The integrated navigation system combining the global navigation satellite system (GNSS) and inertial navigation system (INS) is a crucial method for pose estimation in the field of autonomous driving technologies. Nevertheless, the accuracy of pose estimation is severely compromised when GNSS signals are obstructed or disrupted. To address this issue, this study introduces a multi-mode pose estimation framework designed to ensure accurate pose estimation even under unstable GNSS conditions. By integrating vehicle kinematics model that considers steering characteristics (VKMSC) and the convolutional neural network-long short-term memory (CNN-LSTM) neural network (NN) model into various estimation modes, the framework enhances the robustness of the integrated navigation system against signal interference. The system dynamically selects the optimal estimation strategy based on the degree of GNSS signal disruption. The proposed method has been validated through real-vehicle experiments, which demonstrate its efficacy in providing precise pose estimation across a spectrum of interference scenarios. Under the multipath and non-line-of-sight (MP/NLOS) mode, compared to the integrated navigation system and the fusion of traditional vehicle kinematic models, the proposed method improved positional estimation accuracy by 61.8 % and 19.7 %, respectively. In GNSS outage mode, the proposed method increased the estimation accuracy by 36.5 % and 12.0 %, respectively, compared to the INS navigation system assisted by the VKMSC and CNN-LSTM network model. The proposed method effectively reduces pose estimation errors in the integrated navigation system during interference and suppresses data fluctuations, thereby enhancing the system's precision and robustness.