The effects of various antihypertensive drug treatment on pulse wave velocity in patients with essential hypertension

Abstract

Objective To evaluate the effects of various antihypertensive drug treatment on Brachialankle pulse wave velocity(baPWV) in patients with essential hypertension.Methods 120 patients with essential hypertension were randomly divided into four group treated various antihypentive drug.Group A 30 cases( levamlodipine besylate 2.5 mg once daily),group B 30 cases(perindopril 4 mg once daily),group C 30 cases ( metoprolol succinate sustained-release tablets 47.5 mg once daily),group D 30 cases(valsartan 80 mg once daily) for twelve weeks and thirty health persons with normal blood pressure as the control group.The levels of serum blood lipid and blood glucose,systolic blood pressures(SBP),diastolic blood pressures(DBP)and baPWV were measured respectively in patients with essential hypertension and healthy persons with normal blood pressure.After twelve weeks treatment respectively,the SDP,DBP and baPWV were measured again and were studied in patients with essential hypertension.Results The level of total blood cholesterol(TC) and low-density lipoprotein cholesterol(LDL-C) and SBP,DBP and baPWV in patients with essential hypertension were higher significantly than that of healthy persons with normal blood pressure(P ＜ 0.05).There were no significant difference in levels of blood glucose in patients with essential hypertension and control group(P ＞ 0.05).The SBP,DBP and baPWV were decreased significantly in all four groups( P ＜ 0.05)after treatment.There were significant difference in reduction of systolic blood pressures(△SBP)(30.6 ± 6.7) mm Hgvs(20.7 ± 5.3) mm Hg、(19.6 ± 6.1) mm Hg 、(21.5 ± 4.3) mm Hg and of diastolic blood pressures(/ DBP)(20.8 ± 7.1) mm Hgvs(13.97 ± 7.6) mm Hg、(14.1 ± 6.8) mm Hg、(14.9 ± 4.2) mm Hg in levamlodipine besylate group and the other three groups(P ＜ 0.05).Conclusion levamlodipine besylate,perindopril,metoprolol succinate sustained-release tablets and valsartan can decreased pulse wave velocity,impore elasticity of large arterise and increase the distensibility of aorta in patients with essential hypertension Key words: Essential Hypertension; Pulse wave velocity; Evamlodipine besylate; Perindopril; Metoprolol succinate sustained-release tablets