Abstract
This article is to review the research progress of the sustained-release effect of triple anti-tuberculosis drugs carried by calcium sulfate/poly-amino acid compound in bone tuberculosis lesion, and to investigate the biocompatibility, sustained-release and antituberculosis properties of calcium sulfate/poly-amino acid compound materials from the aspects of tissue engineering modification. Papers from January 2000 to February 2019 are retrieved in PubMed database and Web of Science database. Searching words are “bone tuberculosis, biocompatibility, sustained release, anti-tuberculosis, calcium sulfate/poly-amino acid”. A total number of 26 articles were included. After the artificial sustained release system of calcium sulfate/poly-amino acid containing triple anti-tuberculosis drugs was put into the bone tuberculosis lesion, the anti-tuberculosis drugs could be released slowly and continuously for up to three months according to results of the related papers. This locally sustained release effect is caused by the direct diffusion of anti-tuberculosis drugs from the carriers and the dispersion of drugs caused by the exposure of drug groups between calcium sulfate crystals after the degradation of the artificial material. The drug concentrations of the three antituberculosis drugs in the bone and lumbago major muscle tissues at each detection time point were higher than those in venous blood. Three anti-tuberculosis drugs carried by calcium sulfate/poly-amino acid compound can be simultaneously released and sustained-released into the bone lesion. It is more efficient and faster to kill tuberculosis bacillus than the single-drug slow-release material which was previously studied, and consistent with the principle of using anti-tuberculosis drugs.
Published Version
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