Wearable electronic devices capable of monitoring health parameters and environmental factors are tremendously desirable. Environmental energy harvesting as a power source is crucial to replace traditional batteries. This study aims to contribute to the development of sustainable and efficient wearable devices for health monitoring and environmental sensing. In this study, a self-powered wearable MoS2-based photodetector, integrated with a PDMS-MXene-based triboelectric nanogenerator (TENG) is presented. The TENG generates isometric AC voltage using a diode, and it is used to charge a capacitor for DC voltage output. The photodetector, with a responsivity of 1.25 × 105A/W, specific detectivity of 2×1013 Jones, millisecond response time, enhanced responsivity of 1.1×1010 V/W and specific detectivity of 9.5×1016 Jones while coupled with TENG, successfully measured heart rate using a 660 nm LED and compared well with a commercial pulse meter. Additionally, UV illumination was detected using a 395 nm LED in the AC mode of the TENG. The study’s results support the advancement of flexible, integrated, and sustainable wearable devices, offering solutions to challenges posed by current battery-powered devices.