Blood Group AB Research Articles

Association between ABO-Rh Blood Groups and Type-2 Diabetes Mellitus in Aden, Yemen, 2022

Introduction: Ongoing research is examining the possible role of blood groups in the etiopathogenesis of various medical conditions including type-2 diabetes mellitus (T2DM). The purpose of this research is to identify association of ABO and Rh blood group in patients with T2DM in the Diabetic Center Aden, Yemen, 2022. Methods: A cross-sectional study was conducted in the National Blood Transfusion and Research Center (N.B.T.R.C), Aden between May- September 2022. A total of 226 blood samples were collected from type -2 diabetic patients aged ≥ 18 years in the Diabetic Center, Aden, Yemen. Results: There most common blood group was blood group O (+) followed by A (+) and the least common was blood group AB(-). No association was found between ABO and Rh blood group with either the sex or family history in type-2 diabetic Patients. The most frequent complication observed in the different groups is the neuropathy complications (46.8%) followed by retinopathy complications (40.7%) and finally nephropathy complications (12.5%). Conclusion: No significant association in T2DM patients between ABO – Rh with sex or family history and the most frequent microvascular complication is neuropathy.

Impact of the blood group on postoperative CRP and leukocyte levels after primary total hip and knee arthroplasty.

C-reactive protein (CRP)- and leukocyte levels are common parameters to evaluate the inflammatory response after orthopaedic surgery and rule out infectious complications. Nevertheless, both parameters are vulnerable to disturbing biases and therefore leave room for interpretation. Since blood groups are repeatedly discussed to influence inflammatory response, our aim was to observe their impact on CRP and leukocyte levels after total hip and knee arthroplasty (THA/TKA). Short term postoperative CRP and leukocyte levels of 987 patients, who received either primary TKH (n= 479) or THA (n= 508), were retrospectively correlated with their blood group. ABO, Rhesus and a combination of both blood groups were differentiated. CRP levels after TKA were significantly higher in blood type AB than in type A and O on day 2-4 and also than in type A on day 6-8. Leukocyte levels after THA were significantly higher in blood group type O than in type A on day 6-8 while still remaining in an apathological range. We observed no significant differences between Rhesus types and Rhesus types and CRP or leukocyte levels. We observed significantly increased CRP levels after TKA in patients with blood group AB. Since the elevated CRP levels do not account for early periprosthetic infection, surgeons should include this variation in their postoperative evaluation.

ASSOCIATION BETWEEN BLOOD GROUPS AND COVID-19 OUTCOME CROSS SECTIONAL STUDY

Background: Coronavirus disease 2019 (COVID-19) first started as an epidemic in Wuhan city – China in 2019 then became a pandemic. Certain viral infections showed linkage with certain antigenic determinants of ABO blood groups and Rh factor. Aim of the study: determine the association between blood groups and Rh factor with COVID19 infection in a sample of Iraqi patients. Patients and methods: This cross-sectional retrospective study was conducted among 580 students of a variety of colleges mainly in Baghdad from 6th of December 2021 to 18th of January 2022. An online questionnaire using Google forms was used to collect the data. Results: A total of 580 samples were collected during the study with 358 (61.7%) females samples and 222 (38.3%) males and there was a significant difference between them (P=0.0001). The mean age of the participants was 20.20± 2.716 years. Of the 580 COVID-19 infected samples collected 289 ( 49.8%) were blood group O. 133 (22.9%) were blood Group A then 108(18.6%) were blood group B, and 50 (8.6%) blood group AB while with significant difference (P=0.). About 508 (87.5%) of the samples were Rh + who had COVID-19 infection and the remaining 72(12.5%) were Rh – (P=0.0001). Conclusions: There was an association between Blood group O+ and COVID-19 infection who did not required hospitalization and the blood group AB+ were less susceptible to infection

Associations Between ABO Blood Groups and Diseases in the Digestive System and Vein.

The ABO blood type system is crucial for human blood transfusions. However, the relationships between ABO blood groups and diseases in the digestive system and vein have not been elucidated. We investigated the relationships between ABO blood groups and diseases in the digestive system and vein in this study. A retrospective study on a Chinese population, including 1432 Crohn's disease (CD), 416 ulcerative colitis (UC), 1140 stomach cancer (SC), 841 colorectal cancer (CRC), 384 pancreatic cancer (PC), 520 liver cancer (LC), and 563 venous thrombosis (VT) patients, was performed. Furthermore, 896 healthy subjects were enrolled as normal controls (NC) in this study. The demographic characteristics of patients and NC were compared using the unpaired t-test and χ2 test. Multivariate logistic regression model was used to evaluate the association between ABO blood groups and CD and VT. ABO blood groups distributions in UC, SC, CRC, PC, and LC patients did not differ from that of NC, but CD and VT patients had significant difference of ABO blood group distribution from that of NC (p = 0.015 and p = 0.002, respectively). Patients with CD and VT had considerably lower rates of type O blood (p = 0.011 and p = 0.001, respectively) and significantly higher rates of type AB blood (p = 0.013 and p = 0.022, respectively) than those with NC. Multivariate logistic regression analysis showed the association of CD and VT with non-O blood types was still significant with a higher risk than with blood group O after adjusting for age and gender (OR = 1.355, 95% CI = 1.100-1.670, p = 0.004 and OR = 1.465, 95% CI = 1.131-1.903, p = 0.004, respectively). ABO blood groups distributions in CD and VT patients significantly differed from that of NC. Non-O blood group could be a new predictor for CD and VT.

Who misreports on internet health surveys, and do images of watching eyes discourage misreporting? An online experiment from China

BackgroundFew studies in China have examined correlates of internet health survey misreporting or the effect of interventions to mitigate misreporting. We conducted an experiment to: (1) identify correlates of survey misreporting, and (2) assess the impact of “watching eyes” images on survey misreporting. Exposure to watching eyes has been shown to discourage socially deviant behavior.MethodsIn 2022, a contract survey company recruited 1655 online survey respondents who were ≥ 18 years old and living in China. Participants were randomized to one of four arms. Participants randomized to arms 1 and 3 were asked to report their blood type. Participants randomized to arms 2 and 4 were also asked to report their blood type, but were additionally told they could end the survey early if they reported AB blood type. Participants randomized to arm 3 or 4 (but not arms 1 or 2) were shown an image of watching eyes before being asked to report their blood type.ResultsAmong participants with lower educational attainment, the probability of reporting AB blood type was higher if incentivized to report AB blood (19.05% vs 9.26%), though this difference was not statistically significant (p = 0.189). Among participants incentivized to report AB blood type, the probability of reporting AB blood type was significantly greater among individuals shown watching eyes (19.93% vs 11.56%, p < 0.01).ConclusionInternet health surveys in China must begin assessing and mitigating participant misreporting. Larger studies are needed to elucidate potential mechanisms of association between socioeconomic status, participation incentives, and internet survey misreporting. Exposure to watching eyes may decrease participatory engagement and cooperation.

Blood group AB is associated with reduced blood loss but also elevated cardiovascular mortality in aortocoronary bypass surgery.

Patient blood group (BG) is predictive for von-Willebrand-factor (VWF) and Factor VIII variation. The clinical impact of this ABO-effect on blood loss, cardiovascular complications and outcome has been described for several patient cohorts. The aim of this study was to investigate the impact of patient BG on blood loss and outcome after coronary artery bypass surgery (CABG). Patient records, intraoperative data and perioperative transfusion records of 5713 patients receiving an on-pump CABG procedure between 05/2004 and 12/2018 were analyzed. A logistic regression model for death due to perioperative myocardial ischaemia (PMI) was developed from initially 24 variables by using an univariate and multivariate selection process. BG AB patients required less blood transfusions as compared to the other blood groups, especially in case of emergency operations. However, BG AB patients also had a higher mortality which was due to secondary cardiovascular complications. The impact of blood type on the rate of cardiovascular mortality was confirmed in the logistic regression model. BG AB patients have a worse outcome after CABG surgery due to an increased incidence of fatal cardiovascular complications. As perioperative myocardial ischemia due to graft occlusion appears to be the most likely explanation, stricter anticoagulation for BG AB patients should be discussed.

Distribution of ABO-Rh Blood Group System Among the Students at Shah Abdul Latif University Khairpur, Pakistan

Background: The distribution of ABO and Rh blood groups significantly varies across different populations and is crucial for effective blood bank management and transfusion services. Previous studies have shown diverse patterns in blood group distribution globally, influenced by regional, ethnic, and demographic factors. Objective: This study aimed to analyze the distribution of ABO and Rh blood groups among the student population at Shah Abdul Latif University (SALU), Sindh, Pakistan, and to understand its implications for local healthcare services. Methods: A cross-sectional study was conducted involving 253 students (133 males and 120 females) aged 18 to 24 years. Informed consent was obtained from all participants. The study employed a sterile lancet for blood sample collection via a finger prick. Blood group phenotyping was done using the slide method with monoclonal antiserum A, B, and D. Agglutination results were recorded to determine the ABO blood group and Rh factor. Data analysis was conducted using the Statistical Package for the Social Sciences (SPSS) version 25. Results: The study found that 21.7% of students belonged to blood group A (49.1% Rh positive and 5.5% Rh negative in males, 40% Rh positive and 5.5% Rh negative in females), 35.2% to blood group B (38.2% Rh positive and 6.7% Rh negative in males, 52.8% Rh positive and 2.3% Rh negative in females), 11.1% to blood group AB (57.1% Rh positive in males, 39.3% Rh positive in females), and 32.0% to blood group O (54.3% Rh positive and 2.5% Rh negative in males, 38.3% Rh positive and 4.9% Rh negative in females). Conclusion: The distribution of ABO and Rh blood groups in the student population at SALU exhibits a distinct pattern, emphasizing the importance of regional studies in blood group distribution. These findings have significant implications for blood bank management, transfusion services, and healthcare planning in the region.

Correlation between antibody levels and long-term symptoms in survivors of COVID-19: health outcomes and societal implications

Aims: It was aimed to evaluate the relationship between antibody levels, demographic characteristics, and ongoing symptoms of people who have positive COVID-19 real-time PCR (RT-PCR) tests and donated plasma after the disease. Methods: Patients who voluntarily donated plasma were called by phone, and 105 patients who wanted to participate in the survey were included in the study. Ongoing symptoms, antibody test results, demographic characteristics, and other data of the participants were recorded. Results: IgM was high in patients whose first complaint was fever and muscle pain at the onset of the disease and who used favipiravir for treatment (p=0.030, p=0.035, p=0.007). In those who survived the disease, it was determined that the IgM level decreased after the peak in the first month and the IgG level in the third month; the results were statistically significant. The IgG level decreased with the elapsed time and smoking, and the IgG level was found to be high in those who used favipiravir, hydroxychloroquine, or both during the disease and those in the AB blood type. Conclusion: Some symptoms may persist even after the COVID-19 infection has been overcome. This study will contribute to a better understanding of this disease and the process after it.

Incidence of ABO Blood Groups in Patients with Oral Cancer, Premalignant Conditions, and Lesions: A Prospective Observational Study

Abstract Aim of the Study: The aim was to assess the incidence and to correlate ABO blood groups in patients with oral cancer, premalignant conditions, and lesions. Materials and Methods: It is a prospective observational study. ABO blood grouping was done on 120 cases, of which 60 were with oral cancer, 20 with oral submucous fibrosis, 20 with leukoplakia, and 20 with lichen planus. About 120 healthy subjects were selected after randomization. The obtained data were subjected to statistical analysis. Results: Out of 120 precancerous and cancerous cases, 26 had blood group A (21.6%), 46 had blood group B (38.3%), 5 had blood group AB (4.2%), and 43 had blood group O (35.83%). Among the controls, out of 120 subjects, 24 had blood group A (20%), 40 had blood group B (33.33%), 5 had blood group AB (4.2%), and 51 had blood group O (42.5%). The strength of association between was assessed using the odd’s ratio and found that people with blood group B had 1.24 times higher risk of developing oral precancerous and cancerous lesions compared to people of other blood groups. The relative risk was 1.11 for people with blood group A and 1 for those with blood group AB. The relative risk for people with blood group O was 0.75. Conclusions: In the present study, it was found that people with blood group B are at a greater risk of developing oral malignancies, followed by those with blood group A, AB, and O.

Prospective study of ABO and Rh blood group frequency and distribution among health-care professional students at Hassan Institute of Medical Sciences, Hassan

Background: The presence of immunologically competent agglutinogens in ABO and Rhesus (Rh) system makes these blood groups clinically important. The distribution frequency of these blood groups in various geographical regions is essential for the maintenance of blood bank records, for research studies, etc. This helps in safe transfusion during emergency. Many population-based research works were conducted on the prevalence of blood agglutinogens. The lack of data on these blood antigens among young health-care professional students prompted the conduct of this study on blood groups. Aims and Objectives: The aims and objectives of the study are to ascertain blood group frequencies among health-care professional students and to obtain prospective group of Rh-negative blood donor database. Materials and Methods: Research was accomplished on 400 health-care professional students of HIMS, Hassan, in department of physiology after going through knowledge, attitude, and practice questionnaire. Blood grouping was done by collecting blood from participants by finger prick method on glass slides. Results: In participants, the most common blood group was O (40.8%) with decreasing prevalence of B (34.3%), A (18%), and AB (7%). The frequency of Rh-positive and negative groups was 95.5% and 4.5%, respectively. Conclusion: Among participants, blood group O and blood group AB was most and least common, respectively. The frequency of Rh positive was far higher compared to Rh-negative groups.

A novel method to predict white blood cells after kidney transplantation based on machine learning

Background Abnormal white blood cell count after kidney transplantation is an important adverse clinical outcome. The abnormal white blood cell count in patients after surgery may be caused by the use of immunosuppressive agents and other factors. A lower white blood cell count than normal will greatly increase the probability of adverse outcomes such as infection and reduce the success rate of surgery. Objective To establish a machine learning prediction model of leukocyte drop to abnormal level after kidney transplantation, and provide reference for clinical treatment. Methods A total of 546 kidney transplant patients were selected as the study subjects. The time correlation feature of the ratio of the duration time of each variable to the total time in different intervals was innovatively introduced. Least absolute shrinkage and selection operator algorithm was used for correlation analysis of 85 candidate variables, and the top 20 variables were retained in the end. Eight machine learning algorithms, including Logistic-L1, Logistic-L2, support vector machine, decision tree, random forest, multilayer perceptron, extreme gradient boosting and light gradient boosting machine, were used for the five-fold cross-validation on all data sets, and the algorithm with the best performance was selected as the final prediction algorithm based on the average area under the curve. Results As the final prediction model, the accuracy, sensitivity, specificity and area under the curve values of the multilayer perceptron model in test set were 71.34%, 61.18%, 82.28% and 77.30%, respectively. The most important factors affecting leukopenia after surgery were the proportion of time of lymphocyte less than normal, blood group AB, gender, and platelet CV. Conclusions The multilayer perceptron model explored in this study shows significant potential in predicting abnormal white blood cell counts after kidney transplantation. This model can help stratify risk following transplantation, subject to external and/or prospective validation.

ABO and Rh Blood Group Association with Maternal and Neonatal Outcomes

ABSTRACT Background and Objectives: ABO and Rh blood types are known to have associations with health and disease, but studies on their relationship to pregnancy outcomes have been largely inconclusive. We aimed to examine the associations between ABO and Rh blood groups in pregnant women with maternal–neonatal characteristics and outcomes including hypertensive disorders of pregnancy, gestational diabetes, cesarean section rate, preterm birth, postpartum quantitative blood loss, birth weight, and appearance, pulse, grimace, activity, and respiration scores. Methods: At the time of delivery, 2497 consecutive patients were tested for ABO and Rh blood groups. Only those who delivered singleton infants were included in the analysis (2392 patients, 95.8%). Demographic and clinical data were obtained from the electronic medical record. Associations between blood groups and maternal–neonatal characteristics and outcomes were assessed using logistic regression models. A significance threshold of 0.05 was used for all comparisons. Results: Of the 2392 delivering patients, 46.9% were blood group O, 37.5% were blood group A, 12.2% were blood group B, and 3.4% were blood group AB. In addition, 85.9% were Rh-positive and 14.1% Rh-negative. A total of 2127 (88.9%) women delivered at term. The cesarean section rate was 32.4%, 183 (7.7%) had chronic hypertension, 275 (11.5%) had gestational diabetes, and 396 (16.6%) had a postpartum hemorrhage. The median birth weight was 3330 g (interquartile range 2940–3640). No blood groups were significantly associated with these characteristic and outcome measures. Conclusion: At the time of delivery, no significant associations were identified between ABO and Rh blood groups and maternal–neonatal characteristics and outcomes in this delivery cohort of over 2000 women.

Exploring the Link: A Cross-Sectional Study on the Correlation Between Periodontal Health and ABO &amp; Rh Blood Group Phenotype in Intellectually Disabled Individuals of Dakshina Kannada District

Background and Aim Across the globe individuals with intellectual disabilities ID are frequently noted to exhibit inferior oral hygiene and periodontal health. Previous research has demonstrated a link between periodontal health and blood grouping among apparently healthy individuals with periodontitis patients. This study attempted to assess a relationship between periodontal health and blood grouping phenotypes among individuals with intellectual disabilities in Dakshina Kannada District.Methods In Dakshina Kannada district a cross-sectional survey was conducted among 548 intellectually disabled individuals enrolled in special needs institutions. Among them 115 individuals were identified as having Down syndrome while the remaining 433 individuals had other intellectual disabilities. During the survey oral hygiene indices such as Oral Hygiene Index Simplified OHI-S Gingival index GI and Periodontal Screening and Recording PSR index were measured and ABO blood group patterns were established through self-reports verified by medical records.Results Among 548 intellectually disabled individuals distribution of blood group was as follows 32.11 had blood group A 26.64 had blood group B 23.90 had blood group O and 17.33 had blood group AB. Results of our research indicated that Down syndrome individuals with blood group lsquoOrsquo 41.7 and Rh lsquopositiversquo 58.26 were more susceptible to periodontitis.Conclusion Among intellectually disabled individuals there exists a robust correlation between periodontal health and ABO blood group phenotypes.

Association of ABO/Rh Blood Group with Hypertension in Pre and Postmenopausal Libyan women

BACKGROUND AND AIM: Hypertension is a prevalent and significant public health issue worldwide, affecting a substantial portion of the population. While various risk factors have been implicated in the development of hypertension, including genetics, lifestyle, and hormonal changes, the role of ABO/Rh blood groups in hypertension remains underexplored, particularly in different stages of Libyan women’s life. This research study aimed to investigate the potential association between ABO/Rh blood groups and hypertension in both pre- and post-menopausal Libyan women. METHODOLOGY: A cross sectional study was conducted over a four-month period on a diverse cohort of women aged 35 to 75 years. It involved a total of 200 hypertensive women divided into pre- (n=100) and post-menopausal (n=100) groups. It took place at Tripoli University Hospital, Tajoura Heart Centre and Total Care Clinic. Data were collected through structured interviews, clinical examinations, and blood sample analyses. Blood pressure (BP) measurements and blood group typing were performed using standard medical procedures. A statistical analysis was performed using SPSS program version 26.0. RESULTS: The distribution of ABO blood groups shows that blood group O is the most prevalent blood group among samples (58% in the pre-menopausal and 41% in post-menopausal hypertensives), whereas blood group AB is the least prevalent (only 9% in the pre-menopausal and 7% in post-menopausal hypertensives). One hundred and eighty-one (90.5%) were Rh +ve. Analysis of data revealed significant differences in age distribution as well as in the percentages of Rh +ve and Rh -ve blood groups among pre- and post-menopausal women (p&lt;0.05). However, there was no statistically significant difference in the mean values of BP indices between ABO/Rh blood groups (p&gt;0.05).CONCLUSION: This study showed that ABO/Rh blood group system does not significantly affect BP indices among the pre-menopausal and post-menopausal women. Findings of present study also illustrated that age could potentially influence the connection between blood groups and hypertension. Additionally, among ABO/Rh blood groups, the most observed type was 'O.' However, further investigation is necessary to validate these initial results and better understand the underlying mechanisms behind this relationship

ABO/Rh Blood Group and Cervical Cancer Survival: Results from Our Own and Other Studies.

Background: Cervical cancer is the most common genital cancer worldwide and is mainly caused by a persistent human papillomavirus infection. Well-known prognostic factors are age, histology, stage, stromal invasion, tumor size, and tumor grade. The relationship between the ABO and Rh system with cervical cancer has been studied since the 1950s, though without obtaining clear results. Here we investigated the association between the ABO blood group and Rh system and consecutively treated cervical cancer patients in our department. Methods: Clinical charts of cervical cancer patients treated and followed from 2010 to 2021 were checked for inclusion and exclusion criteria. Clinical and pathological data were recorded in a separate, anonymous, password-protected electronic database. All relevant data were extrapolated and used for final analysis. Results: A population of 143 cervical cancer patients was analyzed in this study. 47.6% (68/143) were blood group O, 36.4% (52/143) were blood group A, 8.4% (12/143) were blood group AB, and 7.7% (11/143) were blood group B. 14.9% (21/141) were RhD negative, while 85.1% (120/141) were RhD positive. No significant association was found between the ABO group and survival. However, patients with blood types B and AB had a higher BMI than the other blood types. RhD-negative patients exhibited a lower age at diagnosis (P=0.035) and had a higher overall survival compared to RhD-positive patients. Conclusions: The RhD factor appears to influence cervical cancer OS, but the data are too weakly significant to draw a definitive conclusion. Further studies with larger samples are needed to confirm this finding and to investigate the true impact of blood groups in female cancers.

ABH status sekretora među studentima univerziteta u kalabaru, Nigerija

Introduction: Secretor status is a critical component of human biology that depends on specific glycoproteins in body fluids and secretions. Its importance lies in its significant impact on health and disease, making it a compelling subject for medical research. This study aimed to determine the prevalence and understanding of secretor status among undergraduates at the University of Calabar, Nigeria. The findings could revolutionize our understanding of secretor status and open new research opportunities. Materials and Methods: The study used across-sectional approach, analyzing blood samples from 100 undergraduate students using the adsorption-inhibition method. Most participants were single (94.0%), and the majority were 100-level students (51.0%). 48 students were in the 21 to 28-year range, while 6.0% were 30 or older. Results: The findings of this study are significant, revealing that a substantial proportion of the participants were secretors, 82 (82.0%), while 18 (18.0%) were non-secretors. Interestingly, most participants (83.0%) were unaware of their secretor status, indicating a potential knowledge gap. Blood group O had the highest number of secretors, 58 (96.7%), followed by blood group A 11 (55.0%), blood group B 7 (63.6%), and the minor blood group AB 6 (66.7%). The most prevalent ethnic group was found among the Efiks (18.1%) followed by Yakurr (16.6%) and the least the Ijaws (3.8%). Conclusion: This study underscores the importance of public education and awareness regarding secretor status and its impact on health and disease.

Clinical Value of Routine Biomarkers for Colorectal Patients: a Retrospective Study.

Colorectal cancer (CRC) has always been one of the most common malignant tumors in the world. Whether the factors related to the diagnosis and risk of CRC can be found from the existing peripheral blood routine indicators. The relevant data of patients with colorectal diseases in our hospital of about ten years were collected, the differences among the biomarkers in serum were analyzed, the risk factors were analyzed by logistic regression, the ROC was drawn, and the diagnostic efficacy was evaluated. Colorectal malignancies and benign diseases in AST, GGT, LDH, D-BIL, ALB, ALP, AchE, CR, TP, PA, RDW, LMR, NMR, TC, TG, HDL-C, CA19-9, CEA, Cyfra21-1, and Fer have statistical differences (p < 0.05). ALB, PLR, CEA, Fer, NLR, TP, GGT, and Cyfra21-1 in different malignant tumor types have statistical differences (p < 0.05). When CEA increased by 1, the risk of colorectal cancer increased by 45.7%. When AchE and HDL-C increased by 1, the risk of colorectal cancer decreased by 32% and 66.8%. Compared with other blood groups, blood group AB colorectal cancer patients had a shallower tumor invasion (p = 0.047). HDL-C were significantly weakly-correlated with tumor size (p < 0.05, |r| < 0.4). CEA, AchE, and HDL-C were combined diagnosed; the sensitivity, PPV, and accuracy were 94.35%, 95.43%, 90.77%, respectively. The occurrence and development of colorectal cancer is the result of multi-factors, and the combined detection of multi-indicators has positive significance for the diagnosis, pathological stage, and prevention of CRC.

Distribution of ABO and Blood Groups among various Caste and Ethnic Groups – A cross-sectional Hospital Based Study in a Teaching Hospital of Western Nepal

Introduction: Red blood cells contain antigens on its membrane which are inherited according to Mendelian Law. Despite the identification of more than 400 red blood cell antigens, ABO and Rhesus blood group systems are clinically most significant. The current study aimed at determining the distribution of blood groups among different caste and ethnic groups of Western Nepal. Methods: A descriptive cross-sectional study conducted among individuals in the Blood Bank of Department of Pathology of a Teaching Hospital from January 2018 to July 2019. Ethical approval was taken from the Institutional Review Committee (Ref. 384). Convenient sampling was done. Data were entered in Microsoft Excel and analysed using Statistical Package for the Social Sciences version 21.0. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: In ABO system, the frequency of O, A, B and AB blood groups were found to be 960(33.9%) (95% Confidence Interval= 32.15-35.64), 930(32.8%) (95% Confidence Interval= 31.11-34.57), 716(25.3%) (95% Confidence Interval= 23.68-26.88) and 226(8.0%) (95% Confidence Interval=6.98-8.98) respectively. Rh positive was the dominant Rhesus blood group, 2758(97.4%) (95% Confidence Interval=96.73-97.94). Blood group O was dominant in Brahmin, Bishwakarma, Gurung, Pariyar, Tamang, Terai Brahmin and Limbu. Conclusions: The frequency distribution pattern of ABO blood group was observed as blood group O&gt;A&gt;B&gt;AB. Variation in the blood group distribution was observed in different ethnic groups.

Relationship between Maternal ABO Blood group and pregnancy complications of adichunchanagiri hospital B.G Nagara -A cross sectional study

ABO blood group has been divulged as a risk factor for perceptible diseased states. The ABO blood group differences may put a patient at specific risk according to their inherited antigens among the obstetrical syndromes like Intrauterine growth restriction, Pre-eclampsia and pre-term labour. Studies conducted have shown Group O individuals had lowest plasma von Willebrand factor and non O group had elevated level of this factor which showed increased thrombotic risk among these individuals. The earlier studies conducted have focused only on preeclampsia but not on other complications of pregnancy and the data available is scarce. The study aims to determine whether maternal ABO blood groups contribute to adverse pregnancy outcomes especially in this part of the country.The study was conducted on 50 pregnant women who were having complications of pregnancy including preeclampsia (PE), cases of Pregnancy induced hypertension (PIH), Gestational Diabetes mellitus (GDM) were considered as study cases and 50 pregnant women with normal pregnancy without any complications were categorized as controls. The study was conducted for a period of 6 months among patients attending Obstetrics and Gynecology department of Adichunchanagiri hospital selected based on convenience sampling procedure. Maternal ABO Blood group of the subjects were determined by Haemagglutination technique.Relationship between maternal ABO Blood group and Pregnancy complications (PE, PIH.GDM) was estimated by calculating odds ratio from logistic regression models using Blood Group O as a reference group and p – value of &amp;#60; 0.05 was considered as statistically significant. The results of the present study have found that maternal AB blood group was highest among preeclampsia and PIH category of cases.The present study conducted have found maternal AB blood group was highest among PIH and preeclampsia category of casesFrom the study conducted we want to conclude non-O blood group had the highest risk compared to O Blood group among pregnancy complications.

Childhood and adulthood passive and active smoking, and the ABO group as risk factors for pancreatic cancer in women.

Active smoking and the A blood group are associated with pancreatic adenocarcinoma (PC) risk. However, potential interactions between those risk factors and the role of passive smoking have been little investigated. We aimed to explore specific and joint associations of passive and active smoking, and effect modification by the ABO blood group in French women. The study included 96,594 women from the E3N prospective cohort, mean age: 49years (SD 6.7). Information on active and passive smoking was reported at inclusion and throughout follow-up. Cases were classified according to the International Classification of Diseases 10. Associations with passive and active smoking and effect modification by the ABO blood group were investigated with multivariable Cox regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI). During a 24-year median follow-up, 346 incident PC cases were identified. Current smoking compared with never and former smoking (HR 1.51 [95% CI 1.08-2.10]), and passive smoking in childhood compared with no childhood exposure (HR 1.47 [95% CI 1.08-2.00]) were associated with increased PC risk, but not passive exposure in adulthood (HR 1.16 [95% CI 0.91-1.47]). Exposure to both passive smoking in childhood and current smoking was associated with a stronger risk (HR 2.80 [95% CI 1.42-5.52]) than exposure to both current smoking and passive smoking only in adulthood (HR 1.68 [95% CI 1.10-2.57]) compared with neither passive nor active smoking. Associations between active smoking and PC risk were strongest in the O or B groups, while associations with passive smoking were strongest in the A or AB blood groups, but the interaction terms were not statistically significant. Both current smoking and passive smoking in childhood were associated with PC risk, with a maximal risk of current smokers exposed to passive smoking during childhood. Possible interactions between blood groups and active or passive smoking must be investigated in a larger series.