesicles (EVs) isolated from plasma of both acute and chronic models, at both active and remission state, 2 h after LIPUS stimulation. miRNA were correlated to the mucosal status by multiplexed immunofluorescence staining using Opal Multiplex IHC (CD4, CD8, CD68, pan-cytokeratin and CD31 markers) and EVs characterized by MACSplex surface epitope detection. Results An enrichment of EVs characterized mainly by stromal and immune cell surface markers was found in both acute and chronic inflammatory states, LIPUS stimulation significantly modulated miRNA profiles and clearly discriminated between active acute and chronic phases. 61 miRNAs in acute and 28 in chronic colitis were specifically and significantly upregulated by LIPUS in the active phase, with a fold change ranging from 2 to 1500 compared to control. Both acute and chronic disease showed a miRNA profile coherent with the active inflammatory state of intestinal mucosa. Only 10 and 23 miRNAs were upregulated in acute and chronic remission respectively. The enhancement of miR-18a-3p and miR-301b-3p in the recovery phases correlated to instetin with reduced immune cell infiltration and epithelial layer regeneration. Conclusion An optimal LIPUS dosage that non-invasively targets the colon induces the tissue to release specific miRNAs that reflect the mucosal status. LIPUS may open a new era of non-image ultrasound diagnostics that works as disruptive liquid biopsy allowing the detection of tissue biomarkers for monitoring IBD disease progression.

P152 Longitudinal immune profiling of peripheral blood in patients with Ulcerative Colitis

Abstract Background Recent literature has established the communication and mutual influence between the gut and the brain, referred to as the gut-brain axis. While inflammatory bowel disease (IBD) poses a risk for neuroinflammation and brain dysfunction, the molecular mechanisms are not fully understood. This study aims to investigate longitudinal changes during Ulcerative Colitis (UC), focusing first on the characterization of peripheral immune cell subsets, circulating cytokines, and extracellular vesicles (EVs). Methods In our study, we examined 19 UC patients in both active (mean age in years: 45,63) and remission phases (mean age in years: 46,16). A gastroenterologist at the Gastroenterology Department from the Otto-von-Guericke University in Magdeburg, Germany assessed all participants, categorizing them into stages using Mayo scoring and calprotectin levels. We analysed peripheral whole blood and plasma samples using different flow cytometry-based approaches. Results Our findings indicate an upregulation of the neutrophil (CD16+, CD15+) numbers during the active stage followed by a significant reduction during remission, indicating an increase in innate inflammation as a first line of defence and a balanced state during remission. Classical (CD14+, CD16-) monocytes were decreased, along with similar results in the intermediate (CD14+, CD16+) subset. Nonclassical monocytes (CD14+, CD16++) increased from the active to the remission stage. Surface expression of activation marker CCR2 was downregulated for all monocyte subsets, whereas CX3CR1 was upregulated specifically in intermediate monocytes during remission. Compared to the active stage peripheral dendritic cell (CD14-, CD16-) numbers increase during remission suggesting less colonic infiltration. Peripheral regulatory T cells (Tregs) (CD127 low/-, CD25+), which are important for the reestablishment of homeostasis are upregulated during remission. Characterization of cytokine levels in plasma revealed an upregulation of the proinflammatory milieu during the active stage, especially with elevated IL-18 and TGF- β1 levels. Finally, those changes were accompanied by alterations of the surface markers expressed by isolated circulating EVs. Conclusion Our initial results indicate the feasibility of evaluating the gut-brain axis through liquid biopsy. We unravel the composition of the peripheral inflammatory milieu during the active phase. Currently we are focusing on the assessment of the CNS-derived metabolites and their bidirectional communication with the gastrointestinal system.

Nailfold Capillaroscopy Analysis Can Add a New Perspective to Biomarker Research in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) includes granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA), all of which are characterised by inflammation of small–medium-sized vessels. Progressive understanding of these diseases has allowed researchers and clinicians to start discussing nailfold video capillaroscopy (NVC) as a future tool for many applications in daily practice. Today, NVC plays a well-established and validated role in differentiating primary from secondary Raynaud’s phenomenon correlated with scleroderma. Nevertheless, there has not been sufficient attention paid to its real potential in the ANCA-associated vasculitis. In fact, the role of NVC in vasculitis has never been defined and studied in a multicentre and multinational study. In this review, we carried out a literature analysis to identify and synthesise the possible role of capillaroscopy for patients with ANCA-associated vasculitis. Methods: Critical research was performed in the electronic archive (PUBMED, UpToDate, Google Scholar, ResearchGate), supplemented with manual research. We searched in these databases for articles published until November 2023. The following search words were searched in the databases in all possible combinations: capillaroscopy, video capillaroscopy, nailfold-video capillaroscopy, ANCA-associated vasculitis, vasculitis, granulomatosis with polyangiitis, EGPA, and microscopic polyangiitis. Results: The search identified 102 unique search results. After the evaluation, eight articles were selected for further study. The literature reported that capillaroscopy investigations documented non-specific abnormalities in 70–80% of AAV patients. Several patients showed neoangiogenesis, capillary loss, microhaemorrhages, and bushy and enlarged capillaries as the most frequent findings. Furthermore, the difference between active phase and non-active phase in AAV patients was clearly discernible. The non-active phase showed similar rates of capillaroscopy alterations compared to the healthy subjects, but the active phase had higher rates in almost all common abnormalities instead. Conclusions: Microvascular nailfold changes, observed in patients affected by vasculitis, may correlate with the outcome of these patients. However, these non-specific abnormalities may help in the diagnosis of vasculitis. As such, new analysis analyses are necessary to confirm our results.

P937 A Retropective Analysis of Micronutrient Status in Inflammatory Bowel Disease

Abstract Background Researchers are increasingly focusing on the influence of micronutrient levels on the initiation and prognosis of Inflammatory Bowel Disease (IBD). Earlier investigations have highlighted a connection between deficiencies in zinc and selenium and an elevated risk of IBD development and unfavorable outcomes. This study seeks to investigate the existing micronutrient status among Chinese patients with IBD and assess whether deficiencies in trace elements are associated with disease activity, extent of intestinal involvement, and the use of biological treatments. Methods This cross-sectional study included patients diagnosed with Crohn's disease (CD) or ulcerative colitis (UC) who underwent plasma micronutrient testing during outpatient or inpatient visits to the Department of Gastroenterology at Peking Union Medical College Hospital from May 2022 to October 2023. Baseline data, the history of biological agent use, and laboratory inflammation parameters such as hsCRP, ESR, and Alb were extracted from the Electronic Medical Record System. Colonoscopy images were examined to assess the extent of intestinal involvement and endoscopic activity. The distribution of micronutrient deficiency among patients with varying disease statuses was explored using the Pearson chi-square test and Mann-Whitney U-test. Results Among the 168 participants with IBD in this study (77 with CD, 91 with UC), a frequent occurrence of deficiencies in copper, selenium, strontium, and zinc was noted. In CD patients in the endoscopic active phase, there was a higher incidence of selenium and zinc deficiencies compared to the remission phase (selenium 0% vs. 11.3%, p=0.17; zinc 4.2% vs. 24.5%, p=0.052). In UC patients during the endoscopic active phase, strontium (14.5% vs. 0%, p=0.053) and zinc (17.7% vs. 3.4%, p=0.094) deficiencies were more likely to occur. CD patients with zinc deficiency and UC patients lacking zinc or selenium showed higher levels of blood hsCRP and ESR but lower levels of serum albumin. UC patients with E3 type involvement were more prone to selenium and strontium deficiencies compared to those with only left colon involvement (selenium 18.5% vs. 2.7%, p=0.025; strontium 14.8% vs. 5.0%, p=0.078). Conclusion This study identified a notable prevalence of micronutrient deficiencies in individuals with IBD, particularly during active phases. Specifically, patients with CD in an inflammatory state are inclined to exhibit zinc deficiency. In the case of UC, the absence of selenium, strontium, and zinc signals a higher level of inflammation. UC patients with involvement of the entire colon are more prone to experiencing deficiencies in selenium and strontium. These findings warrant validation through multi-center study and mechanism invetigation.

N37 Fatigue in Japanese patients with Inflammatory Bowel Disease: a comparative study based on a systematic review

Abstract Background Fatigue is a common symptom in patients with inflammatory bowel disease (IBD), often persisting even when the disease is in a state of remission. In addition, it is associated with a diminished quality of life (QOL). However, in Japan, only few studies have focused on fatigue in patients with IBD. The Functional Assessment of Chronic Illness Therapy–Fatigue (FACIT-F) scale has shown reliability and validity in assessing fatigue in patients with IBD, and studies using this scale have been conducted worldwide. In this study, we aimed to examine the current state of fatigue among Japanese patients with IBD using the FACIT-F scale and compare these findings with data from the global studies through a systematic review. Methods Data from 488 patients with IBD treated at a specialized IBD clinic were analysed. Patient characteristics, such as sex, age, and disease duration, along with FACIT-F scores, height, and weight were included as survey items in the questionnaire administered to patients. Data on the disease names and activities, as determined by the Crohn's disease activity index and partial Mayo score, were obtained from medical records. For international comparison, information on age, sex, country, disease duration, body mass index, and disease activity was extracted from each article and listed alongside FACIT-F scores. We conducted a search on PubMed using the search terms ‘inflammatory bowel disease’ OR ‘Crohn's disease’ OR ‘ulcerative colitis’ AND ‘fatigue’ AND ‘FACIT-F’ OR ‘FACIT’ OR ‘FACIT-fatigue’. After applying our predetermined inclusion criteria, we selected eight studies that met our requirements. Results The articles of the systematic review included population sizes ranging from 100 to 1185 patients. Patients’ age varied between the late 30s and early 50s, and the proportion of male patients ranged from 39% to 66%. The duration of disease was approximately 10 years. The proportion of disease names and activities was diverse. The overall mean FACIT-F scores ranged from 38.9 ± 11.0 to 41.6 ± 8.6, while the medians [interquartile ranges] ranged from 30 [22-39] to 41 [35-47]. For each article that presented the FACIT-F scores as means ± standard deviations, the t-tests revealed no statistically significant differences. Overall, the FACIT-F scores were higher (indicating higher QOL) in the remission phase than in the active phase. Additionally, these scores were higher in male patients than in female patients and in patients with ulcerative colitis than in those with Crohn’s disease. These findings were consistent across all countries included in this study. Conclusion The FACIT-F scores of Japanese patients with IBD demonstrated a similar trend to those of other countries.