Objective: In Ayurveda, majority of skin diseases are dealt under broader term Kushta. As per acharya Charaka, Vipadika kushta is classified under Kshudra kushta. This can be correlated with Palmo-plantar psoriasis, which mainly effects palms and soles of a person causing cracks associated with severe pain, itching, discolouration and burning sensation. In the present study, an effort is made to compare clinical efficacy of Vipadikahara ghrita and taila prepared using go ksheera and arka ksheera in two different batches for the treatment of Vipadika kushta. Intervention: Vipadikahara ghrita & taila is a yamaka preparation that is mentioned in both charaka samhitha and ashtanga hridaya kushta chikitsa adhyaya, in the context of vipadika kushta. In this formulation ksheera is one of the ingredients, where specific type of ksheera to be used is not specified in charaka samhitha. Whereas in ashtanga hridaya commentary by Kaviraj Athrideva Gupta, usage of arka ksheera is mentioned. As specific ksheera is not mentioned in Charaka samhitha, go ksheera is taken and its effect is compared with the arka ksheera. Vipadikahara Ghrita & taila is administered externally for 15 days and changes are noted. Results: Vipadikahara ghrita & taila prepared with go ksheera helped in reducing only pain, whereas that prepared with arka ksheera reduced pain, itching, discolouration and size of the lesion. Conclusion: Hence it can be said that arka ksheera is found to be more effective in the present case study.
 Keywords: Vipadika kushta, Vipadika hara ghrita & taila, Go ksheera, Arka ksheera, Palmo-plantar Psoriasis.