Abstract
The incidence of bone and joint tuberculosis is the highest in extrapulmonary tuberculosis, accounting for 3%-5% of all TB cases and 35%-50% of extrapulmonary tuberculosis. Currently, the clinical treatment is generally excision of the necrotic lesions and then putting anti-tuberculosis drugs to clear the residual tubercle bacillus. However, the drug powders within will soon be washed away by body fluids. Sustained drug loaded scaffolds would on the one hand recover the remaining defect and rebuild the tissues and on the other hand offer sustained local drug release to desired places. Therefore, the efficacy of anti-TB drugs within the organization will be improved greatly and the side effects will be reduced, which is of great clinical value. In this paper, the latest research progress of sustained anti-tuberculosis drug loaded scaffolds is reviewed to provide some ideas for the design of new anti-tuberculosis drug loaded scaffolds. Key words: Bone and joint tuberculosis; Composite scaffolds; Sustained release
Published Version
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